Genes and Nutrition最新文献_第6页

The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport. 母体营养不良对大鼠胎盘转录组的影响：蛋白质限制上调胆固醇转运。

IF 3.3 3区医学

Genes and Nutrition Pub Date : 2016-10-12 eCollection Date: 2016-01-01 DOI: 10.1186/s12263-016-0541-3

Zoe Daniel, Angelina Swali, Richard Emes, Simon C Langley-Evans

{"title":"The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport.","authors":"Zoe Daniel, Angelina Swali, Richard Emes, Simon C Langley-Evans","doi":"10.1186/s12263-016-0541-3","DOIUrl":"10.1186/s12263-016-0541-3","url":null,"abstract":"Background: Fetal exposure to a maternal low protein diet during rat pregnancy is associated with hypertension, renal dysfunction and metabolic disturbance in adult life. These effects are present when dietary manipulations target only the first half of pregnancy. It was hypothesised that early gestation protein restriction would impact upon placental gene expression and that this may give clues to the mechanism which links maternal diet to later consequences.Methods: Pregnant rats were fed control or a low protein diet from conception to day 13 gestation. Placentas were collected and RNA sequencing performed using the Illumina platform.Results: Protein restriction down-regulated 67 genes and up-regulated 24 genes in the placenta. Ingenuity pathway analysis showed significant enrichment in pathways related to cholesterol and lipoprotein transport and metabolism, including atherosclerosis signalling, clathrin-mediated endocytosis, LXR/RXR and FXR/RXR activation. Genes at the centre of these processes included the apolipoproteins ApoB, ApoA2 and ApoC2, microsomal triglyceride transfer protein (Mttp), the clathrin-endocytosis receptor cubilin, the transcription factor retinol binding protein 4 (Rbp4) and transerythrin (Ttr; a retinol and thyroid hormone transporter). Real-time PCR measurements largely confirmed the findings of RNASeq and indicated that the impact of protein restriction was often striking (cubilin up-regulated 32-fold, apoC2 up-regulated 17.6-fold). The findings show that gene expression in specific pathways is modulated by maternal protein restriction in the day-13 rat placenta.Conclusions: Changes in cholesterol transport may contribute to altered tissue development in the fetus and hence programme risk of disease in later life.","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"11 1","pages":"27"},"PeriodicalIF":3.3,"publicationDate":"2016-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65923658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of diets supplemented with different conjugated linoleic acid (CLA) isomers on protein expression in C57/BL6 mice 饲粮中添加不同共轭亚油酸(CLA)异构体对C57/BL6小鼠蛋白质表达的影响

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2016-10-04 DOI: 10.1186/s12263-016-0542-2

L. Casa, E. Rossi, C. Romanelli, L. Gibellini, A. Iannone

引用次数: 6

The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study MTHFR 677C→T风险知识对叶酸摄入量变化的影响:来自Food4Me研究的发现

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2016-09-29 DOI: 10.1186/s12263-016-0539-x

C. O'Donovan, M. Walsh, H. Forster, C. Woolhead, C. Celis-Morales, R. Fallaize, A. Macready, Cyril F M Marsaux, S. Navas-Carretero, R. San-Cristóbal, S. Kolossa, C. Mavrogianni, C. Lambrinou, G. Moschonis, M. Godlewska, A. Surwillo, J. Bouwman, K. Grimaldi, I. Traczyk, C. Drevon, H. Daniel, Y. Manios, J. Martínez, W. Saris, J. Lovegrove, J. Mathers, M. Gibney, L. Brennan, E. Gibney

引用次数: 13

A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes 一项随机、双盲、安慰剂对照的益生菌豆浆和豆浆临床试验:对II型糖尿病患者表观遗传学和氧化应激的影响

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0503-1

M. Hariri, R. Salehi, A. Feizi, M. Mirlohi, R. Ghiasvand, Nahal Habibi

引用次数: 50

Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells miRNA-106b和miRNA-135a对丁酸盐调控的人结肠腺瘤细胞p21和Cyclin D2表达的影响

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0500-4

W. Schlörmann, S. Naumann, C. Renner, M. Glei

引用次数: 8

Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner 细胞外基质基因的变异与体重减轻后的体重恢复有性别特异性

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0506-y

N. Roumans, R. Vink, M. Gielen, M. Zeegers, C. Holst, Ping Wang, A. Astrup, W. Saris, A. Valsesia, J. Hager, M. V. van Baak, E. Mariman

引用次数: 21

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity 骨骼肌线粒体解偶联可以预防NZO小鼠(多基因糖尿病模型)的糖尿病，但不能预防肥胖

