Cytopathology最新文献

Breast Filariasis-Diagnosed by Fine Needle Aspiration Cytology: A Rare Case Report. 乳腺丝虫病-细针抽吸细胞学诊断：罕见病例报告。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-27 DOI: 10.1111/cyt.13510

Aarushi Soota, Anju Khairwa, Rohit Sharma, Mukesh Kumar

引用次数: 0

Unusual Pancreatic Metastasis of Solid Subtype Adenoid Cystic Carcinoma: Reappraisal of MYB and CD117 Immunostaining Utility in Liquid-Based Cytology. 实体亚型腺样囊性癌的异常胰腺转移：重新评估MYB和CD117免疫染色在液体细胞学中的应用。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-21 DOI: 10.1111/cyt.13512

Keita Jinnouchi, Yuki Teramoto, Miho Saeki, Masahiro Hirata, Hironori Haga

引用次数: 0

Diagnosing Malignant Epithelial Neoplasms of the Lung in Cytological Specimens: Cytomorphology, Ancillary Studies and Management. 肺恶性上皮肿瘤的细胞学诊断：细胞形态学、辅助研究和治疗。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-21 DOI: 10.1111/cyt.13511

Magdalena M Brune, Zubair Baloch, Lukas Bubendorf, Spasenija Savic Prince

{"title":"Diagnosing Malignant Epithelial Neoplasms of the Lung in Cytological Specimens: Cytomorphology, Ancillary Studies and Management.","authors":"Magdalena M Brune, Zubair Baloch, Lukas Bubendorf, Spasenija Savic Prince","doi":"10.1111/cyt.13511","DOIUrl":"https://doi.org/10.1111/cyt.13511","url":null,"abstract":"The World Health Organization's (WHO) Reporting System for Lung Cytopathology intends to standardise the diagnosing and reporting of cytology specimens from the lung and aims at enhancing the communication between clinicians and (cyto)pathologists. It is closely connected to the 5th edition of the WHO Classification of Thoracic Tumours. The system includes five diagnostic categories, among them the 'Malignant' diagnostic category that incorporates both primary malignant tumours and metastases. Advancements in bronchoscopy have notably improved the diagnostic capacity of cytological specimens that represent the sole source of tumour material in approximately 40% of all lung carcinoma cases. An accurate diagnosis of malignancy and treatment-guiding classification into specific tumour types and subtypes can reliably be achieved with cytology specimens. They additionally serve as an excellent source for predictive immunocytochemistry (ICC) and molecular testing for targetable oncogenic alterations. This review article provides an overview of the key cytopathological features defining the 'Malignant' category of the WHO Reporting System for Lung Cytopathology for non-small cell carcinomas, neuroendocrine neoplasms and other specific carcinomas and malignancies which can be encountered in cytological specimens of the lung. It further describes the application of ancillary techniques, such as ICC and molecular testing, that have been successfully incorporated into different cytological sample types using various preparation methods.","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Institutional Experience in Lung Endobronchial Ultrasound-Guided Fine Needle Aspiration: Comparing Risk of Malignancy With WHO Reporting System for Lung Cytopathology. 超声引导下肺支气管内细针穿刺的机构经验：与WHO肺细胞病理学报告系统的恶性肿瘤风险比较。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-14 DOI: 10.1111/cyt.13509

