Genes and Nutrition最新文献_第5页

Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner 细胞外基质基因的变异与体重减轻后的体重恢复有性别特异性

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0506-y

N. Roumans, R. Vink, M. Gielen, M. Zeegers, C. Holst, Ping Wang, A. Astrup, W. Saris, A. Valsesia, J. Hager, M. V. van Baak, E. Mariman

引用次数: 21

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity 骨骼肌线粒体解偶联可以预防NZO小鼠(多基因糖尿病模型)的糖尿病，但不能预防肥胖

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0507-x

A. Voigt, Y. Katterle, M. Kahle, R. Kluge, A. Schürmann, H. Joost, S. Klaus

引用次数: 11

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer 咖啡提供了一种天然的多靶点药典来对抗癌症的特征

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0501-3

François Gaascht, M. Dicato, M. Diederich

引用次数: 73

Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes. 采用系统生物学方法研究热量限制和多酚对衰老过程的分子影响。

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 Epub Date: 2015-11-25 DOI: 10.1007/s12263-015-0508-9

Sébastien Lacroix, Mario Lauria, Marie-Pier Scott-Boyer, Luca Marchetti, Corrado Priami, Laura Caberlotto

{"title":"Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes.","authors":"Sébastien Lacroix, Mario Lauria, Marie-Pier Scott-Boyer, Luca Marchetti, Corrado Priami, Laura Caberlotto","doi":"10.1007/s12263-015-0508-9","DOIUrl":"10.1007/s12263-015-0508-9","url":null,"abstract":"Worldwide population is aging, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalizing metabolic risk factors. However, a better understanding of the pleiotropic effects of available nutritional interventions and their influence on the multiple processes affected by aging is needed to select and implement the most promising actions. New methods of analysis are required to tackle the complexity of the interplay between nutritional interventions and aging, and to make sense of a growing amount of -omics data being produced for this purpose. In this paper, we review how various systems biology-inspired methods of analysis can be applied to the study of the molecular basis of nutritional interventions promoting healthy aging, notably caloric restriction and polyphenol supplementation. We specifically focus on the role that different versions of network analysis, molecular signature identification and multi-omics data integration are playing in elucidating the complex mechanisms underlying nutrition, and provide some examples on how to extend the application of these methods using available microarray data. ","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53237040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ferrous carbamoyl glycine on iron state and absorption in an iron-deficient rat model 氨甲酰甘氨酸亚铁对缺铁大鼠铁状态和铁吸收的影响

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0504-0

Yuzhe Zhang, Xiaoming Sun, C. Xie, X. Shu, A. Oso, Z. Ruan, Z. Deng, Xin Wu, Yulong Yin

引用次数: 13

Nutritional biology: a neglected basic discipline of nutritional science. 营养生物学：一门被忽视的营养科学基础学科。

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 Epub Date: 2015-11-19 DOI: 10.1007/s12263-015-0505-z

Frank Döring, Alexander Ströhle

{"title":"Nutritional biology: a neglected basic discipline of nutritional science.","authors":"Frank Döring, Alexander Ströhle","doi":"10.1007/s12263-015-0505-z","DOIUrl":"10.1007/s12263-015-0505-z","url":null,"abstract":"On the basis of a scientific-philosophical analysis, this paper tries to show that the approaches in current nutritional science-including its subdisciplines which focus on molecular aspects-are predominantly application-oriented. This becomes particularly evident through a number of conceptual problems characterized by the triad of 'dearth of theoretical foundation,' 'particularist research questions,' and 'reductionist understanding of nutrition.' The thesis presented here is that an interpretive framework based on nutritional biology is able to shed constructive light on the fundamental problems of nutritional science. In this context, the establishment of 'nutritional biology' as a basic discipline in research and education would be a first step toward recognizing the phenomenon of 'nutrition' as an oecic process as a special case of an organism-environment interaction. Modern nutritional science should be substantively grounded on ecological-and therefore systems biology as well as organismic-principles. The aim of nutritional biology, then, should be to develop near-universal 'law statements' in nutritional science-a task which presents a major challenge for the current science system. ","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53236885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poster Presentations 海报展示

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2010-04-01 DOI: 10.3109/00048674.2010.507066

Jiashen Zhang, Di Xian, Meng Fang

引用次数: 1

Mechanism and regulation of intestinal copper absorption 肠道铜吸收的机制与调控

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2010-01-01 DOI: 10.1007/s12263-010-0202-x

Y. Nose, D. Thiele

引用次数: 2

Intestinal nutrient transport in the cradle of the Mediterranean Diet: 23rd EITG meeting report 地中海饮食摇篮中的肠道营养运输:第23届EITG会议报告