Heart & Lung最新文献

{"title":"The effect of sitting baduanjin in patients with ST-segment elevation acute myocardial infarction after percutaneous coronary intervention: A quasi-experimental study","authors":"Xiaocui Cao,&nbsp;Yanyan Dong,&nbsp;Hongjing Yu,&nbsp;Xuemei Liu,&nbsp;Yuqin Gu,&nbsp;Jian Song,&nbsp;Peng Ouyang,&nbsp;Zehang Hong","doi":"10.1016/j.hrtlng.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.04.003","url":null,"abstract":"<div><h3>Background</h3><p>Early cardiac rehabilitation plays a crucial role in the recovery of patients with ST-segment elevation acute myocardial infarction (STEMI) following percutaneous coronary intervention (PCI). This study sought to determine the effect of a program of sitting Baduanjin exercises on early cardiac rehabilitation.</p></div><div><h3>Objective</h3><p>The goal of this study was to investigate the effects of sitting Baduanjin exercises on cardiovascular and psychosocial functions in patients with STEMI following PCI.</p></div><div><h3>Methods</h3><p>This quasi-experimental study employed a randomized, non-equivalent group design. Patients in the intervention group received daily sitting Baduanjin training in addition to a series of seven-step rehabilitation exercises, whereas those in the control group received only the seven-step rehabilitation training, twice daily. Differences in heart rate variability (HRV) indicators, exercise capacity (Six-Minute Walking Distance; 6-MWD), anxiety (Generalized Anxiety Disorder-7; GAD-7), and depression (Patient Health Questionnaire-9; PHQ-9) between the two study groups during hospitalization were analyzed.</p></div><div><h3>Results</h3><p>Patients in the intervention group exhibited lower rates of abnormalities in the time domain and frequency domain parameters of HRV. The median scores of GAD-7 and PHQ-9 in both groups were lower than those at the time of admission, with the intervention group exhibiting lower scores than the control group (<em>P</em> &lt; 0.001; <em>P</em> &lt; 0.001, respectively). The 6-MWD after the intervention was greater in the intervention group compared to the control group (<em>P</em> = 0.014).</p></div><div><h3>Conclusions</h3><p>We found that sitting Baduanjin training has the potential to enhance HRV, cardiac function, and psychological well-being in patients with STEMI after PCI. This intervention can potentially improve the exercise capacity of a patient before discharge.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140535500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple coronary heart diseases are risk factors for mental health disorders: A mendelian randomization study","authors":"Tianwei Meng ,&nbsp;Zhiping Liu ,&nbsp;Jiawen Liu ,&nbsp;Xiaobing Zhang ,&nbsp;Chengjia Li ,&nbsp;Jiarui Li ,&nbsp;Boyu Wang ,&nbsp;Yinxiong He ,&nbsp;Zengguang Fan ,&nbsp;Shilong Xin ,&nbsp;Jia Chen ,&nbsp;Rui Qie","doi":"10.1016/j.hrtlng.2024.04.009","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.04.009","url":null,"abstract":"<div><h3>Background</h3><p>Previous observational studies have suggested associations between Coronary Heart Disease (CHD) and Mental Health Disorders (MHD). However, the causal nature of these relationships has remained elusive.</p></div><div><h3>Objective</h3><p>The purpose of this study is to elucidate the causal relationships between eight distinct types of CHD and six types of MHD using Mendelian randomization (MR) analysis.</p></div><div><h3>Methods</h3><p>The MR analysis employed a suite of methods including inverse variance-weighted (IVW), MR-Egger, weighted mode, weighted median, and simple mode techniques. To assess heterogeneity, IVW and MR-Egger tests were utilized. MR-Egger regression also served to investigate potential pleiotropy. The stability of IVW results was verified by leave-one-out sensitivity analysis.</p></div><div><h3>Results</h3><p>We analyzed data from over 2,473,005 CHD and 803,801 MHD patients, informed by instrumental variables from large-scale genomic studies on European populations. The analysis revealed a causal increase in the risk of Major Depressive Disorder and Mania associated with Coronary Artery Disease and Myocardial Infarction. Heart Failure was found to causally increase the risk for Bipolar Disorder and Schizophrenia. Atrial Fibrillation and Ischemic Heart Diseases were positively linked to Generalized Anxiety Disorder and Mania, respectively. There was no significant evidence of an association between Hypertensive Heart Disease, Hypertrophic Cardiomyopathy, Pulmonary Heart Disease, and MHD. Reverse MR analysis indicated that MHD do not serve as risk factors for CHD.</p></div><div><h3>Conclusions</h3><p>The findings suggest that specific types of CHD may act as risk factors for certain MHDs. Consequently, incorporating psychological assessments into the management of patients with CHD could be advantageous.