Xiaobing Jin, Madelyn Lew, Brian Smola, Tao Huang, Xin Jing

{"title":"An Institutional Experience in Lung Endobronchial Ultrasound-Guided Fine Needle Aspiration: Comparing Risk of Malignancy With WHO Reporting System for Lung Cytopathology.","authors":"Xiaobing Jin, Madelyn Lew, Brian Smola, Tao Huang, Xin Jing","doi":"10.1111/cyt.13509","DOIUrl":"https://doi.org/10.1111/cyt.13509","url":null,"abstract":"Introduction: Our institution utilises diagnostic frameworks similar to WHO Reporting System for Lung Cytopathology (WHORSLC) for assessment of lung fine needle aspiration (FNA) specimens. This study reports risk of malignancy (ROM) across diagnostic categories for comparison with the WHORSLC published data.Methods: A SNOMED search of the electronic pathology database in our institution (01/2022-12/2023) was conducted to retrieve endobronchial ultrasound (EBUS)-guided lung FNA specimens with a concurrent or subsequent surgical biopsy. Cytologic interpretation of these FNA specimens was performed using diagnostic frameworks similar to WHORSLC. Diagnostic distribution and ROM across the diagnostic categories were evaluated.Results: Among the 280 identified specimens, 125 (45%) were categorised as malignant, followed by 62 (22%) non-diagnostic, 45 (16%) benign, 33 (12%) atypical, and 15 (5%) suspicious for malignancy (SFM). The corresponding biopsies revealed malignancy in all FNAs categorised as malignant or SFM, as well as 57%, 35%, and 20% of atypical, non-diagnostic, and 20% benign cases, respectively. Among the histology-proven malignancies across the diagnostic categories, the majority were primary lung carcinomas, which most commonly were adenocarcinoma. Non-pulmonary malignancies were mostly seen in atypical (36%) followed by non-diagnostic (27%), SFM (13%), and malignant (10%) categories.Conclusion: EBUS-guided lung FNA specimens in our cohort categorised as malignant or SFM showed a higher ROM and cyto-histologic concordance (100%) than those reported by the WHORSLC. While our study resulted in a similar ROM for benign, atypical, and malignant categories, the ROM was lower for the non-diagnostic category. These findings contribute to the limited data available and may help further refine the ROM for different categories within the current WHORSLC framework.","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Well-Differentiated Adenocarcinoma With Papillary Architecture, Focal Residual Cilia, Apical Snouts, and CHEK2 and p53 Mutations. 具有乳头状结构、局灶残余纤毛、尖鼻、CHEK2和p53突变的高分化腺癌。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-14 DOI: 10.1111/cyt.13508

Maria F Gonzalez

引用次数: 0

Clear Cell Neoplasm in Salivary Gland FNA? Maybe It's From Kidney! 涎腺FNA透明细胞肿瘤？也许是从肾里来的！

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-05 DOI: 10.1111/cyt.13506

Isabella Sorice, Anna Maria Carillo, Maria Salatiello, Caterina De Luca, Rosa Maria Di Crescenzo, Vincenzo Damiano, Giovanni Dell'Aversana Orabona, Elena Vigliar, Giancarlo Troncone, Claudio Bellevicine

引用次数: 0

Case Report-Cytopathological Diagnosis of Metastatic Squamous Cell Carcinoma in Vitreous Fluid. 病例报告-玻璃体液中转移性鳞状细胞癌的细胞病理学诊断。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-05 DOI: 10.1111/cyt.13507

Poorva Singh, Katlin T Wilson, Linda Varghese, Jimmie Stewart

引用次数: 0

Fine-Needle Aspiration Cytology Diagnosis of Pleomorphic Adenoma With Spontaneous Infarction in the Salivary Gland: A Multicenter Retrospective Study. 涎腺多形性腺瘤合并自发性梗死的细针穿刺细胞学诊断：一项多中心回顾性研究。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-04-27 DOI: 10.1111/cyt.13500

Jie-Qiong Wang, Ge Li, Shao-Hua Wang, Bo Yang, Yun Liu, Yu Wan, Cong-Gai Huang, Fan Li

