Clinical Outcomes of Intensity Modulated Proton Therapy for Salivary Gland Carcinoma: High Local Control and Quality of Life Preservation.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-03-31 DOI:10.1002/hed.28149

Gaku Takano, Daisuke Kawakita, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Yusuke Tsuzuki, Shuou Sudo, Toshiyuki Toshito, Kensuke Hayashi, Takuma Matoba, Michi Sawabe, Kiyoshi Minohara, Sho Iwaki, Kazuyuki Nakai, Yu Iwase, Shinichi Iwasaki, Hiroyuki Ogino

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引用次数: 0

Abstract

Background: In recent years, particle therapy has shown promise as a local treatment for salivary gland carcinoma (SGC); however, its efficacy and safety remain unclear. This study aimed to evaluate the clinical outcomes of intensity-modulated proton therapy (IMPT) for SGC.

Methods: We performed a single-institution retrospective analysis of patients with SGC who underwent IMPT.

Results: IMPT was performed on 28 SGC patients, of which 18 were for definitive treatment and 10 were for postoperative treatment. The 2-year overall survival (OS), progression-free survival (PFS), and local control (LC) rates for definitive treatment cases were 70.1%, 25.0%, and 82.5%, respectively. The 2-year OS, PFS, and LC rates for postoperative treatment cases were 100%, 80.0%, and 90.0%, respectively. Quality of life scores in the EORTC QLQ-C30 and QLQ-HN35 were preserved for 1 year after treatment.

Conclusions: Our study suggests the efficacy and safety of IMPT in SGC patients.

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.