Heart & Lung最新文献

{"title":"Electrocardiogram parameters in predicting reversible ischemia in myocardial perfusion SPECT: A case-control study","authors":"Seda Gülbahar Ateş ,&nbsp;Hüseyin Emre Tosun ,&nbsp;Gamze Tatar","doi":"10.1016/j.hrtlng.2025.02.010","DOIUrl":"10.1016/j.hrtlng.2025.02.010","url":null,"abstract":"<div><h3>Background</h3><div>Myocardial perfusion single photon emission computed tomography (SPECT) and electrocardiogram(ECG) are crucial modalities in the evaluation of coronary artery disease(CAD) in clinical practice.</div></div><div><h3>Objective</h3><div>To evaluate the relationship between ventricular repolarization parameters, index of cardiac electrophysiological balance (iCEB) from basal electrocardiograms (ECG), and reversible ischemia findings on SPECT.</div></div><div><h3>Methods</h3><div>A total of 45 patients with reversible ischemia on 99m technetium-sestamibi (^99mTc-MIBI) stress-rest myocardial perfusion SPECT and confirmed CAD by coronary angiography were included in the ischemia group. Forty-five patients with normal scans, matched by age and gender with the ischemia patient group, were included in the control group. The two-day 99mTc-MIBI SPECT protocol was performed with adenosine-pharmacologic stress. The presence of ischemia and reversible ischemia size (RIS) were recorded in the ischemia group. The summed stress scores (SSS) were recorded for the ischemia and control groups. The QRS, QTd, cQTd, Tp-Te, Tp-Te/QT, Tp-Te/cQT, iCEB (QT/QRS), and iCEBc (cQT/QRS) were calculated. Correlations between myocardial perfusion SPECT and ECG parameters were evaluated using the Spearman test. Predictors of reversible ischemia were assessed using logistic regression analysis.</div></div><div><h3>Results</h3><div>The ischemia group showed significantly higher values for QRS duration (<em>p</em> = 0.018), cQTmax (<em>p</em> = 0.006), QTd (<em>p</em> = 0.002), and cQTd (<em>p</em> = 0.003). Tp-Te (<em>p</em> = 0.004), Tp-Te/QT ratio (<em>p</em> = 0.003), and Tp-Te/cQT ratio (<em>p</em> = 0.002) were significantly lower in the ischemia group. The multivariate analysis showed that hyperlipidemia, QRS duration, cQTd, and Tp-Te/QTc ratio were found as independent predictors of ischemia.</div></div><div><h3>Conclusion</h3><div>The Tp-Te/cQT ratio, QRS duration, and cQTd might be valuable predictors of reversible ischemia in SPECT, warranting further study.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 56-62"},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between brominated flame retardants and heart failure in U.S. adults: A cross-sectional analysis of national health and nutrition examination survey 2005-2016","authors":"Wei Wang ,&nbsp;Jiaxin Bao ,&nbsp;Yi Lu ,&nbsp;Hao Jiang","doi":"10.1016/j.hrtlng.2025.02.004","DOIUrl":"10.1016/j.hrtlng.2025.02.004","url":null,"abstract":"<div><h3>Background</h3><div>Brominated flame retardants (BFRs) are environmental pollutants widely used in consumer products, which accumulate in human tissues. Despite their prevalence, the potential impact of BFRs on cardiovascular health, particularly heart failure (HF), remains insufficiently explored.</div></div><div><h3>Objectives</h3><div>This study aims to investigate the association between BFR exposure and the prevalence of HF in U.S. adults.</div></div><div><h3>Methods</h3><div>Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2005–2016. To assess the relationship between BFR exposure and HF prevalence, weighted generalized linear regressions (GLMs) were applied. Restricted cubic splines (RCS) were used to examine potential nonlinear associations. Additionally, quantile-weighted quantile sum (WQS) regression and quantile g-computation (QGC) analysis were performed to evaluate the overall effect of BFR mixtures on HF.</div></div><div><h3>Results</h3><div>A total of 6,931 individuals participated, with 219 diagnosed with HF. In the adjusted Model 3, BFRs including PBDE28, PBDE47, PBDE85, PBDE99, PBDE100, PBDE154, and PBB153 were significantly associated with increased odds of HF (all <em>p</em> &lt; 0.05). RCS analysis revealed a significant nonlinear relationship between serum BFRs and HF. The WQS analysis showed a positive association between combined BFR exposure and HF (OR: 1.694; 95 % CI: 1.264, 2.270; <em>p</em> &lt; 0.001), and QGC analysis similarly showed a significant positive association (OR: 1.365; 95 % CI: 1.094, 1.705; <em>p</em> = 0.006).</div></div><div><h3>Conclusion</h3><div>This study suggests a link between BFR exposure and an increased risk of HF. Further research is needed to explore the causal relationship and underlying mechanisms.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 47-55"},"PeriodicalIF":2.