Heart & Lung最新文献

{"title":"Supplemental oxygen prescriptions after hospitalization for coronavirus disease 2019","authors":"Zaidan MF ,&nbsp;Puebla Neira DA ,&nbsp;Lau C ,&nbsp;Nishi SP ,&nbsp;Duarte AD ,&nbsp;Wang J ,&nbsp;Kuo YF ,&nbsp;Sharma G","doi":"10.1016/j.hrtlng.2024.10.015","DOIUrl":"10.1016/j.hrtlng.2024.10.015","url":null,"abstract":"<div><h3>Background</h3><div>The role of home oxygen therapy for patients recovering from Coronavirus Disease 2019 (COVID-19) pneumonia, characterized by impaired gas exchange, is not well-defined.</div></div><div><h3>Objectives</h3><div>To compare the characteristics, duration, odds of receiving, and continuing to receive home oxygen prescriptions between patients discharged home after COVID-19 pneumonia hospitalization and those discharged after non-COVID-19 pneumonia.</div></div><div><h3>Methods</h3><div>From April 2020 to March 2021, 52,951 patients with COVID-19 pneumonia (53.6 % women, 64 % White) were identified, and from January 2019 to December 2019, 26,701 patients with non-COVID pneumonia (53.9 % women, 76.7 % White) were identified, using the Optum Clinformatics Data Mart Database. New oxygen prescriptions were identified through Healthcare Common Procedure Coding Systems codes. Propensity score matching adjusted for confounders, and Cox regression analysis was conducted to compare post-discharge oxygen use.</div></div><div><h3>Results</h3><div>Following hospitalization, oxygen was prescribed to 52,951 patients with COVID-19 pneumonia and 26,701 patients with non-COVID pneumonia in the United States. The COVID-19 pneumonia group were four times more likely to be prescribed supplemental oxygen compared to the non-COVID-19 pneumonia group (OR 4.22; 95 % confidence interval [CI] 3.76–4.74). This trend persisted in sensitivity analyses: ICU patients (OR 4.05; 95 % CI 3.36–4.88) and those who received both ICU admission and mechanical ventilation (OR 3.84; 95 % CI 2.32–6.37). Hispanic patients had the highest likelihood of receiving a supplemental oxygen prescription after discharge (OR 6.75; 95 % CI 5.03–9.05).</div></div><div><h3>Conclusions</h3><div>Post-hospitalization, one in five patients with COVID-19 received prescriptions for supplemental oxygen, which was significantly higher than the proportion of patients with non-COVID-19 pneumonia.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 208-216"},"PeriodicalIF":2.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inpatient mortality and outcomes of COVID-19 among patients with non-ischemic cardiomyopathy: A propensity matched analysis.","authors":"Mirza Faris Ali Baig, Kalyan Chaliki","doi":"10.1016/j.hrtlng.2024.06.018","DOIUrl":"10.1016/j.hrtlng.2024.06.018","url":null,"abstract":"<p><strong>Background: </strong>Patients with chronic medical conditions, particularly cardiovascular diseases, are at a greater risk of adverse outcomes due to COVID-19. The effect of COVID-19 on patients with non-ischemic cardiomyopathy (NICM) is not known well.</p><p><strong>Objectives: </strong>To study the impact of COVID-19 infection on NICM hospital mortality and other outcomes.</p><p><strong>Methods: </strong>This study included a cohort of patients from the 2020 and 2021 National Inpatient Sample databases. Patients hospitalized for COVID-19 with and without NICM were matched using a 1:1 propensity score-matching ratio. Outcomes analyzed were in-hospital mortality, rates of acute kidney injury (AKI), acute myocardial infarction (AMI), cardiogenic shock, cardiac arrest, mechanical ventilation, tracheal intubation, pulmonary embolism (PE), ventricular tachycardia (VT), ventricular fibrillation (VF), length of stay (LOS), and total hospitalization charges.</p><p><strong>Results: </strong>A total of 2,532,652 patients met the inclusion criteria (1,199,008 females [47.3 %], predominantly white 1,456,203 (57.5 %); mean [SD] age 63 [5.4] years), including 64,155 (2.5 %) patients with a history of NICM. Following propensity matching, 10,258 COVID-19 patients with and without NICM were matched. Patients with NICM had higher rates of AMI (11.1 vs. 7.1 %, p < 0.001), cardiogenic shock (2 vs. 0.6 %, p < 0.001), cardiac arrest (4.4 vs. 3.2 %, p < 0.01), mechanical ventilation (13.7 vs 12 %, p < 0.01), VT (8.5 vs. 2.2 %, p < 0.001), and VF (1.0 vs 0.25 %, p < 0.001). The odds ratios for in-hospital mortality, AKI, and PE did not differ significantly.