Health Psychology最新文献

{"title":"Long-term discrimination effects on adolescent health behaviors and well-being in four countries.","authors":"Christine Emmer, Anna Neumer, Frank Kalter, Jutta Mata","doi":"10.1037/hea0001496","DOIUrl":"https://doi.org/10.1037/hea0001496","url":null,"abstract":"<p><strong>Objective: </strong>Adolescence is a pivotal foundation for lifelong health and a phase vulnerable to the adverse effects of discrimination. We assessed the impact of perceived discrimination on adolescent well-being over 2 years and the mediating effects of protective (physical activity, nutrition, and sleep) and risky (substance use) health behaviors.</p><p><strong>Method: </strong>Adolescents (<i>N</i> = 9,957; <i>M</i>_age = 14.90 years) from the Children of Immigrants Longitudinal Survey in Four European Countries multinational panel (a longitudinal survey in four European countries) were examined across three waves. Direct and indirect relationships were analyzed using path models, adjusting for health behaviors, well-being, and control variables (age, gender, socioeconomic status, migration, and religion) assessed in Wave 1.</p><p><strong>Results: </strong>Adolescents reported the most discrimination instances within the school environment. Perceived discrimination at Wave 1 was significantly associated with decreased well-being at Wave 3 (β = -.04, <i>p</i> < .001) and decreased protective (physical activity, β = -.02; nutrition, β = -.04; sleep, β = -.04) and increased risky (substance use, β = .03) health behaviors at Wave 2. Nutrition and sleep mediated the relationship between perceived discrimination and well-being; no mediation was found for physical activity and substance use.</p><p><strong>Conclusions: </strong>Even in observational data with 1-year assessment intervals, detrimental long-term effects of perceived discrimination on adolescent well-being are apparent, mediated through changes in nutrition and sleep behaviors. These results extend previous research-predominantly focusing on substance use-showing that perceived discrimination also predicted fewer protective health behaviors. Adolescence represents a strategic window for addressing discrimination and promoting healthy behaviors and well-being to mitigate long-term health disparities. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional two-sample mendelian randomization analysis identifies a causal relationship between major depressive disorder and allergic diseases.","authors":"Qi Zhang, Ya-Kui Mou, Jia-Jia Yun, Ting Yang, Xiao-Yu Song, Zhen Wang, De-Qin Geng, Xi-Cheng Song, Chao Ren","doi":"10.1037/hea0001487","DOIUrl":"https://doi.org/10.1037/hea0001487","url":null,"abstract":"<p><strong>Background: </strong>Several studies have indicated an association between major depressive disorder (MDD) and allergic diseases (ADs), but the exact causal relationship remains inconclusive. Thus, this study aimed to explore the causal relationship between MDD and ADs employing bidirectional two-sample Mendelian randomization (MR).</p><p><strong>Method: </strong>The summary statistics for MDD were sourced from the Psychiatric Genomics Consortium. Single nucleotide polymorphisms (SNPs) associated with allergic asthma (AAS), allergic rhinitis (AR), and atopic dermatitis, were extracted from the FinnGen Consortium. The inverse variance weighted was primarily used in this MR analysis, with other methods as supplements. Several sensitivity analyses were performed to evaluate heterogeneity and horizontal pleiotropy. A reverse MR analysis was also conducted.</p><p><strong>Results: </strong>The inverse variance weighted method demonstrated a nominally significant association between MDD and an increased risk of AR (<i>OR</i> = 1.191, 95% confidence interval [CI] [1.006, 1.411], <i>p</i> = .042); after removing the two outlier Single nucleotide polymorphisms, a causal relationship was found between genetic susceptibility to MDD and AAS (<i>OR</i> = 1.418, 95% CI [1.207, 1.666], <i>p</i> = .000022). These results passed the heterogeneity and horizontal pleiotropy tests. However, MDD did not cause atopic dermatitis according to our results (<i>OR</i> = 1.049, 95% CI [0.903, 1.219], <i>p</i> = .53). Furthermore, reverse MR analysis unsupported ADs cause MDD.</p><p><strong>Conclusion: </strong>This MR study suggested a nominally significant causal relationship between MDD and increased risk of AR, and a specific condition-based causal relationship between MDD and AAS. In the future, these results need to be validated further. