Head and Neck-Journal for the Sciences and Specialties of the Head and Neck最新文献_第6页

Evaluating the reduction of elective radiotherapy fields for de novo metastatic nasopharyngeal carcinoma in the immunotherapy era. 评估免疫疗法时代减少新发转移性鼻咽癌选择性放疗野的情况。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-25 DOI: 10.1002/hed.27931

Ting Jin, Pei-Jing Li, Qi-Feng Jin, Yong-Hong Hua, Xiao-Zhong Chen

{"title":"Evaluating the reduction of elective radiotherapy fields for de novo metastatic nasopharyngeal carcinoma in the immunotherapy era.","authors":"Ting Jin, Pei-Jing Li, Qi-Feng Jin, Yong-Hong Hua, Xiao-Zhong Chen","doi":"10.1002/hed.27931","DOIUrl":"https://doi.org/10.1002/hed.27931","url":null,"abstract":"Background: This study evaluates the outcomes of omitting the high- and low-risk clinical tumor volume (CTV1 and CTV2) radiation in de novo metastatic nasopharyngeal carcinoma (dnm-NPC) patients in the immunotherapy era.Methods: We retrospectively analyzed 45 consecutive dnm-NPC patients receiving chemotherapy and immunotherapy combined with radiotherapy (CIR) from October 9, 2018 to June 1, 2022. Irradiation was only delivered to the primary tumor and retropharyngeal nodes (GTVnx+rn) and gross cervical lymph nodes (GTVnd).Results: The median follow-up was 45 (range, 15-67) months. There was no recurrence in the omitted elective regions. The 36-month LRRFS, PFS, and OS were 95.4%, 44.6%, and 90.8%, respectively. The main grade 3/4 hematologic toxicities were neutropenia (42.2%), anemia (20.0%), and thrombocytopenia (13.3%). The incidence of acute grade 3/4 dermatitis, mucositis, and xerostomia were 4.4%, 8.9%, and 4.4%, respectively.Conclusions: Omitting CTV1 and CTV2 was well-tolerated and provided favorable clinical outcomes in the era of immunotherapy.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative effectiveness and cost-effectiveness of endoscopic nasopharyngectomy versus intensity-modulated radiotherapy in the treatment of recurrent nasopharyngeal carcinoma: A microsimulation analysis. 治疗复发性鼻咽癌的内窥镜鼻咽切除术与调强放射治疗的有效性和成本效益比较：微观模拟分析。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-23 DOI: 10.1002/hed.27942

Mingjun Rui, Yingcheng Wang

{"title":"Comparative effectiveness and cost-effectiveness of endoscopic nasopharyngectomy versus intensity-modulated radiotherapy in the treatment of recurrent nasopharyngeal carcinoma: A microsimulation analysis.","authors":"Mingjun Rui, Yingcheng Wang","doi":"10.1002/hed.27942","DOIUrl":"https://doi.org/10.1002/hed.27942","url":null,"abstract":"Background: Nasopharyngeal carcinoma (NPC) is a significant health concern in southern China, like Guangdong and Hong Kong. This study aims to predict the effectiveness and cost-effectiveness of two prevalent NPC treatments, intensity-modulated radiotherapy (IMRT) and endoscopic nasopharyngectomy (ENPG).Methods: A microsimulation model was developed to project the long-term outcomes of IMRT and ENPG, simulating 5000 patients with hypothetical locally recurrent NPC for each treatment option. The tumors of patients confined to the nasopharyngeal cavity, the post-naris or nasal septum, the superficial parapharyngeal space, or the base wall of the sphenoid sinus. Analyses were performed from the healthcare system perspectives of Mainland China and the healthcare provider perspective of Hong Kong, with input parameters sourced from the existing literature and databases. The robustness of findings was evaluated through one-way and probabilistic sensitivity analyses.Results: For DFS, ENPG showed a 29% reduction in risk with an HR of 0.71 (95% CI: 0.64-0.77) compared to IMRT. ENPG demonstrated a significant survival benefit in OS with an HR of 0.59 (95% CI: 0.54-0.65), equating to a 41% reduction in mortality risk. In Hong Kong, IMRT and ENPG yielded QALY gains of 4.59 and 6.29, respectively, with ENPG exhibiting an incremental cost-effectiveness ratio (ICUR) of USD 13 057 per QALY. For Mainland China, ENPG denominated the IMRT and the ICUR was USD -1450 QALY. Probabilistic sensitivity analysis showed a 100% probability of ENPG being cost-effective at the willingness-to-pay thresholds of USD 130 490 per QALY in Hong Kong and USD 12 741 per QALY in Mainland China.Conclusion: The analysis confirms that ENPG is more effective and cost-effective than IMRT for treating recurrent NPC in both Hong Kong and Mainland China.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating lymph node ratio into personalized radiotherapy for oral cavity squamous cell carcinoma. 将淋巴结比例纳入口腔鳞状细胞癌的个性化放疗中。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-20 DOI: 10.1002/hed.27938