{"title":"Fine-Needle Aspiration Cytology Diagnosis of Pleomorphic Adenoma With Spontaneous Infarction in the Salivary Gland: A Multicenter Retrospective Study.","authors":"Jie-Qiong Wang, Ge Li, Shao-Hua Wang, Bo Yang, Yun Liu, Yu Wan, Cong-Gai Huang, Fan Li","doi":"10.1111/cyt.13500","DOIUrl":"https://doi.org/10.1111/cyt.13500","url":null,"abstract":"Objective: Spontaneous infarction in salivary gland pleomorphic adenoma (PA) diagnosed by fine-needle aspiration cytology (FNAC) is rarely documented. This study aims to systematically analyse and summarise its cytopathological characteristics to reduce the risk of misdiagnosis and enhance diagnostic precision.Methods: Five histopathologically confirmed cases (2017-2024) from two hospitals were retrospectively analysed. Clinical data, cytopathological findings and histopathology were reviewed, and causes of misdiagnosis were evaluated. Additionally, the cytopathological characteristics of salivary gland PA with spontaneous infarction were systematically analysed and comprehensively summarised, incorporating findings from relevant domestic and international literature.Results: Only two cases (40%) were correctly diagnosed as PA or PA with infarction. Two cases (40%) were misdiagnosed as suspicious of malignancy, and one case (20%) was inconclusive. The cytopathological features are as follows: Fine-needle aspiration (FNA) specimens often appear as milky-white or brownish paste, with or without small tissue fragments. Microscopically, there is a background of necrotic debris with numerous scattered pleomorphic small cells resembling 'naked nuclei', characterised by hyperchromatic and irregular nuclei, accompanied by atypical squamous metaplastic cells, 'ghost cells' and eosinophilic cells with non-atypical nuclei, with or without the presence of tumour-associated glandular epithelial cells, myoepithelial cells, lymphocytes, neutrophils or other inflammatory cells, while mucinous or chondroid stroma is rarely observed or absent, and no abnormal mitotic figures are identified.Conclusion: The cytological features of PA with spontaneous infarction can mimic malignancy. Recognising these features is crucial to reducing diagnostic errors and guiding appropriate management.","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Category: Suspicious for Malignancy. 诊断类别：怀疑为恶性肿瘤。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-04-26 DOI: 10.1111/cyt.13498

Andre L Moreira, Fernando Schmitt

引用次数: 0

Evaluating the Diagnostic Impact of the IAC Yokohama System for Breast Fine Needle Aspiration Biopsy Cytopathology: A Prospective Institutional Study. 评估IAC横滨系统对乳腺细针穿刺活检细胞病理学的诊断影响：一项前瞻性机构研究。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-04-26 DOI: 10.1111/cyt.13499

Chayanika Kala, Rajneesh Srivastava, Sanjay Kala, Lubna Khan, Neetu Purwar

{"title":"Evaluating the Diagnostic Impact of the IAC Yokohama System for Breast Fine Needle Aspiration Biopsy Cytopathology: A Prospective Institutional Study.","authors":"Chayanika Kala, Rajneesh Srivastava, Sanjay Kala, Lubna Khan, Neetu Purwar","doi":"10.1111/cyt.13499","DOIUrl":"https://doi.org/10.1111/cyt.13499","url":null,"abstract":"Introduction: Fine Needle Aspiration Biopsy (FNAB) of the breast is a widely used diagnostic tool for detecting breast lesions, offering high sensitivity and positive predictive value. The International Academy of Cytology (IAC) established the Yokohama System in 2016 to standardise reporting of breast FNAB.Objective: To categorise FNAB samples according to the IAC Yokohama System, assess the ROM for each category and evaluate the sensitivity, specificity and predictive values for malignancy diagnosis.Methods: This prospective observational study involved predominantly younger adults with the majority presenting with a palpable breast mass. FNAB samples were collected, stained and examined microscopically. Categories were assigned according to the Yokohama System, and the results were compared with histopathological examination (HPE). Diagnostic metrics and ROM were calculated using statistical analysis.Results: The study included 428 patients, with malignant cases comprising 49.5% of the samples, benign cases 43.5%, atypical cases 4.2%, suspicious for malignancy cases 1.9% and insufficient material 0.9%. The risk of malignancy (ROM) was 100% for malignant, 87.5% for suspicious for malignancy, 22.2% for atypical, 2.15% for benign and 25% for the insufficient category. Sensitivity, specificity and accuracy varied across groups, with group A, group B and group C showing accuracy at 92.99%, 97.66% and 95.3%, respectively.Conclusion: The IAC Yokohama System effectively categorises breast FNAB samples, provides accurate diagnostic metrics for malignancy and aids clinical decision-making, particularly in resource-limited settings.","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0