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effect of illness perception on motor function in cardioembolic stroke patients using the fear-avoidance model: The mediating role of kinesiophobia","authors":"Yunmei Ding ,&nbsp;Shouwei Yue ,&nbsp;Jing Li ,&nbsp;Lu Wang ,&nbsp;Jiayun Gu ,&nbsp;Yan Cui","doi":"10.1016/j.hrtlng.2025.02.006","DOIUrl":"10.1016/j.hrtlng.2025.02.006","url":null,"abstract":"<div><h3>Background</h3><div>Cardioembolic stroke is the most common cause of ischemic stroke, and patients frequently have motor dysfunction as well as psychological disorders. Both physical and psychological causes can have an impact on a patient's motor function.</div></div><div><h3>Objectives</h3><div>In this study, we used the fear-avoidance model to examine the impact of patients' illness perception and kinesiophobia (excessive fear of exercise) on their motor function.</div></div><div><h3>Methods</h3><div>Between June 2021 and February 2022, we conducted a cross-sectional study of 319 participants diagnosed with cardioembolic stroke in the selected hospitals. Correlation analyses and mediation effects tests were used to analyze the relationship between patients' illness perception, kinesiophobia, and motor function.</div></div><div><h3>Results</h3><div>The total motor function score of the patients was (21.39 ± 29.30), the total kinesiophobia score was (48.51 ± 8.33), and the total illness perception score was (53.37 ± 16.82). There was a negative correlation between illness perception and motor function (<em>r</em> = -0.734, <em>P</em> &lt; 0.001), a negative correlation between kinesiophobia and motor function (<em>r</em> = -0.522, <em>P</em> &lt; 0.001), and a positive correlation between illness perception and kinesiophobia (<em>r</em> = 0.508, <em>P</em> &lt; 0.001); kinesiophobia played a mediating role between illness perception and motor function (β = -0.63, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The findings revealed that individuals with cardioembolic strokes had poor motor function, as well as negative illness perception and kinesiophobia. Negative illness perception had a direct impact on patients' motor function as well as an indirect effect via kinesiophobia. The fear-avoidance model contributes to understanding the process of reduced motor function in cardioembolic stroke patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 39-46"},"PeriodicalIF":2.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dental floss use and atherosclerotic cardiovascular disease in American adults","authors":"Jiaqing Fei MPH ,&nbsp;Xiaoyan Gong MPH","doi":"10.1016/j.hrtlng.2025.02.003","DOIUrl":"10.1016/j.hrtlng.2025.02.003","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerotic cardiovascular disease (ASCVD) remains a major cause of global morbidity and mortality. Emerging research suggests that oral hygiene practices, particularly dental floss use, may reduce the risk of ASCVD.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to examine the association between dental floss use and ASCVD prevalence.</div></div><div><h3>Methods</h3><div>Data from NHANES participants who completed home interviews and dental evaluations were analyzed. ASCVD was defined as angina, stroke, myocardial infarction, or coronary artery disease. Dental floss use was self-reported over the past seven days. Covariates included demographic, socioeconomic, lifestyle, and clinical factors. Weighted logistic regression was used to assess the relationship between dental floss use and ASCVD prevalence.</div></div><div><h3>Results</h3><div>This study included a total sample of 7253 participants with a mean age of 53.8±14.6 years. The sample consisted of 47.6 % male participants. The ethnic composition included 64.3 % Non-Hispanic White. Regular dental floss use was correlated with a lower likelihood of developing ASCVD and Stringent Criteria (infarction or stroke), with ORs of 0.76 (95 % CI: 0.60, 0.97) <em>p</em>=0.028 and 0.68 (95 % CI: 0.49, 0.94) <em>p</em>=0.022, respectively. Flossing 3–4 days/week was associated with reduced ASCVD risk, OR = 0.57 (95 % CI: 0.38, 0.84) <em>p</em>=0.006. Similar reductions were seen for stringent criteria: flossing 3–4 days/week: OR = 0.57 (95 % CI: 0.32, 0.99) <em>p</em>=0.047, flossing ≥5 days/week: OR = 0.69 (95 % CI: 0.47, 1.00) <em>p</em>=0.049.</div></div><div><h3>Conclusions</h3><div>Regular dental floss use may reduce the risk of ASCVD. These results support the inclusion of oral hygiene practices in cardiovascular disease prevention strategies.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 32-38"},"PeriodicalIF":2.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Board of Directors","authors":"","doi":"10.1016/S0147-9563(25)00021-4","DOIUrl":"10.1016/S0147-9563(25)00021-4","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"70 ","pages":"Page vii"},"PeriodicalIF":2.