Cytopathology最新文献

Detection of Toxoplasma Gondii Tachyzoites in Cerebrospinal Fluid: Once in a Blue Moon Finding. 脑脊液中刚地弓形虫速殖子的检测：千载难逢的发现。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-06-23 DOI: 10.1111/cyt.70005

Ananthanarayanan Udupi Suryanarayana, Vidhya Vikashini Balasubramaniam, Kalisetty Prashanthi, Debasis Gochhait, Hariswar Pari

引用次数: 0

Implementation of a Multi-Gene Molecular Panel at Fine Needle Aspiration Biopsy (FNAB) Thyroid Samples: A Compelling Diagnostic and Prognostic Model. 在细针穿刺活检（FNAB）甲状腺样本中实现多基因分子面板：一个令人信服的诊断和预后模型。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-06-18 DOI: 10.1111/cyt.70004

Angeliki Margoni, Kostas A Papavassiliou, Athanasios G Papavassiliou

引用次数: 0

The Methylation Test Is Highly Sensitive for HPV-Associated Endocervical Adenocarcinoma and Could Be Helpful as a Cytological Ancillary Test in Women With a PAP-Smear Diagnosis of Severe Glandular Lesion (AGC-NEO+). 甲基化试验对hpv相关的宫颈内腺癌高度敏感，可以作为pap涂片诊断为严重腺体病变（AGC-NEO+）的妇女的细胞学辅助试验。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-06-13 DOI: 10.1111/cyt.70001

Iva Kinkorová Luňáčková, Ondrej Ondič, Jana Němcová, Kateřina Černá, Jan Chytra, Jiří Bouda

{"title":"The Methylation Test Is Highly Sensitive for HPV-Associated Endocervical Adenocarcinoma and Could Be Helpful as a Cytological Ancillary Test in Women With a PAP-Smear Diagnosis of Severe Glandular Lesion (AGC-NEO+).","authors":"Iva Kinkorová Luňáčková, Ondrej Ondič, Jana Němcová, Kateřina Černá, Jan Chytra, Jiří Bouda","doi":"10.1111/cyt.70001","DOIUrl":"https://doi.org/10.1111/cyt.70001","url":null,"abstract":"Objective: The limitations of PAP smears in diagnosing severe cervical glandular lesions motivate the development of ancillary methods to facilitate their detection. This prospective cytology-histology and molecular study aims to investigate methylation test performance by establishing the test sensitivity and its relevance to patient management.Method: LBC samples were prospectively acquired after 3 months following the primary conventional PAP-smear screening diagnosis of AGC-NEO (atypical glandular cells, favour neoplastic) and AIS. An HPV test and methylation test were performed. Corresponding subsequent biopsy reports were collected.Results: Seven hundred and seventy Pap tests were signed out as AGC-NEO+. Complete study data were available for 85 cases (AIS in 46 cases, EA in 39 cases) that were further analysed. The methylation test was positive in 95.3% (81/85) cases, negative in 3.5% (3/85, AIS in two cases, EA in one case) and unanalysable in one sample (1.2%). HPV genotyping revealed a multi-infection rate of 29%. The presence of HPV types 16 and 18 was detected in 84% (72/85) of lesions, and HPV type 45 in 12% (10/85).Conclusions: The methylation test shows a high sensitivity of 95.3% and reliably identifies histologically confirmed AIS+ lesions. This argues for further investigation into its performance characteristics and consideration of its use, especially as a pre-surgical triaging test in sensitive cases if the AIS+ lesion is suspected in pregnant women or nullipara.","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Diagnostic Clues of BCOR-CCNB3 Sarcoma in Fine-Needle Aspiration Specimens. 揭示细针穿刺标本中BCOR-CCNB3肉瘤的诊断线索

IF 1.2 4区医学

Cytopathology Pub Date : 2025-06-11 DOI: 10.1111/cyt.70000

Qingjie Wang, Diwei Zhou, Jingmin Zhong, Zhecheng Yan, Zhaorong Niu

引用次数: 0

Breast Filariasis-Diagnosed by Fine Needle Aspiration Cytology: A Rare Case Report. 乳腺丝虫病-细针抽吸细胞学诊断：罕见病例报告。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-27 DOI: 10.1111/cyt.13510

Aarushi Soota, Anju Khairwa, Rohit Sharma, Mukesh Kumar

引用次数: 0

Unusual Pancreatic Metastasis of Solid Subtype Adenoid Cystic Carcinoma: Reappraisal of MYB and CD117 Immunostaining Utility in Liquid-Based Cytology. 实体亚型腺样囊性癌的异常胰腺转移：重新评估MYB和CD117免疫染色在液体细胞学中的应用。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-21 DOI: 10.1111/cyt.13512

Keita Jinnouchi, Yuki Teramoto, Miho Saeki, Masahiro Hirata, Hironori Haga

引用次数: 0

Diagnosing Malignant Epithelial Neoplasms of the Lung in Cytological Specimens: Cytomorphology, Ancillary Studies and Management. 肺恶性上皮肿瘤的细胞学诊断：细胞形态学、辅助研究和治疗。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-21 DOI: 10.1111/cyt.13511

