Association of FHIT gene variant and salty food preference with the incidence of metabolic syndrome.

IF 3.3 3区 医学 Q2 GENETICS & HEREDITY
Jihyun Kim, Suyeon Lee, Shiva Raj Acharya, Dayeon Shin
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引用次数: 0

Abstract

Background: Taste perception plays a critical role in determining dietary choices and adherence to specific dietary patterns, which may lead to metabolic syndrome (MetS). The fragile histidine triad diadenosine triphosphatase (FHIT) gene plays a key role in cellular processes such as apoptosis and DNA repair, and thus may be an important factor in metabolic regulation. Despite this, the relationship between preference for salty foods, FHIT variants, and MetS is still largely unexplored. This study aimed to investigate the interaction between salty food preference and FHIT variation on the risk of MetS in middle-aged Korean adults.

Results: Over a mean follow-up of 10.6 years, 796 MetS cases were recorded. With regard to MetS incidence, the interaction between the FHIT rs2006807 variant and salty food preference was shown in women. Notably, women with the CA/CC genotype who preferred salty foods had a 1.42-fold higher incidence of MetS compared to those with the AA genotype who disliked salty foods (hazard ratio 1.42, 95% confidence interval 1.03-1.97).

Conclusions: This study highlights the potential impact of genetic factors and taste preferences when combined on the risk of MetS. Specifically, our findings suggest a significant genetic association between the FHIT rs2006807 variant and preference for salty foods, indicating that genetic predisposition may influence dietary choices. These results imply that personalized nutritional strategies that consider both genetic variations and individual dietary preferences may be effective in preventing MetS.

FHIT基因变异和咸食偏好与代谢综合征发病率的关系。
背景:味觉在决定饮食选择和坚持特定饮食模式方面起着关键作用,这可能导致代谢综合征(MetS)。脆弱的组氨酸三二腺苷三磷酸酶(FHIT)基因在细胞凋亡和DNA修复等细胞过程中起关键作用,因此可能是代谢调节的重要因素。尽管如此,对咸味食物的偏好、FHIT变体和MetS之间的关系在很大程度上仍未被探索。本研究旨在探讨咸食偏好和FHIT变异对韩国中年成年人MetS风险的相互作用。结果:在平均10.6年的随访中,记录了796例MetS病例。在met发病率方面,FHIT rs2006807变异与女性的盐性食物偏好之间存在相互作用。值得注意的是,CA/CC基因型的女性喜欢吃咸的食物,与不喜欢吃咸的AA基因型的女性相比,MetS的发生率高1.42倍(风险比1.42,95%可信区间1.03-1.97)。结论:这项研究强调了遗传因素和口味偏好对MetS风险的潜在影响。具体来说,我们的研究结果表明FHIT rs2006807变异与咸食偏好之间存在显著的遗传关联,表明遗传易感性可能影响饮食选择。这些结果表明,考虑遗传变异和个人饮食偏好的个性化营养策略可能有效预防MetS。
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来源期刊
Genes and Nutrition
Genes and Nutrition 生物-遗传学
CiteScore
6.60
自引率
0.00%
发文量
14
审稿时长
6-12 weeks
期刊介绍: This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.
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