</p><p><strong>Conclusion: </strong>A History of NICM does not affect COVID-19 mortality but increases the risk of cardiovascular complications.</p>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"68 ","pages":"160-165"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated biological age mediates the associations between sleep patterns and chronic respiratory diseases: Findings from the UK Biobank Cohort","authors":"Dongze Chen ,&nbsp;Zekang Su ,&nbsp;Yali Zhang ,&nbsp;Yi Bai ,&nbsp;Guiping Hu ,&nbsp;Yi Zhou ,&nbsp;Zhisheng Liang","doi":"10.1016/j.hrtlng.2024.10.012","DOIUrl":"10.1016/j.hrtlng.2024.10.012","url":null,"abstract":"<div><h3>Background</h3><div>Unhealthy sleep patterns and accelerated biological age are frequently associated with multiple chronic respiratory diseases (CRDs), including COPD, asthma, and interstitial lung disease (ILD). However, few studies have explored the role of biological age in the relationship between sleep patterns and CRDs.</div></div><div><h3>Objectives</h3><div>To explore the association between sleep patterns and CRD, and the extent to which biological age mediates the relationship between sleep patterns and CRD.</div></div><div><h3>Methods</h3><div>This was a prospective cohort study based on UK Biobank. The sleep score was derived from five self-reported sleep traits: sleep duration, daytime sleepiness, chronotype, snoring, and insomnia. The score ranged from 0 (least healthy) to 5 (healthiest). Biological age was represented by PhenoAgeAccel.</div></div><div><h3>Results</h3><div>Among 303,588 participants, 11,105 (3.7 %), 9,380 (3.1 %), and 1,667 (0.5 %) were diagnosed with asthma, COPD, and ILD, respectively. Each 1-point increase in the sleep score was associated with a 0.156-year reduction in PhenoAgeAccel, and 14.3 %, 12.4 %, and 6.7 % reduction in asthma, COPD, and ILD, respectively. For each 1-year increase in PhenoAgeAccel, the risk of asthma, COPD, and ILD increased by 2.8 %, 4.3 %, and 5.7 %, respectively. PhenoAgeAccel mediated the associations between the sleep score and asthma, COPD, and ILD, with a mediated proportion (95 % CI) of 2.81 % (2.35 % to 3.27 %), 4.94 % (4.23 % to 5.66 %), and 12.48 % (10.43 % to 14.53 %), respectively.</div></div><div><h3>Conclusion</h3><div>A better sleep score was significantly associated with younger biological age and decreased risk of CRDs, with biological age playing a mediating role in the association between sleep score and CRDs.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 192-201"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and cardiac biomarkers in pulmonary arterial hypertension: The prognostic role of IL-34","authors":"Hasan Ata Bolayır ,&nbsp;Mehdi Karasu MD ,&nbsp;Mehmet Ali Gelen MD ,&nbsp;Yusuf Akın MD ,&nbsp;Erkan Çeçen MD ,&nbsp;Uğur Küçük MD ,&nbsp;Aykut Bulu MD","doi":"10.1016/j.hrtlng.2024.10.010","DOIUrl":"10.1016/j.hrtlng.2024.10.010","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary artery pressure with significant morbidity and mortality. Inflammatory processes are crucial in PAH pathogenesis, with inflammatory cells and mediators present early in disease progression. IL-34 involvement in inflammatory pathways suggests that IL-34 could be an important player in the progression of PAH, influencing both pulmonary pressures and vascular changes.</div></div><div><h3>Objective</h3><div>The purpose of this study was to investigate the correlation between IL-34 levels and pulmonary arterial hypertension (PAH), aiming to enhance the understanding of the molecular mechanisms underlying PAH and explore IL-34′s potential as a biomarker.</div></div><div><h3>Methods</h3><div>Consecutive PAH patients diagnosed via right-heart catheterization at Malatya Turgut Ozal Eğitim ve Araştırma Hastanesi (Dec 2022 - Apr 2024) were enrolled. Patients were classified into low-risk and high-risk groups based on comprehensive risk assessments that included clinical parameters, hemodynamic measurements and biomarkers, in-line with ESC/ERS guidelines. Serum IL-34, hs-CRP, and NT-proBNP levels were measured and compared with those of healthy controls. Echocardiographic assessments and statistical analyses, including ROC analysis, were conducted to evaluate biomarker significance and predictive capabilities.