Heart & LungPub Date : 2025-06-27DOI: 10.1016/j.hrtlng.2025.06.004
Sanne H.B. van Dijk MSc, BA , Marjolein G.J. Brusse-Keizer PhD , Tanja Effing PhD , Eline H. Ploumen MD, PhD , Paul D.L.P.M. van der Valk MD, PhD , Job van der Palen PhD , Carine J.M. Doggen PhD , Anke Lenferink PhD
{"title":"The interplay between symptom deterioration of chronic obstructive pulmonary disease and chronic heart failure","authors":"Sanne H.B. van Dijk MSc, BA , Marjolein G.J. Brusse-Keizer PhD , Tanja Effing PhD , Eline H. Ploumen MD, PhD , Paul D.L.P.M. van der Valk MD, PhD , Job van der Palen PhD , Carine J.M. Doggen PhD , Anke Lenferink PhD","doi":"10.1016/j.hrtlng.2025.06.004","DOIUrl":"10.1016/j.hrtlng.2025.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) commonly co-exist and share symptoms, which complicates disease management. It is unclear how COPD and CHF deterioration inter(re)act.</div></div><div><h3>Objective</h3><div>This study aimed to assess the interplay between COPD and CHF deterioration on group and individual level.</div></div><div><h3>Methods</h3><div>Total daily COPD- and CHF-symptom intensity scores (SIS) were calculated based on increased symptoms of COPD (dyspnea, sputum purulence and color, coughing, wheezing, fever) and CHF (sudden weight increase, swelling, nocturnal dyspnea), as reported by patients in one-year daily symptom diaries. The COPD-CHF interplay was assessed visually and statistically (on group and individual level) by mixed models.</div></div><div><h3>Results</h3><div>From a multicenter trial (<em>N</em> = 201), 33 patients with COPD and CHF (72.4 ± 7.8 years, 24 men (72.7 %)) were included. On group level, increased CHF-SIS positively predicted next day’s COPD-SIS (<em>p</em> = 0.02). However, on individual level, the direction and strength of the associations between CHF-SIS and subsequent COPD-SIS varied substantially. Vice versa, increased COPD-SIS also predicted next day’s CHF-SIS on group level (<em>p</em> < 0.001). On individual level, the direction of the associations varied less, although strength differed from negligible to strongly positive.</div></div><div><h3>Conclusions</h3><div>On group level, CHF deterioration predicts an increase in next day’s COPD symptom score, as well as vice versa. Individual-level associations reinforce the group-level results for COPD provoking CHF symptoms, but not for CHF provoking COPD symptoms. The COPD-CHF interplay should be monitored and, if present, acted upon to optimize patient disease management.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 57-64"},"PeriodicalIF":2.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart & LungPub Date : 2025-06-26DOI: 10.1016/j.hrtlng.2025.06.007
Mengyuan Qiao , Yingyang Li , Pan Liu , Yanhua Liu , Niuniu Sun , Mengzhen Qin , Haiyan Wang
{"title":"U-shaped relationship between weight-adjusted waist index and acute exacerbation of chronic obstructive pulmonary disease in critically ill patients","authors":"Mengyuan Qiao , Yingyang Li , Pan Liu , Yanhua Liu , Niuniu Sun , Mengzhen Qin , Haiyan Wang","doi":"10.1016/j.hrtlng.2025.06.007","DOIUrl":"10.1016/j.hrtlng.2025.06.007","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between obesity and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has long been a topic of interest, and the newly introduced weight-adjusted waist circumference index (WWI) has better stability in differentiating between visceral fat and muscle mass. However, the relationship between WWI and AECOPD is unclear.</div></div><div><h3>Objective</h3><div>To investigate the potential relationship between WWI and AECOPD in critically ill patients.</div></div><div><h3>Methods</h3><div>A total of 986 participants with COPD were included in the present study. The relationship between WWI and AECOPD was explored using logistic regression, subgroup analyses, smoothed curve fitting, and threshold effect analysis models.</div></div><div><h3>Results</h3><div>As a continuous variable, the risk of AECOPD increased by 23.0 % for each unit increase in WWI. When WWI was used as a categorical variable, the risk of AECOPD increased by 62 % at the fourth quartile of WWI compared with the first quartile. In the adjusted model, potential nonlinear relationships were analyzed by smoothed curve fitting and saturated threshold effects, and a U-shaped relationship between WWI and risk of AECOPD was found, with an inflection point of 9.77. Before the inflection point, WWI was negatively associated with AECOPD; after the inflection point, they were positively associated. In the subgroup analyses, the relationship between WWI and AECOPD risk remained stable after adjustment for all covariates considered.</div></div><div><h3>Conclusion</h3><div>There is a U-shaped relationship between WWI and AECOPD, with both lower and higher levels of WWI increasing the risk of disease progression in patients with AECOPD.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 42-48"},"PeriodicalIF":2.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart & LungPub Date : 2025-06-26DOI: 10.1016/j.hrtlng.2025.06.005
