Heart & Lung最新文献

{"title":"The impact of intraosseous vs intravenous vascular access during resuscitation in out-of-hospital cardiac arrest: A comprehensive systematic review and meta-analysis","authors":"Shree Rath ,&nbsp;Mohamed R. Abdelraouf ,&nbsp;Wajeeh Hassan ,&nbsp;Qasim Mehmood ,&nbsp;Muhammad Ansab ,&nbsp;Hazem Mohamed Salamah ,&nbsp;Pranjal Kumar Singh ,&nbsp;Anuraag Punukollu ,&nbsp;Hritvik Jain ,&nbsp;Raheel Ahmed","doi":"10.1016/j.hrtlng.2025.03.005","DOIUrl":"10.1016/j.hrtlng.2025.03.005","url":null,"abstract":"<div><h3>Background</h3><div>Out-of-hospital cardiac arrest (OHCA) is a known cause of mortality worldwide, especially in Western countries. One of the various treatment strategies includes vascular access for the administration of life-saving drugs such as epinephrine and lidocaine. While intravenous (IV) access is traditionally performed, recent studies have evaluated the use of intraosseous (IO) access as an alternative.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy of IV vs IO in improvement in patient outcomes with OHCA</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across five databases to identify studies comparing IV access to IO access in patients with OHCA. Statistical analysis via the ‘meta’ package and a random effects model was used and subgrouping was performed across adjusted and unadjusted values.</div></div><div><h3>Results</h3><div>Nineteen studies were included, with a total of 239,486 patients with OHCA (IV = 154,073; IO = 85,413). The incidence of return of spontaneous circulation (ROSC) was significantly lower in the IO group than in the IV group (OR = 0.71; 95 % CI: 0.65, 0.78; <em>p</em> &lt; 0.01), which was consistent across unadjusted and adjusted values. Additionally, the IO group had lower survival rates at admission, at discharge and at 30 days. The IO group had poorer neurological outcomes (OR = 0.64; 95 % CI: 0.49, 0.84; <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Our meta-analysis revealed the superiority of intravenous vascular access over intraosseous access in adult patients suffering from OHCA. However, further randomized trials are needed to confirm these results.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"72 ","pages":"Pages 20-31"},"PeriodicalIF":2.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic role of neutrophil–lymphocyte glycemic index in patients with pulmonary embolism","authors":"Mehmet Seyfettin Saribas ,&nbsp;Muhammet Ali Erinmez ,&nbsp;Mert Cemre Unal ,&nbsp;Tamer Colak","doi":"10.1016/j.hrtlng.2025.03.004","DOIUrl":"10.1016/j.hrtlng.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary embolism (PE) is a life-threatening condition characterized by significant morbidity and mortality. Its pathophysiology involves inflammation and stress hyperglycemia. The neutrophil-lymphocyte glycemic index (NLGI) integrates these components to offer a novel prognostic tool.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate the prognostic value of NLGI in predicting in-hospital mortality and major adverse events (MAEs) among patients diagnosed with PE.</div></div><div><h3>Methods</h3><div>A retrospective analysis included patients diagnosed with PE using computed tomography pulmonary angiography or ventilation/perfusion scans. Exclusion criteria included chronic PE, diabetes, renal/liver disease, or missing data. NLGI was calculated based on neutrophil count, lymphocyte count, and plasma glucose levels. The primary and secondary outcomes were in-hospital mortality and MAEs, respectively. Logistic regression and receiver operating characteristic (ROC) analyses were performed to assess prognostic performance.</div></div><div><h3>Results</h3><div>Among 281 patients, in-hospital mortality occurred in 10.3 %, while 17.8 % experienced MAEs. Elevated NLGI was significantly associated with higher mortality and MAEs. Logistic regression confirmed NLGI as an independent predictor of both outcomes. ROC analysis revealed that NLGI showed a higher AUC (0.854) in predicting in-hospital mortality compared to other markers.</div></div><div><h3>Conclusions</h3><div>NLGI is a robust, independent predictor of in-hospital mortality and MAEs in PE patients. Its simplicity and strong predictive capability make it a valuable tool for early risk stratification in clinical practice.