Linmei Zhang, Enzhao Zhu, Shaokang Cao, Zisheng Ai, Jiansheng Su

{"title":"Integrating lymph node ratio into personalized radiotherapy for oral cavity squamous cell carcinoma.","authors":"Linmei Zhang, Enzhao Zhu, Shaokang Cao, Zisheng Ai, Jiansheng Su","doi":"10.1002/hed.27938","DOIUrl":"https://doi.org/10.1002/hed.27938","url":null,"abstract":"Purpose: The use of postoperative radiotherapy (PORT) in patients with oral squamous cell carcinoma (OCSCC) lacks clear boundaries due to the non-negligible toxicity accompanying its remarkable cancer-killing effect. This study aims at validating the ability of deep learning models to develop individualized PORT recommendations for patients with OCSCC and quantifying the impact of patient characteristics on treatment selection.Methods: Participants were categorized into two groups based on alignment between model-recommended and actual treatment regimens, with their overall survival compared. Inverse probability treatment weighting was used to reduce bias, and a mixed-effects multivariate linear regression illustrated how baseline characteristics influenced PORT selection.Results: 4990 patients with OCSCC met the inclusion criteria. Deep Survival regression with Mixture Effects (DSME) demonstrated the best performance among all the models and National Comprehensive Cancer Network guidelines. The efficacy of PORT is enhanced as the lymph node ratio (LNR) increases. Similar enhancements in efficacy are observed in patients with advanced age, large tumors, multiple positive lymph nodes, tongue involvement, and stage IVA. Early-stage (stage 0-II) OCSCC may safely omit PORT.Conclusions: This is the first study to incorporate LNR as a tumor character to make personalized recommendations for patients. DSME can effectively identify potential beneficiaries of PORT and provide quantifiable survival benefits.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Circulating tumor HPV DNA in the management of HPV+ oropharyngeal cancer and its correlation with MRI” 更正 "HPV+口咽癌治疗中的循环肿瘤HPV DNA及其与核磁共振成像的相关性"

