Genes and Nutrition最新文献

{"title":"Western Diet and fecal microbiota transplantation alter phenotypic, liver fatty acids, and gut metagenomics and metabolomics in Mtarc2 knockout mice.","authors":"Katarzyna Unrug-Bielawska, Zuzanna Sandowska-Markiewicz, Kazimiera Pyśniak, Magdalena Piątkowska, Paweł Czarnowski, Krzysztof Goryca, Andrzej Mróz, Natalia Żeber-Lubecka, Urszula Wójcik-Trechcińska, Aneta Bałabas, Michalina Dąbrowska, Piotr Surynt, Mariusz Radkiewicz, Michał Mikula, Jerzy Ostrowski","doi":"10.1186/s12263-025-00772-x","DOIUrl":"10.1186/s12263-025-00772-x","url":null,"abstract":"","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"13"},"PeriodicalIF":3.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of skin cancer prevention properties of probiotics.","authors":"Shatila Torabi, Yalda Nahidi, Seyede Zahra Ghasemi, Amirali Reihani, Alireza Samadi, Nahid Ramezanghorbani, Elham Nazari, Sima Davoudi","doi":"10.1186/s12263-025-00770-z","DOIUrl":"10.1186/s12263-025-00770-z","url":null,"abstract":"<p><p>Bacteria play a crucial role in human health and disease pathogenesis. In recent years, the therapeutic potential of probiotics has gained increasing attention, with studies suggesting their application in treating various diseases, including cancer. We evaluated clinical data supporting the use of oral and topical probiotics for skin malignancies by conducting a literature search in PubMed and Google Scholar. Although limited, clinical trials investigating probiotics in cancer prevention and treatment have shown promising results, particularly in controlling tumor progression and enhancing therapeutic outcomes. Emerging research suggests that probiotics may contribute to skin cancer prevention by modulating the gut and skin microbiomes, enhancing immune responses, exerting antioxidant and anti-inflammatory effects, and inducing apoptosis. Given their antiproliferative and pro-apoptotic effects on carcinoma cells, probiotic-based therapies may serve as potential cancer-preventive agents and adjunctive treatments during conventional therapies. Key findings from our review highlight the ability of probiotics to influence cancer progression through immune regulation, apoptosis induction, and modulation of inflammatory pathways. However, further well-designed clinical trials are needed to validate these findings and establish probiotics as a viable therapeutic approach in oncology.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"12"},"PeriodicalIF":3.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arjunolic acid inhibits Wnt3a-mediated macrophage M2 polarization to suppress osteosarcoma progression.","authors":"Jun Li, Shuang Zhang, Chao Yu, Xia Chen, Weiye Zhong, Yi Shen","doi":"10.1186/s12263-025-00771-y","DOIUrl":"10.1186/s12263-025-00771-y","url":null,"abstract":"<p><strong>Background: </strong>Osteosarcoma (OS) is a bone tumor characterized by a high recurrence rate and poor prognosis. Arjunolic acid (AA), the most abundant triterpene component in Cyclocarya paliurus, is reported to have anti-tumor effects. Its specific role in OS is still unknown, which we aim to investigate in our study.</p><p><strong>Methods: </strong>An OS mouse model was established to investigate the effects of AA. Subsequently, M2 macrophages and M0 macrophages pretreated with AA were co-cultured with OS cells. The impact of AA on OS cell behavior (proliferation, apoptosis, migration, and invasion) was evaluated via EdU staining, flow cytometry, and Transwell assays. Concurrently, the expression of M1- and M2-associated genes (CD86, CD163, IL-6, Arg1) was quantified to assess AA's regulatory role in macrophages within the tumor microenvironment (TME). Knockdown or overexpression of Wnt3a in AA-treated M0 macrophages to determine whether AA modulates Wnt3a-mediated M2 polarization, which was further validated in vivo.</p><p><strong>Results: </strong>In vivo, AA inhibited tumor progression in OS mice. Concurrently, AA-treated macrophages inhibited OS cell malignant behavior, and AA inhibited OS cell-mediated macrophage M2-type polarization. Mechanistically, AA inhibits the malignant behavior of OS cells and inhibits tumor progression in OS mice by suppressing Wnt3a-mediated macrophage M2 polarization. Additionally, AA-induced macrophage conversion to a pro-inflammatory phenotype in the TME of OS mice.</p><p><strong>Conclusion: </strong>Our experiment demonstrated that AA from Cyclocarya paliurus inhibits Wnt3a-mediated M2 macrophage polarization to suppress the progression of osteosarcoma, providing a pharmacological foundation for developing therapies against OS.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"11"},"PeriodicalIF":3.