Heart & Lung最新文献

{"title":"NYHA classification deterioration and quality of life in heart failure inpatients: A chain mediation analysis of cognitive impairment and depression","authors":"Jin Yang ,&nbsp;You Pu ,&nbsp;Mingjun He ,&nbsp;Tianyi Wang ,&nbsp;Ting Ye ,&nbsp;Yunman Huang ,&nbsp;Yunfeng Di ,&nbsp;Xianqin Zhang ,&nbsp;Zheng Yang","doi":"10.1016/j.hrtlng.2025.04.033","DOIUrl":"10.1016/j.hrtlng.2025.04.033","url":null,"abstract":"<div><h3>Background</h3><div>Health-related quality of life (HRQoL) is a key indicator of the prognosis of heart failure (HF) patients. Although the association between the New York Heart Association (NYHA) class and HRQoL has been widely recognized, the underlying mechanisms of this association have not been fully elucidated.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the mediating role of cognitive impairment and depressive symptoms in NYHA class and HRQoL in HF patients.</div></div><div><h3>Methods</h3><div>We used a convenience sampling method to select HF patients hospitalized between December 2023 and April 2024 in China. General information, NYHA class, cognitive function, depressive symptoms, and HRQoL were assessed. We conducted mediated effects analyses using the \"Bruce\" package in the R software.</div></div><div><h3>Results</h3><div>A total of 313 HF patients were included in this study. The HRQoL scores of the patients were 62.60 ± 13.94. NYHA class, cognitive impairment, and depressive symptoms were positively correlated with the HRQoL scores. Mediation effect analysis showed that the mediation effects of cognitive impairment, depressive symptoms, and the combination of the two between NYHA class and HRQoL were 0.059, 0.119, and 0.044, accounting for 9.08 %, 18.30 %, and 6.77 % of the total effect, respectively.</div></div><div><h3>Conclusion</h3><div>NYHA class in HF patients directly and indirectly impacts HRQoL through cognitive impairment and depressive symptoms. Healthcare providers should prioritize joint assessment of cognitive function and depression symptoms, implementing comprehensive interventions to mitigate NYHA class effects on HRQoL.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"73 ","pages":"Pages 95-103"},"PeriodicalIF":2.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can ChatGPT accurately detect atrial fibrillation using smartwatch ECG?","authors":"Yuval Avidan ,&nbsp;Ibrahim Naoum ,&nbsp;Razi Khoury ,&nbsp;Sameha Zahra ,&nbsp;Nissan Ben Dov ,&nbsp;Jorge E Schliamser ,&nbsp;Asaf Danon ,&nbsp;Amir Aker","doi":"10.1016/j.hrtlng.2025.04.032","DOIUrl":"10.1016/j.hrtlng.2025.04.032","url":null,"abstract":"<div><h3>Background</h3><div>Current guidelines require physician confirmation for smartwatch-diagnosed atrial fibrillation (AF), increasing telemedicine workloads. The newest ChatGPT-4o (GPT-4o) incorporates advanced image input capabilities.</div></div><div><h3>Objective</h3><div>To assess GPT-4o’s performance in identifying AF from smartwatch recordings.</div></div><div><h3>Methods</h3><div>Consecutive 120 patients with AF and 60 controls with sinus rhythm (SR), confirmed by conventional 12-lead ECG, recorded single-lead ECGs using an Apple Watch (AW) Series 6®. Two blinded cardiologists independently classified the smartwatch recordings as AF, SR, or undetermined. GPT-4o was subsequently prompted to analyze all smartwatch ECGs.</div></div><div><h3>Results</h3><div>Six AF cases were excluded due to undetermined AW-ECG recordings, leaving 114 AF patients (mean age: 73.4 ± 10.4 years) and 60 controls. The AW algorithm achieved 97.3 % and 100 % accuracy for AF and SR, respectively, while GPT-4o correctly analyzed 47.3 % of AF and 71.6 % of SR tracings. None of the AF characteristics—chronicity, heart rate, QRS width, fibrillatory wave amplitude, or R-wave amplitude and polarity—were predictive of GPT-4o's diagnostic accuracy.</div></div><div><h3>Conclusion</h3><div>The current capabilities of GPT-4o are insufficient to make a reliable diagnosis of AF from smartwatch ECGs. Despite the theoretical appeal of leveraging this innovative technology for such purpose, the findings highlight that human expertise remains indispensable. Consumers must remain aware of the current limitations of this technology.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"73 ","pages":"Pages 90-94"},"PeriodicalIF":2.