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140536870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersection of social determinants of health with ventricular assist device therapy: An integrative review","authors":"Mireille Chehade,&nbsp;Komal Patel Murali,&nbsp;Victoria Vaughan Dickson ,&nbsp;Margaret M. McCarthy","doi":"10.1016/j.hrtlng.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.04.002","url":null,"abstract":"<div><h3>Background</h3><p>Social determinants of health (SDOH) may influence the clinical management of patients with heart failure. Further research is warranted on the relationship between SDOH and Ventricular Assist Device (VAD) therapy for heart failure.</p></div><div><h3>Objectives</h3><p>The purpose of this integrative review was to synthesize the state of knowledge on the intersection of SDOH with VAD therapy.</p></div><div><h3>Methods</h3><p>Guided by Whittemore and Knafl's methodology, this literature search captured three concepts of interest including VAD therapy, SDOH, and their domains of intersection with patient selection, decision-making, treatment outcome, and resource allocation. CINAHL, Embase, PsycINFO, PubMed, and Web of Science were searched in March 2023. Articles were included if they were peer-reviewed publications in English, published between 2006 and 2023, conducted in the United States, and examined VAD therapy in the context of adult patients (age ≥ 18 years).</p></div><div><h3>Results</h3><p>22 quantitative studies meeting the inclusion criteria informed the conceptualization of SDOH using the Healthy People 2030 framework. Four themes captured how the identified SDOH intersected with different processes relating to VAD therapy: patient decision-making, healthcare access and resource allocation, patient selection, and treatment outcomes. Most studies addressed the intersection of SDOH with healthcare access and treatment outcomes.</p></div><div><h3>Conclusion</h3><p>This review highlights substantial gaps in understanding how SDOH intersect with patient and patient selection for VAD. More research using mixed methods designs is warranted. On an institutional level, addressing bias and discrimination may have mitigated health disparities with treatment outcomes, but further research is needed for implementing system-wide change. Standardized assessment of SDOH is recommended throughout clinical practice from patient selection to outpatient VAD care.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Heart Failure Patient Foundation Position Statement on Research and Patient Involvement","authors":"Marilyn A. Prasun PhD, RN, CCNS, CHFN, FAHA (Carle BroMenn Medical Center Endowed Professor) ,&nbsp;Annette Hubbell PhD, RN (Assistant Professor) ,&nbsp;Lisa Rathman MSN, CRNP, CHFN (Acute Care Heart Failure Nurse Practitioner) ,&nbsp;Kelly D. Stamp PhD, NP-C, RN, CHFN, FAHA, FAAN (Associate Professor & Associate Dean of Academic Programs)","doi":"10.1016/j.hrtlng.2024.04.005","DOIUrl":"10.1016/j.hrtlng.2024.04.005","url":null,"abstract":"<div><h3>Background</h3><p>Heart Failure (HF) is a growing global public health problem affecting approximately 64 million people worldwide.</p></div><div><h3>Objectives</h3><p>The Heart Failure Patient Foundation developed a position statement to advocate for adult patients with HF to be an active participant in research and for HF leaders to integrate patients throughout the research process.</p></div><div><h3>Methods</h3><p>A review of the literature and best practices was conducted. Based on the evidence, the HF Patient Foundation made recommendations regarding the inclusion of adult patients with HF throughout the research process.</p></div><div><h3>Results</h3><p>Healthcare clinicians, researchers and funding agencies have a role to ensure rigorous quality research is performed and implemented into practice. Inclusion of adult patients with HF throughout the research process can improve the lives of patients and families while advancing HF science.</p></div><div><h3>Conclusions</h3><p>The HF Patient Foundation strongly advocates that patients with HF be involved in research from inception of the project through dissemination of findings to improve patient outcomes.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Board of Directors","authors":"","doi":"10.1016/S0147-9563(24)00037-2","DOIUrl":"https://doi.org/10.1016/S0147-9563(24)00037-2","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147956324000372/pdfft?md5=cf7345c44fe5223306ce6b466544f2b3&pid=1-s2.0-S0147956324000372-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140349902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-flow nasal cannula therapy versus conventional oxygen therapy for adult patients after cardiac surgery: A systemic review and meta-analysis","authors":"Chuantao Liu,&nbsp;Qihong Lin,&nbsp;Dongyu Li","doi":"10.1016/j.hrtlng.2024.03.008","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.03.008","url":null,"abstract":"<div><h3>Background</h3><p>Oxygen therapy constitutes a crucial element of post-cardiac operative care. The study assessed the effectiveness of high-flow nasal cannula (HFNC) in comparison to conventional oxygen therapy (COT).