</div></div><div><h3>Results</h3><div>The mean age of low-risk and high-risk PAH patients was 42 ± 7.2 years and 45 ± 5.5 years, respectively. The mean age of the control group was 40 ± 6.4 years. Males comprised 54.29 % of the low-risk group, 56 % of the high-risk group, and 53.3 % of the control group. IL-34 and hs-CRP levels were significantly elevated in PAH patients compared to controls. IL-34 correlated positively with systolic pulmonary artery pressure, RA area, and NT-proBNP levels. Multivariate analysis revealed that IL-34 and hs-CRP were independent predictors of PAH. IL-34 levels&gt;29.8 pg/mL predicted PAH with 78 % sensitivity and 69 % specificity, while levels &gt;44.4 pg/mL predicted high-risk PAH with 84 % sensitivity and 77 % specificity.</div></div><div><h3>Conclusion</h3><div>Elevated IL-34 and hs-CRP levels are associated with PAH severity and right ventricular dysfunction, suggesting IL-34′s potential as a diagnostic and prognostic biomarker. Further research is needed to validate these findings and explore IL-34-targeted therapies in pH management.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 202-207"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to death after compassionate extubation in medical and neuroscience intensive care units","authors":"Elaine Chen MD ,&nbsp;Nicholas Kosinski BA ,&nbsp;Ramandeep Kaur PhD","doi":"10.1016/j.hrtlng.2024.10.005","DOIUrl":"10.1016/j.hrtlng.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>Medical ICU (MICU) and neuroscience ICU (NSICU) populations undergoing compassionate extubation (CE) may have different characteristics that affect post-procedure outcomes.</div></div><div><h3>Objectives</h3><div>To contrast clinical characteristics and evaluate time to death (TTD) following CE in MICU and NSICU populations.</div></div><div><h3>Methods</h3><div>Single-center retrospective cohort study of patients who completed CE in a MICU or NSICU in 2021. Data were obtained by manual chart abstraction. A Mann-Whitney U test was used to compare characteristics between the clinical units.</div></div><div><h3>Results</h3><div>Fifty patients were included in the study, 27 were in the MICU and 23 in the NSICU. Median age was 68 years. Patients in the MICU had a longer LOS before CE than those in the NSICU (10.0 vs. 3.0 days, p=0.001). Patients in the MICU experienced a shorter median TTD after CE than those in the NSICU (25 vs. 195 mins, p=0.004). MICU patients had a higher pre-hospital burden of illness (median CCI 6 vs 3, p=0.003), and a higher degree of organ failure at CE (median SOFA 12 vs 6, p&lt;0.001), with more severe hypoxemia (PaO2/FiO2 ratio of 149 vs 360, p&lt;0.001). Most MICU patients died of infection or cancer, compared with NSICU patients who had intracranial hemorrhage or ischemic stroke.</div></div><div><h3>Conclusion</h3><div>Patients in the NSICU underwent CE after shorter time in the ICU and survived longer afterwards than MICU patients. Patients in the MICU have a higher pre-hospital severity of illness and a higher level of organ failure at the time of CE compared with NSICU patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 185-191"},"PeriodicalIF":2.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lived experiences of persons with heart transplantation: A systematic literature review and meta-synthesis","authors":"Safae Nour El Hadi RN, MSc ,&nbsp;Renzo Zanotti RN, PhD ,&nbsp;Matteo Danielis RN, PhD","doi":"10.1016/j.hrtlng.2024.10.013","DOIUrl":"10.1016/j.hrtlng.2024.10.013","url":null,"abstract":"<div><h3>Background</h3><div>Heart transplantation (HT) recipients often report improved quality of life and increased overall happiness, viewing the transplantation as a rebirth and a second chance at life. However, interpretations of normality vary among individuals. Understanding patients' and caregivers’ experiences in depth is crucial to adjust clinical care paths and avoid complications.</div></div><div><h3>Objective</h3><div>To examine the experiences of patients and caregivers after cardiac transplantation.</div></div><div><h3>Methods</h3><div>A systematic search of the literature was performed from January 1, 2013, to September 30, 2023, using the MEDLINE (PubMed), CINHAL (EBSCO), SCOPUS, Web of Science, and Embase (OVID) databases. Full-text, primary qualitative articles written in English, which reported patients’ experiences of daily life after HT, were included.