Yijia Xiao , Jiajia Cai , Yingjie Su
{"title":"The association between atherogenic index of plasma and cardiovascular disease in hypertension: a cross-sectional and longitudinal study","authors":"Yijia Xiao , Jiajia Cai , Yingjie Su","doi":"10.1016/j.hrtlng.2025.06.005","DOIUrl":"10.1016/j.hrtlng.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>The use of low-density lipoprotein (LDL)-lowering drugs has reduced cardiovascular disease (CVD) risk significantly, but residual risk from dyslipidemia remains. Thus, exploring comprehensive lipid indices to assess and predict the impact of the lipid profile on CVD is necessary.</div></div><div><h3>Objective</h3><div>This study intends to explore the association of atherogenic index of plasma(AIP) with CVD in hypertension.</div></div><div><h3>Methods</h3><div>This post hoc analysis used data from the Systolic Blood Pressure Intervention Trial (SPRINT). Logistic regression and Cox proportional hazards regression were applied to explore the relationship between AIP and CVD, with subgroup analyses conducted. Non-linear relationships were also examined through trend analysis.</div></div><div><h3>Results</h3><div>In the cross-sectional study (<em>n</em> = 9323), AIP was positively correlated with clinical CVD(OR, 1.58 [95 %CI, 1.23, 2.04]), and the trend tests were significant(p<0.05). This positive association exists in different subgroups. In the longitudinal study(<em>n</em> = 8458), AIP was significantly and positively correlated with primary outcome(HR 1.62, 95 %CI 1.15, 2.27), CVD death(HR 2.45, 95 %CI 1.04, 5.77), myocardial infarction(HR 1.97, 95 %CI 1.15, 3.37) and peripheral arterial disease(HR 2.52, 95 %CI 1.31, 4.87). Trend tests were significant for the primary outcome, myocardial infarction, and peripheral arterial disease (<em>p</em> < 0.05), with positive correlations observed across most subgroups.</div></div><div><h3>Conclusion</h3><div>The level of AIP is positively correlated with clinical CVD in cross-sectional study. Moreover, in the longitudinal study, the higher the level of AIP, the greater the risk of subsequent adverse cardiovascular events(primary outcome). This positive correlation exists independently of MI and PAD events.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 49-56"},"PeriodicalIF":2.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart & LungPub Date : 2025-06-25DOI: 10.1016/j.hrtlng.2025.06.006
Mei Yang, Yilin Zhang, Wenjie Fang, Wenjie Sun, Ziwei Geng, Xiuzhen Fan
{"title":"Identification of patient-reported core information needs and associated factors in hospitalized patients with heart failure: A network analysis","authors":"Mei Yang, Yilin Zhang, Wenjie Fang, Wenjie Sun, Ziwei Geng, Xiuzhen Fan","doi":"10.1016/j.hrtlng.2025.06.006","DOIUrl":"10.1016/j.hrtlng.2025.06.006","url":null,"abstract":"<div><h3>Background</h3><div>The lack of identified core information needs in patients with heart failure significantly hinders the development and implementation of personalized educational interventions.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to identify the core information needs and explore the factors associated with information needs in patients with heart failure.</div></div><div><h3>Methods</h3><div>A total of 307 inpatients with heart failure were recruited from three cardiovascular units of a general hospital between February and December 2023. Self-reported questionnaires were used to assess patients’ sociodemographic and clinical characteristics, information needs, self-efficacy, social support, and health literacy. Network analysis and multiple linear regression were employed to analyze the data.</div></div><div><h3>Results</h3><div>The mean total score for information needs was 2.91 ± 0.50, with 42.3 % of patients with heart failure exhibiting a high level of information needs. Network analysis showed that the top four information needs were “exercise/physical activity” (strength = 1.09), “nutrition” (strength = 0.88), “emergency/safety” (strength = 0.83), and “diagnosis and treatment” (strength = 0.81). Self-efficacy, health literacy, age, and participation in cardiac rehabilitation lectures were associated with information needs.</div></div><div><h3>Conclusions</h3><div>A considerable proportion of patients with heart failure exhibit high levels of information needs. The top four information needs are “exercise/physical activity”, “nutrition”, “emergency/safety”, and “diagnosis and treatment”. Self-efficacy, health literacy, age, and participation in cardiac rehabilitation lectures are related to information needs. Therefore, healthcare providers should give priority to core information needs in patients with heart failure. Developing educational strategies based on patients’ individualized characteristics may be conducive to addressing their information needs.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 27-34"},"PeriodicalIF":2.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart & LungPub Date : 2025-06-25DOI: 10.1016/j.hrtlng.2025.06.003