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of sacubitril-valsartan versus angiotensin converting enzyme inhibitor or angiotensin receptor blocker among patients with heart failure and ejection fraction at/less than 60 %: A retrospective, observational, parallel cohort, multi-group study","authors":"Nancy M. Albert ,&nbsp;James F. Bena ,&nbsp;Shannon L Morrison ,&nbsp;J. Bradley Williams ,&nbsp;Kathleen Faulkenberg ,&nbsp;Rahul Khairnar ,&nbsp;Trejeeve Martyn","doi":"10.1016/j.hrtlng.2025.04.027","DOIUrl":"10.1016/j.hrtlng.2025.04.027","url":null,"abstract":"<div><h3>Background</h3><div>Real-world heart failure (HF) and all-cause hospitalization, HF-related emergency care visits, all-cause mortality and the composite of all-cause or HF hospitalization or HF-related emergency visit remain high, due to underuse of core HF medications.</div></div><div><h3>Objectives</h3><div>A better understanding of real-world clinical outcomes is needed based on sacubitril-valsartan vs. angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) use among patients with HF and a wide range of ejection fractions.</div></div><div><h3>Methods</h3><div>Data retrieved from a multi-center, multi-state healthcare system database of patients prescribed sacubitril-valsartan were matched to those on ACEI/ARB based on age, sex, EF, comorbidity status, systolic blood pressure and index date site (hospital or ambulatory). Six- and 12-month outcomes based on sacubitril-valsartan vs. ACEI/ARB were assessed using linear, logistic, and Poisson models with generalized estimating equations.</div></div><div><h3>Results</h3><div>Patients (<em>N</em> = 4188; 2094/cohort) were well matched based on characteristics; 29.8 % were female, mean (SD) age was 64.3 (13.1) years, systolic blood pressure was 122.0 (16.2) mmHg, EF% was 29.1 (9.9); nearly half were in NYHA FC II and 422 (10.1 %) had EF of 41–60 %. Frequency of non-study medications at baseline was 92.6 % beta-blocker, 43.2 % mineralocorticoid receptor antagonist and 64.2 % loop diuretic. Compared to ACEI/ARB, all 6 and 12-month clinical outcomes were improved among patients using sacubitril-valsartan (all 12-month <em>p</em>&lt;.001).</div></div><div><h3>Conclusions</h3><div>Among patients with HF and EF up to 60 %, sacubitril-valsartan use was associated with lower 12-month morbidity and mortality. Providers and clinicians need to advocate for use of sacubitril-valsartan per hierarchical renin angiotensin system inhibitor national guideline recommendations.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"73 ","pages":"Pages 64-73"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between patent foramen ovale and chronic obstructive pulmonary disease: A systematic review and meta-analysis","authors":"Sruthy Balakumar ,&nbsp;Naya Nadeem ,&nbsp;Areeba Asghar MSc ,&nbsp;Claudia Frankfurter ,&nbsp;Ashley Farrell MLIS, AHIP ,&nbsp;Eduardo Flores-Umanzor MD, PhD ,&nbsp;Eric Horlick MDCM ,&nbsp;Lusine Abrahamyan MD, MPH, PhD","doi":"10.1016/j.hrtlng.2025.04.024","DOIUrl":"10.1016/j.hrtlng.2025.04.024","url":null,"abstract":"<div><h3>Background</h3><div>Patent foramen ovale (PFO) is a defect in the intra-atrial septum that occurs when the foramen ovale does not close postnatally. Chronic obstructive pulmonary disease (COPD) is a respiratory condition that causes airflow obstruction.</div></div><div><h3>Objective</h3><div>This systematic review aimed to consolidate current evidence on the association between PFO and COPD outcomes.</div></div><div><h3>Methods</h3><div>We searched Medline, Embase, and Cochrane databases from inception to November 2023 for studies conducted among adults who have been diagnosed with COPD and underwent testing for PFO. A structured data extraction sheet was created to collect data from selected studies. A meta-analysis with a random effects model was considered when feasible.</div></div><div><h3>Results</h3><div>The initial search identified 765 records. After screening for eligibility, we included six cross-sectional and three case report studies. In cross-sectional studies, patients with COPD had almost three times higher odds of having PFO than controls (OR = 2.72, 95 % CI: 1.57 to 4.70, <em>I²</em> =0 %). When comparing COPD patients with and without PFO, the pooled mean difference was -2.99 mmHg; 95 % CI:5.55 to -0.44, <em>I²</em> =77 %) in oxygen saturation (SaO2), -6.85 mmHg (95 %CI:11.71 to -2.39, <em>I²</em> =35 %) in arterial oxygen partial pressure (PaO2) and 9.65 mmHg (95 %CI: 3.38 to 12.92, <em>I²</em> =0 %) in pulmonary arterial pressure.