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"72 ","pages":"Pages 13-19"},"PeriodicalIF":2.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waist circumference and body surface area and the risk of developing new-onset atrial fibrillation: A systematic review and meta-analysis of observational studies","authors":"Shayan Shojaei ,&nbsp;Hanieh Radkhah MD ,&nbsp;Iman Akhlaghipour ,&nbsp;Arya Nasimi Shad ,&nbsp;Alireza Azarboo ,&nbsp;Asma Mousavi","doi":"10.1016/j.hrtlng.2025.02.008","DOIUrl":"10.1016/j.hrtlng.2025.02.008","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with significant health consequences. Identifying modifiable risk factors, such as obesity, is crucial. While body mass index (BMI) is linked to increased AF risk, the association between new-onset AF (NOAF) and other anthropometric measures like waist circumference (WC) and body surface area (BSA) warrants further investigation.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis aimed to compare mean WC and BSA between individuals who developed NOAF and those who did not.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search up to February 2024 for studies comparing mean WC and BSA in groups with and without incident NOAF. Participants had no prior AF history. We used a random-effects model to calculate standardized mean differences (SMDs) and 95 % confidence intervals (CIs). Subgroup analyses explored NOAF occurrence following coronary artery bypass graft (CABG) surgery, in the absence of any preceding procedure, and after other cardiac procedures.</div></div><div><h3>Results</h3><div>Our analysis of 34 studies revealed that adults with NOAF had significantly higher WC (SMD = 0.20, 95 % CI 0.01; 0.39) and BSA (SMD = 0.06, 95 % CI 0.01; 0.11) compared to those without NOAF. Subgroup analysis showed a more pronounced association in individuals developing NOAF after CABG (SMD = 0.33, 95 % CI 0.17; 0.48) and in those without any prior procedure before NOAF diagnosis (SMD = 0.23, 95 % CI 0.08; 0.38) versus those without NOAF.</div></div><div><h3>Conclusion</h3><div>Higher WC and BSA appear to be significantly associated with an increased risk of NOAF, with the relations being more pronounced in specific subgroups.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"72 ","pages":"Pages 1-12"},"PeriodicalIF":2.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to enhance nurses' adherence to central line-associated bloodstream infection prevention bundles in the ICU setting: A systematic review","authors":"Diaa Bou Hamdan RN, MSN ,&nbsp;Sarah Hatahet RN, MSN ,&nbsp;Heba Khalil RN, PhD ,&nbsp;Khalil M. Yousef RN, PhD","doi":"10.1016/j.hrtlng.2025.02.009","DOIUrl":"10.1016/j.hrtlng.2025.02.009","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of central line-associated bloodstream infection (CLABSI) in the ICU continues to rise. Despite existing CLABSI bundles to prevent infections, adherence remains suboptimal.</div></div><div><h3>Objective</h3><div>To identify and synthesize the evidence about strategies used to enhance nurses’ adherence to CLABSI prevention bundles.</div></div><div><h3>Methods</h3><div>Five databases were searched: CINAHL, MEDLINE, PubMed, Cochrane Library, and SCOPUS. Eligible studies were those published between 2012–2024, and investigated the adherence to central line bundles and strategies to improve adherence in the ICU. Two reviewers independently screened, critically appraised, and extracted data using Joanna Briggs Institute tools. The review protocol was registered on PROSPERO (CRD42024513345).</div></div><div><h3>Results</h3><div>Seven studies met the inclusion criteria, including four quality improvement projects and three quasi-experimental studies. The studies ranged in quality from moderate to high, with scores between 68.75 %-88.88 %. These studies explored various strategies to enhance nurses' adherence to CLABSI prevention bundles. Strategies included education, leadership, and auditing/feedback mechanisms. Education was the primary strategy utilized and included simulation and online training. Active participation in decision making, transparency in sharing CLABSI outcome data, celebrating achievements, and electronic documentation were essential aspects of leadership support to promote adherence. Implementing these strategies led to significant improvements in nurses’ adherence to bundle (&lt;0.01).