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-11 DOI: 10.1002/hed.27929

{"title":"Correction to “Circulating tumor HPV DNA in the management of HPV+ oropharyngeal cancer and its correlation with MRI”","authors":"","doi":"10.1002/hed.27929","DOIUrl":"10.1002/hed.27929","url":null,"abstract":"Campo F, Paolini F, Manciocco V, et al. Circulating tumor HPV DNA in the management of HPV+ oropharyngeal cancer and its correlation with MRI. Head Neck. 2024;46(9):2206–2213. doi: 10.1002/hed.27866. Epub 2024 Jul 9. PMID: 38979763.In paragraph 3.2, ctHPVDNA at diagnosis: “117 consecutive patients were prospectively enrolled in the study. In the study, 69 patients were p16+/HPV16+, 3 were p16/HPV33+, 6 were p16/HPV35+, 12 were p16+/HPV, 24 were p16 /HPV, and 1 was p16 /HPV16+.” This should have read:“117 consecutive patients were prospectively enrolled in the study. In the study, 71 patients were p16+/HPV16+, 3 were p16/HPV33+, 6 were p16/HPV35+, 12 were p16+/HPV, 24 were p16 /HPV, and 1 was p16 /HPV16+.”In paragraph 3.3, Longitudinal monitoring of ctHPVDNA: “To test for correlation of treatment response with ctHPVDNA, we collected sequential post-treatment blood samples in 60 of the 82 patients.” This should have read:“To test for correlation of treatment response with ctHPVDNA, we collected sequential post-treatment blood samples in 60 of the 83 patients.”We apologize for these errors.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.27929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoradiotherapy plus immunotherapy for locoregionally advanced nasopharyngeal carcinoma: A cost-effectiveness analysis. 化放疗加免疫疗法治疗局部晚期鼻咽癌：成本效益分析。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-08 DOI: 10.1002/hed.27932

Kun Liu, Youwen Zhu, Shan Li, Hong Zhu

{"title":"Chemoradiotherapy plus immunotherapy for locoregionally advanced nasopharyngeal carcinoma: A cost-effectiveness analysis.","authors":"Kun Liu, Youwen Zhu, Shan Li, Hong Zhu","doi":"10.1002/hed.27932","DOIUrl":"https://doi.org/10.1002/hed.27932","url":null,"abstract":"Background: Research focused on the addition of immune checkpoint inhibitors (ICIs) to radiotherapeutic regimens in patients with cancer has become increasingly common, revealing promising improvements in efficacy outcomes. In patients with locoregionally advanced nasopharyngeal carcinoma (NPC), combining immunotherapy with chemoradiotherapy can facilitate the significant prolongation of survival, emphasizing the need for pharmacoeconomic studies focused on the clinical uptake of these innovative treatment regimens.Methods: A three-state Markov model was developed based on clinical data from the randomized phase 3 CONTINUUM trial and used to compare the cost-effectiveness of chemoradiotherapy plus sintilimab (sintilimab group) to chemoradiotherapy alone (standard group), analyzing outcomes including incremental cost-effectiveness ratio (ICER), incremental net monetary benefit (INMB), and incremental net-health benefit (INHB) values at a willingness-to-pay (WTP) threshold corresponding to three times the Chinese GDP per capita ($37 035 per quality-adjusted life year [QALY]).Results: The total costs for patients in the sintilimab and standard groups (QALYs [LYs]) were $92 116 (6.68 [10.03]) and $53 255 (3.75 [5.55]), respectively, for an ICER of $13 230/QALY ($8672/LY), an INMB of $70 021 with INHB of 1.89 QALYs. Using the selected WTP threshold. On the standard WTP threshold, the prevalence of sintilimab group as the primary treatment was 90.55% in China. The establishment of the model is stable.Conclusions: Adding sintilimab to chemoradiotherapeutic regimens represents an innovative and cost-effective means for patients with locoregionally advanced NPC management in China.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical outcome of salvage surgery in patients with recurrent oral cavity cancer: A systematic review and meta-analysis 复发性口腔癌患者挽救手术的临床疗效：系统回顾和荟萃分析。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-07 DOI: 10.1002/hed.27928

Oh-Hyeong Lee MD, Jooin Bang MD, Geun-Jeon Kim MD, PhD, Dong-il Sun MD, PhD, Sang-Yeon Kim MD, PhD