</div></div><div><h3>Conclusions</h3><div>Evidence, based on a few and small size studies, indicates that PFO presence may be associated with worse outcomes in COPD patients. The long-term impact of these findings on COPD outcomes and the need for identifying high-risk patients for PFO screening should be evaluated.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"73 ","pages":"Pages 33-41"},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-induced oxyhemoglobin desaturation is an independent risk factor for sustained nocturnal hypoxemia in adults with precapillary pulmonary hypertension: A cross-sectional study","authors":"Marcia S. Murta ,&nbsp;Ricardo L.M. Duarte ,&nbsp;Daniel Waetge ,&nbsp;David Gozal ,&nbsp;Alexandre P. Cardoso ,&nbsp;Fernanda C.Q. Mello","doi":"10.1016/j.hrtlng.2025.04.021","DOIUrl":"10.1016/j.hrtlng.2025.04.021","url":null,"abstract":"<div><h3>Background</h3><div>Nocturnal hypoxemia (NH) negatively impacts the prognosis of several chronic cardiopulmonary diseases.</div></div><div><h3>Objectives</h3><div>To assess the risk factors associated with sustained NH in adults with precapillary pulmonary hypertension (pPH).</div></div><div><h3>Methods</h3><div>This cross-sectional study was performed between June 2021 and June 2024. Outpatients with a hemodynamic diagnosis of pPH (Groups 1 and 4) were consecutively recruited. Sustained NH was defined as ≥ 30 % of the percentage of time spent with oxygen saturation (SpO₂) &lt;90 % during a home sleep apnea test (HSAT). Clinical, laboratory, hemodynamic, echocardiographic, functional, and exercise-related variables were collected blindly regarding the HSAT data. We considered a difference in SpO₂ [resting – final] (Δ SpO₂) ≥ 3 % as indicative of exercise-induced oxyhemoglobin desaturation (EID) by the six-minute walk test. Multiple logistic regression analysis was used to identify possible predictive factors for the occurrence of NH.</div></div><div><h3>Results</h3><div>Fifty-two pPH adults were included (71.2 % were females). Thirty-one patients (59.6 %) were classified as having NH. In the univariate logistic regression analysis, four parameters were identified as risk factors for the presence of NH: mean pulmonary artery pressure (<em>p</em> = 0.023), right atrial mean pressure (<em>p</em> = 0.037), systolic pulmonary arterial pressure (<em>p</em> = 0.042) and EID (<em>p</em> = 0.003). However, only EID was an independent predictor for detecting NH with an adjusted odds ratio of 10.590 (95 % confidence interval: 1.095–102.420); <em>p</em> = 0.042.</div></div><div><h3>Conclusions</h3><div>EID is an easily implementable risk factor for prolonged NH, suggesting that adults with pPH who experience EID have a high probability of also experiencing NH.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"73 ","pages":"Pages 26-32"},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based return-to-work assessment system for acute myocardial infarction patients within 12 months","authors":"Xiaojun Wu ,&nbsp;Shiyu Wang ,&nbsp;Haoning Cui ,&nbsp;Xianghui Zheng ,&nbsp;Xinyu Hou ,&nbsp;Zhuozhong Wang ,&nbsp;Qifeng Li ,&nbsp;Qi Liu ,&nbsp;Tianhui Cao ,&nbsp;Yang Zheng ,&nbsp;Jian Wu ,&nbsp;Bo Yu","doi":"10.1016/j.hrtlng.2025.04.020","DOIUrl":"10.1016/j.hrtlng.2025.04.020","url":null,"abstract":"<div><h3>Background</h3><div>Returning to work is a critical indicator of recovery after acute myocardial infarction (AMI), and accurate identification of patients with low return-to-work rates is critical for timely intervention.</div></div><div><h3>Objectives</h3><div>To develop a machine learning (ML) model for predicting the return-to-work in AMI patients.</div></div><div><h3>Methods</h3><div>A retrospective study of data from 539 AMI patients was conducted using the Incidence Rate of Heart Failure After Acute Myocardial Infarction With Optimal Treatment database. Patients were randomly divided into training cohort and validation cohort (7:3). Seven ML algorithms were used to establish a prediction model for the training cohort. Model performance is evaluated by the area under the receiver operating characteristic curve (AUC), accuracy, F1 score, and Brier score.