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Efficacy and safety of iloprost in the treatment of pulmonary arterial hypertension: A systematic review and meta-analysis","authors":"Mustafa Oğuz MD ,&nbsp;Murat Demirci MD","doi":"10.1016/j.hrtlng.2025.02.005","DOIUrl":"10.1016/j.hrtlng.2025.02.005","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Page 106"},"PeriodicalIF":2.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natriuretic peptide testing in veterans hospitalized with heart failure: Potential differences by sex","authors":"Parul U. Gandhi MD ,&nbsp;Tessa Runels MPH ,&nbsp;Ling Han MD, PhD, MS ,&nbsp;Melissa Skanderson MSW ,&nbsp;Lori A. Bastian MD, MPH ,&nbsp;Cynthia A. Brandt MD, MPH ,&nbsp;Ronald G. Hauser MD ,&nbsp;Shelli L. Feder PhD, FNP-C ,&nbsp;Benjamin Rodwin MD ,&nbsp;Melissa M. Farmer PhD ,&nbsp;Bevanne Bean-Mayberry MD ,&nbsp;Sebastian Placide MD ,&nbsp;Allison E. Gaffey PhD ,&nbsp;Kathleen M. Akgün MD, MS","doi":"10.1016/j.hrtlng.2025.02.001","DOIUrl":"10.1016/j.hrtlng.2025.02.001","url":null,"abstract":"<div><h3>Background</h3><div>Natriuretic peptide testing (NPT) is recommended to assist in diagnosis and prognostication during heart failure hospitalization (HFH). NPT on admission for HFH and sex-based variation in NPT are unknown.</div></div><div><h3>Objectives</h3><div>We investigated the utilization of NPT among Veterans with HFH, evaluated for sex-based differences, and examined associations with demographic, clinical, and facility characteristics.</div></div><div><h3>Methods</h3><div>Among Veterans with HFH in the Veterans Affairs Healthcare System between October 2015-September 2020, we assessed the rate of NPT on admission and sex-based differences in NPT. We determined associations with demographic, clinical covariates, (comorbidities, laboratory values, loop diuretic use), and facility characteristics using logistic regression.</div></div><div><h3>Results</h3><div>Of 55,935 patients with HFH (women=1237 (2.2 %)), women were younger (68.3 versus 72.8 years, <em>p</em> &lt; 0.001), less likely to have cardiac comorbidities, and more likely to have ejection fraction &gt;40 %. Admission NPT occurred in 78.3 % of patients (men=78.4 %, women=74.7 %; <em>p</em> = 0.002). In adjusted analyses for clinical and facility-related factors, women were 15 % less likely to receive NPT compared with men [odds ratio =0.85, 95 % CI (0.75, 0.98)]. In sex-stratified models, atrial fibrillation and prior loop diuretic use were associated with increased likelihood of NPT and previous NPT was associated with decreased likelihood in both sexes. Overall associations were similar in both sexes.</div></div><div><h3>Conclusions</h3><div>Women were less likely to receive NPT during HFH compared to men, potentially risking greater delays in HF diagnosis and treatment. Further investigation should examine the impact of the absence of admission NPT on clinical outcomes and identify strategies to improve obtaining NPT in all patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 25-31"},"PeriodicalIF":2.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECMO cannulation across New England","authors":"Ammar Bhatti DO ,&nbsp;Chaitan K. Narsule MD ,&nbsp;Michael A. Frakes APRN, EMT-P ,&nbsp;Vahé Ender EMT-P ,&nbsp;Jason E. Cohen DO ,&nbsp;Susan R. Wilcox MD","doi":"10.1016/j.hrtlng.2025.01.015","DOIUrl":"10.1016/j.hrtlng.2025.01.015","url":null,"abstract":"<div><h3>Background</h3><div>Over the last 15 years, clinicians have increasingly used extracorporeal membrane oxygenation (ECMO) as a rescue technique, including cannulating patients in community hospitals without ECMO capabilities, leading to secondary ECMO transports.</div></div><div><h3>Objectives</h3><div>The objective was to evaluate the changes in cannulations and the number of cannulating centers over time.</div></div><div><h3>Methods</h3><div>This is a retrospective review of transports across New England to ECMO centers in Boston from 2011 to 2022.</div></div><div><h3>Results</h3><div>Over the years studied, 202 patients were cannulated and transported. VA ECMO was the most common configuration. This was a high-acuity cohort, with 26.4 % of VA ECMO patients having undergone cannulation during cardiopulmonary resuscitation (ECPR) and 6.1 % having central cannulation. The number of cannulations per year increased from 6 patients in 2011 to 36 in 2019 (<em>p</em> = 0.055). Cannulating centers also increased from 3 in 2011 to 14 in 2022. ECPR showed a similar trend, with increases in both ECPR patients and ECPR sites per year (<em>p</em> = 0.055).</div></div><div><h3>Conclusions</h3><div>The number of ECMO cannulations in the community has increased, with a high-acuity cohort of many patients undergoing ECPR. The number of patients cannulated at non-ECMO centers highlights the need for transport organizations and ECMO centers to address the needs of this high-acuity patient population.