Nathan R Kerr, W David Arnold, R Scott Rector, Taylor J Kelty
{"title":"The Role of Liver and Muscle-derived Exerkines in Cognitive Resilience.","authors":"Nathan R Kerr, W David Arnold, R Scott Rector, Taylor J Kelty","doi":"10.1249/JES.0000000000000403","DOIUrl":"https://doi.org/10.1249/JES.0000000000000403","url":null,"abstract":"<p><p>Exercise is one of the most effective ways to improve cognition. Exercise orchestrates a coordinated response across multiple peripheral tissues, including skeletal muscle and liver, which release circulatory factors capable of influencing neural function. This emerging framework expands our understanding from exercise-mediated adaptations within the central nervous system to body-wide adaptations that converge to promote cognitive function. SUMMARY: A review of exercise-induced secretion of circulatory factors from the skeletal muscle and liver that are capable of influencing cognition.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149301811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caitlin Bemis, Ethan Wold, Tim van der Zee, Carissa Mallonee, Jenna Monroy, Jeffrey Olberding, Manny Azizi, Simon Sponberg, Monica Daley, Kiisa Nishikawa
{"title":"Beyond Hill-Type Models: Aligning Experiments and Modeling to Understand Dynamic Muscle Function.","authors":"Caitlin Bemis, Ethan Wold, Tim van der Zee, Carissa Mallonee, Jenna Monroy, Jeffrey Olberding, Manny Azizi, Simon Sponberg, Monica Daley, Kiisa Nishikawa","doi":"10.1249/JES.0000000000000399","DOIUrl":"https://doi.org/10.1249/JES.0000000000000399","url":null,"abstract":"<p><p>Muscle models underpin how exercise, rehabilitation, and human-movement sciences infer muscle force during activity, yet profound gaps remain between traditional measures and models of muscle function and the dynamic features of muscle in natural movement. We review evidence for these gaps, highlight new experiments to bridge them, and suggest directions to improve models of dynamic muscle function. Summary: We propose reframing muscle as a dynamic mechanical system, integrating new experiments and models to predict function during natural movement.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vicky L Goosey-Tolfrey, Thomas Rietveld, Rowie J F Terpstra-Janssen, Riemer J K Vegter
{"title":"Mobility Continuum for Manual Wheelchair Use: From Rehabilitation to Para Sport.","authors":"Vicky L Goosey-Tolfrey, Thomas Rietveld, Rowie J F Terpstra-Janssen, Riemer J K Vegter","doi":"10.1249/JES.0000000000000398","DOIUrl":"https://doi.org/10.1249/JES.0000000000000398","url":null,"abstract":"","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lee M Margolis, François Haman, John P O'Hara, Gareth A Wallis
{"title":"Exogenous Carbohydrate Metabolism Under Energy Deficit and Environmental Stress.","authors":"Lee M Margolis, François Haman, John P O'Hara, Gareth A Wallis","doi":"10.1249/JES.0000000000000397","DOIUrl":"https://doi.org/10.1249/JES.0000000000000397","url":null,"abstract":"<p><p>Physiological stress of environmental exposure and energy deficit impairs the absorption, transport, and utilization of exogenous carbohydrate for fuel during exercise. Blunted exogenous carbohydrate oxidation may require alternative fueling strategies to optimize carbohydrate metabolism to support physical performance. This review will overview the impact of physiological stress on exogenous carbohydrate oxidation and potential interventions to support physical performance. Summary: Physiological stress exposure limits the effectiveness of carbohydrate supplementation to spare endogenous substrate oxidation by impeding exogenous carbohydrate oxidation.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The stretch-shortening cycle effect: History-dependent muscle properties matter.","authors":"Daniel Hahn, Wolfgang Seiberl, Tobias Siebert","doi":"10.1249/JES.0000000000000400","DOIUrl":"https://doi.org/10.1249/JES.0000000000000400","url":null,"abstract":"<p><p>The SSC effect - increased force, work, and power during shortening of stretch-shortening cycles compared with shortening alone - has long been attributed to stretch reflexes, preactivation, elastic recoil, and muscle-tendon unit decoupling. However, we hypothesize that contractile component mechanisms related to residual force enhancement can contribute substantially to the SSC effect. This article reviews current evidence for this history-dependent SSC-effect hypothesis. Summary: The contractile mechanism underlying residual force enhancement, especially titin, can substantially contribute to the stretch-shortening cycle effect.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bruce Rogers, Pablo R Fleitas-Paniagua, Juan M Murias
