Current Topics in Developmental Biology最新文献_第2页

Regulation of erythroid development by iron metabolism. 铁代谢对红细胞发育的调节。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-08-20 DOI: 10.1016/bs.ctdb.2026.06.005

Muhammad Ishfaq, Yvette Y Yien

引用次数: 0

Olivocerebellar circuit development as a substrate for dystonia pathogenesis. 腰小脑回路的发育是肌张力障碍发病的基础。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/bs.ctdb.2025.11.003

Cheryl Brandenburg, Jason S Gill, Roy V Sillitoe

{"title":"Olivocerebellar circuit development as a substrate for dystonia pathogenesis.","authors":"Cheryl Brandenburg, Jason S Gill, Roy V Sillitoe","doi":"10.1016/bs.ctdb.2025.11.003","DOIUrl":"10.1016/bs.ctdb.2025.11.003","url":null,"abstract":"Despite the progress in identifying genetic and molecular contributors to dystonia, the synaptic and circuit mechanisms that disrupt motor maturation and serve as the substrate for disease pathogenesis are only beginning to emerge. In this chapter, we highlight evidence implicating the olivocerebellar node as a key site of pathogenesis in the dystonia network. As an example of aberrant olivocerebellar circuit activity leading to dystonia, here we examine a mouse model in which excitatory neurotransmission is silenced at inferior olive to cerebellum synapses upon Vglut2 mediated conditional complex spike knockout (CSKO mice). In this model, dystonic postures emerge postnatally in a time-locked manner coinciding with disrupted olivocerebellar circuit refinement. These mice fail to undergo typical transitions from rudimentary to coordinated motor behaviors, implicating cerebellar activity as a critical driver of motor maturation, which we link to clinical observations from human patients. Anatomical and physiological evidence suggests that loss of climbing fiber signaling impairs Purkinje cell and cerebellar nuclei development, disrupting cerebellar output. We propose that a subset of dystonia etiologies, conceptually, reflect perpetual immaturity of motor commands due to these cerebellar circuit deficits, potentially identifying critical periods to restore proper motor function. Formulating dystonia as an immature motor state raises the intriguing perspective that broader etiologies of dystonia (both cerebellar and otherwise) may in part reflect a reversion of the developed motor network, similar to how strokes and neurodegenerative diseases \"uncover\" primitive reflexes. As a result, the CSKO mouse model provides a framework for understanding diverse etiologies of dystonia and highlights cerebellar output as a promising therapeutic target across developmental and acquired forms.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"167 ","pages":"379-411"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles. 细胞间环核苷酸动力学介导哺乳动物排卵前卵泡卵母细胞减数分裂。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-04-30 DOI: 10.1016/bs.ctdb.2026.04.008

Jeremy R Egbert

{"title":"Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles.","authors":"Jeremy R Egbert","doi":"10.1016/bs.ctdb.2026.04.008","DOIUrl":"10.1016/bs.ctdb.2026.04.008","url":null,"abstract":"The cell cycle of the mammalian oocyte arrests in prophase around the time of birth and remains in meiotic arrest as it grows interdependently with increasing layers of surrounding somatic cells as a structure called an ovarian follicle. Within preovulatory follicles, gap junction communication between somatic cells and the oocyte allow cyclic nucleotides to maintain equilibrium concentrations that prevent premature meiotic resumption. Intercellular communication is also required for the mid-cycle surge in luteinizing hormone to alter cyclic nucleotide dynamics and cause the oocyte cell cycle to resume. In this review, the increasingly well-understood mechanisms by which meiotic arrest and meiotic resumption occur will be summarized, along with recent developments made possible by an improved cyclic nucleotide sensor and imaging techniques. These studies have uncovered new aspects of this process and helped clarify the required role of epidermal growth factor receptor signaling in meiotic resumption. Growing evidence that the cyclic nucleotide-associated participants in oocyte cell cycle regulation, first described in rodents, appear to be universal across mammals will also be summarized. This understanding has fostered new approaches to assisted reproductive technologies (ARTs) in domesticated animals and humans.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"169 ","pages":"193-235"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellar nuclei output pathways regulate motor and non-motor behaviors through forebrain circuits. 小脑核输出通路通过前脑回路调节运动和非运动行为。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-03-18 DOI: 10.1016/bs.ctdb.2026.01.009