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship closeness in the context of chronic pain: Daily benefits and challenges for partners.","authors":"Lynn M Martire, Harry T Reis, John M Felt, Yan Huang","doi":"10.1037/hea0001481","DOIUrl":"https://doi.org/10.1037/hea0001481","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the divergent effects of daily relationship closeness on partners of individuals with chronic back pain (ICBPs). It examines whether greater daily closeness (emotional, behavioral, and cognitive) is associated with both increased partner distress due to ICBP's pain and more positive marital interactions.</p><p><strong>Method: </strong>Data were drawn from a 30-day daily diary study involving 147 older couples, where one partner suffers from chronic back pain. Participants completed daily surveys on pain experiences, distress, and relationship closeness using tablet computers. Multivariate multilevel models tested the moderating effects of closeness on the association between ICBP's pain-related experiences (severity, interference, and catastrophizing) and partner pain-related distress, while also assessing its impact on marital interaction quality.</p><p><strong>Results: </strong>As predicted, emotional closeness moderated the link between ICBP's pain severity and partner distress, with stronger distress reported on days of high emotional closeness. Emotional closeness was also associated with more positive marital interactions that day. Contrary to expectation, there was a stronger effect of ICBP's pain catastrophizing on partner distress on days of low behavioral closeness (i.e., less often working together on projects and engaging in outside interests together). Cognitive closeness showed a similar pattern, but the interaction was not statistically significant after inclusion of covariates.</p><p><strong>Conclusion: </strong>These findings illustrate a complex interplay between closeness and personal well-being in couples managing chronic illness and suggest the need for interventions that target both the benefits and potential costs of closeness. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The illness representations-physical well-being interplay over time in breast cancer patients.","authors":"Evangelos C Karademas, Ilan Roziner, Ketti Mazzocco, Ruth Pat-Horenczyk, Berta Sousa, Albino J Oliveira-Maia, Georgios Stamatakos, Haridimos Kondylakis, Eleni Kolokotroni, Sílvia Almeida, Raquel Lemos, Johanna Mattson, Panagiotis Simos, Paula Poikonen-Saksela","doi":"10.1037/hea0001499","DOIUrl":"https://doi.org/10.1037/hea0001499","url":null,"abstract":"<p><strong>Objective: </strong>Many studies have shown the prospective relation of illness representations to breast cancer patients' well-being. Still, very few have examined their bidirectional relationship over time. Here, the long-term mutual effects between physical well-being and illness representations were examined at the within-person level.</p><p><strong>Method: </strong>Female patients with breast cancer were enrolled in the study 2-5 weeks after the surgery or biopsy (baseline <i>N</i> = 706; <i>M</i>_age = 54.93). Several illness representations (i.e., illness consequences, timeline, personal control, and emotional representations) and physical well-being (i.e., general physical functioning and specific breast and arm symptoms) were assessed at 6, 12, and 18 months after patients' inclusion in the study (years of data collection: 2019-2021). Two random-intercept cross-lagged panel models were used to examine whether intrapersonal changes in the two variables predicted each other across time.</p><p><strong>Results: </strong>The findings showed strong general relations between illness representations and physical well-being at the between-person level. However, only changes in timeline and emotional representations predicted intrapersonal subsequent changes in physical functioning and arm and breast symptoms, respectively. No other cross-lagged effects were found.</p><p><strong>Conclusions: </strong>While illness representations are significantly associated with physical well-being at the between-person level, their impact significantly varies at the within-person level. The findings reflect the complex relationships between these factors in patients with breast cancer and point to the need for new theoretical approaches to better depict their long-term intrapersonal interplay. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological predictors of physical activity and sedentary time from childhood to adolescence.","authors":"Bror M Ranum, Lars Wichstrøm, Silje Steinsbekk","doi":"10.1037/hea0001494","DOIUrl":"https://doi.org/10.1037/hea0001494","url":null,"abstract":"<p><strong>Objective: </strong>Physical activity (PA) declines, while sedentariness increases, in the transition from childhood to adolescence. Factors to prevent such changes need to be identified. External structures for PA decrease with age, and individual characteristics play a more significant role. Prior research has indicated that well-regulated individuals with high perceived athletic competence (PAC) have more PA and less sedentariness. However, whether improvement in these characteristics predicts increased PA and reduced sedentariness in the longer term is unknown and, thus, the aim of the present inquiry. We also test potential age and sex differences.</p><p><strong>Method: </strong>A sample from two Norwegian birth cohorts (analytical sample: <i>n</i> = 858, 51.8% girls) was biennially assessed from age 6 to 18. Accelerometry was used to measure PA and sedentary time. Executive functions (teacher report), effortful control/conscientiousness (parent and self-report), and PAC (self-report) constituted the predictors. A random intercept cross-lagged panel model was applied, which adjusts for unobserved time-invariant confounding effects.</p><p><strong>Results: </strong>Increased conscientiousness predicted increased levels of PA from age 6 to 18 but was unrelated to later changes in sedentary time. Individuals who gained PAC also increased their PA and spent less time on sedentary activities. Changes in executive functions were unrelated to future changes in PA and sedentary time. No age or sex differences were found.</p><p><strong>Conclusion: </strong>Increased conscientiousness and PAC predicted increased PA from childhood to late adolescence. PAC predicted reduced sedentary time. Enhancing conscientiousness and PAC may benefit interventions to promote PA in youth. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of depressive symptoms and influencing factors among breast cancer patients: A longitudinal study.","authors":"Shiyi Chen, Minghong Tang, Zhihui Gu, Li Liu, Hui Wu, Mengyao Li","doi":"10.1037/hea0001480","DOIUrl":"https://doi.org/10.1037/hea0001480","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer patients suffer from depressive symptoms during treatments and may show different trajectories of depressive symptoms. The health ecology model provides an integrated perspective for explaining the factors influencing depressive symptoms. This study aimed to (a) analyze the trajectories of depressive symptoms that may occur in breast cancer patients and (b) explore their influencing factors by the health ecology model.</p><p><strong>Method: </strong>A total of 236 participants (<i>Mdn</i>_age = 55 years) finally completed three valid surveys. The patients answered a personal information sheet, the Self-rating Depression Scale, the Family Environment Scale, the Satisfaction With Life Scale, and the Fear of Progression Questionnaire-Short Form. Data were collected after surgery, 3 months after surgery, and 6 months after surgery. Latent Growth Mixture Modeling was used to identify distinct trajectories of depressive symptoms in patients. Influencing factors of trajectory memberships were identified using multinomial logistic regression.</p><p><strong>Results: </strong>Three distinct trajectory groups (\"slowly rising\"; <i>n</i> = 210, 89%, \"persistently low\"; <i>n</i> = 13, 5.5%, and \"fluctuating\"; <i>n</i> = 13, 5.5%) were revealed for depressive symptoms. Life satisfaction, family environment, and fear of progression were associated with an increasing trend of depressive symptoms, and family environment was associated with a fluctuating trend.</p><p><strong>Conclusion: </strong>Our findings demonstrated the diversity of depressive symptoms changes, along with the impact of factors in psychological behaviors layer and interpersonal networks layer. It helps to identify breast cancer patients at higher risk of increasing or fluctuating depressive symptoms, thereby allowing for relevant psychological interventions. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential gene expression in response to AWARENESS: A randomized controlled trial of an intersectional minority stress intervention.","authors":"Annesa Flentje, Gowri Sunder, Adam W Carrico, Kesava Asam, Torsten B Neilands, Nadra E Lisha, James Dilley, Elena Flowers, Kord Kober, Bradley Aouizerat","doi":"10.1037/hea0001451","DOIUrl":"10.1037/hea0001451","url":null,"abstract":"<p><strong>Objective: </strong>Past correlational research has shown that minority stress has direct and indirect effects on the biology of sexual minority people. This pilot randomized controlled trial (RCT) examined the potential of AWARENESS, a nine-session cognitive behavioral intervention to reduce intersectional minority stress, to alter gene expression related to immune function, inflammation, and HIV disease progression.