{"title":"Genetic Pathways Underlying Individual Differences in Regular Physical Activity.","authors":"Eco J C de Geus","doi":"10.1249/JES.0000000000000305","DOIUrl":"https://doi.org/10.1249/JES.0000000000000305","url":null,"abstract":"<p><p>Twin and family studies show a strong contribution of genetic factors to physical activity (PA) assessed by either self-report or accelerometers. PA heritability is around 43% across the lifespan. Genome-wide association studies have implied biological pathways related to exercise ability and enjoyment. A polygenic score based on genetic variants influencing PA could help improve the success of intervention programs.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"51 1","pages":"2-18"},"PeriodicalIF":5.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jody L Greaney, Ashley M Darling, Erika F H Saunders, David M Almeida
{"title":"Daily Stress and Microvascular Dysfunction: The Buffering Effect of Physical Activity.","authors":"Jody L Greaney, Ashley M Darling, Erika F H Saunders, David M Almeida","doi":"10.1249/JES.0000000000000310","DOIUrl":"10.1249/JES.0000000000000310","url":null,"abstract":"<p><p>Although often short-lived, emotional responsiveness to daily stressors ( i.e. , routine and sometimes unexpected everyday hassles) is associated with increased cardiovascular disease (CVD), morbidity, and mortality. Here, we present the novel hypothesis that a disruption of microvascular homeostasis is a key antecedent. In addition, we postulate that physical activity may mitigate the psychobiological consequences of daily stress, thereby limiting pathophysiological CVD-related sequelae.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"51 1","pages":"19-26"},"PeriodicalIF":5.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10370847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From the Editor.","authors":"Sandra K Hunter","doi":"10.1249/JES.0000000000000309","DOIUrl":"https://doi.org/10.1249/JES.0000000000000309","url":null,"abstract":"","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"51 1","pages":"1"},"PeriodicalIF":5.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10330344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ketogenic Diets and Mitochondrial Function: Benefits for Aging But Not for Athletes.","authors":"Suraj J Pathak, Keith Baar","doi":"10.1249/JES.0000000000000307","DOIUrl":"https://doi.org/10.1249/JES.0000000000000307","url":null,"abstract":"<p><p>As humans age, we lose skeletal muscle mass, even in the absence of disease (sarcopenia), increasing the risk of death. Low mitochondrial mass and activity contributes to sarcopenia. It is our hypothesis that a ketogenic diet improves skeletal muscle mitochondrial mass and function when they have declined because of aging or disease, but not in athletes where mitochondrial quality is high.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"51 1","pages":"27-33"},"PeriodicalIF":5.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/62/essr-51-27.PMC9762714.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ross D Wilkinson, Melissa R Mazzo, Daniel F Feeney
{"title":"Rethinking the Statistical Analysis of Neuromechanical Data.","authors":"Ross D Wilkinson, Melissa R Mazzo, Daniel F Feeney","doi":"10.1249/JES.0000000000000308","DOIUrl":"https://doi.org/10.1249/JES.0000000000000308","url":null,"abstract":"<p><p>Researchers in neuromechanics should upgrade their statistical toolbox. We propose linear mixed-effects models in place of commonly used statistical tests to better capture subject-specific baselines and treatment-associated effects that naturally occur in neuromechanics. Researchers can use this approach to handle sporadic missing data, avoid the assumption of conditional independence in observations, and successfully model complex experimental protocols.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"51 1","pages":"43-50"},"PeriodicalIF":5.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuromechanics of the Rate of Force Development.","authors":"Alessandro Del Vecchio","doi":"10.1249/JES.0000000000000306","DOIUrl":"https://doi.org/10.1249/JES.0000000000000306","url":null,"abstract":"<p><p>The rate at which an individual can develop force during rapid voluntary contractions can be influenced by both the neural drive to a muscle and its intrinsic musculotendinous properties. We hypothesize that the maximal rate of force development across human individuals is mainly attributable to the rate of motor unit recruitment.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"51 1","pages":"34-42"},"PeriodicalIF":5.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xu Zhang, Davis A Englund, Zaira Aversa, Sarah K Jachim, Thomas A White, Nathan K LeBrasseur
{"title":"Exercise Counters the Age-Related Accumulation of Senescent Cells.","authors":"Xu Zhang, Davis A Englund, Zaira Aversa, Sarah K Jachim, Thomas A White, Nathan K LeBrasseur","doi":"10.1249/JES.0000000000000302","DOIUrl":"10.1249/JES.0000000000000302","url":null,"abstract":"<p><p>We propose the beneficial effects of exercise are in part mediated through the prevention and elimination of senescent cells. Exercise counters multiple forms of age-related molecular damage that initiate the senescence program and activates immune cells responsible for senescent cell clearance. Preclinical and clinical evidence for exercise as a senescence-targeting therapy and areas needing further investigation are discussed.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"50 4","pages":"213-221"},"PeriodicalIF":4.9,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680689/pdf/nihms-1850269.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10451345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response.","authors":"Edward F Coyle, Heath M Burton, Remzi Satiroglu","doi":"10.1249/JES.0000000000000297","DOIUrl":"https://doi.org/10.1249/JES.0000000000000297","url":null,"abstract":"","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":"231"},"PeriodicalIF":5.7,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33469116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew A Romero, Petey W Mumford, Paul A Roberson, Shelby C Osburn, Kaelin C Young, John M Sedivy, Michael D Roberts
{"title":"Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle.","authors":"Matthew A Romero, Petey W Mumford, Paul A Roberson, Shelby C Osburn, Kaelin C Young, John M Sedivy, Michael D Roberts","doi":"10.1249/JES.0000000000000301","DOIUrl":"10.1249/JES.0000000000000301","url":null,"abstract":"<p><p>Retrotransposons are gene segments that proliferate in the genome, and the Long INterspersed Element 1 (LINE-1 or L1) retrotransposon is active in humans. Although older mammals show enhanced skeletal muscle L1 expression, exercise generally reverses this trend. We hypothesize skeletal muscle L1 expression influences muscle physiology, and additional innovative investigations are needed to confirm this hypothesis.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"50 4","pages":"185-193"},"PeriodicalIF":5.7,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651911/pdf/nihms-1844782.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10094157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise and Sport Sciences Reviews: 2021 Paper of the Year.","authors":"Roger M Enoka","doi":"10.1249/JES.0000000000000292","DOIUrl":"https://doi.org/10.1249/JES.0000000000000292","url":null,"abstract":"","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":"173-174"},"PeriodicalIF":5.7,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33469113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}