Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Cadaveric Anatomical Study of Orbit-Preserving Ophthalmic Neurectomy via Endoscopic and Exoscopic Techniques.","authors":"Lachlan Crawford, Mark Midwinter, Benedict Panizza","doi":"10.1002/hed.28099","DOIUrl":"https://doi.org/10.1002/hed.28099","url":null,"abstract":"<p><strong>Background: </strong>Perineural spread of cutaneous head and neck squamous cell carcinoma is most effectively managed by surgical resection with a clear central margin at the affected nerve. For ophthalmic nerve disease, there is no clear consensus regarding the extent of spread which is resectable via an orbit-preserving neurectomy, either in regard to oncological outcome or technical feasibility.</p><p><strong>Methods: </strong>Cadaveric anatomical study of 10 human orbits, with endoscopic and exoscopic dissection of the frontal division of the ophthalmic nerve, to quantify the maximal extent of resection via orbit-preserving techniques and to discern the advantages and disadvantages of exoscopic versus endoscopic visualization aids.</p><p><strong>Results: </strong>Mean achievable resection length measured from the supraorbital ridge was 40.9 mm (n = 10). No branching patterns were identified which would preclude neurectomy as an oncologically sound option.</p><p><strong>Conclusions: </strong>Orbit-preserving resection of the ophthalmic nerve is technically feasible to a distance of approximately 4 cm, encompassing the majority of Williams Zone 1.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic Disparities in Diagnosis and Treatment of Anxiety and Depressive Disorders in Head and Neck Cancer Survivors.","authors":"Tyler J Gallagher, Ryan S Chung, Nyree Khachikyan, Matthew E Lin, Niels C Kokot","doi":"10.1002/hed.28103","DOIUrl":"https://doi.org/10.1002/hed.28103","url":null,"abstract":"<p><strong>Background: </strong>The associations between head and neck cancer (HNC) and anxiety and depression are well-known, but knowledge regarding the association between demographic factors and rates of diagnosis and treatment for these disorders among HNC survivors is incomplete.</p><p><strong>Methods: </strong>This retrospective study utilized propensity score matching to compare rates of selected new anxiety and/or depressive disorder diagnoses among HNC survivors and treatment of those disorders by sex, race, ethnicity, and language.</p><p><strong>Results: </strong>Results suggested lower likelihood of anxiety and/or depressive disorder diagnosis among individuals of male sex, and any minority, African American, Asian, and Other race, while diagnosis rates were higher among native Hawaiian/Pacific Islanders. Treatment with pharmacotherapy was less likely among individuals of male sex, any minority and African American Asian race, Hispanic ethnicity, and Spanish language.</p><p><strong>Conclusions: </strong>This study suggests that mental health diagnosis and treatment among HNC survivors may be inequitable, although further research is necessary to confirm these associations and understand underlying mechanisms.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoblastoma-Like Tumor of the Tongue With IDH1 Mutation: A Case Report and Literature Review.","authors":"Dongpo Li, Guangqi Li, Ye Wang, Hailei Shi, Shuangyi Wang, Xiaohong Zhan","doi":"10.1002/hed.28104","DOIUrl":"https://doi.org/10.1002/hed.28104","url":null,"abstract":"<p><strong>Background: </strong>Lipoblastoma-like tumors (LLTs) are uncommon lipogenic neoplasms that predominantly occur in the vulva of female individuals. This study presents a novel case of LLT located on the tongue with an IDH1 mutation. Both the site of occurrence and molecular alterations are reported for the first time.</p><p><strong>Case presentation: </strong>A 65-year-old female patient presented to the hospital 1 month ago with an incidental finding of a multinodular mass at the right lingual margin. We performed an incision along the outer edge of the mass and completely excised it 0.5 cm beyond its periphery. The final pathological diagnosis after routine examination confirmed a lipoblastoma-like tumor. Furthermore, Next-generation sequencing revealed the presence of mutations in IDH1.