Health Psychology最新文献

{"title":"Bidirectional two-sample mendelian randomization analysis identifies a causal relationship between major depressive disorder and allergic diseases.","authors":"Qi Zhang, Ya-Kui Mou, Jia-Jia Yun, Ting Yang, Xiao-Yu Song, Zhen Wang, De-Qin Geng, Xi-Cheng Song, Chao Ren","doi":"10.1037/hea0001487","DOIUrl":"10.1037/hea0001487","url":null,"abstract":"<p><strong>Background: </strong>Several studies have indicated an association between major depressive disorder (MDD) and allergic diseases (ADs), but the exact causal relationship remains inconclusive. Thus, this study aimed to explore the causal relationship between MDD and ADs employing bidirectional two-sample Mendelian randomization (MR).</p><p><strong>Method: </strong>The summary statistics for MDD were sourced from the Psychiatric Genomics Consortium. Single nucleotide polymorphisms (SNPs) associated with allergic asthma (AAS), allergic rhinitis (AR), and atopic dermatitis, were extracted from the FinnGen Consortium. The inverse variance weighted was primarily used in this MR analysis, with other methods as supplements. Several sensitivity analyses were performed to evaluate heterogeneity and horizontal pleiotropy. A reverse MR analysis was also conducted.</p><p><strong>Results: </strong>The inverse variance weighted method demonstrated a nominally significant association between MDD and an increased risk of AR (<i>OR</i> = 1.191, 95% confidence interval [CI] [1.006, 1.411], <i>p</i> = .042); after removing the two outlier Single nucleotide polymorphisms, a causal relationship was found between genetic susceptibility to MDD and AAS (<i>OR</i> = 1.418, 95% CI [1.207, 1.666], <i>p</i> = .000022). These results passed the heterogeneity and horizontal pleiotropy tests. However, MDD did not cause atopic dermatitis according to our results (<i>OR</i> = 1.049, 95% CI [0.903, 1.219], <i>p</i> = .53). Furthermore, reverse MR analysis unsupported ADs cause MDD.</p><p><strong>Conclusion: </strong>This MR study suggested a nominally significant causal relationship between MDD and increased risk of AR, and a specific condition-based causal relationship between MDD and AAS. In the future, these results need to be validated further. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"810-820"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin-deep resilience in the Black women's experiences living with lupus study.","authors":"Kara W Chung, Connor D Martz, Brendan Lutz, Natalie Slopen, Bridget J Goosby, Tamika Webb-Detiege, David H Chae","doi":"10.1037/hea0001469","DOIUrl":"10.1037/hea0001469","url":null,"abstract":"<p><strong>Objective: </strong>The skin-deep resilience hypothesis suggests that Black Americans from disadvantaged backgrounds who attain academic or professional success despite social obstacles may paradoxically experience adverse physical health outcomes. This study examined skin-deep resilience among a sample of Black women with systemic lupus erythematosus (SLE), a disease sensitive to psychosocial stress.</p><p><strong>Method: </strong>Data were from 426 Black women with SLE from metropolitan Atlanta, Georgia, United States, recruited to the Black Women's Experiences Living with Lupus (BeWELL) Study. Multivariable linear regression models examined cross-sectional associations between adverse childhood experiences (ACEs) and SLE disease activity, and whether educational attainment and racial discrimination moderated this relationship.</p><p><strong>Results: </strong>There was a significant three-way interaction between educational attainment, ACEs, and racial discrimination, <i>F</i>(26, 399) = 2.92, <i>p</i> = .02. Racial discrimination was positively associated with disease activity; however, the relationship between discrimination and disease activity was the strongest among those who displayed high \"resilience,\" indicated by those attaining a graduate degree despite experiencing high childhood adversity (≥ 3 ACEs). There was no interaction between educational attainment and discrimination among those who experienced low childhood adversity (< 3 ACEs).</p><p><strong>Conclusion: </strong>Findings indicate that among Black women living with SLE, resilience to childhood adversity conferred worse physical health resulting from greater exposure to racial discrimination. Although educational attainment is traditionally conceptualized as protective for health, it may come with unintended physiological tolls for high-achieving Black women with SLE from disadvantaged backgrounds. Interventions aimed at \"building resilience\" without addressing underlying structural and social inequities could exacerbate racial health inequities. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"800-809"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relaxation techniques in chronic nonspecific neck pain: A systematic review and meta-analysis.","authors":"Julián Ángel Basco-López, Eva Rodríguez-Gutiérrez, Ana Torres-Costoso, Sara Reina-Gutiérrez, Purificación López-Muñoz, Sergio Núñez de Arenas-Arroyo, Juan Avendaño-Coy, Rubén Fernández-Rodríguez","doi":"10.1037/hea0001486","DOIUrl":"10.1037/hea0001486","url":null,"abstract":"<p><strong>Objective: </strong>Although previous evidence has shown positive results of conservative interventions on chronic pain, the specific effect of relaxation techniques on chronic nonspecific neck pain (CNNP) has not been studied. Thus, this study aimed to determine the effectiveness of relaxation techniques on neck pain intensity and pain-related disability in this population.</p><p><strong>Method: </strong>We systematically searched five databases from inception to November 2023 for randomized controlled trials comparing the effects of relaxation techniques versus physical therapy interventions and versus control on pain intensity and pain-related disability. A random-effect method was used for pooling the standardized mean difference and its related 95% confidence intervals (CIs) with the DerSimonian-Laird method. Meta-regression models were conducted to determine the influence of age, sex, and intervention characteristics on the effect estimates.</p><p><strong>Results: </strong>A total of 16 studies involving 1,384 adults (aged 30-56 years) with CNNP were included. The pooled standardized mean difference for relaxation techniques versus physical therapy intervention was not significantly different for pain intensity (-0.14; 95% CI = [-0.57, 0.30]) or pain-related disability (-0.02; 95% CI = [-0.37, 0.34]). Compared with the control condition, the relaxation technique significantly improved pain intensity (-0.48; 95% CI = [-0.79, -0.16]) and pain-related disability (-0.45; 95% CI = [-0.79, -0.11]).</p><p><strong>Conclusion: </strong>Relaxation techniques should be considered as an effective therapeutic strategy in the rehabilitation of CNNP since they may have a moderate effect on reducing pain and disability compared to the control condition. However, no differences were observed between relaxation techniques and physical therapy interventions. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"756-768"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological predictors of physical activity and sedentary time from childhood to adolescence.","authors":"Bror M Ranum, Lars Wichstrøm, Silje Steinsbekk","doi":"10.1037/hea0001494","DOIUrl":"10.1037/hea0001494","url":null,"abstract":"<p><strong>Objective: </strong>Physical activity (PA) declines, while sedentariness increases, in the transition from childhood to adolescence. Factors to prevent such changes need to be identified. External structures for PA decrease with age, and individual characteristics play a more significant role. Prior research has indicated that well-regulated individuals with high perceived athletic competence (PAC) have more PA and less sedentariness. However, whether improvement in these characteristics predicts increased PA and reduced sedentariness in the longer term is unknown and, thus, the aim of the present inquiry. We also test potential age and sex differences.</p><p><strong>Method: </strong>A sample from two Norwegian birth cohorts (analytical sample: <i>n</i> = 858, 51.8% girls) was biennially assessed from age 6 to 18. Accelerometry was used to measure PA and sedentary time. Executive functions (teacher report), effortful control/conscientiousness (parent and self-report), and PAC (self-report) constituted the predictors. A random intercept cross-lagged panel model was applied, which adjusts for unobserved time-invariant confounding effects.</p><p><strong>Results: </strong>Increased conscientiousness predicted increased levels of PA from age 6 to 18 but was unrelated to later changes in sedentary time. Individuals who gained PAC also increased their PA and spent less time on sedentary activities. Changes in executive functions were unrelated to future changes in PA and sedentary time. No age or sex differences were found.</p><p><strong>Conclusion: </strong>Increased conscientiousness and PAC predicted increased PA from childhood to late adolescence. PAC predicted reduced sedentary time. Enhancing conscientiousness and PAC may benefit interventions to promote PA in youth. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"789-799"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of psychological well-being on health: Systematic review and meta-analysis of hypertension, overweight/obesity, and mortality, including suicide.","authors":"Virginia Basterra-Gortari, Carmen Sayón-Orea, Miguel A Martinez-Gonzalez, Maira Bes-Rastrollo","doi":"10.1037/hea0001475","DOIUrl":"10.1037/hea0001475","url":null,"abstract":"<p><strong>Objectives: </strong>Psychological well-being (PWB) has demonstrated health-protective effects, but its impact on specific causes of death and cardiovascular risk factors incidence has received limited attention. This systematic review and meta-analysis (PROSPERO Registration: CRD42023387665) examine any positive dimension of PWB's association with the incidence of hypertension, overweight/obesity, metabolic syndrome, deaths from suicide, and noncommunicable disease mortality in the general adult population.</p><p><strong>Method: </strong>PubMed and PsycINFO were searched up to June 3, 2023. Random-effects meta-analyses estimated different outcome effect sizes. Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines were followed. Heterogeneity was assessed using the <i>I</i>² statistic, studies quality with the Newcastle-Ottawa scale, publication bias through funnel plots, and Egger's test. Subgroup (PWB dimensions, sex, quality assessment, sample size, follow-up period, and publication dates) and metaregression analyses were conducted.</p><p><strong>Results: </strong>The search identified 6,200 studies, with 159 articles eligible for review and 130 for meta-analysis. Higher PWB was associated with lower all-cause mortality (<i>OR</i> = 0.798, 95% confidence interval [CI] [0.773, 0.823], <i>I</i>² = 88.03%), and mortality from causes like suicide (<i>OR</i> = 0.505, 95% CI [0.337, 0.756], <i>I</i>² = 0.0%), cancer (OR = 0.924, 95% CI [0.858, 0.995], <i>I</i>² = 35.42%), cardiovascular disease (<i>OR</i> = 0.769, 95% CI [0.712, 0.832], <i>I</i>² = 55.64%), stroke (<i>OR</i> = 0.726, 95% CI [0.615, 0.858], <i>I</i>² = 56.96%), coronary heart disease (<i>OR</i> = 0.823, 95% CI [0.735, 0.922], <i>I</i>² = 45.03%), and hypertension incidence (<i>OR</i> = 0.921, 95% CI [0.860, 0.987], <i>I</i>² = 68.91%). No significant association was found for overweight/obesity incidence (<i>OR</i> = 0.922, 95% CI [0.801, 1.061], <i>I</i>² = 0.0%). Common sources of heterogeneity could not be identified.</p><p><strong>Conclusion: </strong>Higher PWB was associated with lower noncommunicable disease mortality, likely including suicide, and lower hypertension incidence. The limited number of studies on some outcomes, along with potential publication bias and heterogeneity, constrain definitive conclusions. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"745-755"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrimination and misconceptions about human immunodeficiency virus among gay and bisexual men.","authors":"Manuel F Ramirez, A Janet Tomiyama, Patrick A Wilson","doi":"10.1037/hea0001474","DOIUrl":"10.1037/hea0001474","url":null,"abstract":"<p><strong>Objective: </strong>Despite improvements in structural and biomedical interventions to stop the spread of human immunodeficiency virus (HIV), gay and bisexual men continue to be disproportionately impacted by HIV. One potential barrier to the uptake of HIV health care services is misconception about HIV prevention. Given high levels of societal stigma related to HIV and homophobia, we grounded the current study in the Health Stigma and Discrimination Framework and proposed that experiences of everyday discrimination would be associated with the endorsement of stigmatizing misconceptions about HIV prevention among gay and bisexual men. We also examined whether comfort with health care providers would mediate such association and whether differences by race and ethnicity existed.</p><p><strong>Method: </strong>Gay and bisexual men in New York (<i>N</i> = 293) completed a survey between 2017 and 2018 assessing everyday experiences of discrimination, comfort with health care providers, misconceptions about HIV prevention, and demographics.