Differences in PD-L1, PD-L2, and EGFR Expression Between Naive and Recurrent Tumors in Patients With Head and Neck Squamous Cell Carcinoma: A Retrospective Study.

IF 2.3 3区 医学 Q1 OTORHINOLARYNGOLOGY
Ryosuke Sato, Takahiro Inoue, Risa Wakisaka, Hiroki Komatsuda, Michihisa Kono, Hidekiyo Yamaki, Kenzo Ohara, Takumi Kumai, Akemi Kosaka, Takayuki Ohkuri, Toshihiro Nagato, Kan Kishibe, Hiroya Kobayashi, Miki Takahara
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引用次数: 0

Abstract

Background: The efficacy of anti-PD-1 and EGFR therapies for head and neck squamous cell carcinoma (HNSCC) can be predicted using various markers; however, the stability of these markers remains unclear.

Methods: In this retrospective study, laboratory findings and tissue expression of PD-L1, PD-L2, and EGFR were analyzed in 79 paired naive and recurrent HNSCC tumors. Laboratory findings were also analyzed in nonrecurrent patients using a propensity score-matched analysis. PD-L1 and PD-L2 expression levels were assessed using tumor proportion score (TPS) and combined positive score (CPS), whereas EGFR was evaluated using the H-score.

Results: White blood cell, neutrophil, lymphocyte, and monocyte counts and lymphocyte-monocyte ratios were significantly lower in the patients after the first-line treatment regardless of recurrence. PD-L1, PD-L2, and EGFR expression changed in 30%-40% of tumor pairs. Immune but not tumoral PD-L1 positivity rates were significantly higher in the patients with early recurrence.

Conclusions: The expression of immune checkpoints including PD-L1 in naive tumors does not reflect those in recurrent tumors. Increasing PD-L1 expression in immune cells may cause early recurrence of HNSCC.

PD-L1、PD-L2和EGFR在头颈部鳞状细胞癌患者初发和复发肿瘤中的表达差异:一项回顾性研究
背景:抗pd -1和EGFR治疗头颈部鳞状细胞癌(HNSCC)的疗效可以通过各种标志物来预测;然而,这些标记的稳定性仍不清楚。方法:在这项回顾性研究中,分析了79对初发和复发的HNSCC肿瘤的实验室结果和组织中PD-L1、PD-L2和EGFR的表达。使用倾向评分匹配分析也分析了非复发患者的实验室结果。使用肿瘤比例评分(TPS)和联合阳性评分(CPS)评估PD-L1和PD-L2表达水平,而使用h评分评估EGFR。结果:不论复发与否,一线治疗后患者白细胞、中性粒细胞、淋巴细胞、单核细胞计数及淋巴细胞/单核细胞比值均显著降低。30%-40%的肿瘤对中PD-L1、PD-L2和EGFR表达发生变化。在早期复发的患者中,免疫而非肿瘤的PD-L1阳性率明显更高。结论:PD-L1等免疫检查点在初发肿瘤中的表达不能反映复发肿瘤中的表达。免疫细胞中PD-L1表达升高可能导致HNSCC早期复发。
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来源期刊
CiteScore
7.00
自引率
6.90%
发文量
278
审稿时长
1.6 months
期刊介绍: Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.
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