Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献

{"title":"Poor Diet and Oral Cavity Cancer Risk in Smoking and Non-Smoking Men and Women: An Analysis of Three US Cohorts","authors":"Mateo Useche,&nbsp;Luis Gomez-Castillo,&nbsp;Kara Cushing-Haugen,&nbsp;Rocco Ferrandino,&nbsp;Neal Futran,&nbsp;Emily Marchiano,&nbsp;Cristina P. Rodriguez,&nbsp;Holly R. Harris,&nbsp;Brittany Barber","doi":"10.1002/hed.70317","DOIUrl":"10.1002/hed.70317","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Oral cavity cancer (OCC) incidence is rising among non-smokers and younger individuals without traditional risk factors. While carcinogenic exposures such as tobacco and alcohol are well studied, the association between unhealthy dietary patterns and OCC has been minimally explored. This study evaluated the association between dietary patterns and OCC risk in men and women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective cohort study used data from three large U.S. longitudinal cohorts: the Nurses' Health Study (<i>n</i> = 68 715, 1986–2016), Nurses' Health Study II (<i>n</i> = 93 887, 1991–2017), and the Health Professionals Follow-up Study (<i>n</i> = 47 923, 1986–2016). Participants included 162 602 women and 47 923 men without cancer at baseline. Dietary intake was assessed every 4 years using validated food frequency questionnaires. Three dietary patterns were evaluated: Western, Prudent, and the Alternative Healthy Eating Index-2010 (AHEI). Cox proportional hazard models estimated hazard ratios and 95% confidence intervals (CIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over 30 years of follow-up, 226 incident OCC cases were identified (124 in women and 102 in men). Among women, lower adherence to the Prudent and AHEI dietary patterns had higher OCC risk (HR for lowest vs. highest quartile, HR 1.86, 95% CI 1.03–3.35, and HR 2.17, 95% CI 1.24–3.77, respectively). Among non- or light-smoking and non- or light-drinking women, low adherence to the Prudent diet significantly increased OCC risk (HR for lowest vs. highest quartile 2.94, 95% CI 1.06–8.10). No associations were observed in men. Formal tests for interaction by sex were not statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Low adherence to Prudent and AHEI dietary patterns was associated with a higher risk of OCC in women but not men that warrants further investigation in larger pooled studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3004-3015"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.70317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147935471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Swallowing and Salivary Changes With CLR 131 and Re-Irradiation in Recurrent Head and Neck Cancer","authors":"Jenni Wu,&nbsp;Sara Gustafson,&nbsp;Meredith Hyun,&nbsp;Roxana Alexandridis,&nbsp;Mark Nicosia,&nbsp;Timothy McCulloch,&nbsp;Justine Bruce,&nbsp;Randall Kimple,&nbsp;Nicole Rogus-Pulia","doi":"10.1002/hed.70309","DOIUrl":"10.1002/hed.70309","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients with recurrent head and neck cancer (HNC) often present with severe, persistent dysphagia and xerostomia following prior chemoradiation. Although swallowing impairments and salivary dysfunction have been reported in this population, prior longitudinal studies have not examined changes in salivary composition or how these changes relate to swallowing physiology.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study characterized longitudinal changes in swallowing and salivary function—including composition—following treatment with CLR 131, a novel tumor-selective radiotherapeutic, combined with external beam radiation therapy (EBRT).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Twelve patients with locoregionally recurrent HNC demonstrating CLR 131 uptake on SPECT/CT imaging were enrolled. Videofluoroscopic swallowing (VFS) studies and stimulated saliva collections were performed at baseline, 3, 6, and 12 months posttreatment. Outcomes included Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) scores, swallowing temporal measures, patient-reported dysphagia using Eating Assessment Tool (EAT-10), and salivary flow rate, pH, and extensional viscosity.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;At baseline, participants demonstrated significantly worse swallowing and salivary function than published normative data (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Most swallowing measures remained stable following treatment; however, time to laryngeal vestibule closure with 5 mL pudding was prolonged at 3 months (&lt;i&gt;p&lt;/i&gt; &lt; 0.02). Stimulated salivary flow rate declined significantly at 12 months (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), while pH decreased at 3 months (&lt;i&gt;p&lt;/i&gt; &lt; 0.05) and extensional viscosity increased at 6 months (&lt;i&gt;p&lt;/i&gt; &lt; 0.02). From baseline to 3 months, EAT-10 scores were strongly associated with salivary pH and viscosity changes (&lt;i&gt;r&lt;/i&gt; = 0.84 and −0.99, respectively). No swallowing timing measures predicted DIGEST safety or efficiency grades.