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling taurine's protective role in ischemic stroke: insights from bidirectional Mendelian randomization and LC-MS/MS analysis.","authors":"Tianyi Wang, Xuyang Huang, Xinyue Zhang, Na Li, Kaizhi Lu, Yong Zeng","doi":"10.1186/s12263-025-00769-6","DOIUrl":"10.1186/s12263-025-00769-6","url":null,"abstract":"<p><p>Ischemic stroke remains a leading cause of mortality and disability globally, emphasizing the urgent need for innovative preventative and therapeutic strategies. Taurine, a critical amino sulfonic acid, has garnered attention for its neuroprotective effects, yet its precise role in ischemic stroke remains elusive. This study utilized a bidirectional Mendelian Randomization (MR) approach to explore the causal relationship between plasma taurine levels and ischemic stroke risk, employing genome-wide association study (GWAS) datasets. In parallel, a novel high-sensitivity liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to quantify plasma taurine levels in ischemic stroke patients and healthy controls. Our findings reveal a significant inverse association between taurine levels and stroke risk, with IVW analysis showing beta = -0.001 and P = 0.0085. Furthermore, LC-MS/MS analysis demonstrated that plasma taurine levels in patients with ischemic stroke were notably lower at 36.07 ± 5.37 μmol/L compared to controls at 108.66 ± 25.11 μmol/L, confirming taurine's potential as a protective factor. These results suggest taurine as a promising biomarker and therapeutic target for stroke prevention and recovery. This study not only highlights the importance of taurine in cerebrovascular health but also provides a foundation for personalized intervention strategies.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"10"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolome profiling across liver lobes and metabolic shifts of the MASLD mice.","authors":"Xiaolin Ma, Wenbo Bian, Wenting Song, Yitong Lu, Zhen Wang, Zhenyu Yao, Qiuhui Xuan","doi":"10.1186/s12263-025-00768-7","DOIUrl":"https://doi.org/10.1186/s12263-025-00768-7","url":null,"abstract":"<p><strong>Background: </strong>The mammalian liver executes its vital functions through intricate hepatic biochemistry. However, the complexity of the liver metabolome and its dynamic alterations during metabolic dysfunction-associated steatotic liver disease (MASLD) remain poorly understood.</p><p><strong>Methods: </strong>We established progressive MASLD mouse models through high-fat diet (HFD) and high-fat/high-cholesterol (HFHC) dietary-feeding across multiple time points. Utilizing liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and lipidomics, we systematically mapped the metabolome atlas of the mouse liver across five anatomical segments during the progression of MASLD.</p><p><strong>Results: </strong>By integration of data from two assays, we structurally annotated 426 lipids and 118 polar metabolites. The temporal progression of HFD feeding (0, 8, and 16 weeks) resulted in gradual metabolic deterioration across various liver segments. In HFHC-fed mice, metabolic alterations surged sharply from 0 to 8 weeks, followed by moderate progression until 16 weeks in different liver segments. Elevated levels of glycerolipids and cholesteryl esters, along with fluctuating acylcarnitine and fatty acid levels across various liver segments, suggested impaired energy metabolism and disrupted fatty acid oxidation. As MASLD progresses, a shift in sphingolipid metabolism, linked to inflammation, was observed, accompanied by significant alterations in phospholipid turnover patterns. Additionally, amino acid profiles in the livers of HFD-fed and HFHC-fed mice were altered, potentially influencing the regulation of energy metabolism, inflammation, and oxidative stress. These metabolic changes in lipids and amino acids displayed segment-specific patterns, indicating varying sensitivities to inflammation and mitochondrial β-oxidation across different liver lobes. Notably, the left lateral lobe showed heightened sensitivity to metabolic disturbances during MASLD progression.</p><p><strong>Conclusion: </strong>Our findings provided in-depth understanding in hepatic metabolites of MASLD, offering a comprehensive resource for further investigation.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"9"},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring causal relationships between circulating micronutrients and age-related eye diseases: a Mendelian randomization study.","authors":"Xiang Cao, Zijiao Xu, Boyang Zhang, Zhixin Jiang, Xiaoyong Yuan","doi":"10.1186/s12263-025-00767-8","DOIUrl":"10.1186/s12263-025-00767-8","url":null,"abstract":"<p><strong>Background: </strong>With the global population aging, age-related eye diseases (AREDs) such as senile cataract (SC), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) are becoming increasingly significant public health concerns. The rising prevalence of AREDs underscores the urgent need for effective prevention and treatment strategies. This study aimed to explore the causal relationships between circulating micronutrients (CMs) and AREDs.</p><p><strong>Methods: </strong>A bidirectional two-sample Mendelian randomization (MR) analysis was conducted using genetic variants as instrumental variables to assess the effects of fifteen CMs (vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folate, carotene, copper, calcium, iron, magnesium, potassium, selenium, zinc) on AREDs. Data were sourced from large-scale genome-wide association studies (GWAS). The primary analytical method employed was inverse-variance weighted (IVW), supplemented by sensitivity analyses to confirm the robustness of the results.