Current Topics in Developmental Biology最新文献_第2页

Retinoic acid homeostasis and disease. 视黄酸平衡与疾病

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1016/bs.ctdb.2024.11.001

Maureen A Kane

{"title":"Retinoic acid homeostasis and disease.","authors":"Maureen A Kane","doi":"10.1016/bs.ctdb.2024.11.001","DOIUrl":"10.1016/bs.ctdb.2024.11.001","url":null,"abstract":"Retinoids, particularly all-trans-retinoic acid (ATRA), play crucial roles in various physiological processes, including development, immune response, and reproduction, by regulating gene transcription through nuclear receptors. This review explores the biosynthetic pathways, homeostatic mechanisms, and the significance of retinoid-binding proteins in maintaining ATRA levels. It highlights the intricate balance required for ATRA homeostasis, emphasizing that both excess and deficiency can lead to severe developmental and health consequences. Furthermore, the associations are discussed between ATRA dysregulation and several diseases, including various genetic disorders, cancer, endometriosis, and heart failure, underscoring the role of retinoid-binding proteins like RBP1 in these conditions. The potential for gene-environment interactions in retinoid metabolism is also examined, suggesting that dietary factors may exacerbate genetic predispositions to ATRA-related pathologies. Methodological advancements in quantifying ATRA and its metabolites are reviewed, alongside the challenges inherent in studying retinoid dynamics. Future research directions are proposed to further elucidate the role of ATRA in health and disease, with the aim of identifying therapeutic targets for conditions linked to retinoid signaling dysregulation.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"201-233"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination of nephrogenesis with branching of the urinary collecting system, the vasculature and the nervous system. 肾形成与泌尿系统、脉管系统和神经系统分支的协调。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.ctdb.2024.11.008

Dagmar Iber, Malte Mederacke, Roman Vetter

引用次数: 0

Kidney development at a glance: metabolic regulation of renal progenitor cells. 肾脏发育概览：肾祖细胞的代谢调节。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.ctdb.2024.11.009

K Kurtzeborn, S S El-Dahr, N Pakkasjärvi, G G Tortelote, S Kuure

{"title":"Kidney development at a glance: metabolic regulation of renal progenitor cells.","authors":"K Kurtzeborn, S S El-Dahr, N Pakkasjärvi, G G Tortelote, S Kuure","doi":"10.1016/bs.ctdb.2024.11.009","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2024.11.009","url":null,"abstract":"The aberrant regulation of renal progenitor cells during kidney development leads to congenital kidney anomalies and dysplasia. Recently, significant progress has been made in understanding the metabolic needs of renal progenitor cells during mammalian kidney development, with evidence indicating that multiple metabolic pathways play essential roles in determining the cell fates of distinct renal progenitor populations. This review summarizes recent findings and explores the prospects of integrating this novel information into current diagnostic and treatment strategies for renal diseases. Reciprocal interactions between various embryonic kidney progenitor populations establish the foundation for normal kidney organogenesis, with the three principal kidney structures-the nephrons, the collecting duct network, and the stroma-being generated by nephron progenitor cells, ureteric bud/collecting duct progenitor cells, and interstitial progenitor cells. While energy metabolism is well recognized for its importance in organism development, physiological function regulation, and responses to environmental stimuli, research has primarily focused on nephron progenitor metabolism, highlighting its role in maintaining self-renewal. In contrast, studies on the metabolic requirements of ureteric bud/collecting duct and stromal progenitors remain limited. Given the importance of interactions between progenitor populations during kidney development, further research into the metabolic regulation of self-renewal and differentiation in ureteric bud and stromal progenitor cells will be critical.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"15-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinoids and retinoid-binding proteins: Unexpected roles in metabolic disease. 维甲酸和维甲酸结合蛋白：代谢性疾病中的意外作用

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1016/bs.ctdb.2024.10.001

William S Blaner, Jisun Paik, Pierre-Jacques Brun, Marcin Golczak

{"title":"Retinoids and retinoid-binding proteins: Unexpected roles in metabolic disease.","authors":"William S Blaner, Jisun Paik, Pierre-Jacques Brun, Marcin Golczak","doi":"10.1016/bs.ctdb.2024.10.001","DOIUrl":"10.1016/bs.ctdb.2024.10.001","url":null,"abstract":"Alterations in tissue expression levels of both retinol-binding protein 2 (RBP2) and retinol-binding protein 4 (RBP4) have been associated with metabolic disease, specifically with obesity, glucose intolerance and hepatic steatosis. Our laboratories have shown that this involves novel pathways not previously considered as possible linkages between impaired retinoid metabolism and metabolic disease development. We have established both biochemically and structurally that RBP2 binds with very high affinity to very long-chain unsaturated 2-monoacylglycerols like the canonical endocannabinoid 2-arachidonoyl glycerol (2-AG) and other endocannabinoid-like substances. Binding of retinol or 2-MAGs involves the same binding pocket and 2-MAGs are able to displace retinol binding. Consequently, RBP2 is a physiologically relevant binding protein for endocannabinoids and endocannabinoid-like substances and is a nexus where the very potent retinoid and endocannabinoid signaling pathways converge. When Rbp2-null mice are challenged orally with fat, this gives rise to elevated levels in the proximal small intestine of both 2-AG and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) in the proximal small intestine. We propose that elevation of GIP concentrations upon high fat diet feeding gives rise to obesity and the other elements of metabolic disease seen in Rbp2-null mice. Unexpectedly, we observed that RBP4 is present in secretory granules of the GIP-secreting intestinal K-cells and is co-secreted with GIP in response to a stimulus that provokes GIP secretion. Moreover, RBP4 is co-secreted along with glucagon from pancreatic alpha-cells in response to a secretory stimulus. The association during the secretory process of RBP4 with potent hormones that regulate metabolism (GIP and glucagon) accounts for at least some of the metabolic disease seen upon overexpression of Rbp4.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"89-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple roles for retinoid signaling in craniofacial development. 类视黄醛信号在颅面发育中的多重作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-07 DOI: 10.1016/bs.ctdb.2024.09.002