</p><p><strong>Conclusions: </strong>This study presents the first documented case of LLT, thereby expanding its anatomical site of tongue and confirming the presence of a significant IDH1 mutation, thus enhancing our understanding of the molecular alterations in LLT.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial-to-Lateral Approach in Neck Dissection","authors":"Keigo Honda,&nbsp;Koichi Omori,&nbsp;Atsushi Suehiro,&nbsp;Yo Kishimoto,&nbsp;Tsuyoshi Kojima,&nbsp;Kiyomi Hamaguchi,&nbsp;Yoshitaka Kawai,&nbsp;Shintaro Fujimura,&nbsp;Ken Iwanaga,&nbsp;Yuji Kitada","doi":"10.1002/hed.28105","DOIUrl":"10.1002/hed.28105","url":null,"abstract":"<p>This video introduces a medial-to-lateral neck dissection technique in the management of head and neck cancer, emphasizing the importance of the middle layer of the deep cervical fascia as a key surgical landmark. The technique involves systematic dissection from superficial lymphatic tissue (Paddle 1) to deeper structures (Paddles 2 and 3), offering better visualization and preservation of functionally important structures, such as the cervical nerves. This approach enhances surgical precision, minimizes nerve damage, and optimizes lymphatic tissue removal.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 4","pages":"1306-1310"},"PeriodicalIF":2.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.28105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transoral Surgery Versus Radiotherapy as Primary Treatment for HPV-Related Oropharyngeal Cancer in the Elderly.","authors":"Andrea Costantino, Bruce Haughey, Jianbin Zhu, Uthman Alamoudi, J Scott Magnuson","doi":"10.1002/hed.28097","DOIUrl":"https://doi.org/10.1002/hed.28097","url":null,"abstract":"<p><strong>Background: </strong>This study compares the oncological outcomes of primary transoral surgery (TOS) and primary radiotherapy (RT) in elderly patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC).</p><p><strong>Methods: </strong>This retrospective cohort study included patients with cT1-2 HPV-related OPSCC from the National Cancer Database (NCDB).</p><p><strong>Results: </strong>A total of 2566 patients were included, with 73.9% receiving primary RT and 22.3% undergoing primary TOS. Subgroup analysis showed a higher 5-year overall survival (OS) rate for primary TOS (81.6%; 95% CI: 79.6%-83.6%) compared to primary RT (70.7%; 95% CI: 68.3%-73.1%), with an adjusted hazard ratio (HR) of 0.64 (95% CI: 0.50-0.81; p < 0.001) after propensity score matching. Notably, only (13.6%) of patients diagnosed in 2020 underwent primary TOS, with a significant decline over the study period.</p><p><strong>Conclusions: </strong>This study suggests that primary TOS may offer better survival outcomes for elderly patients with HPV-related OPSCC compared to primary RT.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Factors for Free Flap Failure in Head and Neck Reconstruction.","authors":"Quentin Hennocq, Jean-Baptiste Caruhel, Mourad Benassarou, Jebrane Bouaoud, André Chaine, Angélique Girod, Nicolas Graillon, Sylvie Testelin, Mélika Amor-Sahli, Jean-Philippe Foy, Chloé Bertolus","doi":"10.1002/hed.28095","DOIUrl":"https://doi.org/10.1002/hed.28095","url":null,"abstract":"<p><strong>Background: </strong>The failure rate of free flaps varies from 0.8% to 10.6% in the literature in head and neck reconstruction. The primary objective was to identify prognostic factors for free flap failure.</p><p><strong>Methods: </strong>We prospectively included all consecutive free flaps performed between August 2021 and January 2024, and used a multivariate Cox proportional hazard model.