Youssef EL BAHI, Soukaina LOULIDI, Samia RKHA, Mohamed LOUKID
{"title":"Tuberculosis in Morocco: Disease duration, weight loss and malnutrition","authors":"Youssef EL BAHI, Soukaina LOULIDI, Samia RKHA, Mohamed LOUKID","doi":"10.1016/j.hrtlng.2025.06.003","DOIUrl":"10.1016/j.hrtlng.2025.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Tuberculosis remains a serious challenge in public health worldwide. Changes in patients' delays in diagnosis and illness can complicate the disease. Understanding the factors affecting the delays is crucial to the development of effective prevention and treatment strategies.</div></div><div><h3>Objectives</h3><div>The aim of our study is to analyze and identify the association between the duration of illness, weight status and changes in dietary habits of TB patients as well as addressing the importance of dietary habits in improving tuberculosis outcomes.</div></div><div><h3>Methods</h3><div>A cross-sectional study was carried out on a sample of 480 tuberculosis patients.</div></div><div><h3>Results</h3><div>The results revealed that the mean (SD) duration of the disease was 5.98 months (6.8), while the mean (SD) diagnostic duration was 3.35 months (6.01). Significant difference was observed in diagnostic duration between TB types (<strong><em>p</em> = 0.018</strong>). Mean weight loss during the disease (SD) was 7.34 kg (5.21) with a significant difference between age groups (<strong><em>p</em> < 0.001</strong>) and between TB types (<strong><em>p</em> < 0.001</strong>). During the disease, patients lost an average of 1.72 kg/m<sup>2</sup> of their BMI (<strong><em>p</em> < 0.001</strong>). Around 84 % of patients have changed their eating habits. Weight loss and changes in dietary habits were significantly associated with increased disease duration.</div></div><div><h3>Conclusions</h3><div>Changes in eating habits, marked by weight loss and reduction in patients’ food intake significantly prolonged the disease's duration. Healthcare professionals are called to be aware of the impact of eating habits on the progression and duration of tuberculosis, and to encourage their patients to adopt healthy eating practices.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 35-41"},"PeriodicalIF":2.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical correlates and prognostic significance of cardiopulmonary recovery time after 6-minute walk test in COPD versus interstitial lung disease patients","authors":"Elif Yıldırım, Nisanur Tutuş, Yagmur Aydogdu, Ipek Ozmen","doi":"10.1016/j.hrtlng.2025.06.001","DOIUrl":"10.1016/j.hrtlng.2025.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Cardiopulmonary recovery time after 6-min walk test (6MWT) is a novel and easily interpretable marker of clinical outcomes, which has not been studied yet in the setting of chronic obstructive pulmonary disease (COPD) versus interstitial lung disease (ILD).</div></div><div><h3>Objectives</h3><div>This study aimed to investigate clinical correlates and prognostic significance of cardiopulmonary recovery time after 6MWT in COPD versus ILD patients.</div></div><div><h3>Methods</h3><div>A total of 117 patients with COPD (<em>n</em> = 52) or ILD (<em>n</em> = 65) were evaluated in terms of pulmonary function, disease impact and 6MWT parameters including 6-min walk distance (6MWD) and cardiopulmonary recovery time. Predictors of adverse clinical outcomes (emergency admissions, hospitalizations, mortality) were also evaluated via multivariate logistic regression analysis.</div></div><div><h3>Results</h3><div>The 6MWD was significantly shorter in the COPD group than in the ILD group (median(min-max) 389.5(84.0597.0) vs. 476.0(120.0635.0) m, <em>p</em> < 0.001). SpO2 recovery time (<em>r</em>=-0.370, <em>p</em> = 0.037) and HRR time (<em>r</em>=-0.425, <em>p</em> = 0.017) were negatively correlated with DLCO in the ILD group. Increase in SpO2 recovery time predicted increased risk of overall adverse clinical outcomes in the ILD group (OR 1.009, <em>p</em> = 0.040). HRR time had no significant role in predicting the risk of adverse clinical outcomes in COPD and ILD groups.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that SpO2 recovery time during 6MWT may be a simple and practical novel marker to determine risk for future emergency admissions, hospitalizations and mortality in ILD patients but not in COPD patients. HRR time had no significant role in predicting adverse clinical outcomes in both COPD and ILD groups.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 19-26"},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart & LungPub Date : 2025-06-18DOI: 10.1016/j.hrtlng.2025.05.015
Xiaoli Zhao , Kai Luo , Huihui Ma , Xinyi Yang , Rong Luo , Xiaoping Li