</div></div><div><h3>Conclusion</h3><div>Education, leadership, and audit mechanisms improve adherence to CLABSI bundles. Yet, the current evidence lacks randomized controlled trails that can establish effectiveness of these strategies. Future research should also investigate the long-term effect of these strategies on adherence, and the influence of organizational culture on CLABSI bundle adherence.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 98-105"},"PeriodicalIF":2.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can apelins guide the diagnosis of coronary artery disease in COPD patients?","authors":"Alperen Aksakal ,&nbsp;Buğra Kerget ,&nbsp;Burcu Nur Gülbahar ,&nbsp;Esra Laloğlu ,&nbsp;Leyla Sağlam","doi":"10.1016/j.hrtlng.2025.03.003","DOIUrl":"10.1016/j.hrtlng.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Apelins are adipokines known for their anti-inflammatory, vasodilator, and antiatherosclerotic effects. They are involved in the pathogenesis of chronic diseases like chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD).</div></div><div><h3>Objectives</h3><div>This study aims to investigate apelin as a potential biomarker for early diagnosis and management of CAD in COPD patients.</div></div><div><h3>Methods</h3><div>The study included 73 stable COPD patients admitted between June 2023 and June 2024 and 35 healthy volunteers matched by age and gender. COPD patients were categorized into two groups: those without CAD (Group 1) and those with CAD (Group 2). Serum levels of apelin 12, 13, 17, and 36 were measured using ELISA.</div></div><div><h3>Results</h3><div>Serum apelin levels were significantly lower in COPD patients than in controls (<em>p</em> &lt; 0.001). Among COPD patients, those with CAD showed lower serum apelin levels compared to those without CAD (<em>p</em> = 0.005 for apelin 12, <em>p</em> &lt; 0.001 for apelin 13, 17, and 36). ROC analysis indicated high sensitivity and specificity for apelin 13 and 36 in predicting CAD in COPD patients. Apelin 13 and 36 were positively correlated with ejection fraction (EF) (<em>R</em> = 0.43, <em>p</em> = 0.01; <em>R</em> = 0.4, <em>p</em> = 0.01), and apelin 12 was positively correlated with FEV1 and FVC (<em>R</em> = 0.24, <em>p</em> = 0.04; <em>R</em> = 0.27, <em>p</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>While CAD worsens the prognosis in COPD patients, it remains underdiagnosed. Serum apelin, especially apelin 13 and 36, may assist in the early diagnosis and management of CAD in COPD patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 90-97"},"PeriodicalIF":2.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventability of readmissions for patients with heart failure - A scoping review","authors":"Sibo Liu ,&nbsp;Nicholas Graves ,&nbsp;Chenxinan Ma ,&nbsp;Jingxiang Pan ,&nbsp;Yewei Xie ,&nbsp;Shan Yin Audry Lee ,&nbsp;Sameera Senanayake ,&nbsp;Sanjeewa Kularatna","doi":"10.1016/j.hrtlng.2025.03.002","DOIUrl":"10.1016/j.hrtlng.2025.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure (HF) remains a significant global health issue and poses challenges to patient families and healthcare systems through index hospitalizations and subsequent readmissions. The readmission rate has been utilized as a quality indicator, and a proportion of readmissions are perceived preventable. However, the definitions and measures of preventability remain unclear and inconsistent, lacking an explicit integration, analysis, and critique of current evidence.</div></div><div><h3>Objectives</h3><div>This scoping review aims to improve the understanding of the definitions and measures of preventable readmissions for patients with HF, by identifying the judgements in published literature and examining the reasonings behind them.</div></div><div><h3>Methods</h3><div>Systematic literature searches with a search strategy combining three compartments describing preventability, readmission, and HF were conducted. The inclusion and exclusion were performed against prespecified eligibility criteria.