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;These findings suggest that CLR 131 + EBRT did not exacerbate objective swallowing impairment in the early post-treatment period, but patient-reported dysphagia was sensitive to post-treatment salivary alterations. Integrating salivary assessments with instrumental and patient-reported outcomes may enhance detection of functional toxicity and guide targeted dysphagia management in recurrent HNC.&lt;/p&gt;\u0000 &lt;","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3032-3042"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13271771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Chemoradiotherapy Versus Primary Surgery for Non-Metastatic Sinonasal Rhabdomyosarcoma in Adolescents and Adults","authors":"Tian Wang,&nbsp;Chuang Huang,&nbsp;Yi Li,&nbsp;Tianci Tang,&nbsp;Kai Xue,&nbsp;Xinmao Song","doi":"10.1002/hed.70319","DOIUrl":"10.1002/hed.70319","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Sinonasal rhabdomyosarcoma (SNRMS) is a rare malignancy with a poor prognosis. This study aimed to determine the optimal treatment modality for SNRMS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Fifty-five patients with SNRMS were treated at our institution between December 2012 and November 2022. Demographic characteristics, treatment information, and follow-up data were collected and analyzed. The log-rank tests were used to compare the differences between treatment groups, and overall survival (OS), progression-free survival (PFS), local failure-free survival (LFS), and distant metastasis-free survival (DMFS) were estimated using the Kaplan–Meier method. Cox proportional hazards models were used to determine the factors associated with OS and PFS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 2-year OS, PFS, LFS, and DMFS rates were 55.6%, 46.5%, 51.9%, and 52.1%, respectively. Surgery was not associated with improved 2-year OS (52.0% vs. 58.1%, <i>p</i> = 0.51), PFS (44.4% vs. 48.4%, <i>p</i> = 0.45), LFS (48.4% vs. 54.8%, <i>p</i> = 0.27), or DMFS (48.0% vs. 54.8%, <i>p</i> = 0.63) rates. Multivariate Cox regression analysis showed that primary chemoradiotherapy and intensity-modulated radiotherapy (IMRT)/volumetric modulated arc radiotherapy (VMAT) independently predicted improved OS and PFS, and lack of response to induction chemotherapy (IC) independently was associated with poorer OS and PFS. Multivariate logistic regression analysis showed that IMRT/VMAT and primary chemoradiotherapy were the factors associated with a lower risk of local recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Primary chemoradiotherapy may represent the optimal treatment. Primary chemoradiotherapy, response to IC, and radiation technique were the independent prognostic factors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3023-3031"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.70319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Phase II Trial of Consolidation Pembrolizumab After Definitive Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: KCSG HN19-09, CONPELAN Study","authors":"Sang Hoon Chun,&nbsp;Seyoung Seo,&nbsp;Jang Ho Cho,&nbsp;Keon-Uk Park,&nbsp;Sang-Cheol Lee,&nbsp;Yong Won Choi,&nbsp;Tak Yun,&nbsp;Seong Hoon Shin,&nbsp;Sung-Bae Kim,&nbsp;Seungeun Lee,&nbsp;Chang Ho Ahn,&nbsp;Bhumsuk Keam","doi":"10.1002/hed.70329","DOIUrl":"10.1002/hed.70329","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The benefit of consolidation programmed cell death protein 1 (PD-1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with stages II–IVB NPC were randomized (2:1) to pembrolizumab 200 mg or placebo every 3 weeks for up to 17 cycles after chemoradiotherapy. The primary endpoint was 3-year progression-free survival (PFS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-three patients were randomized (pembrolizumab, <i>n</i> = 34; placebo, <i>n</i> = 19). The 3-year PFS rates were 56.5% and 57.8% in the pembrolizumab and placebo arms, respectively (one-sided <i>p</i> = 0.142; stratified HR, 0.408). Grade 3 or higher adverse events occurred only in the pembrolizumab arm (8.8%). In an exploratory analysis (<i>n</i> = 40), high intratumoral TIL density was associated with reduced recurrence in the pembrolizumab arm (OR, 0.04; <i>p</i> = 0.010) but not the placebo arm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Consolidation pembrolizumab did not improve PFS in unselected locally advanced NPC. Exploratory immune profiling suggested a predictive signal warranting prospective