</p><p><strong>Results: </strong>Controlling for relevant covariates, regression analyses showed that more experiences of discrimination were associated with greater misconceptions about HIV, <i>b</i> = 0.23, <i>t</i>(284) = 6.240, <i>p</i> = .002. Next, although discrimination was negatively associated with comfort with health care providers, the overall mediation was not significant. Finally, moderation analyses revealed that the relationship between discrimination and misconceptions only held for non-Latine men (<i>p</i> = .002). Latine men had overall greater levels of misconceptions about HIV prevention regardless of discrimination experiences.</p><p><strong>Conclusions: </strong>Given the pervasiveness of discrimination, stigma-reduction interventions will be pivotal in redressing the HIV epidemic and should be implemented alongside other culturally sensitive HIV reduction strategies. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"769-778"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The illness representations-physical well-being interplay over time in breast cancer patients.","authors":"Evangelos C Karademas, Ilan Roziner, Ketti Mazzocco, Ruth Pat-Horenczyk, Berta Sousa, Albino J Oliveira-Maia, Georgios Stamatakos, Haridimos Kondylakis, Eleni Kolokotroni, Sílvia Almeida, Raquel Lemos, Johanna Mattson, Panagiotis Simos, Paula Poikonen-Saksela","doi":"10.1037/hea0001499","DOIUrl":"10.1037/hea0001499","url":null,"abstract":"<p><strong>Objective: </strong>Many studies have shown the prospective relation of illness representations to breast cancer patients' well-being. Still, very few have examined their bidirectional relationship over time. Here, the long-term mutual effects between physical well-being and illness representations were examined at the within-person level.</p><p><strong>Method: </strong>Female patients with breast cancer were enrolled in the study 2-5 weeks after the surgery or biopsy (baseline <i>N</i> = 706; <i>M</i>_age = 54.93). Several illness representations (i.e., illness consequences, timeline, personal control, and emotional representations) and physical well-being (i.e., general physical functioning and specific breast and arm symptoms) were assessed at 6, 12, and 18 months after patients' inclusion in the study (years of data collection: 2019-2021). Two random-intercept cross-lagged panel models were used to examine whether intrapersonal changes in the two variables predicted each other across time.</p><p><strong>Results: </strong>The findings showed strong general relations between illness representations and physical well-being at the between-person level. However, only changes in timeline and emotional representations predicted intrapersonal subsequent changes in physical functioning and arm and breast symptoms, respectively. No other cross-lagged effects were found.</p><p><strong>Conclusions: </strong>While illness representations are significantly associated with physical well-being at the between-person level, their impact significantly varies at the within-person level. The findings reflect the complex relationships between these factors in patients with breast cancer and point to the need for new theoretical approaches to better depict their long-term intrapersonal interplay. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":"779-788"},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial disparities in the efficacy of traditional versus acceptance-based behavioral weight loss.","authors":"Reena Chabria, Charlotte J Hagerman, Nikki Crane, Marny Ehmann, Francesca M Knudsen, Kristal Lyn Brown, Evan Forman, Meghan L Butryn","doi":"10.1037/hea0001537","DOIUrl":"https://doi.org/10.1037/hea0001537","url":null,"abstract":"<p><strong>Objective: </strong>Standard behavioral weight loss (SBT) is a first-line intervention for obesity, but its efficacy with Black adults is limited. Some preliminary work suggests that acceptance-based behavioral therapy (ABT), which integrates mindful decision making, experiential acceptance, and reflection on values, may be a better fit for the needs of Black adults. In this fully powered secondary data analysis, we compared the efficacy of SBT and ABT for Black adults.</p><p><strong>Method: </strong>Black and non-Hispanic White adults (<i>N</i> = 737) with overweight or obesity (body mass index = 27-50 kg/m²) were enrolled in one of the five randomized controlled trials investigating the effectiveness of ABT versus SBT. Analyses assessed the impact of race, treatment condition, and their interaction on percent weight loss at posttreatment and first follow-up assessment while controlling for clinical trial.