</div></div><div><h3>Results</h3><div>A total of 15 papers were identified. Substantial heterogeneity was observed in study characteristics and judgement of preventability. The proportion of readmissions deemed preventable ranged vastly from 6.66 % to 86 % and required careful interpretation due to inconsistency of denominators. The reasonings behind preventability can be categorized into four groups based on nature, focus, and purpose.</div></div><div><h3>Conclusions</h3><div>There is currently no consensus on definitions and measures of preventable readmissions for patients with HF. Scattered research efforts were observed with inconsistent and unstandardized methods, criteria, and data used for judgement of preventability. Adopting an identical readmission calculation framework is critical for fair comparison. The timeframe of readmission is worth further reconsideration and investigation. Comprehensive, explicit, and disease-specific judgement criteria for preventable readmissions are urgently needed.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 81-89"},"PeriodicalIF":2.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multidisciplinary transition of care approach to reduce 30-day readmissions in heart failure patients","authors":"Christina L. Craigo DNP MSN ACNP AACC ,&nbsp;Claire M. Dow MSN AGACNP FNP ,&nbsp;Yervant M. Malkhasian PharmD ,&nbsp;Margo B. Minissian PhD, ACNP, AACC ,&nbsp;Ronit Zadikany MD FACC ,&nbsp;Raymond Zimmer MD FACC","doi":"10.1016/j.hrtlng.2025.03.001","DOIUrl":"10.1016/j.hrtlng.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>While advancements in pharmacologic and device therapies have improved survival, one in five adults with heart failure (HF) patients is readmitted within 30 days of discharge. Thus, the epidemic of HF is largely one of increasing hospitalizations.</div></div><div><h3>Objective</h3><div>To determine if a comprehensive HF program reduces 30-day readmission rate.</div></div><div><h3>Methods</h3><div>A convenience sample of adults with Medicare and HF (N = 1617) admitted to a large academic medical center were identified. Patients received HF education by a specialized registered nurse while inpatient and were seen by a pharmacist prior to discharge. Post-discharge, patients were called by a pharmacist within 72 h, followed by an ambulatory care manager for 90 days, and scheduled for a multidisciplinary clinic visit with a nurse practitioner within 7 days of hospitalization. High risk patients were referred to a community health worker (CHW). Clinic services included phlebotomy, education, point-of-care ultrasound, intravenous diuretic administration, and referrals to appropriate services. Data were analyzed descriptively.</div></div><div><h3>Results</h3><div>The 30-day readmission rate was 18.39 % (N = 930) during the intervention period compared to 22.71 % (N = 617) at baseline, resulting in a 4.32 % reduction, <em>p</em> value 0.0325. Approximately 40 percent of the patient cohort was over age 85. Pharmacy was able to contact greater than 86 % of patients post discharge. Only half of patients were agreeable to ambulatory care management. Less than half (42 %) of eligible patients were seen in the post-discharge clinic. The CHW supported approximately 146 patients in a 9-month period.</div></div><div><h3>Conclusions</h3><div>A real-world comprehensive multidisciplinary team approach to the management of HF patients can reduce 30-day hospital readmissions.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 76-80"},"PeriodicalIF":2.4,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AAHFN leadership message","authors":"","doi":"10.1016/j.hrtlng.2025.02.011","DOIUrl":"10.1016/j.hrtlng.2025.02.011","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Page A1"},"PeriodicalIF":2.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing perceptions of leading causes of death in a diverse sample of community-dwelling women in the United States","authors":"Yoshimi Fukuoka PhD, RN, FAAN (Professor) ,&nbsp;Diane Dagyong Kim MA, PhD (student) ,&nbsp;Haruno Suzuki MS, RN, PhD (student) ,&nbsp;Kenji Sagae PhD (Professor) ,&nbsp;Holli A. DeVon PhD, RN, FAAN, FAHA (Professor) ,&nbsp;Thomas J. Hoffmann PhD (Professor) ,&nbsp;Jingwen Zhang PhD (Associate Professor)","doi":"10.1016/j.hrtlng.2025.02.007","DOIUrl":"10.1016/j.hrtlng.2025.02.007","url":null,"abstract":"<div><h3>Background</h3><div>Heart disease is the leading cause of death (LCOD) for women in the United States. However, despite decades of public health campaigns, awareness of heart disease among women, especially those with racial/ethnic minority backgrounds and young women, significantly declined from 2009 to 2019.