Exploring causal relationships between circulating micronutrients and age-related eye diseases: a Mendelian randomization study.

IF 3.3 3区医学 Q2 GENETICS & HEREDITY

Genes and Nutrition Pub Date : 2025-03-28 DOI:10.1186/s12263-025-00767-8

Xiang Cao, Zijiao Xu, Boyang Zhang, Zhixin Jiang, Xiaoyong Yuan

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引用次数: 0

Abstract

Background: With the global population aging, age-related eye diseases (AREDs) such as senile cataract (SC), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) are becoming increasingly significant public health concerns. The rising prevalence of AREDs underscores the urgent need for effective prevention and treatment strategies. This study aimed to explore the causal relationships between circulating micronutrients (CMs) and AREDs.

Methods: A bidirectional two-sample Mendelian randomization (MR) analysis was conducted using genetic variants as instrumental variables to assess the effects of fifteen CMs (vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folate, carotene, copper, calcium, iron, magnesium, potassium, selenium, zinc) on AREDs. Data were sourced from large-scale genome-wide association studies (GWAS). The primary analytical method employed was inverse-variance weighted (IVW), supplemented by sensitivity analyses to confirm the robustness of the results.

Results: The MR analysis revealed significant protective effects of selenium against SC (OR = 0.961, 95% CI = 0.932-0.991, P = 0.012) and DR (OR = 0.927, 95% CI = 0.870-0.987, P = 0.019). Furthermore, higher genetically predicted magnesium levels were associated with a reduced risk of AMD (OR = 0.679, 95% CI = 0.515-0.895, P = 0.006). However, no significant causal relationships were observed between the other CMs and glaucoma or other AREDs.

Conclusions: These findings provided valuable insights into the complex interplay between CMs and AREDs, offering potential pathways for developing targeted nutritional interventions and public health strategies to mitigate the risk of these debilitating conditions.

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探索循环微量营养素与年龄相关性眼病之间的因果关系：一项孟德尔随机研究

背景：随着全球人口老龄化，老年性白内障（SC）、老年性黄斑变性（AMD）、青光眼和糖尿病性视网膜病变（DR）等老年性眼病（AREDs）日益成为重要的公共卫生问题。AREDs患病率的上升凸显了制定有效预防和治疗策略的迫切需要。本研究旨在探讨循环微量营养素（CMs）与AREDs之间的因果关系。方法：采用双向双样本孟德尔随机化（MR）分析方法，以遗传变异为工具变量，评估15种CMs（维生素A、维生素B6、维生素B12、维生素C、维生素D、维生素E、叶酸、胡萝卜素、铜、钙、铁、镁、钾、硒、锌）对AREDs的影响。数据来源于大规模全基因组关联研究（GWAS）。采用的主要分析方法是反方差加权（IVW），并辅以敏感性分析来确认结果的稳健性。结果：MR分析显示硒对SC （OR = 0.961, 95% CI = 0.932-0.991, P = 0.012）和DR （OR = 0.927, 95% CI = 0.870-0.987, P = 0.019）具有显著的保护作用。此外，较高的遗传预测镁水平与AMD风险降低相关（OR = 0.679, 95% CI = 0.515-0.895, P = 0.006）。然而，其他CMs与青光眼或其他AREDs之间没有明显的因果关系。结论：这些发现为CMs和AREDs之间复杂的相互作用提供了有价值的见解，为制定有针对性的营养干预措施和公共卫生策略提供了潜在途径，以减轻这些衰弱性疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes and Nutrition 生物-遗传学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.