Masahiro Nakamura, Lisa L Sandell

{"title":"Multiple roles for retinoid signaling in craniofacial development.","authors":"Masahiro Nakamura, Lisa L Sandell","doi":"10.1016/bs.ctdb.2024.09.002","DOIUrl":"10.1016/bs.ctdb.2024.09.002","url":null,"abstract":"Retinoic acid (RA) signaling plays multiple essential roles in development of the head and face. Animal models with mutations in genes involved in RA signaling have enabled understanding of craniofacial morphogenic processes that are regulated by the retinoid pathway. During craniofacial morphogenesis RA signaling is active in spatially restricted domains defined by the expression of genes involved in RA production and RA breakdown. The spatial distribution of RA signaling changes with progressive development, corresponding to a multiplicity of craniofacial developmental processes that are regulated by RA. One important role of RA signaling occurs in the hindbrain. There RA contributes to specification of the anterior-posterior (AP) axis of the developing CNS and to the neural crest cells (NCC) which form the bones and nerves of the face and pharyngeal region. In the optic vesicles and frontonasal process RA orchestrates development of the midface, eyes, and nasal airway. Additional roles for RA in craniofacial development include regulation of submandibular salivary gland development and maintaining patency in the sutures of the cranial vault.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"33-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fertilization mechanisms in hermaphroditic ascidians and nematodes: Common mechanisms with mammals and plants. 雌雄同体海鞘和线虫的受精机制：哺乳动物和植物的共同机制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI: 10.1016/bs.ctdb.2025.01.010

Hitoshi Sawada, Takako Saito, Yoshihiro Shimada, Hitoshi Nishimura

引用次数: 0

The action of retinoic acid on spermatogonia in the testis. 维甲酸对睾丸精原细胞的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1016/bs.ctdb.2024.10.005

Shelby L Havel, Michael D Griswold

{"title":"The action of retinoic acid on spermatogonia in the testis.","authors":"Shelby L Havel, Michael D Griswold","doi":"10.1016/bs.ctdb.2024.10.005","DOIUrl":"10.1016/bs.ctdb.2024.10.005","url":null,"abstract":"For mammalian spermatogenesis to proceed normally, it is essential that the population of testicular progenitor cells, A undifferentiated spermatogonia (Aundiff), undergoes differentiation during the A to A1 transition that occurs at the onset of spermatogenesis. The commitment of the Aundiff population to differentiation and leaving a quiescent, stem-like state gives rise to all the spermatozoa produced across the lifespan of an individual, and ultimately determines male fertility. The action of all-trans retinoic acid (atRA) on the Aundiff population is the determining factor that induces this change. Sertoli cells, omnipresent, nurse cells within the mammalian testis are responsible for synthesizing the atRA that prompts this change in the neonatal testicular environment. The mechanism of atRA synthesis and signaling has been robustly explored and, in this review, we have summarized what is currently known about the action of testicular atRA at the onset of spermatogenesis. We have combined this with evidence gained from prominent genetic studies that have further elucidated the function of genes critical to atRA synthesis. We have additionally described the effects of the first pulse of atRA delivered to the germ cells of the testis, which has been investigated using WIN 18,446 treatment which prevents atRA synthesis and induces spermatogenic synchrony. This method provides unparalleled resolution into cell and stage specific testicular changes, and combined with transgenic animal models, has allowed researchers to elucidate much regarding the onset of spermatogenesis.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"143-166"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of chromatin-related epigenetic modulations in CAKUT. 染色质相关表观遗传调控在CAKUT中的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.ctdb.2024.11.006

Luise König, Miriam Schmidts

引用次数: 0

Understanding developing kidneys and Wilms tumors one cell at a time. 了解肾脏和肾母细胞肿瘤的一次一个细胞的发展。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-02-03 DOI: 10.1016/bs.ctdb.2024.11.005

Nine Solee Pop, Karamjit Singh Dolt, Peter Hohenstein

引用次数: 0

The multifaceted roles of retinoids in eye development, vision, and retinal degenerative diseases. 类维甲酸在眼睛发育、视力和视网膜退行性疾病中的多方面作用。