Cytopathology最新文献

{"title":"Plasmablastic Lymphoma in the Submandibular Region Diagnosed by FNAC: A Case Report and Literature Review","authors":"Sibele Nascimento de Aquino,&nbsp;Cinthia Veronica Bardález López de Cáceres,&nbsp;Hélen Kaline Farias Bezerra,&nbsp;Pablo Agustin Vargas,&nbsp;Márcio Ajudarte Lopes","doi":"10.1111/cyt.13457","DOIUrl":"10.1111/cyt.13457","url":null,"abstract":"<p>FNAC is effective in the diagnosis of plasmablastic lymphoma. Immunophenotypic profile and morphological features are crucial for accurate diagnosis and cell block is an excellent tool for IHC. The literature review confirms the importance of FNAC as a diagnostic tool for PBL.</p><p>The authors present a literature review of FNAC-diagnosed plasmablastic lymphoma (PBL) cases and present a case of PBL in an HIV patient diagnosed by FNAC. Immunophenotypic profile and morphological features are crucial for accurate diagnosis and cell block is an excellent tool for IHC. The current study highlights the efficacy of FNAC in diagnosing PBL.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 2","pages":"187-196"},"PeriodicalIF":1.2,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine Needle Aspiration of CD20-Negative Diffuse Large B Cell Lymphoma Presenting as an Anterior Neck Mass","authors":"Connor Hartzell,&nbsp;Emily F. Mason,&nbsp;Christopher O'Conor","doi":"10.1111/cyt.13454","DOIUrl":"10.1111/cyt.13454","url":null,"abstract":"<p>Aggressive lymphoma of the neck presenting with life-threatening airway compromise requires quick diagnosis, which can be rendered with fine needle aspiration cytology. In atypical cases, using multiple B cell markers can be helpful to avoid misdiagnosis.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 2","pages":"197-200"},"PeriodicalIF":1.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Mimicker Cells in Cerebrospinal Fluid","authors":"Catherine M. Alexander,&nbsp;Luis F. Carrillo","doi":"10.1111/cyt.13453","DOIUrl":"10.1111/cyt.13453","url":null,"abstract":"<p>Germinal matrix cells are immature-appearing cells that can be present in the cerebrospinal fluid of premature neonates with intraventricular hemorrhage. These cells can mimic neoplastic cells and are an important morphologic pitfall.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 1","pages":"103-104"},"PeriodicalIF":1.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocytic-rich effusion","authors":"Jaiden Townsend,&nbsp;Miguel Perez-Machado","doi":"10.1111/cyt.13448","DOIUrl":"10.1111/cyt.13448","url":null,"abstract":"<p>Cytopathology plays a crucial role in the diagnosis and management of lymphocytic effusions, which are fluid collections rich in lymphocytes often associated with conditions like infections, malignancies, and autoimmune diseases. By examining the cytological features of the cells present in the effusion, cytopathologists can help distinguish between benign and malignant processes, identify specific infectious agents, and provide insights into underlying disease mechanisms. This information is vital for guiding treatment decisions and monitoring disease progression, making cytopathology an essential tool in the clinical evaluation of lymphocytic effusions.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 2","pages":"201-203"},"PeriodicalIF":1.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting Cholangiocarcinoma in the Setting of Primary Sclerosing Cholangitis: Is Biliary Tract Fluorescence In Situ Hybridization Helpful?","authors":"Lauren J. Miller,&nbsp;Isabella M. Holmes,&nbsp;Heather I. Chen-Yost,&nbsp;Brian Smola,&nbsp;Madelyn Lew,&nbsp;Judy Pang","doi":"10.1111/cyt.13452","DOIUrl":"10.1111/cyt.13452","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction/Objective</h3>\u0000 \u0000 <p>Biliary brushing cytology (BB) to detect cholangiocarcinoma (CCA) is integral in the surveillance of patients with primary sclerosing cholangitis (PSC). Since reactive changes can mimic carcinoma, indeterminant results are frequent. Fluorescence in situ hybridization (FISH) using the UroVysion probe set has been advocated to enhance the detection of CCA. This study evaluates the performance of FISH for detecting CCA in patients with and without PSC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A query of our pathology database for atypical and suspicious BB with concurrent FISH results was performed from 2014 to 2021. FISH (using UroVysion probe set containing centromere enumeration probes to chromosomes 3, 7, and 17) was positive if at least 5 cells demonstrated polysomy. Electronic medical records were reviewed to identify patients with PSC and CCA. CCA was confirmed by pathology or clinical impression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 65 patients (103 BB) in the PSC cohort, 59 patients (94 BB) without CCA and 6 patients (9 BB) with CCA were identified. 