Genes and Nutrition最新文献_第5页

The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study MTHFR 677C→T风险知识对叶酸摄入量变化的影响:来自Food4Me研究的发现

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2016-09-29 DOI: 10.1186/s12263-016-0539-x

C. O'Donovan, M. Walsh, H. Forster, C. Woolhead, C. Celis-Morales, R. Fallaize, A. Macready, Cyril F M Marsaux, S. Navas-Carretero, R. San-Cristóbal, S. Kolossa, C. Mavrogianni, C. Lambrinou, G. Moschonis, M. Godlewska, A. Surwillo, J. Bouwman, K. Grimaldi, I. Traczyk, C. Drevon, H. Daniel, Y. Manios, J. Martínez, W. Saris, J. Lovegrove, J. Mathers, M. Gibney, L. Brennan, E. Gibney

引用次数: 13

A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes 一项随机、双盲、安慰剂对照的益生菌豆浆和豆浆临床试验:对II型糖尿病患者表观遗传学和氧化应激的影响

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0503-1

M. Hariri, R. Salehi, A. Feizi, M. Mirlohi, R. Ghiasvand, Nahal Habibi

引用次数: 50

Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells miRNA-106b和miRNA-135a对丁酸盐调控的人结肠腺瘤细胞p21和Cyclin D2表达的影响

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0500-4

W. Schlörmann, S. Naumann, C. Renner, M. Glei

引用次数: 8

A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population 新加坡华人n-3和n-6血浆脂肪酸的全基因组关联研究

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0502-2

R. Dorajoo, Ye Sun, Y. Han, Tingjing Ke, Ayala Burger, Xuling Chang, H. Low, W. Guan, R. Lemaitre, C. Khor, Jian-Min Yuan, W. Koh, C. Ong, E. Tai, Jianjun Liu, R. Dam, C. Heng, Y. Friedlander

引用次数: 81

Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner 细胞外基质基因的变异与体重减轻后的体重恢复有性别特异性

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0506-y

N. Roumans, R. Vink, M. Gielen, M. Zeegers, C. Holst, Ping Wang, A. Astrup, W. Saris, A. Valsesia, J. Hager, M. V. van Baak, E. Mariman

引用次数: 21

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity 骨骼肌线粒体解偶联可以预防NZO小鼠(多基因糖尿病模型)的糖尿病，但不能预防肥胖

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0507-x

A. Voigt, Y. Katterle, M. Kahle, R. Kluge, A. Schürmann, H. Joost, S. Klaus

引用次数: 11

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer 咖啡提供了一种天然的多靶点药典来对抗癌症的特征

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0501-3

François Gaascht, M. Dicato, M. Diederich

引用次数: 73

Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes. 采用系统生物学方法研究热量限制和多酚对衰老过程的分子影响。

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 Epub Date: 2015-11-25 DOI: 10.1007/s12263-015-0508-9

Sébastien Lacroix, Mario Lauria, Marie-Pier Scott-Boyer, Luca Marchetti, Corrado Priami, Laura Caberlotto

{"title":"Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes.","authors":"Sébastien Lacroix, Mario Lauria, Marie-Pier Scott-Boyer, Luca Marchetti, Corrado Priami, Laura Caberlotto","doi":"10.1007/s12263-015-0508-9","DOIUrl":"10.1007/s12263-015-0508-9","url":null,"abstract":"Worldwide population is aging, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalizing metabolic risk factors. However, a better understanding of the pleiotropic effects of available nutritional interventions and their influence on the multiple processes affected by aging is needed to select and implement the most promising actions. New methods of analysis are required to tackle the complexity of the interplay between nutritional interventions and aging, and to make sense of a growing amount of -omics data being produced for this purpose. In this paper, we review how various systems biology-inspired methods of analysis can be applied to the study of the molecular basis of nutritional interventions promoting healthy aging, notably caloric restriction and polyphenol supplementation. We specifically focus on the role that different versions of network analysis, molecular signature identification and multi-omics data integration are playing in elucidating the complex mechanisms underlying nutrition, and provide some examples on how to extend the application of these methods using available microarray data. ","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53237040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ferrous carbamoyl glycine on iron state and absorption in an iron-deficient rat model 氨甲酰甘氨酸亚铁对缺铁大鼠铁状态和铁吸收的影响

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0504-0

Yuzhe Zhang, Xiaoming Sun, C. Xie, X. Shu, A. Oso, Z. Ruan, Z. Deng, Xin Wu, Yulong Yin

引用次数: 13

Nutritional biology: a neglected basic discipline of nutritional science. 营养生物学：一门被忽视的营养科学基础学科。

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 Epub Date: 2015-11-19 DOI: 10.1007/s12263-015-0505-z

Frank Döring, Alexander Ströhle

{"title":"Nutritional biology: a neglected basic discipline of nutritional science.","authors":"Frank Döring, Alexander Ströhle","doi":"10.1007/s12263-015-0505-z","DOIUrl":"10.1007/s12263-015-0505-z","url":null,"abstract":"On the basis of a scientific-philosophical analysis, this paper tries to show that the approaches in current nutritional science-including its subdisciplines which focus on molecular aspects-are predominantly application-oriented. This becomes particularly evident through a number of conceptual problems characterized by the triad of 'dearth of theoretical foundation,' 'particularist research questions,' and 'reductionist understanding of nutrition.' The thesis presented here is that an interpretive framework based on nutritional biology is able to shed constructive light on the fundamental problems of nutritional science. In this context, the establishment of 'nutritional biology' as a basic discipline in research and education would be a first step toward recognizing the phenomenon of 'nutrition' as an oecic process as a special case of an organism-environment interaction. Modern nutritional science should be substantively grounded on ecological-and therefore systems biology as well as organismic-principles. The aim of nutritional biology, then, should be to develop near-universal 'law statements' in nutritional science-a task which presents a major challenge for the current science system. ","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53236885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0