</p><p><strong>Results: </strong>The MR analysis revealed significant protective effects of selenium against SC (OR = 0.961, 95% CI = 0.932-0.991, P = 0.012) and DR (OR = 0.927, 95% CI = 0.870-0.987, P = 0.019). Furthermore, higher genetically predicted magnesium levels were associated with a reduced risk of AMD (OR = 0.679, 95% CI = 0.515-0.895, P = 0.006). However, no significant causal relationships were observed between the other CMs and glaucoma or other AREDs.</p><p><strong>Conclusions: </strong>These findings provided valuable insights into the complex interplay between CMs and AREDs, offering potential pathways for developing targeted nutritional interventions and public health strategies to mitigate the risk of these debilitating conditions.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"8"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the future of nutrigenomics: dietitians' perceptions on integration in Indian practice.","authors":"Naomi Angelo Dias Do Rosario, Devaki Gokhale, Manisha Gore","doi":"10.1186/s12263-024-00760-7","DOIUrl":"10.1186/s12263-024-00760-7","url":null,"abstract":"<p><strong>Background: </strong>Nutrigenomics, the study of nutrient-gene interactions, holds immense potential for alleviating India's overburdened healthcare system and improving overall health-related quality of life. Yet, its utility remains in the nascent stages. To understand the factors affecting the implementation of nutrigenomics, we investigate the perceptions of practising dietetic professionals.</p><p><strong>Objective: </strong>The purpose of this study was to investigate the perceptions of Indian dietetic professionals related to the implementation of Nutrigenomics and to understand the factors affecting it.</p><p><strong>Methods: </strong>A total of 249 Indian dietetic professionals participated in an online survey between April 2024 - May 2024. This data was then statistically analyzed using the Chi-square test and Fisher's Exact test. Furthermore, in-depth interviews were conducted for 10 out of the 249 participants, the data collected from the interviews were analysed using reflexive thematic analysis.</p><p><strong>Results: </strong>Majority of the dietetic professionals had high awareness (97.2%) and interest (87.5%) in incorporating genetic testing into their practice. While the survey identified several barriers to its integration, such as high costs, (p-value = 0.000), lack of clinical trials (p-value = 0.013), and ethical concerns (p-value = 0.023). The in-depth interviews highlighted the need for increased education, standardization of testing panels, and collaboration among healthcare professionals to enhance the feasibility of nutrigenomics integration.</p><p><strong>Conclusion: </strong>Indian dietetic professionals express a positive outlook on integrating nutrigenomics into mainstream healthcare practice. However, successful establishment of personalized nutrition in India also requires addressing key challenges with respect to education, cost, training, development of regulatory frameworks and raising public awareness.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"7"},"PeriodicalIF":3.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11917134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Nigella sativa silver nanocomposite as an alternative therapy against thioacetamide nephrotoxicity.","authors":"Fatma M El-Demerdash, Ansam B Al Mhanna, Raghda A El-Sayed, Tarek M Mohamed, Maha M Salem","doi":"10.1186/s12263-025-00766-9","DOIUrl":"10.1186/s12263-025-00766-9","url":null,"abstract":"<p><p>Nigella sativa (N. sativa) L. (Ranunculaceae), commonly referred to as black cumin, has a long history of usage as an herbal remedy. It has been utilized conventionally and in clinical settings to treat various illnesses. Six groups of male Wister rats were randomly selected as Gp I, represented as control; Gp II administered N. sativa aqueous extract (NSAE); 200 mg/kg/d, Gp III received N. sativa silver nanocomposite (NS-Ag-NC); 0.25 mg/kg/d; Gp IV administered thioacetamide (TAA);100 mg/kg; thrice weekly and Gps V and VI administered NSAE and NS-Ag-NC with TAA for six weeks, respectively. Findings showed that GC-MS analysis of NSAE has a high concentration of phytochemicals with strong antioxidant activity. Results revealed that TAA administration elevated TBARS, H₂O₂, PCC, NO levels, kidney function parameters, LDH activity, and up-regulated TNF-α, IL-1β, NF-kβ, and COX-2 gene expressions. In contrast, enzymatic and non-enzymatic antioxidants and ALP activity were extensively diminished. Also, severe abnormalities in lipid profile, hematological parameters, and histopathological features were noted. On the other hand, the administration of NSAE or NS-Ag-NC followed by TAA intoxication reduces renal impairment, restores the antioxidant system, and downregulates the expression of TNF-α, IL-1β, NF-kβ, and COX-2 genes in rats' renal tissues. Collectively, NS-Ag-NC has more prevalent nephroprotective impacts than NSAE and can adjust the oxidant/antioxidant pathways besides their anti-inflammatory efficacy against TAA toxicity.