Andrew S Lee, Alexandra L Joyner

{"title":"Cerebellar nuclei output pathways regulate motor and non-motor behaviors through forebrain circuits.","authors":"Andrew S Lee, Alexandra L Joyner","doi":"10.1016/bs.ctdb.2026.01.009","DOIUrl":"10.1016/bs.ctdb.2026.01.009","url":null,"abstract":"The adult cerebellum is involved in modulating most, if not all, behaviors via its direct or indirect projections throughout the central nervous system. Its involvement in higher order behaviors is most prominent in human, where the lateral cerebellum (hemispheres) has expanded along with areas in the cerebral cortex that regulate language, emotions and cognition. An important aspect of wiring of the brain, is how the circuitry is established during normal development and activity, compared to how it is established when a developmental defect occurs, such as an injury that kills cells or a genetic mutation that alters the activity of specific neurons or changes the transcriptional output. One way to assess the impact of these two modes of circuit formation is to compare the robustness of specific behaviors in rodents in the two conditions, and thereby infer what behaviors are normally controlled by specific cerebellar cells/regions and which behavior modules or neural circuits they participate in. Inhibition of groups of neurons in the adult brain has been used to define what behaviors the cells control. While such an approach can define neural circuit function under normal developmental conditions, it does not reveal the underlying ability of the neural circuits to rewire, or wire in a different way when faced with a developmental perturbation. In the latter, cells that normally would be involved in a behavior might no longer control the behavior and instead a new set of neurons might control the behavior. In this chapter, we address these issues by describing what is considered the normal functions of subgroups of the cerebellar nuclei output neurons based on inhibiting/lesioning neurons in the adult and compare this to how the circuits appear to function following disruption of neurons by inhibiting their activity, removing them or introducing gene mutations during development.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"167 ","pages":"135-175"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of macrophages in testis function. 巨噬细胞在睾丸功能中的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-04-25 DOI: 10.1016/bs.ctdb.2026.04.004

Satoko Matsuyama, Sudhanshu Bhushan, Tony DeFalco

{"title":"Role of macrophages in testis function.","authors":"Satoko Matsuyama, Sudhanshu Bhushan, Tony DeFalco","doi":"10.1016/bs.ctdb.2026.04.004","DOIUrl":"10.1016/bs.ctdb.2026.04.004","url":null,"abstract":"The testis is a unique organ that simultaneously supports spermatogenesis and steroidogenesis, and it must maintain host defense against infection while suppressing excessive immune responses in an environment that includes germ cell antigens that emerge after sexual maturation. Testicular macrophages reside in the testicular interstitium starting in fetal life and localize near Leydig cells and around seminiferous tubules. Through cytokine and lipid mediator production, phagocytosis of dying cells, and antigen presentation, testicular macrophages can influence both steroidogenesis and spermatogenesis. In this chapter, we summarize the key components underlying testicular immune privilege, including the blood-testis barrier (BTB), immunosuppressive factors, and immune cell constituents in the testis, and we provide an overview of the development and maintenance of testicular macrophages and their interactions with major testicular cell types such as Leydig cells. We also outline changes that occur during inflammation and summarize links between testicular macrophages and disease states, including infertility and aging. Finally, we discuss future research directions and potential intervention strategies focused on testicular macrophages.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"169 ","pages":"51-96"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell fate decision and lineage specification mechanisms in hematopoiesis. 造血过程中细胞命运决定和谱系规范机制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-08-11 DOI: 10.1016/bs.ctdb.2026.06.001

In-Won Lee, Yesenia Earth, Yoon-A Kang

引用次数: 0

Unraveling spermatogenesis: A single-cell genomics perspective. 解开精子发生：单细胞基因组学的观点。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-04-01 DOI: 10.1016/bs.ctdb.2026.03.003