</div></div><div><h3>Results</h3><div>The search yielded 5,114 articles; 13 articles that fully met the inclusion criteria were selected for extraction and synthesis. The inductive approach led to the identification of 28 codes, which were then grouped into seven categories and three themes: 1) Undergoing an emotionally charged journey, 2) Balancing personal health and social dynamics, and 3) Fostering existential reflection.</div></div><div><h3>Conclusions</h3><div>This review underscores the importance of further research and the development of a standardized assessment framework for post-HT patients, emphasizing the need to consider not just clinical factors but also psychological and personal aspects to improve outcomes and quality of life. Additionally, the review identified a lack of comprehensive information about the experiences of caregivers, highlighting the need for further studies to better understand and support their roles in the post-transplant journey.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 174-184"},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of day of admission on patients admitted with complete heart block: Analyzing the weekend effect","authors":"Nahush Roop Bansal ,&nbsp;Abdulmajeed Alharbi ,&nbsp;Shahnaz Rehman ,&nbsp;Ragheb Assaly","doi":"10.1016/j.hrtlng.2024.10.007","DOIUrl":"10.1016/j.hrtlng.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Complete heart block (CHB) is a conduction disorder that can be fatal if not treated promptly. Admission on a week or weekend day may influence the outcomes of cardiac emergencies, such as CHB.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to determine the effects of weekday vs. weekend admissions in terms of CHB outcomes.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted using the National Inpatient Sample database to study the outcomes of adult patients admitted with complete heart block. Outcomes were compared between the patients admitted on weekends (midnight Friday to midnight Sunday) and weekdays.</div></div><div><h3>Results</h3><div>Thirty-four thousand three hundred ninety-five patients were included, of which 7350 (21.37 %) were admitted on weekends. Mean age for included patients was 75.69 years, with 43.23 % females. Compared to those admitted on weekdays, participants admitted on weekends had similar mortality (aOR 0.73; 95 % CI 0.46–1.16), longer length of stay (mean increase 0.74 days; <em>P</em> &lt; 0.01) and higher hospital charges (mean increase $10,540.82; <em>P</em> &lt; 0.01). Weekend admissions were associated with higher rates of cardiac arrest (adjusted OR 1.40; 95 % CI 1.07–1.84; <em>P</em> = 0.02) and higher rates of cardiogenic shock (adjusted OR 1.40; 95 % CI 1.07–1.83; <em>P</em> = 0.01) and similar rates of permanent pacemaker implantation (adjusted OR 0.88; 95 % CI 0.77–1.01; <em>P</em> = 0.06), but had longer delay to permanent pacemaker (mean increase 0.46 days; <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Hospital and administrative-level strategies are needed to address the differences between the weekend and weekday CHB admissions.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 168-173"},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-morbidities and Disparities in Heart Failure Care, How Are We Doing?","authors":"Linda Ordway MS, NP","doi":"10.1016/j.hrtlng.2024.10.002","DOIUrl":"10.1016/j.hrtlng.2024.10.002","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Page A1"},"PeriodicalIF":2.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LUDT-ADHF trial: Lung ultrasound-guided diuretic therapy for hospitalized patients with acute decompensated heart failure: An open-label clinical trial","authors":"Masoud Kashoob MD ,&nbsp;Salim Al-Busaidi MD ,&nbsp;Juhaina Salim Al-Maqbali MSc ,&nbsp;Amira Al-Badi MD ,&nbsp;Aya Aalhamad MD ,&nbsp;Zubaida Al Falahi MD ,&nbsp;Aisha Al Huraizi MD ,&nbsp;Hatem Al Farhan MD ,&nbsp;Khalfan Al Zeedy MD ,&nbsp;Abdul Hakeem Al Hashim MD ,&nbsp;Mohammed H Al-Ghailani MD ,&nbsp;Muhammad Shoaib FRACP ,&nbsp;Haitham El Bingawi MD ,&nbsp;Abdullah M. Al Alawi FACP,FRACP","doi":"10.1016/j.hrtlng.2024.10.001","DOIUrl":"10.1016/j.hrtlng.2024.10.001","url":null,"abstract":"<div><div><strong>Background</strong> Acute Decompensated Heart Failure (ADHF) constitutes a major reason for hospital admissions and significantly contributes to increased morbidity and mortality. Limited research indicates that lung ultrasound (LUS) may enhance the care for patients with ADHF.