Genes and Nutrition最新文献

{"title":"Mechanism of continuous high temperature affecting growth performance, meat quality, and muscle biochemical properties of finishing pigs","authors":"Xianyong Ma, Li Wang, Z. Shi, Wei Chen, Xuefen Yang, You-jun Hu, C. Zheng, Zong-yong Jiang","doi":"10.1186/s12263-019-0643-9","DOIUrl":"https://doi.org/10.1186/s12263-019-0643-9","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-019-0643-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45927852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary protein sources and tumoral overexpression of <i>RhoA</i>, <i>VEGF-A</i> and <i>VEGFR2</i> genes among breast cancer patients.","authors":"Ali Shokri, Saeed Pirouzpanah, Mitra Foroutan-Ghaznavi, Vahid Montazeri, Ashraf Fakhrjou, Hojjatollah Nozad-Charoudeh, Gholamreza Tavoosidana","doi":"10.1186/s12263-019-0645-7","DOIUrl":"10.1186/s12263-019-0645-7","url":null,"abstract":"<p><strong>Background: </strong>High protein intake may promote angiogenesis giving support to the development of metastasis according to the experimental data. However, nutritional epidemiologic evidence is inconsistent with metastasis. Therefore, we aimed to study the association between dietary intake of protein and tumoral expression levels of <i>Ras homologous gene family member A</i> (<i>RhoA</i>), <i>vascular endothelial growth factor-A</i> (<i>VEGF-A</i>), and <i>VEGF receptor-2</i> (<i>VEGFR2</i>) in primary breast cancer (BC) patients.</p><p><strong>Methods: </strong>Over this consecutive case series, 177 women primary diagnosed with histopathologically confirmed BC in Tabriz (Iran) were enrolled between May 2011 and November 2016. A validated food frequency questionnaire was completed for eligible participants. Fold change in gene expression was measured using quantitative real-time PCR. Principal component factor analysis (PCA) was used to express dietary groups of proteins.</p><p><strong>Results: </strong>Total protein intake was associated with the expression level of <i>VEGF-A</i> in progesterone receptor-positive (PR+: <i>β</i> = 0.296, <i>p</i> < 0.01) and <i>VEGFR2</i> in patients with involvement of axillary lymph node metastasis (ALNM+: <i>β</i> = 0.295, <i>p</i> < 0.01) when covariates were adjusted. High animal protein intake was correlated with overexpression of <i>RhoA</i> in tumors with estrogen receptor-positive (ER+: <i>β</i> = 0.230, <i>p</i> < 0.05), ALNM+ (<i>β</i> = 0.238, <i>p</i> < 0.05), and vascular invasion (VI+: <i>β</i> = 0.313, <i>p</i> < 0.01). Animal protein intake was correlated with the overexpression of <i>VEGFR2</i> when tumors were positive for hormonal receptors (ER+: <i>β</i> = 0.299, <i>p</i> < 0.01; PR+: <i>β</i> = 0.296, <i>p</i> < 0.01). Based on the PCA outputs, protein provided by whole meat (white and red meat) was associated inversely with <i>RhoA</i> expression in ALNM+ (<i>β</i> = - 0.253, <i>p</i> < 0.05) and premenopausal women (<i>β</i> = - 0.285, <i>p</i> < 0.01) in adjusted models. Whole meat was correlated with <i>VEGFR2</i> overexpression in VI+ (<i>β</i> = 0.288, <i>p</i> < 0.05) and premenopausal status (<i>β</i> = 0.300, <i>p</i> < 0.05) in adjusted models. A group composed of dairy products and legumes was correlated with the overexpression of <i>RhoA</i> (<i>β</i> = 0.249, <i>p</i> < 0.05) and <i>VEGF-A</i> (<i>β</i> = 0.297, <i>p</i> < 0.05) in VI+.</p><p><strong>Conclusions: </strong>Based on the multivariate findings, the dietary protein could associate with the overexpression of <i>RhoA</i> and <i>VEGF-VEGFR2</i> in favor of lymphatic and vascular metastasis in BC patients.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"14 ","pages":"22"},"PeriodicalIF":3.3,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41220696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the 12q24 locus associated with fish intake frequency by genome-wide meta-analysis in Japanese populations","authors":"Maki Igarashi, S. Nogawa, K. Kawafune, Tsuyoshi Hachiya, Shoko Takahashi, Huijuan Jia, Kenji Saito, H. Kato","doi":"10.1186/s12263-019-0646-6","DOIUrl":"https://doi.org/10.1186/s12263-019-0646-6","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2019-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-019-0646-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43750514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat’s liver","authors":"J. Drag, A. Goździalska, M. Knapik-Czajka, A. Gawedzka, K. Gawlik, J. Jaśkiewicz","doi":"10.1186/s12263-017-0551-9","DOIUrl":"https://doi.org/10.1186/s12263-017-0551-9","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"12 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2017-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-017-0551-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65923976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny","authors":"T. Furuse, Kunio Miyake, T. Kohda, H. Kaneda, T. Hirasawa, Ikuko Yamada, Tomoko Kushida, Misho Kashimura, Kimio Kobayashi, F. Ishino, T. Kubota, S. Wakana","doi":"10.1186/s12263-016-0550-2","DOIUrl":"https://doi.org/10.1186/s12263-016-0550-2","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"1 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2017-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-016-0550-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65923936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells","authors":"Raffaella Comitato, B. Guantario, G. Leoni, K. Nesaretnam, Maria Beatrice Ronci, R. Canali, F. Virgili","doi":"10.1186/s12263-016-0543-1","DOIUrl":"https://doi.org/10.1186/s12263-016-0543-1","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"11 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-016-0543-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65923713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: 18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation","authors":"A. Mahmoud, Hussein S. Al Dera","doi":"10.1186/s12263-016-0548-9","DOIUrl":"https://doi.org/10.1186/s12263-016-0548-9","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"11 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2016-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-016-0548-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65923912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon","authors":"Y. Bae, Sung-Eun Kim, Seong Yeon Hong, T. Park, Sang Gyu Lee, Myung‐Sook Choi, Mi-Kyung Sung","doi":"10.1186/s12263-016-0547-x","DOIUrl":"https://doi.org/10.1186/s12263-016-0547-x","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"11 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2016-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-016-0547-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65923820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats","authors":"Soon-Sen Leow, Julia Bolsinger, A. Prończuk, K. Hayes, R. Sambanthamurthi","doi":"10.1186/s12263-016-0545-z","DOIUrl":"https://doi.org/10.1186/s12263-016-0545-z","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"11 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2016-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-016-0545-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65923777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improper hydration induces global gene expression changes associated with renal development in infant mice","authors":"Chong-Su Kim, Dong-Mi Shin","doi":"10.1186/s12263-016-0544-0","DOIUrl":"https://doi.org/10.1186/s12263-016-0544-0","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"11 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2016-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12263-016-0544-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65923762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}