</div></div><div><h3>Objectives</h3><div>The aim of this study was to compare the differences in heart disease awareness as the LCOD among Black, Hispanic, White, and Asian/Other women groups.</div></div><div><h3>Methods</h3><div>In this cross-sectional, online survey study, 422 community-dwelling women were analyzed. Heart disease as the LCOD was categorized as the correct answer. We implemented log-linear models via a Poisson regression to estimate unadjusted and adjusted relative risks [RRs] of race in predicting correct knowledge of LCOD.</div></div><div><h3>Results</h3><div>The mean age was 41.2 (±12.9) years. The sample represents 39.8 % Hispanic, 28.4 % White, 19.9 % Black, 11.9 % Asian/others. After adjusting for age and cardiovascular disease risks, Black and Hispanic women, as compared to White women, had significantly lower awareness of heart disease as the LCOD [(Adjusted RR=0.69, 95 % CI: 0.52, 0.92); (Adjusted RR= 0.78, 95 % CI: 0.78 -0.94), respectively]. Additionally, physical inactivity and hypertension medication intake were significantly associated with this level of awareness (<em>P</em> &lt; 0.5).</div></div><div><h3>Conclusion</h3><div>Lower heart disease awareness in Black and Hispanic women persists. It is crucial to develop more effective approaches to close this disparity. Testing new methods, such as applying artificial intelligence to send more culturally appropriate and personalized messages, is urgently needed to raise women's awareness of their heart disease risk.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 69-75"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the oral probiotic Familact on dyspnea management in COPD patients: A randomized controlled trial","authors":"Mehdi Aghamohammadi ,&nbsp;Samad Ghodrati ,&nbsp;Nooshin Jalili ,&nbsp;Roghayeh Jafari ,&nbsp;Effat Rafiee ,&nbsp;Koorosh Kamali ,&nbsp;Mahsa Ghasemi ,&nbsp;Javad Alizargar","doi":"10.1016/j.hrtlng.2025.02.002","DOIUrl":"10.1016/j.hrtlng.2025.02.002","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence suggests that oral probiotics may enhance the immune response in respiratory diseases, offering potential benefits in managing Chronic Obstructive Pulmonary Disease (COPD).</div></div><div><h3>Objectives</h3><div>This trial aims to evaluate whether the addition of the oral probiotic Familact to standard therapies significantly enhances dyspnea management in COPD patients compared to standard treatment alone.</div></div><div><h3>Methods</h3><div>In this single-blind randomized clinical trial 60 COPD patients randomly allocated into the control and intervention groups (<em>n</em> = 30). Over three months, the control group received standard treatment, while the intervention group received standard treatment plus oral Familact. Spirometry was conducted twice, and dyspnea was assessed four times using the Borg Scale Ratings (BORG) and Modified Medical Research Council Dyspnea Scale Scores in COPD patients (MMRC) scales and were evaluated using repeated measurement analysis.</div></div><div><h3>Results</h3><div>No significant change was observed in FEV1 post-intervention, but MMRC and BORG scores showed a statistically significant improvement in the intervention group compared to the control group (<em>P</em> &lt; 0.01). Repeated measures tests based on estimated marginal means revealed significant MMRC differences within groups over time, with inter-group differences notable only between the first and second measurements. BORG showed significant within- and between-group differences at all time points, confirmed by post hoc tests.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that Familact, as an oral probiotic can significantly alleviate dyspnea in COPD patients, as reflected in notable improvements in BORG and MMRC scores. These findings underscore the potential of probiotics as an adjunctive therapy for COPD, particularly in improving patient-reported outcomes related to respiratory difficulty.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 63-68"},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}