validation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3103-3112"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.70329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharyngocutaneous Fistula After Total Laryngectomy: IFOS Consensus on Prevention, Diagnosis, and Management","authors":"Antonino Maniaci,&nbsp;Carlos Chiesa-Estomba,&nbsp;Aleix Rovira,&nbsp;Antoine Melkane,&nbsp;Armando De Virgilio,&nbsp;Bernard Lyons,&nbsp;Aina Brunet,&nbsp;Christian Calvo Henríquez,&nbsp;Enyi Ofo,&nbsp;Federica Maria Parisi,&nbsp;Giacomo Spinato,&nbsp;Giannicola Iannella,&nbsp;Giovanni Cammaroto,&nbsp;Giuditta Mannelli,&nbsp;Isabel Vilaseca,&nbsp;Jérôme R. Lechien,&nbsp;Luiz Paulo Kowalski,&nbsp;Marc Tobed,&nbsp;Maria Rosaria Barillari,&nbsp;Marta Filauro,&nbsp;Matthew R. Naunheim,&nbsp;Miguel Mayo-Yáñez,&nbsp;Johannes J. Fagan,&nbsp;Ricard Simo,&nbsp;Salvatore Lavalle,&nbsp;Gianluca Ferini,&nbsp;Giuseppe Lombardo,&nbsp;Skander Kedous,&nbsp;Mario Lentini,&nbsp;Sheng-Po Hao,&nbsp;Simone Mauramati,&nbsp;Tareck Ayad,&nbsp;Andy Bertolin,&nbsp;Paolo Boscolo-Rizzo,&nbsp;Alberto Maria Saibene,&nbsp;Nicolas Fakhry","doi":"10.1002/hed.70436","DOIUrl":"10.1002/hed.70436","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Importance&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Significant international variations exist for prevention methods, diagnostic, and management criteria for pharyngocutaneous fistula.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To formulate best practice management guidelines for pharyngocutaneous fistula after total laryngectomy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Design&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Modified Delphi consensus study conducted between January 2024 and November 2025 using two rounds of a structured survey. Levels of consensus were evaluated through a 9-point Likert scale and predefined cutoffs: strong consensus (≥ 80% in 7–9 range, median ≥ 9), consensus (≥ 80% in 7–9 range, median 8–9), near-consensus (≥ 70% in 7–9 range), or no-consensus (&lt; 70% agreement).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;International multicenter study. Participation of experts from 18 countries of America, Europe, Asia, South America, and Oceania, under the guidance of the International Federation of Oto-rhino-laryngological Societies (IFOS).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Participants&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A multidisciplinary international panel of 36 experts in head and neck surgery, otolaryngology, radiation oncology, radiology, and plastic surgery. The panelists were chosen for their clinical expertise in the area of total laryngectomy and pharyngocutaneous fistula management; published work in the form of peer-reviewed publications, as well as geographical representation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Outcomes and Measures&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The level of consensus in 59 statements regarding fistula definition and classification, preoperative risk factors, prevention strategies, diagnostic modalities, conservative management protocols, surgical intervention criteria, nutritional support, and patient outcomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A consensus or strong consensus was reached on 30 of 59 statements (50.8%). Strong consensus levels were reached for preoperative nutrition optimization (median 9.0), postoperative enteral feeding support (median 9.0), standardized surveillance protocols (median 9.0), and revision surgery for persisting fistulae (median 9.0). Consensus was also achieved for the use of vascularized tissue reinforcement in selected high-risk settings, although the preferred reconstructive strategy varied according to flap type and clinical scenario. Of the 29 statements, 5 (8.5%) were excluded at Round 1 as a","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"2953-2976"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submental Island Flap Versus Free Flap Reconstruction in Oral Squamous Cell Carcinoma After Neoadjuvant Immunochemotherapy: A Propensity Score Matched Analysis","authors":"Defeng Chen,&nbsp;Hongli Zhang,&nbsp;Liyuan Dai,&nbsp;Xu Zhang,&nbsp;Wei Du,&nbsp;Junhui Yuan,&nbsp;Qigen Fang","doi":"10.1002/hed.70322","DOIUrl":"10.1002/hed.70322","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The optimal reconstructive approach following neoadjuvant immunochemotherapy (NICT) and surgery for locally advanced oral squamous cell carcinoma (OSCC) remains debated. This study compared pedicled submental island flap (SIF) and free flap (FF) reconstruction in this contemporary treatment setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective comparative study of 212 consecutive patients with locally advanced OSCC treated with NICT followed by surgery. Propensity score matching (1:1) yielded a balanced cohort of 54 SIF and 54 FF patients. Outcomes included