Md Habibur Rahman, Huayu Qi, Tin-Lap Lee

{"title":"Unraveling spermatogenesis: A single-cell genomics perspective.","authors":"Md Habibur Rahman, Huayu Qi, Tin-Lap Lee","doi":"10.1016/bs.ctdb.2026.03.003","DOIUrl":"10.1016/bs.ctdb.2026.03.003","url":null,"abstract":"Spermatogenesis is a highly coordinated male developmental process essential for passing on genetic information and fertility. The process features a series of complex cellular and genomic transitions. The main objective of this review is to provide a synthesis of changes single-cell genomics have brought to the male germline. This review begins with an account of the journey from rudimentary, low resolution, and throughput microarray technologies to the advanced and sophisticated, high throughput single-cell RNA sequencing (scRNA-seq) technologies that have provided the means for the generation of extensive and comprehensive \"cell atlases\" of the testis. The review focuses on the resolution of long-standing controversies associated with the spermatogonial stem cells (SSCs) niche regarding continuum of germ cell differentiation, and germ cell differentiation and stem cell specification. The frontiers of single-cell based DNA techniques such as Single-Cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) and single-cell DNA methylation will then be discussed. We focus on the perinatal period crucial for the epigenetic priming of the foundational stem cell pool and chromatin remodeling that facilitates the histone-to-protamine transition. The regenerative capacity of the germline and the single-cell identified subsets and metabolic gates that are capable of restoring the ability to conceive post-injury tissues are also explored. Finally, we will go over the prospective views on the use of multi-omics and new spatial transcriptomics. These tools not only provide molecular components of interest within the cells, but also the cellular constituents of the seminiferous tubule and their spatial location within the tubule. This novel information will help translate the molecular discovery into potential clinical applications for male infertility treatment.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"168 ","pages":"429-451"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell shape dynamics during mouse peri-implantation development and embryo dormancy. 小鼠着床期发育和胚胎休眠期间的细胞形态动力学。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2025-11-05 DOI: 10.1016/bs.ctdb.2025.10.001

Deepthi Chandramohan, Fei Chen, Rui Chen, Ivan Bedzhov

引用次数: 0

Meiotic crossover control: Interplay between the recombination process and chromosome organization. 减数分裂交叉控制：重组过程与染色体组织之间的相互作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-01-28 DOI: 10.1016/bs.ctdb.2026.01.003

Shunxin Wang, Liangran Zhang

{"title":"Meiotic crossover control: Interplay between the recombination process and chromosome organization.","authors":"Shunxin Wang, Liangran Zhang","doi":"10.1016/bs.ctdb.2026.01.003","DOIUrl":"10.1016/bs.ctdb.2026.01.003","url":null,"abstract":"Meiosis exclusively occurs in the germ cells of eukaryotic organisms during sexual reproduction. A striking feature of this process is meiotic recombination, which results in the formation of DNA crossovers between the paternal and maternal chromosomes. Crossovers are pivotal in ensuring the accurate segregation of chromosomes during gamete formation, resulting in offspring that possess half of their progenitor's chromosome complement. Furthermore, crossovers play a crucial role in promoting genetic diversity within the offspring. The process of meiotic recombination is implemented in meiotic chromosomes by direct interaction between recombination complexes and the underlying loop/axis architecture of chromosomes. Consequently, CO patterning is subject to tight regulation by meiotic chromosome structures. Significant advances have been made in recent years in understanding the molecular mechanisms underlying these processes. We summarize the prevailing perspective on the organization of meiotic chromosomes, the meiotic recombination, with particular emphasis on CO patterning, and their interaction. We also provide a review of the current models for potential mechanisms for these processes.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"168 ","pages":"281-315"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular regulation of spermatogenesis: Insights from spatial transcriptomics. 精子发生的分子调控：来自空间转录组学的见解。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-02-03 DOI: 10.1016/bs.ctdb.2026.01.004

Fei-Chen Wang, Zhen He, Hai-Ping Tao, Qi-En Yang

引用次数: 0