Prognostic role of neutrophil–lymphocyte glycemic index in patients with pulmonary embolism

IF 2.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart & Lung Pub Date : 2025-03-20 DOI:10.1016/j.hrtlng.2025.03.004

Mehmet Seyfettin Saribas , Muhammet Ali Erinmez , Mert Cemre Unal , Tamer Colak

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引用次数: 0

Abstract

Background

Pulmonary embolism (PE) is a life-threatening condition characterized by significant morbidity and mortality. Its pathophysiology involves inflammation and stress hyperglycemia. The neutrophil-lymphocyte glycemic index (NLGI) integrates these components to offer a novel prognostic tool.

Objectives

This study aimed to evaluate the prognostic value of NLGI in predicting in-hospital mortality and major adverse events (MAEs) among patients diagnosed with PE.

Methods

A retrospective analysis included patients diagnosed with PE using computed tomography pulmonary angiography or ventilation/perfusion scans. Exclusion criteria included chronic PE, diabetes, renal/liver disease, or missing data. NLGI was calculated based on neutrophil count, lymphocyte count, and plasma glucose levels. The primary and secondary outcomes were in-hospital mortality and MAEs, respectively. Logistic regression and receiver operating characteristic (ROC) analyses were performed to assess prognostic performance.

Results

Among 281 patients, in-hospital mortality occurred in 10.3 %, while 17.8 % experienced MAEs. Elevated NLGI was significantly associated with higher mortality and MAEs. Logistic regression confirmed NLGI as an independent predictor of both outcomes. ROC analysis revealed that NLGI showed a higher AUC (0.854) in predicting in-hospital mortality compared to other markers.

Conclusions

NLGI is a robust, independent predictor of in-hospital mortality and MAEs in PE patients. Its simplicity and strong predictive capability make it a valuable tool for early risk stratification in clinical practice.

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来源期刊

Heart & Lung 医学-呼吸系统

CiteScore

4.60

自引率

3.60%

发文量

184

审稿时长

35 days

期刊介绍： Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.