</p></div><div><h3>Objectives</h3><p>The aim of the study was to assess the effectiveness of HFNC in comparison to COT for adult patients following cardiac surgery.</p></div><div><h3>Methods</h3><p>We conducted a comprehensive search of Embase, PubMed, Scopus, Cochrane Library, and Web of Science databases from inception until April 18, 2023, to identify randomized controlled trials (RCTs) and crossover studies that compared the efficacy of HFNC with COT in adult patients following cardiac surgery.</p></div><div><h3>Results</h3><p>The meta-analysis included nine studies, consisting of eight RCTs and one crossover study. Compared with COT, HFNC could reduce the need for escalation of respiratory support (RR 0.67, 95% CI: 0.48 to 0.93, <em>P</em> = 0.02), decrease arterial partial pressure of carbon dioxide (PaCO₂) levels (MD -3.14, 95% CI: -4.90 to -1.39, <em>P</em>&lt;0.001), and increase forced expiratory volume in 1 second (FEV₁) levels (MD 0.08, 95% CI: 0.02 to 0.15, <em>P</em> = 0.02). There was no significant difference between the HFNC and COT groups in terms of mortality, intubation rate, respiratory rate, heart rate, intensive care unit and hospital length of stay, arterial partial pressure of oxygen (PaO₂), forced vital capacity, and complications of atrial fibrillation and delirium.</p></div><div><h3>Conclusion</h3><p>Compared with COT, HFNC could decrease the need for escalation of respiratory support, lower PaCO₂ levels, and elevate FEV₁ levels in patients following cardiac surgery.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147956324000475/pdfft?md5=862ff95c5c48ace6aedf9c998057a17d&pid=1-s2.0-S0147956324000475-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: “Nursing Care of the Patient Hospitalized with Heart Failure: Executive Summary: A Scientific Statement from the American Association of Heart Failure Nurses” [Heart Lung. 64(2024).A1-A5/doi:10.1016/j.hrtlng.2024.01.008. Epub 2024 Feb 7].","authors":"Meg Fraser (Chair) DNP, ANP-C, CHFN, FHFSA ,&nbsp;Stephanie G. Barnes MSN, AGPCNP-C, CHFN ,&nbsp;Carol Barsness MS, RD, LD, CNSC ,&nbsp;Craig Beavers PharmD ,&nbsp;Cynthia J. Bither ACNP, ANP, AACC, CHFN ,&nbsp;Samantha Boettger RN, BSN, CHFN ,&nbsp;Christine Hallman DNP, APRN, ACHPN, A-GNP-C ,&nbsp;Anne Keleman LICSW, APHSW-C ,&nbsp;Lauren Leckliter RN, MSN ,&nbsp;Colleen K. McIlvennan PhD, DNP, ANP-C, FHFSA ,&nbsp;Cemal Ozemek PhD, ACSM-CEP ,&nbsp;Amit Patel MD ,&nbsp;Natalie W. Pierson MSN, RN, NC-BC, FHFSA ,&nbsp;Courtney Shakowski PharmD, MS, FHFSA ,&nbsp;S. Craig Thomas MSN, ACNP, ACNS, CHFN ,&nbsp;Tara Whitmire DNP, APRN-NP, CHFN ,&nbsp;Kelley M. Anderson PhD, RN, FNP, CHFN","doi":"10.1016/j.hrtlng.2024.03.009","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.03.009","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147956324000499/pdfft?md5=d957fab3bc00dae9ea7bb415ebbf9862&pid=1-s2.0-S0147956324000499-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140343970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary isoflavone intake is inversely associated with remnant cholesterol in US adults: A cross-sectional study","authors":"Jing Cao ,&nbsp;Jinqi Zhu ,&nbsp;Sue Zhao","doi":"10.1016/j.hrtlng.2024.03.010","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.03.010","url":null,"abstract":"<div><h3>Background</h3><p>Several studies have shown that dietary isoflavones are negatively correlated with total cholesterol and low-density lipoprotein cholesterol. However, few studies have investigated the link between dietary isoflavones and remnant cholesterol (RC).</p></div><div><h3>Objectives</h3><p>We used the National Health and Nutrition Examination Survey (NHANES) database to explore the association between dietary isoflavone intake and RC.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted with 4731 participants aged ≥ 20 years from the 2007–2008, 2009–2010, and 2017–2018 NHANES databases. We adopted univariate and multiple linear regression analysis and restricted cubic spline (RCS) to assess the relationship between dietary isoflavone intake and RC. Moreover, we conducted stratified and interaction analyses to ensure the stability of the results and identify specific populations.</p></div><div><h3>Results</h3><p>The weighted multifactor linear regression model showed a negative correlation between dietary isoflavone intake and remnant cholesterol (Model 2, β = -0.049, 95% CI: (-0.096, -0.002), <em>P</em> = 0.040). The RCS analysis indicated that there was an L-shaped negative correlation between dietary isoflavone intake and RC (<em>P</em>-value for non-linearity was 0.0464). Stratified analyses showed the inverse relationship between dietary isoflavone intake and RC persisted in most subgroups and there was no interaction except for the recreational activity group.</p></div><div><h3>Conclusions</h3><p>Our study found a non-linear and negative association between dietary isoflavone intake and RC in US adults, so we hypothesized that consuming an isoflavone-rich diet may help reduce blood RC and further reduce the risk of cardiovascular disease.