{"title":"Heart Rate Variability DFA a1: From Lab to Consumer Exercise Prescription and Monitoring.","authors":"Bruce Rogers, Pablo R Fleitas-Paniagua, Juan M Murias","doi":"10.1249/JES.0000000000000401","DOIUrl":"https://doi.org/10.1249/JES.0000000000000401","url":null,"abstract":"<p><p>Detecting exercise intensity thresholds is key for optimizing endurance training prescriptions for performance and recovery. Over the past several years an index of heart rate variability representing fractal correlation properties (DFA a1) has been investigated with respect to exercise intensity threshold demarcation and durability. We intend to show that sufficient data has accumulated to recommend it for widespread consumer use in tested populations. Summary: Validated consumer hardware, software, along with strong study results, support using DFA a1 monitoring to evaluate training zones and durability.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonard H Epstein, Kyle D Flack, James Roemmich, Jennifer L Temple
{"title":"Exercise Reinforcement: The Motivation to be Physically Active.","authors":"Leonard H Epstein, Kyle D Flack, James Roemmich, Jennifer L Temple","doi":"10.1249/JES.0000000000000394","DOIUrl":"10.1249/JES.0000000000000394","url":null,"abstract":"<p><p>Research is needed to understand how to motivate people to be active. There are wide individual differences in the reinforcing value of exercise, which predicts physical activity, and can be increased in sedentary adults. We include a computational model of how exercise reinforcement is related to physical activity and ideas on the choice between active versus sedentary alternatives.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":"183-194"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise and Sport Sciences Reviews: 2025 Paper of the Year.","authors":"Lyndsey E DuBose, Kerrie L Moreau","doi":"10.1249/JES.0000000000000396","DOIUrl":"10.1249/JES.0000000000000396","url":null,"abstract":"","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":"165-166"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jenelle K Dziano, Jonathan P Ariyaratnam, Melissa E Middeldorp, Prashanthan Sanders, Adrian D Elliott
{"title":"Exercise for Atrial Fibrillation: Unmasking Comorbidities and Improving Treatment.","authors":"Jenelle K Dziano, Jonathan P Ariyaratnam, Melissa E Middeldorp, Prashanthan Sanders, Adrian D Elliott","doi":"10.1249/JES.0000000000000391","DOIUrl":"10.1249/JES.0000000000000391","url":null,"abstract":"<p><p>Atrial fibrillation is associated with significant symptoms, comorbidities, and shared pathophysiological features with heart failure with preserved ejection fraction. We propose that exercise testing, including cardiopulmonary exercise testing and exercise cardiac imaging, can unmask subclinical cardiac dysfunction, guide diagnosis and inform intervention. Exercise training has a key role in atrial fibrillation management, improving arrhythmia burden, atrial remodeling and quality of life.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":"195-204"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Timothy M Kistner, Emmanuel Katsanis, Richard J Simpson
{"title":"Augmenting β 2 -Adrenergic Signaling During Exercise to Enhance Antitumor Immune Function.","authors":"Timothy M Kistner, Emmanuel Katsanis, Richard J Simpson","doi":"10.1249/JES.0000000000000395","DOIUrl":"10.1249/JES.0000000000000395","url":null,"abstract":"<p><p>Exercise is emerging as a powerful adjuvant therapy during cancer treatment, partly due to its immunomodulatory effects. However, the moderate- to vigorous-intensity exercise required for optimal immune-boosting effects is a barrier for many patients. β1 -selective blockade may bias β2 -adrenergic signaling to amplify immune responses at lower exercise intensities, offering a clinically feasible strategy for all cancer patients.</p>","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":" ","pages":"212-220"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}