disease-free survival (DFS), overall survival (OS), operative time, complications, recovery milestones, and patient-reported quality of life (QoL) assessed via EORTC QLQ-C30/H&amp;N35 at baseline, 3, 6, and 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Operative time and hospital stay were significantly shorter for SIF (4.5 ± 1.1 vs. 6.3 ± 1.4 h, <i>p</i> &lt; 0.001; 8.1 ± 2.5 vs. 11.8 ± 3.1 days, <i>p</i> &lt; 0.001). Flap survival and major complication rates were comparable (<i>p</i> &gt; 0.05). Median follow-up was 38.5 months. No significant differences were observed in DFS (HR = 0.90, 95% CI: 0.41–1.98, <i>p</i> = 0.796) or OS (HR = 0.83, 95% CI: 0.34–2.00, <i>p</i> = 0.678). However, QoL recovery was superior in the SIF group, with significantly greater improvements in Global QoL (81.5 ± 8.2 vs. 73.9 ± 10.1, <i>p</i> &lt; 0.001), physical and social functioning, and head and neck-specific symptoms (swallowing, speech) at 12 months. Linear mixed models confirmed a favorable SIF trajectory over time (time-by-group interaction <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In patients with locally advanced OSCC undergoing NICT, SIF reconstruction offers comparable oncologic safety to FF while facilitating faster surgical recovery and yielding superior long-term functional and quality of life outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3052-3063"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Absolute Neutrophil Count With Outcomes in Patients With Head and Neck Cancer Receiving Definitive Chemoradiation","authors":"Jasmin Gill,&nbsp;Jas Virk,&nbsp;Mus'ab Azam,&nbsp;Fatemeh Fekrmandi,&nbsp;Austin Iovoli,&nbsp;Mark Farrugia,&nbsp;Ayham Al-Afif,&nbsp;Kimberly Wooten,&nbsp;Vishal Gupta,&nbsp;Ryan McSpadden,&nbsp;Moni A. Kuriakose,&nbsp;Michael R. Markiewicz,&nbsp;Wesley L. Hicks Jr,&nbsp;Sung Jun Ma,&nbsp;Anurag K. Singh","doi":"10.1002/hed.70324","DOIUrl":"10.1002/hed.70324","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Systematic inflammation plays an integral role in tumor development and metastasis. High neutrophil counts, among various peripheral blood biomarkers, have been shown to be associated with worse outcomes in multiple cancer types. To evaluate the absolute neutrophil count (ANC) as a prognostic biomarker in head and neck cancer, we performed an observational cohort study of patients undergoing definitive chemoradiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Our institutional database was queried for patients with non-metastatic head and neck cancer who underwent definitive chemoradiation between June 2007 and April 2023. ANC was analyzed as a continuous variable. Cox multivariable analysis (MVA), Fine-Gray MVA, and propensity score matching with its median value as a cutoff were performed. Subgroup analyses were performed among p16-positive cohorts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 668 patients who met our criteria. Median follow up was 30.3 months (interquartile range 9.9–60.7). Elevated ANC as a continuous variable was associated with worse overall survival (OS; adjusted hazards ratio [aHR] 1.02, 95% confidence interval [CI] 1.01–1.04, <i>p</i> = 0.003), progression free survival (PFS; aHR 1.03, 95% CI 1.01–1.04, <i>p</i> &lt; 0.001), and distant failure (DF; aHR 1.03, 95% CI 1.01–1.05, <i>p</i> = 0.007), but not locoregional failure (LRF; aHR 1.02, 95% CI 1.00–1.05, <i>p</i> = 0.10). Similar findings were noted among 278 matched pairs. Among 344 patients with p16-positive tumors, high ANC was associated with worse OS (aHR 1.03, 95% CI 1.00–1.06, <i>p</i> = 0.046), PFS (aHR 1.05, 95% CI 1.02–1.07, <i>p</i> &lt; 0.001), LRF (aHR 1.08, 95% CI 1.05–1.12, <i>p</i> &lt; 0.001), and DF (aHR 1.04, 95% CI 1.01–1.08, <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study suggested that elevated ANC was an independent, adverse prognostic factor for worse survival and distant metastasis outcomes. It was also associated with worse locoregional failure among patients with p16-positive tumors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3113-3119"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Rehabilitation of the Scapular Tip in Maxillary Reconstruction","authors":"Leba M. Sarkis,&nbsp;John Lee,&nbsp;Karl Cuddy,&nbsp;Brian Rittenberg,&nbsp;Majd Al Mardini,&nbsp;Christopher MKL Yao,&nbsp;Sharon Tzelnick,&nbsp;David Goldstein,&nbsp;Ralph Gilbert,&nbsp;John R. de Almeida","doi":"10.1002/hed.70251","DOIUrl":"10.1002/hed.70251","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The fibula-free flap has traditionally been utilized to perform dental rehabilitation following maxillectomy. The purpose of this study is to present our experience with dental implantation of the scapula–tip-free flap in midface reconstruction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifteen adult patients underwent midface reconstruction