</p><p><strong>Method: </strong>Between 2016 and 2019, 25 sexual minority men living with HIV with recent substance use (n = 12 in AWARENESS and n = 13 in control) were enrolled, a subset with complete gene expression data among the 41 individuals within the parent RCT. Blood samples were taken prior to the intervention, at the 9-week conclusion of the intervention, and at 4 months postrandomization, and leukocyte RNA was sequenced for all samples. The authors examined differential expression analyses of single genes and overrepresentation analysis of gene sets.</p><p><strong>Results: </strong>Neither AWARENESS nor the control condition was related to the differential expression of single genes. Overrepresentation analysis suggested that AWARENESS was related to changes over time in gene expression in leukocyte RNA in 52 gene sets (q < .05), many of which are related to immune function, while the active control condition was related to changes in gene expression among genes in only one gene set. When AWARENESS was compared to the control condition, four gene sets evidenced an overrepresentation of genes reflecting change over time.</p><p><strong>Conclusions: </strong>This RCT suggests that AWARENESS is associated with changes in gene expression, primarily focused on changes in genes associated with immune processes. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":"44 3","pages":"291-296"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial of a relationship education and HIV prevention program for young male couples: Biomedical and behavioral outcomes.","authors":"Michael E Newcomb, Gregory Swann, Elizabeth L Addington, Kathryn Macapagal, Judith T Moskowitz, Elissa L Sarno, Sarah W Whitton, Brian Mustanski","doi":"10.1037/hea0001448","DOIUrl":"10.1037/hea0001448","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the efficacy of the 2GETHER relationship education and HIV prevention program for young male couples in reducing the risk for HIV.</p><p><strong>Method: </strong>We conducted a randomized controlled trial of 2GETHER relative to an attention-matched and highly active positive affect enhancement program for couples. We randomized 128 young male couples (N = 256) to 2GETHER or control from 2017 to 2021. Primary biomedical outcome (i.e., rectal chlamydia and gonorrhea) was measured at baseline and 12 months and self-reported condomless anal sex was measured every 3 months across 12-month follow-up. Secondary outcomes were other HIV prevention and risk behaviors, relationship functioning, and substance use. We used multilevel models in MPlus to account for clustering with dyads and within-person change over time. Effects of time (for self-reported outcomes) were modeled using latent growth curves at the between-couple level.</p><p><strong>Results: </strong>We observed no differences between conditions in outcomes, but there was a significant change in outcomes across 12 months. Rates of rectal sexually transmitted infections and self-reported condomless anal sex decreased significantly in both conditions. We also observed significant increases in HIV testing, improvement in relationship communication, and reduction in alcohol-related problems in both conditions across 12 months.</p><p><strong>Conclusion: </strong>Couples in both the 2GETHER and positive affect enhancement programs showed improvement in biomedical and behavioral indicators of HIV risk, as well as improvement in relationship communication, but without a treatment effect we cannot conclude improvement resulted from the interventions. Couple-based programs that promote connectedness, including relationship education and positive affect enhancement, have a strong potential to reduce young couples' HIV risk. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":"44 3","pages":"297-309"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersectional discrimination, mental health, and health care access among transgender women in Brazil.","authors":"Ala Koreitem, A Rain Mocello, Jose Luis Gomez, Gustavo Saggese, Torsten Neilands, Maria Amelia de Sousa Mascena Veras, Sheri A Lippman, Jae Sevelius","doi":"10.1037/hea0001447","DOIUrl":"10.1037/hea0001447","url":null,"abstract":"<p><strong>Objectives: </strong>Intersectional discrimination leads to negative health outcomes among transgender (trans) women. To address the need for validated tools to measure experiences of intersectional discrimination, we evaluated the performance of the Intersectional Discrimination Index (InDI) and measured associations with mental health and health care engagement among trans women in São Paulo, Brazil.