Magdalena M Brune, Zubair Baloch, Lukas Bubendorf, Spasenija Savic Prince

{"title":"Diagnosing Malignant Epithelial Neoplasms of the Lung in Cytological Specimens: Cytomorphology, Ancillary Studies and Management.","authors":"Magdalena M Brune, Zubair Baloch, Lukas Bubendorf, Spasenija Savic Prince","doi":"10.1111/cyt.13511","DOIUrl":"https://doi.org/10.1111/cyt.13511","url":null,"abstract":"The World Health Organization's (WHO) Reporting System for Lung Cytopathology intends to standardise the diagnosing and reporting of cytology specimens from the lung and aims at enhancing the communication between clinicians and (cyto)pathologists. It is closely connected to the 5th edition of the WHO Classification of Thoracic Tumours. The system includes five diagnostic categories, among them the 'Malignant' diagnostic category that incorporates both primary malignant tumours and metastases. Advancements in bronchoscopy have notably improved the diagnostic capacity of cytological specimens that represent the sole source of tumour material in approximately 40% of all lung carcinoma cases. An accurate diagnosis of malignancy and treatment-guiding classification into specific tumour types and subtypes can reliably be achieved with cytology specimens. They additionally serve as an excellent source for predictive immunocytochemistry (ICC) and molecular testing for targetable oncogenic alterations. This review article provides an overview of the key cytopathological features defining the 'Malignant' category of the WHO Reporting System for Lung Cytopathology for non-small cell carcinomas, neuroendocrine neoplasms and other specific carcinomas and malignancies which can be encountered in cytological specimens of the lung. It further describes the application of ancillary techniques, such as ICC and molecular testing, that have been successfully incorporated into different cytological sample types using various preparation methods.","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Institutional Experience in Lung Endobronchial Ultrasound-Guided Fine Needle Aspiration: Comparing Risk of Malignancy With WHO Reporting System for Lung Cytopathology. 超声引导下肺支气管内细针穿刺的机构经验：与WHO肺细胞病理学报告系统的恶性肿瘤风险比较。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-14 DOI: 10.1111/cyt.13509

Xiaobing Jin, Madelyn Lew, Brian Smola, Tao Huang, Xin Jing

{"title":"An Institutional Experience in Lung Endobronchial Ultrasound-Guided Fine Needle Aspiration: Comparing Risk of Malignancy With WHO Reporting System for Lung Cytopathology.","authors":"Xiaobing Jin, Madelyn Lew, Brian Smola, Tao Huang, Xin Jing","doi":"10.1111/cyt.13509","DOIUrl":"https://doi.org/10.1111/cyt.13509","url":null,"abstract":"Introduction: Our institution utilises diagnostic frameworks similar to WHO Reporting System for Lung Cytopathology (WHORSLC) for assessment of lung fine needle aspiration (FNA) specimens. This study reports risk of malignancy (ROM) across diagnostic categories for comparison with the WHORSLC published data.Methods: A SNOMED search of the electronic pathology database in our institution (01/2022-12/2023) was conducted to retrieve endobronchial ultrasound (EBUS)-guided lung FNA specimens with a concurrent or subsequent surgical biopsy. Cytologic interpretation of these FNA specimens was performed using diagnostic frameworks similar to WHORSLC. Diagnostic distribution and ROM across the diagnostic categories were evaluated.Results: Among the 280 identified specimens, 125 (45%) were categorised as malignant, followed by 62 (22%) non-diagnostic, 45 (16%) benign, 33 (12%) atypical, and 15 (5%) suspicious for malignancy (SFM). The corresponding biopsies revealed malignancy in all FNAs categorised as malignant or SFM, as well as 57%, 35%, and 20% of atypical, non-diagnostic, and 20% benign cases, respectively. Among the histology-proven malignancies across the diagnostic categories, the majority were primary lung carcinomas, which most commonly were adenocarcinoma. Non-pulmonary malignancies were mostly seen in atypical (36%) followed by non-diagnostic (27%), SFM (13%), and malignant (10%) categories.Conclusion: EBUS-guided lung FNA specimens in our cohort categorised as malignant or SFM showed a higher ROM and cyto-histologic concordance (100%) than those reported by the WHORSLC. While our study resulted in a similar ROM for benign, atypical, and malignant categories, the ROM was lower for the non-diagnostic category. These findings contribute to the limited data available and may help further refine the ROM for different categories within the current WHORSLC framework.","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Well-Differentiated Adenocarcinoma With Papillary Architecture, Focal Residual Cilia, Apical Snouts, and CHEK2 and p53 Mutations. 具有乳头状结构、局灶残余纤毛、尖鼻、CHEK2和p53突变的高分化腺癌。

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-14 DOI: 10.1111/cyt.13508

Maria F Gonzalez

引用次数: 0

Clear Cell Neoplasm in Salivary Gland FNA? Maybe It’s From Kidney! 涎腺FNA透明细胞肿瘤？也许是从肾里来的！

IF 1.2 4区医学

Cytopathology Pub Date : 2025-05-05 DOI: 10.1111/cyt.13506

Isabella Sorice, Anna Maria Carillo, Maria Salatiello, Caterina De Luca, Rosa Maria Di Crescenzo, Vincenzo Damiano, Giovanni Dell’Aversana Orabona, Elena Vigliar, Giancarlo Troncone, Claudio Bellevicine

引用次数: 0