with dental implantation using the scapula tip between January 2013 and December 2023. Implant success was defined as maintenance of the implant after 6 months of healing with associated functional prosthetic rehabilitation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 35 implants were placed into 15 scapula-free flaps. There were four implant failures (11.4%) that occurred in three patients (20%) during the study period resulting in an overall implant success rate of 88.6% with a median follow-up period of 2.8 years. All patients were restored with a removable implant overdenture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Dental implantation can be achieved in the scapula tip following maxillectomy with a high degree of success.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3083-3088"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.70251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Label-Free Detection Using Tapered Optical Fiber System for Head and Neck Cancer and Infectious Biomolecules","authors":"Casey Collet,&nbsp;Cong Deng,&nbsp;De-Chen Lin,&nbsp;Cheyhun Nam,&nbsp;Chaminda Ranathunga,&nbsp;Partha Banerjee,&nbsp;Uttam Sinha","doi":"10.1002/hed.70267","DOIUrl":"10.1002/hed.70267","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the feasibility of a tapered optical fiber sensor (TOFS) platform for sensitive detection of a cancer-associated biomarker and a viral target in biologically relevant media.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Design</h3>\u0000 \u0000 <p>Experimental proof-of-concept study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>TOFS devices were functionalized with antibody–antigen complexes directed against interleukin-8 (IL-8) and human coronavirus OC43 (HCoV-OC43). IL-8 detection was evaluated in phosphate-buffered saline, and HCoV-OC43 detection was evaluated in saliva. Sensor performance was assessed by measuring optical phase changes generated by target binding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>TOFS detected IL-8 at low concentrations in phosphate-buffered saline, supporting its utility for sensitive protein detection. The platform also detected HCoV-OC43 in saliva, demonstrating feasibility in a complex biologic matrix. Together, these results show that TOFS can be adapted to distinct targets in different media while maintaining high analytical sensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrates the feasibility of TOFS as a rapid, portable, and potentially low-cost sensing platform for biomarker and pathogen detection. Further validation in clinically derived specimens is warranted to define its role in point-of-care diagnostic applications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3089-3096"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Parapharyngeal Benign Tumors via Combined Transcervical–Submandibular and Transoral Endoscopic Approach","authors":"Zhangwei Hu,&nbsp;Renqiang Ma,&nbsp;Jie Deng,&nbsp;Wei Sun,&nbsp;Lin Chen,&nbsp;Weiping Wen,&nbsp;Wenbin Lei","doi":"10.1002/hed.70301","DOIUrl":"10.1002/hed.70301","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To compare outcomes of the combined transcervical–submandibular and transoral endoscopic approach versus the open transcervical parotid approach and transoral endoscopic surgery alone, and to clarify the indications and advantages of the combined technique.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective observational study was conducted at a tertiary academic hospital in China between January 2013 and December 2024. A total of 114 consecutive patients with histologically confirmed benign parapharyngeal space tumors underwent the open transcervical parotid approach (<i>n</i> = 48), transoral endoscopic surgery alone (<i>n</i> = 42), or the combined transcervical-submandibular and transoral endoscopic approach (<i>n</i> = 24). Tumor size, intraoperative blood loss, hospitalization duration, tracheotomy rates, en-bloc resection rates, and surgery-related complications were compared among the three groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The combined surgery group had significantly larger tumors and a lower incidence of surgery-related complications. No statistically significant differences were observed among the three approaches in tracheostomy rates, intraoperative blood loss, operative duration, or hospitalization duration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The combined approach appears effective in reducing complications associated with resection of large, anatomically complex benign parapharyngeal tumors, particularly those involving critical neurovascular structures. This technique shows clinical value and warrants broader application.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"48 11","pages":"3043-3051"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}