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140342250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the training satisfaction questionnaire for family members (TSQ-FM) entering the ICU during an isolation disease outbreak","authors":"Francesca Trotta MSN (PhD Student),&nbsp;Francesco Petrosino MSN (PhD Student),&nbsp;Gianluca Pucciarelli PhD, FAHA (Assistant Professor),&nbsp;Rosaria Alvaro MSN, FAAN, FESC (Professor),&nbsp;Ercole Vellone PhD, FAAN, FESC (Associate Professor),&nbsp;Davide Bartoli MSN (PhD Student)","doi":"10.1016/j.hrtlng.2024.03.004","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.03.004","url":null,"abstract":"<div><h3>Background</h3><p>The presence of family members in an isolated ICU during an isolation disease outbreak is restricted by hospital policies because of the infectious risk. This can be overcome by conferring to family members the skill and the ability to safely don and doff the personal protective equipment (PPE) through a nurse-led training intervention and assess their satisfaction, to respond to the need to define a safe, effective and quality care pathway focused on Family-Centered Care (FCC) principles.</p></div><div><h3>Objective</h3><p>the study aimed to build a valid and reliable instrument for clinical practice to assess family members’ satisfaction to allow ICU nurses to restore family integrity in any case of infectious disease outbreak that requires isolation.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted to test the psychometric properties. The questionnaire was constructed based on a literature review on the needs of family members in the ICU. 76 family members were admitted to a COVID-ICU. Cronbach's coefficient, Geomin rotated loading, and EFA were applied to assess the reliability and validity of the instrument.</p></div><div><h3>Results</h3><p>The Kaiser-Mayer-Olkin (KMO) measure was 0.662, the Bartlett sphericity test showed a significant <em>p-value</em> (χ²=448.33; df=45; <em>p</em> &lt; 0.01), Cronbach's alpha coefficient was.896. A further CFA analysis confirmed that all fit indices were acceptable. The results showed satisfactory validity and reliability, which could be generalized and extended to any outbreak of isolation disease.</p></div><div><h3>Conclusions</h3><p>This study provides a valid and reliable instrument for clinical practice to maintain family integrity in the dyadic relationship between the patient and the family member, even during an emergency infectious disease outbreak that requires isolation.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140341703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious respiratory pathogens among patients with acute exacerbation of idiopathic pulmonary fibrosis during the coronavirus disease 2019 pandemic in Japan","authors":"Kentaro Akata ,&nbsp;Kei Yamasaki ,&nbsp;Takako Kawaguchi ,&nbsp;Yosuke Chiba ,&nbsp;Konomi Sennari ,&nbsp;Saki Shigemi ,&nbsp;Kazuki Nemoto ,&nbsp;Midori Funada ,&nbsp;Katsunori Suzuki ,&nbsp;Kazuhiro Yatera","doi":"10.1016/j.hrtlng.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.03.007","url":null,"abstract":"<div><h3>Background</h3><p>Few studies have investigated the prevalence of pathogens in patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), specifically, the interactions between respiratory pathogens and AE-IPF during the coronavirus disease 2019 (COVID-19) pandemic.</p></div><div><h3>Objectives</h3><p>We aimed to analyze pathogens in patients with AE-IPF between September 2020 and December 2022.</p></div><div><h3>Methods</h3><p>This retrospective observational study was conducted at our hospital between September 2020 and December 2022. In patients with AE-IPF, pre-hospitalization polymerase chain reaction (PCR) tests for respiratory pathogens, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were performed using multiplex PCR or Smart Gene assay with nasopharyngeal swab specimens. Microbiological assays, including Gram staining, sputum cultures, blood cultures, and urinary antigen tests for <em>Streptococcus pneumoniae</em> and <em>Legionella pneumophila</em>, were also performed.</p></div><div><h3>Results</h3><p>Forty-nine patients with AE-IPF were included. The median age was 75 years old and 42 (86 %) were male. Only one of the 49 patients (2 %) was positive for SARS-CoV-2. Two of 28 patients (7 %) were positive for human rhinovirus/enterovirus. No bacteria were detected in sputum culture, blood culture, or urinary antigen tests.</p></div><div><h3>Conclusions</h3><p>The detection frequency of SARS-CoV-2 infection in patients with AE-IPF was lower than that of human rhinovirus/enterovirus. Continuous analysis for the presence of pathogens is necessary for appropriate infection control because respiratory viruses may increase as the coronavirus pandemic subsides.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140339367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}