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0507-x

A. Voigt, Y. Katterle, M. Kahle, R. Kluge, A. Schürmann, H. Joost, S. Klaus

引用次数: 11

A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population. 新加坡华人n-3和n-6血浆脂肪酸的全基因组关联研究。

IF 3.3 3区医学

Genes and Nutrition Pub Date : 2015-11-01 Epub Date: 2015-11-19 DOI: 10.1007/s12263-015-0502-2

Rajkumar Dorajoo, Ye Sun, Yi Han, Tingjing Ke, Ayala Burger, Xuling Chang, Hui Qi Low, Weihua Guan, Rozenn N Lemaitre, Chiea-Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Choon Nam Ong, E Shyong Tai, Jianjun Liu, Rob M van Dam, Chew-Kiat Heng, Yechiel Friedlander

{"title":"A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population.","authors":"Rajkumar Dorajoo, Ye Sun, Yi Han, Tingjing Ke, Ayala Burger, Xuling Chang, Hui Qi Low, Weihua Guan, Rozenn N Lemaitre, Chiea-Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Choon Nam Ong, E Shyong Tai, Jianjun Liu, Rob M van Dam, Chew-Kiat Heng, Yechiel Friedlander","doi":"10.1007/s12263-015-0502-2","DOIUrl":"10.1007/s12263-015-0502-2","url":null,"abstract":"Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the relevance of these findings has not been evaluated extensively in other ethnic groups. The primary aim of this study was to evaluate for genetic loci associated with n-3 and n-6 PUFAs and to validate the role of recently identified index loci using data from a Singaporean Chinese population. Using a GWAS approach, we evaluated associations with plasma concentrations of three n-3 PUFAs [alphalinolenic acid (ALA), eicosapentaenoic acid and docosahexaenoic acid], four n-6 PUFAs [linoleic acid (LA), gammalinolenic acid, dihomogammalinolenic acid (DGLA) and arachidonic acid], and estimates of delta-5 desaturase and delta-6 desaturase activities among the participants (N = 1361) of the Singaporean Chinese Health Study. Our results reveal robust genome-wide associations (p value <5 × 10(-8)) with ALA, all four n-6 PUFAs, and delta-6 desaturase activity at the FADS1/FADS2 locus. We further replicated the associations between common index variants at the NTAN1/PDXDC1 locus and n-6 PUFAs LA and DGLA, and between the JMJD1C locus and n-6 PUFA LA (p value between 0.0490 and 9.88 × 10(-4)). These associations were independent of dietary intake of PUFAs. In aggregate, we show that genetic loci that influence plasma concentrations of n-3 and n-6 PUFAs are shared across different ethnic groups. ","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"10 1","pages":"53"},"PeriodicalIF":3.3,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53236502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer 咖啡提供了一种天然的多靶点药典来对抗癌症的特征

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 DOI: 10.1007/s12263-015-0501-3

François Gaascht, M. Dicato, M. Diederich

引用次数: 73

Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes. 采用系统生物学方法研究热量限制和多酚对衰老过程的分子影响。

IF 3.5 3区医学

Genes and Nutrition Pub Date : 2015-11-01 Epub Date: 2015-11-25 DOI: 10.1007/s12263-015-0508-9

Sébastien Lacroix, Mario Lauria, Marie-Pier Scott-Boyer, Luca Marchetti, Corrado Priami, Laura Caberlotto

{"title":"Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes.","authors":"Sébastien Lacroix, Mario Lauria, Marie-Pier Scott-Boyer, Luca Marchetti, Corrado Priami, Laura Caberlotto","doi":"10.1007/s12263-015-0508-9","DOIUrl":"10.1007/s12263-015-0508-9","url":null,"abstract":"Worldwide population is aging, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalizing metabolic risk factors. However, a better understanding of the pleiotropic effects of available nutritional interventions and their influence on the multiple processes affected by aging is needed to select and implement the most promising actions. New methods of analysis are required to tackle the complexity of the interplay between nutritional interventions and aging, and to make sense of a growing amount of -omics data being produced for this purpose. In this paper, we review how various systems biology-inspired methods of analysis can be applied to the study of the molecular basis of nutritional interventions promoting healthy aging, notably caloric restriction and polyphenol supplementation. We specifically focus on the role that different versions of network analysis, molecular signature identification and multi-omics data integration are playing in elucidating the complex mechanisms underlying nutrition, and provide some examples on how to extend the application of these methods using available microarray data. ","PeriodicalId":55123,"journal":{"name":"Genes and Nutrition","volume":"10 1","pages":"58"},"PeriodicalIF":3.5,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53237040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0