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 20-24"},"PeriodicalIF":2.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of breathing exercises performed with virtual reality on dyspnea, anxiety and quality of life in COPD patients: A randomized controlled trial","authors":"Derya Şimşekli ,&nbsp;Mehtap Tan","doi":"10.1016/j.hrtlng.2025.01.014","DOIUrl":"10.1016/j.hrtlng.2025.01.014","url":null,"abstract":"<div><h3>Background</h3><div>Breathing exercises can reduce dyspnea and anxiety in COPD patients and improve quality of life. To ensure these benefits are sustained, it is essential to incorporate engaging and innovative applications that capture patients' attention.</div></div><div><h3>Objectives</h3><div>This study aimed to determine the effects of breathing exercises performed with virtual reality on dyspnea, anxiety, and quality of life in COPD patients.</div></div><div><h3>Methods</h3><div>The research was conducted in randomized controlled experimental design with 48 COPD patients. In collecting research data, the COPD Patient Information Form, the Respiratory Function Test Evaluation Form, the COPD Assessment Test (CAT), the Modified Medical Research Council (mMRC) Dyspnea Scale, the Hospital Anxiety and Depression Scale (HAD-A), the St. George Respiratory Questionnaire (SGRQ) and the Virtual Reality Experience Evaluation Form were used. The Virtual Reality Breathing Exercise Group (VRBE-G) and control group (CG) were created by block randomization. VRBE-G performed breathing exercises with virtual reality 3 times a week for 8 weeks. The participants and the statistician were blinded. Repeated measures ANOVA test was performed to determine the group-time interaction, and independent samples <em>t</em>-test and Man Whitney U test were used for comparison between groups.</div></div><div><h3>Results</h3><div>In intra- and inter-group comparisons, it was determined that there was a statistically significant difference in VRBE-G compared to CG in terms of CAT score, mMRC dyspnea score, HAD-A and SGRQ total score (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>It was determined that breathing exercises applied to COPD patients with virtual reality reduced dyspnea and anxiety and increased the quality of life.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 7-13"},"PeriodicalIF":2.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond first-day biomarkers: The critical role of peak cardiac troponin I in sepsis prognosis","authors":"Dandan Zhao ,&nbsp;Huimin Li ,&nbsp;Yongdi Lin ,&nbsp;Lizhen Liu ,&nbsp;Lina Xu ,&nbsp;Dan Zhang ,&nbsp;Yu Fu ,&nbsp;Jiang Hong ,&nbsp;Congliang Miao","doi":"10.1016/j.hrtlng.2025.01.013","DOIUrl":"10.1016/j.hrtlng.2025.01.013","url":null,"abstract":"<div><h3>Background</h3><div>Sepsis is a global health challenge with high mortality rates. It demands timely risk identification and biomarker-based strategies to optimize ICU management and outcomes.</div></div><div><h3>Objectives</h3><div>To explore the prognostic value of cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP) in predicting 28-day mortality in septic patients.</div></div><div><h3>Methods</h3><div>We analyzed clinical data of septic ICU patients at Shanghai General Hospital. We used Cox models and ROC curves to assess the association between cTnI and BNP levels and 28-day mortality, and their prognostic accuracy.</div></div><div><h3>Results</h3><div>A total of 333 septic patients were included in this study (mean age [SD], 64.7 [15.2] years; 65.8 % male), of whom 63 (18.9 %) patients died during 28 days. Elevated peak cTnI levels, identified in 233 patients (70.0 %), were independently associated with higher 28-day mortality in septic patients, even after adjusting for SOFA scores, BNP, and other confounding variables. (adjusted HR 2.33, 95 % CI 1.08–5.04, <em>P</em> = 0.03). However, neither first-day cTnI nor BNP levels remained independent predictors of 28-day mortality. Sensitivity analyses for the magnitude of cTnI elevation as a predictive variable also yielded similar results. Compared to first-day cTnI, first-day BNP, and peak BNP, the peak cTnI had the most significant and modest area under the ROC curve (AUC: 0.64 [0.57–0.71]).</div></div><div><h3>Conclusion</h3><div>Elevated peak cTnI or the magnitude of cTnI, rather than first-day, could independently predict the risk of 28-day mortality in septic patients. This finding highlighted the importance of dynamic monitoring cTnI levels for risk stratification identification and management in septic patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"71 ","pages":"Pages 14-19"},"PeriodicalIF":2.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143314191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}