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"6"},"PeriodicalIF":3.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of FHIT gene variant and salty food preference with the incidence of metabolic syndrome.","authors":"Jihyun Kim, Suyeon Lee, Shiva Raj Acharya, Dayeon Shin","doi":"10.1186/s12263-025-00762-z","DOIUrl":"10.1186/s12263-025-00762-z","url":null,"abstract":"<p><strong>Background: </strong>Taste perception plays a critical role in determining dietary choices and adherence to specific dietary patterns, which may lead to metabolic syndrome (MetS). The fragile histidine triad diadenosine triphosphatase (FHIT) gene plays a key role in cellular processes such as apoptosis and DNA repair, and thus may be an important factor in metabolic regulation. Despite this, the relationship between preference for salty foods, FHIT variants, and MetS is still largely unexplored. This study aimed to investigate the interaction between salty food preference and FHIT variation on the risk of MetS in middle-aged Korean adults.</p><p><strong>Results: </strong>Over a mean follow-up of 10.6 years, 796 MetS cases were recorded. With regard to MetS incidence, the interaction between the FHIT rs2006807 variant and salty food preference was shown in women. Notably, women with the CA/CC genotype who preferred salty foods had a 1.42-fold higher incidence of MetS compared to those with the AA genotype who disliked salty foods (hazard ratio 1.42, 95% confidence interval 1.03-1.97).</p><p><strong>Conclusions: </strong>This study highlights the potential impact of genetic factors and taste preferences when combined on the risk of MetS. Specifically, our findings suggest a significant genetic association between the FHIT rs2006807 variant and preference for salty foods, indicating that genetic predisposition may influence dietary choices. These results imply that personalized nutritional strategies that consider both genetic variations and individual dietary preferences may be effective in preventing MetS.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"5"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in triglyceride-rich lipoprotein particle profiles in response to one-week on a low fat or Mediterranean diet by TCF7L2 rs7903146 genotype: a randomized crossover dietary intervention trial.","authors":"Chao-Qiang Lai, Julie E Gervis, Laurence D Parnell, Alice H Lichtenstein, Jose M Ordovas","doi":"10.1186/s12263-025-00763-y","DOIUrl":"10.1186/s12263-025-00763-y","url":null,"abstract":"<p><strong>Background: </strong>The TCF7L2 gene is a significant genetic factor contributing to the risk of metabolic and cardiovascular diseases (CVD). We previously found that subjects with the TT genotype of TCF7L2 rs7903146 variant, who consume a low-fat diet (LF) had a higher incidence of stroke than subjects with the CC genotype. Yet this association was abolished in subjects with the TT genotype who consumed a Mediterranean-type diet (MetD). However, the mechanism by which MetD diet modulates the association between TCF7L2 and CVD risk is unclear. This study aims to validate these findings under real-world conditions and clinical practice to elucidate the biological mechanisms involved in this correlation.</p><p><strong>Methods: </strong>Thirty-five participants with BMI ranging from 27 to 34 kg/m² were recruited based on rs7903146 genotype. Of those consented to participate, 21 had the CC and 14 had the TT genotype. Participants were randomly assigned to two dietary intervention groups, ensuring an equal distribution of CC and TT carriers. Each participant followed one of two diets (LF or MetD) for one week, followed by a 10-day washout period before switching to the other diet for one week. Blood samples were collected before and after each diet for metabolomic analysis using nuclear magnetic resonance (NMR) spectroscopy. The differential effect of the diets on triglyceride-rich lipoproteins was determined based on TCF7L2 genotype.</p><p><strong>Results: </strong>The MetD significantly reduced triglyceride-rich lipoprotein concentrations compared to the LF diet. After consuming the LF diet, TT carriers exhibited more small VLDL particles, potentially contributing to CVD risk compared to CC carriers. However, this difference in risk was not observed with the MetD. Furthermore, the order in which the two diets were crossed affected the triglyceride-rich lipoprotein profile, with LF-MetD regimen showing a stronger effect on triglyceride-rich lipoproteins (TRL) levels than the MetD-LF regimen.</p><p><strong>Conclusions: </strong>Our findings suggest that rs7903146 TT carriers benefit more from a MetD than a LF diet in terms of their triglyceride-rich lipoprotein profile, which may reduce their risk of CVD. These results support the notion that genotype is a factor in determining the extent to which the MetD affects cardiovascular health.</p>","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"20 1","pages":"4"},"PeriodicalIF":3.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}