{"title":"Influence of heart failure phenotypes on prognosis of patients with hypertrophic cardiomyopathy","authors":"Xiaoli Zhao , Kai Luo , Huihui Ma , Xinyi Yang , Rong Luo , Xiaoping Li","doi":"10.1016/j.hrtlng.2025.05.015","DOIUrl":"10.1016/j.hrtlng.2025.05.015","url":null,"abstract":"<div><h3>Background</h3><div>Hypertrophic cardiomyopathy (HCM) is a highly heterogeneous disease with variable timings of complication onset and progression, whether different heart failure (HF) phenotypes are associated with adverse outcomes in HCM was incompletely unknown.</div></div><div><h3>Objective</h3><div>To explore the association of different HF phenotypes with all-cause mortality, cardiovascular events, and sudden death in HCM patients.</div></div><div><h3>Methods</h3><div>This retrospective, observational cohort study included 2292 HCM patients from 13 tertiary hospitals over the period from 1996 to 2021. The patients were categorized into four groups: without HF (HCM-non-HF), HF with highly preserved ejection fraction (HCM-HFhpEF) (LVEF ≥60 %), HF with low-normal ejection fraction (HCM-HFlnEF) (LVEF 50 %–59 %) and HF with reduced ejection fraction (HCM-HFrEF) (LVEF <50 %). Kaplan-Meier and Cox proportional hazards models were employed to evaluate the prognostic differences among HCM patients with different HF phenotypes.</div></div><div><h3>Results</h3><div>Overall, of 2292 patients included, the mean age was 56.95 ± 15.24 years, 38.5 % were female, with a median follow-up period of 4.5 years. All-cause death, cardiovascular events, and sudden death occurred in 19.3 %, 11.0 %, and 4.8 %, respectively. Compared with patients with HFhpEF, those with HFlnEF and HFrEF exhibited a higher risk of all-cause death [HCM-HFlnEF: adjusted hazard ratio (aHR): 1.50, 95 % confidence interval (CI): 1.16–1.95; HCM-HFrEF: aHR 2.35, 95 % CI:1.71–3.24] and cardiovascular events (HCM-HFlnEF: aHR: 1.71, 95 % CI:1.23–2.39; HCM-HFrEF: aHR 2.09, 95 % CI: 1.35–3.23), whereas there was no significant association with sudden death; those without HF did not demonstrate increased mortality risk.</div></div><div><h3>Conclusions</h3><div>Our study suggested that HCM patients with HFlnEF and HFrEF were associated with an significantly increased risk of all-cause and cardiovascular events.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 12-18"},"PeriodicalIF":2.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart & LungPub Date : 2025-06-10DOI: 10.1016/j.hrtlng.2025.05.016
Haixia Xu , Peng Xu , Mengqi Li , Yinhao Jiang , Jianfeng Xu , Weizhong Feng , Libo Jin , Linqi Li , Jiacheng Wu
{"title":"Sleep duration and cardiovascular disease causal association: A two-sample Mendelian randomization study","authors":"Haixia Xu , Peng Xu , Mengqi Li , Yinhao Jiang , Jianfeng Xu , Weizhong Feng , Libo Jin , Linqi Li , Jiacheng Wu","doi":"10.1016/j.hrtlng.2025.05.016","DOIUrl":"10.1016/j.hrtlng.2025.05.016","url":null,"abstract":"<div><h3>Background</h3><div>An increasing number of studies have recently suggested a relationship between sleep duration and cardiovascular disease (CVD). However, a correlation between the two has not been studied.</div></div><div><h3>Objective</h3><div>The aim of this study was to investigate a correlation between sleep duration and CVD.</div></div><div><h3>Methods</h3><div>This study is based on summary data from genome-wide association studies (GWAS), across various races, regarding sleep duration and 12 major cardiovascular diseases. We utilized two-sample Mendelian randomization (MR), a method specifically designed to analyze correlation, to investigate whether sleep duration directly affects risk of developing CVD. Our primary analysis used the inverse variance weighting (IVW) method to examine the effect of sleep duration on multiple cardiovascular conditions. Additionally, we employed maximum likelihood, MR-Egger regression, weighted median, and weighted mode methods to ensure the robustness of our findings.</div></div><div><h3>Results</h3><div>This study revealed a correlation between over-sleeping and three cardiovascular conditions (valvular heart disease, myocardial infarction, and heart failure) with significant negative correlations (<em>P</em> < 0.05). No significant correlation was found with the remaining nine cardiovascular conditions (<em>P</em> > 0.05). Furthermore, we found that under-sleeping had a correlation with four cardiovascular conditions (non-ischemic cardiomyopathy, cardiac arrhythmias, valvular heart disease, and atrial fibrillation) with significant positive correlations (<em>P</em> < 0.05) butnot with the remaining eight cardiovascular conditions (<em>P</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Over-sleeping was negatively correlated with several cardiovascular diseases, whereas under-sleeping was positively correlated with others, suggesting that lack of sleep may increase the risk of certain cardiovascular conditions.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 1-11"},"PeriodicalIF":2.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}