</p><p><strong>Results: </strong>We included 307 free flaps, performed on 274 patients. Age, cardiovascular risk, radiotherapy history, type of flap, type of arterial anastomosis, and ischemia duration were not statistically linked to the risk of flap failure. In multivariate analysis, a venous anastomosis to the anterior jugular vein or to the superior thyroid vein were associated with an increased risk of flap failure, such as per- or postoperative revision of the anastomoses.</p><p><strong>Conclusions: </strong>The choice of venous anastomosis, appear to have a greater influence on the success or failure of a microvascularized transfer than patient characteristics.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resectable Sinonasal Mucosal Melanoma in the Immunotherapy Era: Upfront Surgery vs. Neoadjuvant Therapy.","authors":"Aya F Salem, Melissa M Chen, Michelle D Williams, David M Swanson, Jennifer L McQuade, Rodabe N Amaria, Ehab Y Hanna, Andrew J Bishop, Ahsan S Farooqi, B Ashleigh Guadagnolo, Shirley Y Su, Devarati Mitra","doi":"10.1002/hed.28098","DOIUrl":"https://doi.org/10.1002/hed.28098","url":null,"abstract":"<p><strong>Objective: </strong>We aim to evaluate outcomes for patients with resectable SNMM treated in the immunotherapy era.</p><p><strong>Methods: </strong>Thirty-seven patients with resectable SNM were identified using our institutional database between 2016 and 2023.</p><p><strong>Results: </strong>Patients receiving neoadjuvant Ipi/Nivo (46%, n = 17) were more likely to have disease involving the sinuses and/or the skull base (71% vs. 35%, p = 0.05). The overall response rate to Ipi/Nivo was 24%. Two-year LRFS from the start of therapy was 63%, and from the end of local therapy was 78%. Two-year PFS was 49%. The patients who received Ipi/Nivo with evidence of response (n = 4, 24%) had better PFS (2-year PFS 100% vs. 15%, p = 0.02) and LRFS (2-year LRFS 100% vs. 31%, p = 0.08).</p><p><strong>Conclusions: </strong>Outcomes for resectable SNMM patients continue to be poor in the immunotherapy era. In the context of selection bias, neoadjuvant Ipi/Nivo was not associated with better outcomes in all-comers. However, those with evidence of response to Ipi/Nivo had better prognosis.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngeal Squamous Cell Carcinoma Incidence and Survival Trends in the United States: A Population-Based Analysis of Two Decades.","authors":"Neel R Sangal, Katherine Xu, Praneet Kaki, Steven Cannady, Robert M Brody","doi":"10.1002/hed.28077","DOIUrl":"https://doi.org/10.1002/hed.28077","url":null,"abstract":"<p><strong>Importance: </strong>Laryngeal cancer has undergone a complex evolution in incidence, management, and standards of care over the past 20 years. Disease-wide demographic and survival risk factors have yet to be elucidated.</p><p><strong>Objective: </strong>Examine incidence, management, and survival trends in laryngeal cancer from 2000 to 2019.</p><p><strong>Design, setting, and participants: </strong>The Surveillance, Epidemiology, and End Results database was utilized to identify age-adjusted incidence rates (AAIRs) of laryngeal squamous cell carcinoma (LSCCa) from 2000 to 2019. Joinpoint regression was conducted to identify annual percentage changes (APCs). Chi-squared analysis was used to find changes in demographic, clinicopathologic, and treatment changes over the study period. Finally, univariate Kaplan-Meier and COX multivariate regressions were conducted to identify survival differences.</p><p><strong>Results: </strong>There were 46 266 cases of LSCCa identified between 2000 and 2019 with AAIR of 2.7 per 100 000 person-years with APC of -2.6% [95% CI: -2.8% to 2.4%]. These rates have largely been down-trending among demographic substratifications. Age at initial diagnosis has been increasing (64.6 → 66.0, p < 0.001). Higher median household income was associated with lower AAIR (35 000 5.3; > $75 000 2.2) and increased annual percentage decrease (< $35 000, -1.1%*; > $75 000, -3.2%*). There were no other clinically significant differences in demographic and clinicopathologic trends although persistent demographic differences were noted. Late T-stage at diagnosis has increased over the study period (T3, 18% → 23%, p < 0.001). Treatment with primary chemoradiotherapy has increased significantly (20.0% → 27.0%, p < 0.001). On univariate analysis, there were no significant differences in survival; however, on multivariate analysis, there has been a progressive improvement in disease-specific and overall survival over 5-year bins. Late-stage disease had a progressive improvement in survival with each treatment period on both univariate and multivariate analysis.