{"title":"Clinical outcome of salvage surgery in patients with recurrent oral cavity cancer: A systematic review and meta-analysis","authors":"Oh-Hyeong Lee MD, Jooin Bang MD, Geun-Jeon Kim MD, PhD, Dong-il Sun MD, PhD, Sang-Yeon Kim MD, PhD","doi":"10.1002/hed.27928","DOIUrl":"10.1002/hed.27928","url":null,"abstract":"This systematic review and meta-analysis investigated the impact of salvage surgery on 5-year overall survival (OS) and prognostic factors in recurrent oral cavity cancer (rOCC) patients. Relevant literature before May 2022 was reviewed, including retrospective cohort studies and observational studies comparing salvage surgery to other treatments. Risk-of-bias assessments were conducted using the Newcastle–Ottawa scale. Statistical and subgroup analyses assessed the impact of salvage surgery on 5-year OS and prognostic factors. 3036 documents were initially retrieved, with 14 retrospective cohort studies (2069 participants) included. Meta-analysis of 5-year OS in salvage surgery patients yielded a rate of 43.0%. Subgroup analysis showed higher OS in Asians (49.9% vs. 36.9%, p = 0.003) and late-relapse (63.8% vs. 30.0%, p = 0.004) groups. Prognostic factors revealed hazards associated with nodal recurrence, extranodal extension, and perineural invasion. Salvage surgery is a viable option for rOCC patients, showing favorable 5-year OS outcomes. Low publication bias enhances study reliability, but its single-arm design limits conclusions on salvage surgery superiority over other treatments.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of osteoradionecrosis in patients with head and neck cancer treated with radiation therapy. 预防接受放射治疗的头颈部癌症患者发生骨坏死。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-08-30 DOI: 10.1002/hed.27927

Amara Naseer, Sinead Brennan, Denise MacCarthy, John Edward O'Connell, Eleanor O'Sullivan, Michelle Leech

引用次数: 0

Effectiveness and outcomes of endoscopic resection for superficial pharyngeal squamous cell carcinomas. 咽浅鳞状细胞癌内窥镜切除术的效果和结果。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-08-29 DOI: 10.1002/hed.27924

Naohiro Nakamura, Tomofumi Sakagami, Minaki Shimizu, Kensuke Suzuki, Takuo Fujisawa, Takuya Shijimaya, Sanshiro Kobayashi, Yu Takahashi, Tomomitsu Tahara, Yuri Noda, Koji Tsuta, Makoto Naganuma

{"title":"Effectiveness and outcomes of endoscopic resection for superficial pharyngeal squamous cell carcinomas.","authors":"Naohiro Nakamura, Tomofumi Sakagami, Minaki Shimizu, Kensuke Suzuki, Takuo Fujisawa, Takuya Shijimaya, Sanshiro Kobayashi, Yu Takahashi, Tomomitsu Tahara, Yuri Noda, Koji Tsuta, Makoto Naganuma","doi":"10.1002/hed.27924","DOIUrl":"https://doi.org/10.1002/hed.27924","url":null,"abstract":"Background: With the development of endoscopic imaging, superficial pharyngeal squamous cell carcinoma can now be detected during routine endoscopy. Recently, the effectiveness of endoscopic resection for superficial pharyngeal squamous cell carcinoma have been reported.Methods: This study had a retrospective single-center design that included patients with superficial pharyngeal squamous cell carcinoma who underwent endoscopic resection. A total 47 patients with 53 lesions were analyzed.Results: En bloc and R0 resection rates were 83.0% and 56.6%. Local recurrence and cervical lymph node metastasis (CLNM) were detected in 1 and 3 patients during follow-up. The macroscopic type 0-I was an independent factor for CLNM. The 3-year cumulative incidence of metachronous pharyngeal squamous cell carcinoma following endoscopic resection was 33.0%, and the 5-year overall survival rate was 89.2%.Conclusions: Endoscopic resection is an effective treatment for superficial pharyngeal squamous cell carcinomas, and the macroscopic type 0-I is a useful predictor of CLNM.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual pathology reports for improved collaboration at multidisciplinary head and neck tumor board. 可视化病理报告改善多学科头颈部肿瘤委员会的协作。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-08-29 DOI: 10.1002/hed.27926