</p><p><strong>Results: </strong>The interaction effects between race and treatment condition on weight loss were trending toward significance (<i>p</i> < .05) at posttreatment, <i>F</i>(1, 729) = 2.74, <i>p</i> = .089, but not at follow-up, <i>F</i>(1, 729) = .003, <i>p</i> = .957. Pairwise comparisons revealed that the disparity in posttreatment weight loss between Black and White participants in the SBT condition (<i>M</i> = 3.5%, <i>p</i> = .001) was attenuated in the ABT condition (<i>M</i> = 1.5%, <i>p</i> = .05).</p><p><strong>Conclusions: </strong>ABT has promise for supporting Black adults in weight loss attempts, although weight regain after treatment remains persistent for Black and White adults alike. Future research is warranted to continue developing this treatment approach as a tool to reduce health disparities. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The social ambivalence and disease model: Childhood trauma as an antecedent factor linking spousal ambivalence to inflammation.","authors":"Bert N Uchino, Tracey Tacana, Joshua Landvatter, Brian W Baucom, Timothy W Smith, Samantha Joel, Christopher Fagundes","doi":"10.1037/hea0001532","DOIUrl":"https://doi.org/10.1037/hea0001532","url":null,"abstract":"<p><strong>Objective: </strong>Ambivalence in relationships is related to health-relevant biological outcomes. However, the antecedent processes that contribute to this association are unknown. The primary aim of this study was to test the prediction of the social ambivalence and disease model, which highlights the potential role of childhood trauma as an antecedent factor linking spousal ambivalence to inflammation.</p><p><strong>Method: </strong>A sample of 107 heterosexual couples who had been married for at least 10 years was recruited. Participants completed the social relationship index to assess spousal ambivalence and the Childhood Trauma Questionnaire. Blood was drawn to determine levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 as measures of inflammation.</p><p><strong>Results: </strong>Consistent with the social ambivalence and disease model, there was a significant indirect effect in which childhood trauma was related to greater spousal ambivalence which in turn was associated with higher hs-CRP levels. No evidence for the statistical mediational model was found for interleukin-6.</p><p><strong>Conclusions: </strong>These results highlight the potential role of childhood trauma as an antecedent factor linking spousal ambivalence to hs-CRP. It also highlights potential pathways that might be targeted for interventions pending further work. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulated cytokine production, attachment, and emotional well-being in dementia spousal caregivers.","authors":"Daniel L Argueta, Sarah Roberts, Kelly N Brice, E Lydia Wu-Chung, Vincent D Lai, Jensine Paoletti-Hatcher, Bryan T Denny, Charles Green, Samantha Henry, Luis D Medina, Paul E Schulz, Jennifer Stinson, Cobi Heijnen, Christopher P Fagundes","doi":"10.1037/hea0001533","DOIUrl":"https://doi.org/10.1037/hea0001533","url":null,"abstract":"<p><strong>Background: </strong>Proinflammatory cytokine production may be related to poor emotional adjustment in dementia spousal caregivers. People who display attachment insecurity may be at increased risk for adverse caregiving experiences and poor psychosocial outcomes.</p><p><strong>Objective: </strong>This study aimed to understand whether proinflammatory cytokine production was associated with anticipatory grief, caregiver burden, and depressive symptoms and whether those relationships were stronger for caregivers higher on attachment anxiety or avoidance.</p><p><strong>Method: </strong>A sample of 103 dementia spousal caregivers provided self-report data on demographics, health information, and psychosocial outcomes. We also determined lipopolysaccharide-induced whole-blood interleukin-6, interleukin-1β, tumor necrosis factor-α, and interleukin-10 production and combined these cytokines into a composite score.</p><p><strong>Results: </strong>Higher cytokine production was associated with increased anticipatory grief and depressive symptoms. Proinflammatory cytokine production was only associated with anticipatory grief, caregiver burden, and depressive symptoms for those high on attachment anxiety or avoidance.</p><p><strong>Discussion: </strong>Targeting individuals who display a proinflammatory phenotype and report attachment insecurity may be a key first step in preventing poor caregiving adjustment in dementia spousal caregivers. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":55066,"journal":{"name":"Health Psychology","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}