</p><p><strong>Method: </strong>Using baseline data from the Manas por Manas randomized controlled trial (n = 392), we characterized participant experiences of intersectional discrimination using the InDI-anticipated (InDI-A), day-to-day (InDI-D), and major (InDI-M) discrimination subscales. We evaluated the validity of the InDI-A using confirmatory factor analysis, and reliability using Cronbach's coefficient alpha (Cα) and explored relationships between each subscale, mental health, and health care engagement.</p><p><strong>Results: </strong>A single-factor solution yielded excellent for InDI-A. All subscales demonstrated good reliability: InDI-A (Cα = .85); InDI-D (lifetime Cα = .84, past-year Cα = .87), InDI-M (lifetime Cα = .78, past-year Cα = .76). A one-unit increase in anticipated discrimination was associated with severe psychological distress, adjusted odds ratio (AOR) = 2.13, 95% confidence interval (CI) [1.57, 2.89], p < .0001, and suicidality (AOR = 1.44, 95% CI [1.08, 1.93], p < .05). Similar patterns emerged for major and day-to-day discrimination. We observed important differences by race. Anticipated discrimination was associated with higher odds of HIV testing (AOR = 1.46, 95% CI [1.08, 1.97], p = .013). Discrimination was not associated with accessing primary care.</p><p><strong>Conclusion: </strong>The InDI is a valid and reliable tool for measuring intersectional discrimination among Brazilian trans women; InDI scores are strongly associated with negative mental health sequelae. Interventions are needed to mitigate structural barriers to care in Brazil, where poor mental health and HIV prevalence are high among trans women. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":"44 3","pages":"256-265"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood-level adversity and inflammation among sexual minority men living with HIV.","authors":"Delaram Ghanooni, Adam W Carrico, Annesa Flentje, Patricia I Moreno, Audrey Harkness, Samantha Dilworth, Savita Pahwa, Suresh Pallikkuth, Seann Regan, Bradley E Aouizerat, Dustin T Duncan","doi":"10.1037/hea0001479","DOIUrl":"10.1037/hea0001479","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study investigated the associations of neighborhood-level factors with immune activation, systemic inflammation, and leukocyte telomere length in 110 sexual minority men with human immunodeficiency virus.</p><p><strong>Method: </strong>From 2013 to 2017, sexual minority men with human immunodeficiency virus who used stimulants were recruited in San Francisco, California and provided blood samples to measure the markers of immune activation, systemic inflammation, and leukocyte telomere length. To measure neighborhood-level indices, the home address for each participant was geocoded and linked to data from the Centers for Disease Control and Prevention. Hierarchical linear modeling was employed to investigate the associations of neighborhood-level factors with systemic inflammation and leukocyte telomere length.</p><p><strong>Results: </strong>After adjusting for age, stimulant use, self-reported income, level of education, and race and ethnicity, residing in neighborhoods with greater percentages of poverty (β = .33, p < .001) and a higher proportion of racial/ethnic minority residents (β = .26, p < .05) were independently associated with higher levels of interleukin-6. Additionally, residing in neighborhoods with higher percentage of uninsured individuals was independently associated with higher tumor necrosis factor-alpha (β = .24, p < .05). Indices of neighborhood-level adversity were additionally associated with providing a urine sample that was reactive for stimulants (OR = 1.31, p = .002), which was, in turn, associated with shorter leukocyte telomere length (β = -.31, p < .05).</p><p><strong>Conclusions: </strong>Future longitudinal research should examine the biobehavioral pathways linking neighborhood-level factors and stimulant use with systemic inflammation and cellular aging. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":"44 3","pages":"188-196"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11856452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}