Carly Fassler, Pratyusha Yalamanchi, Marina Aweeda, Julie Rezk, Barbara Murphy, Natalie A Lockney, Ryan Whitaker, Ryan Rigsby, Joseph Aulino, Emily Hosokawa, Mitra Mehrad, Kim Ely, James S Lewis, Evan Derman, Ed LaHood, Sarah L Rohde, Robert J Sinard, Eben L Rosenthal, Michael C Topf

{"title":"Visual pathology reports for improved collaboration at multidisciplinary head and neck tumor board.","authors":"Carly Fassler, Pratyusha Yalamanchi, Marina Aweeda, Julie Rezk, Barbara Murphy, Natalie A Lockney, Ryan Whitaker, Ryan Rigsby, Joseph Aulino, Emily Hosokawa, Mitra Mehrad, Kim Ely, James S Lewis, Evan Derman, Ed LaHood, Sarah L Rohde, Robert J Sinard, Eben L Rosenthal, Michael C Topf","doi":"10.1002/hed.27926","DOIUrl":"https://doi.org/10.1002/hed.27926","url":null,"abstract":"Purpose: Multidisciplinary tumor boards (TB) are the standard for discussing complex head and neck cancer cases. During TB, imaging and microscopic pathology is reviewed, but there is typically no visualization of the resected cancer.Methods: A pilot study was conducted to investigate the utility of visual pathology reports at weekly TB for 10 consecutive weeks. Faculty-level participants completed a pre-survey and post-survey to assess understanding of resected cancer specimens.Results: Providers (n = 25) across seven medical specialties completed pre-survey and post-survey. Following intervention, providers reported significant improvement in understanding of anatomic orientation of the specimen and sites of margin sampling (mean 47.4-96.1, p < 0.001), ability to locate the site of a positive margin (mean 69.5-91.1, p < 0.001), and confidence in treatment plans created (mean 69.5-89.2, p < 0.001) with the addition of visual pathology reports.Conclusions: Visual pathology reports improve provider understanding of resected cancer specimens at multidisciplinary TB.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression analysis of SOX2 and SOX9 in patients with oral squamous cell carcinoma. 口腔鳞状细胞癌患者中 SOX2 和 SOX9 的表达分析。

IF 2.3 3区医学

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-08-23 DOI: 10.1002/hed.27925

Sonja Steen, Dominik Horn, Christa Flechtenmacher, Jürgen Hoffmann, Kolja Freier, Oliver Ristow, Jochen Hess, Julius Moratin

{"title":"Expression analysis of SOX2 and SOX9 in patients with oral squamous cell carcinoma.","authors":"Sonja Steen, Dominik Horn, Christa Flechtenmacher, Jürgen Hoffmann, Kolja Freier, Oliver Ristow, Jochen Hess, Julius Moratin","doi":"10.1002/hed.27925","DOIUrl":"https://doi.org/10.1002/hed.27925","url":null,"abstract":"Background: Lately SOX2 and SOX9, transcription factors associated with stemness-like phenotypes of cancer cells, have been linked to tumor growth, metastasis, and resistance to therapy.Methods: This study aimed on evaluating the expression of SOX2 and SOX9 in a large cohort of patients with OSCC including primary and recurrent tumors and corresponding lymph node metastases. Semiautomatic digital pathology scoring was used to determine protein expression and survival analysis was performed to evaluate its prognostic significance.Results: We found a significant downregulation of SOX9 from primary disease to lymph node metastases (p < 0.001). SOX9 expression and the subgroup SOX2lowSOX9high were significantly correlated with worse overall survival (p < 0.05). Additionally, SOX2lowSOX9high expression pattern was confirmed as independent prognosticator for overall survival.Conclusions: These results indicate the relevant role of SOX2 and SOX9 in patients with OSCC and show the clinical relevance for further investigation on the molecular mechanisms underlying SOX-related gene expression.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0