33 non-PSC patients (41 BB) with CCA were included for comparison. Positive FISH was highest in non-PSC patients with CCA (10/41 BB, 24%). Positive FISH was seen in both PSC with (1/9 BB, 11%) and without (2/94 BB, 2%) CCA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>FISH positivity was lower than expected and was positive in PSC patients without CCA. These results question the clinical utility of FISH for CCA surveillance in PSC patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 2","pages":"150-155"},"PeriodicalIF":1.2,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytology Is No Longer ‘Just Cytology’: The Clear Message of the XII. Congress of Molecular Cytopathology in Naples","authors":"Aleš Ryška","doi":"10.1111/cyt.13451","DOIUrl":"10.1111/cyt.13451","url":null,"abstract":"<p>The editorial summarises the key messages of the very successful XII. Congress of Molecular Cytopathology in Naples. The programme of this meeting covered many burning issues from all areas of cytology—from molecular testing to the role of liquid biopsy to the unification of terminology and its impact on patient management.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"35 6","pages":"662-663"},"PeriodicalIF":1.2,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical Approach to Reporting Based on the International System for Serous Fluid Cytopathology","authors":"Eliisa Viljanen,&nbsp;Ivana Kholová,&nbsp;Ashish Chandra","doi":"10.1111/cyt.13450","DOIUrl":"10.1111/cyt.13450","url":null,"abstract":"<p>The International System for Serous Fluid Cytopathology (TIS) is intended for reporting cytological specimens from serous cavities: pleural, abdominal and pericardial cavities. TIS is being adopted into practice in cytology laboratories worldwide. In this system, there are six diagnostic categories: non-diagnostic, negative for malignancy, atypia of undetermined significance, suspicious for malignancy, malignant-primary and malignant-secondary. Malignant-primary category almost always implies malignant mesothelioma and malignant-secondary usually refers to metastasis from carcinoma but also to involvement of serous cavity by haematolymphoid and other malignancies. When evaluating effusion cytological specimen adequacy, the factors that must be considered are sample volume, cellular content and cellular preservation. In the diagnostic analysis and interpretation, it is helpful to consider systematically all basic cytomorphological components in a sample. The basic components are architecture, cell populations, cell size, cytoplasm, nuclei and background elements. One important requirement for a successful evaluation of an effusion cytological specimen is sufficient clinical and radiological information in a referral. Clinical information may guide ancillary testing. In the present review, we provide a practical and educational approach to reporting serous effusion cytology based on the TIS.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 1","pages":"12-22"},"PeriodicalIF":1.2,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Medullary Thyroid Carcinoma Presenting as an Incidental Posterior Mediastinal Mass","authors":"Chaya Goldberg,&nbsp;DeAnna Diaz,&nbsp;Tamar Brandler","doi":"10.1111/cyt.13449","DOIUrl":"10.1111/cyt.13449","url":null,"abstract":"<p>Medullary thyroid carcinoma (MTC) is an uncommon neuroendocrine tumour that is usually asymptomatic at its onset and therefore may not present clinically until the patient has developed advanced or metastatic disease. Common metastatic sites include cervical lymph nodes, liver, bone and lung. This is the case of a patient who presented with an incidental posterior mediastinal mass. Because the posterior mediastinum is an unusual location for MTC, MTC was not a consideration and preliminary histopathological testing did not include calcitonin, which would have been diagnostic. This case highlights the importance of testing for calcitonin more regularly when encountering a mass of unknown origin with neuroendocrine morphology, which may lead to earlier detection of MTC and thus improved prognosis.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 1","pages":"71-74"},"PeriodicalIF":1.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare case of stromal predominant Wilm's tumour with rhabdomyoblastic differentiation in FNAC smears","authors":"Anjali Gupta,&nbsp;Radhika Srinivasan,&nbsp;Manish Rohilla,&nbsp;Nandita Kakkar,&nbsp;Nitin J. Peters","doi":"10.1111/cyt.13445","DOIUrl":"10.1111/cyt.13445","url":null,"abstract":"<p>The FNAC smear and histopathology of stromal predominant Wilm's tumour with rhabdomyoblastic Differentiation along with immunostaining in a 7-year-old male.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p><p>In this paper, the diagnostic potential of FNAC in identifying rare histological variants of paediatric renal tumours is highlighted.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 2","pages":"211-215"},"PeriodicalIF":1.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenosquamous carcinoma arising within a long-standing intrapulmonary bronchogenic cyst in an adult presenting with hyponatraemia","authors":"Adeyinka Akinsanya,&nbsp;Sheila Segura,&nbsp;Harvey Cramer,&nbsp;Hector Mesa","doi":"10.1111/cyt.13446","DOIUrl":"10.1111/cyt.13446","url":null,"abstract":"<p>A 74-year-old woman's persistent hyponatraemia led to the discovery of an adenosquamous carcinoma within an intrapulmonary bronchogenic cyst (IPBC), diagnosed 59 years prior. This is the first reported case of such a transformation in an IPBC.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p><p>An adenosquamous carcinoma, originating from an intrapulmonary bronchogenic cyst identified 59 years prior, was discovered during the workup for a patient's unexplained, persistent hyponatraemia.</p>","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":"36 1","pages":"75-78"},"PeriodicalIF":1.2,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}