</p><p><strong>Conclusions and relevance: </strong>There has been a progressively significant decrease in age-adjusted incidence of LSCCa with increased utilization of primary chemoradiotherapy. When adjusted for associated characteristics, there has been a continuing improvement in survival over the study period, primarily in late-stage disease.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Stratification for Trial Enrichment Considering Loco-Regional Failure in Head and Neck Cancer: UICC8 Versus Purpose-Built Failure-Type Specific Risk Prediction Model.","authors":"Katrin Håkansson, Daha Hassan Muse, Anna Bäck, Jacob H Rasmussen, Anne Marie Lindegaard, Lena Specht, Jeppe Friborg, Hedda Haugen Cange, Ivan R Vogelius","doi":"10.1002/hed.28085","DOIUrl":"https://doi.org/10.1002/hed.28085","url":null,"abstract":"<p><strong>Background: </strong>A previously published failure-type specific risk model showed good performance in the original cohort.</p><p><strong>Aim: </strong>to validate the model and separate patients with high- and low-risk loco-regional failure (LRF).</p><p><strong>Goal: </strong>to identify patients potentially suitable for treatment intensification trials.</p><p><strong>Methods: </strong>Validation data: 756 patients from two institutions (different countries). Predictive performance was evaluated by Brier scores and AUCs. Discriminatory performance was compared to Union for International Cancer Control (UICC) staging (versions 7 and 8).</p><p><strong>Results: </strong>The model's 3-year AUC for LRF was 65%, significantly better than UICC7 staging, but no significant difference to UICC8. Model-based risk stratification and UICC8 both identified high-risk patient groups with 3-year LRF ≈30%. The population mean was 18%.</p><p><strong>Conclusions: </strong>The model performed well on a group level. UICC8 staging performed equally well. Although developed for the endpoint of OS, an improvement from UICC version 7 to version 8 was evident also for the prediction of LRF.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Adjuvant Radiotherapy for Early-Stage Oral Cavity Cancer With Minor Adverse Features; A Single Institute Experience.","authors":"Eyal Yosefof, Nofar Edri, Noga Kurman, Gideon Bachar, Thomas Shpitzer, Aviram Mizrachi, Aron Popovtzer","doi":"10.1002/hed.28093","DOIUrl":"https://doi.org/10.1002/hed.28093","url":null,"abstract":"<p><strong>Background: </strong>The role of post-operative radiotherapy (PORT) in early-stage (T1-T2N0M0) oral tongue squamous cell carcinoma (OTSCC) with minor adverse features (MAF) including perineural invasion (PNI) and poorly differentiated carcinoma (PDC) is not well described. We aimed to study the role of PORT among these patients.</p><p><strong>Methods: </strong>A retrospective review of patients treated for early-stage OTSCC between 2000 and 2022 in a tertiary-care referral center while comparing patients treated by surgery and PORT with patients treated by surgery alone.</p><p><strong>Results: </strong>One hundred fifty-four patients were included and 36 (23.4%) received PORT. The PORT subgroup had a significantly higher rate of MAF. Survival rates were similar between the two sub-groups. PORT demonstrated a trend toward improved overall survival (odds ratio = 0.406, p = 0.07). Patients with PNI or PDC treated with PORT experienced improved survival rates.</p><p><strong>Conclusion: </strong>PORT has an important role when treating early-stage OTSCC with MAF. It should be considered especially among patients with PNI or PDC.</p>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}