</div><div><strong>Objective</strong>s The purpose of this study was to evaluate the impact of LUS-guided diuretic therapy on reducing length of hospital stay (LOS) and 90-day readmissions among patients with ADHF.</div><div><strong>Methods</strong> This open-label, non-randomized clinical trial included patients with ADHF managed with diuretics based on LUS findings of B-lines and pleural effusion (LUS group) compared to those receiving standard care (control group). The primary outcome was LOS during the index admission, and secondary outcomes included 90-day ADHF readmissions, all-cause readmissions, and safety parameters like acute kidney injury, hypokalemia, and hypotension.</div><div><strong>Results</strong> The study included a total of 77 patients, segregated into two groups: control and LUS. The median age of the patients was 68 years, with women slightly outnumbering men (53.25%, n=41). The most prevalent comorbidities were hypertension (88.31%, n=68), diabetes mellitus (59.74%, n=46), and chronic kidney disease (66.23%, n=51). The LUS group had a shorter LOS, though not statistically significant (4 vs five days, p= 0.175). Patients in the LUS group had significantly fewer 90-day ADHF readmissions compared to the control group (10.53% vs. 35.9%; p&lt;0.01). Survival analysis demonstrated that the LUS group had a longer time to 90-day ADHF readmissions, with a hazard ratio (HR) of 0.24 (95% CI: 0.08–0.75, p=0.014). For 90-day all-cause readmissions, the LUS group also showed a longer time to readmission compared to controls, with an HR of 0.45 (95% CI: 0.200–1.005, p=0.046). For other safety measures, there was no significant difference in the incidence of adverse events, including acute kidney injury, hypokalaemia, or hypotension, between the LUS and control groups.</div><div><strong>Conclusion</strong> LUS might reduce in-hospital mortality and readmissions among adults with acute decompensated HF. However, further double-blinded randomized clinical trials are needed to confirm these preliminary results.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 155-162"},"PeriodicalIF":2.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender and age predict advanced heart failure in gene-negative patients with hypertrophic cardiomyopathy","authors":"Fangfang Ji ,&nbsp;Xueshou Yu ,&nbsp;Wenxu Sheng ,&nbsp;Wenxiu Zhang ,&nbsp;Ying Wei ,&nbsp;Xiaobin Ji ,&nbsp;Zhengyi Shan ,&nbsp;Lin Qi","doi":"10.1016/j.hrtlng.2024.10.006","DOIUrl":"10.1016/j.hrtlng.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Patients with hypertrophic cardiomyopathy (HCM) may develop concomitant advanced heart failure (HF). However, there is limited data on the clinical outcomes of HCM patients without sarcomere gene mutations who have advanced HF.</div></div><div><h3>Objectives</h3><div>To identify prognostic factors for advanced HF in gene-negative patients within a large HCM cohort.</div></div><div><h3>Methods</h3><div>A total of 1529 unrelated patients with HCM were enrolled between 1999 and 2018, and followed throughout the study period. All patients underwent genotyping through whole exome or panel sequencing. From this cohort, 735 patients without mutations were studied. We assessed the effects of family history, clinical findings, and echocardiographic parameters on the development of advanced HF. Multivariable Cox proportional hazards regression analysis was conducted to identify risk factors associated with advanced HF.</div></div><div><h3>Results</h3><div>Of the 735 gene-negative patients studied, the mean age was 52.5±13.2 years, 69.5% were male, and the mean follow-up duration was 3.2±2.3 years. During this period, 97 patients (13.2%) developed advanced HF. Using multivariable analysis, we identified significant risk factors for advanced HF: female gender (adjusted hazard ratio [HR] 2.499, 95% confidence interval [CI] 1.531–4.081, P&lt;0.001) and older age at enrollment (adjusted HR 1.298, 95% CI 1.00–1.682, P=0.049). These findings suggest that female patients and those enrolled at an older age are at a higher risk for developing advanced HF.</div></div><div><h3>Conclusion</h3><div>Female gender and older age may predict a higher risk of advanced HF in gene-negative patients with HCM. Early detection and proactive treatment are crucial for managing and preventing complications in these patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"69 ","pages":"Pages 163-167"},"PeriodicalIF":2.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}