</div></div><div><h3>Results</h3><div>This study included 539 AMI patients (median [IQR] age, 50.0 [45.0, 54.0] years; 505 (93.7 %) were male, and 431 (80.0 %) returned to work within one year after discharge. The best-performing model was eXtreme gradient boosting, which achieved an AUC of 0.821 (95 % CI, 0.736–0.907), an accuracy of 0.802 (95 % CI, 0.733–0.861), and an F1 score of 0.873. The return-to-work score and stratification established based on this model can effectively distinguish patients into low, medium, and high probability groups (33.3 % vs. 60.0 % vs. 91.7 %, <em>P</em> &lt; 0.001). The model was deployed on an open website <span><span>https://amirtw.streamlit.app/</span><svg><path></path></svg></span>, providing a convenient evaluation and analysis tool for medical staff.</div></div><div><h3>Conclusion</h3><div>A new return-to-work ML model was developed, which may help identify patients with low return-to-work rates and may become an effective management tool for AMI patients.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"73 ","pages":"Pages 19-25"},"PeriodicalIF":2.4,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Out-of-hospital cardiac arrest: A 10-year analysis of survival and neurological outcomes","authors":"Daniel Schwaiger,&nbsp;Armin Krösbacher,&nbsp;Christine Eckhardt,&nbsp;Lukas Schausberger,&nbsp;Michael Baubin,&nbsp;Sasa Rajsic","doi":"10.1016/j.hrtlng.2025.04.003","DOIUrl":"10.1016/j.hrtlng.2025.04.003","url":null,"abstract":"<div><div><strong>Background</strong> Out-of-hospital cardiac arrest (OHCA) is a major public health issue with low survival rates.</div><div><strong>Objective</strong> Identification of predictors for survival and good neurological outcomes following OHCA.</div><div><strong>Methods</strong> This retrospective study included all OHCA patients between January 2014 and December 2023. Data was collected from the local resuscitation registry and hospital electronic medical records. Neurological outcomes were measured using the Cerebral Performance Category (CPC) scale.</div><div><strong>Results</strong> At hospital admission return of spontaneous circulation (ROSC) was achieved in 36 % of cases (411/1128), with overall survival rates of 29 % (328/1128) at 24 h and 16 % (178/1128) at 30 days, respectively. Good neurological outcomes (CPC 1 and 2) were observed in 13 % (144/1128) of patients. The main suspected cause of cardiac arrest was cardiac origin (54 %, 608/1128), followed by hypoxia (11 %, 127/1128). Survivors were significantly younger (60 vs 71 years, <em>p</em> &lt; 0.001), were less disabled (<em>p</em> &lt; 0.001), had a higher incidence of witnessed cardiac arrest (80 % vs 69 %, <em>p</em> = 0.018), received more often bystander cardiopulmonary resuscitation (CPR, 62 % vs 47 %, <em>p</em> = 0.003) or Dispatcher Assisted-CPR (44 % vs 32 %, <em>p</em> = 0.004). Moreover, patients who survived at least 30 days had a higher incidence of shockable initial rhythm (57 % vs 24 %, <em>p</em> &lt; 0.001).</div><div><strong>Conclusions</strong> Patients who survived at least 30 days were younger and male, had less disability, a shockable initial rhythm, and a cardiac arrest in public.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"73 ","pages":"Pages 1-8"},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrating Excellence: AAHFN Fellowship Program and the Impact of Heart Failure Nurses","authors":"Linda Wick DNP, MSN, APRN, CHFN","doi":"10.1016/j.hrtlng.2025.04.006","DOIUrl":"10.1016/j.hrtlng.2025.04.006","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"72 ","pages":"Pages A2-A3"},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amiodarone Prophylaxis against postoperative atrial fibrillation in off-pump coronary artery bypass","authors":"Jaskirat Gill MD ,&nbsp;Ami G Shah PharmD, BCCCP ,&nbsp;Gabriele Di Luozzo MD ,&nbsp;Julie Mei PharmD ,&nbsp;Justin Carale PharmD ,&nbsp;Kristy Huang PharmD ,&nbsp;Anna S. Mueller MD ,&nbsp;Marcelina Victory-Stewart RN ,&nbsp;Seana Friedman DNP, RN ,&nbsp;Emilia Bagiella PhD ,&nbsp;Omar Lattouf MD ,&nbsp;John D. Puskas MD ,&nbsp;Mekeleya Yimen MD ,&nbsp;Himani V. Bhatt DO, MPA","doi":"10.1016/j.hrtlng.2025.03.009","DOIUrl":"10.1016/j.hrtlng.2025.03.009","url":null,"abstract":"<div><h3>Background</h3><div>Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, with incidence increasing based on surgical complexity. While the CHA₂DS₂-VASc score has been validated to predict POAF risk, standardized prophylactic strategies remain unclear. This study evaluates the safety and efficacy of a low-dose oral amiodarone protocol for POAF prevention in high-risk patients undergoing isolated OPCAB procedures.</div></div><div><h3>Objective</h3><div>To evaluate the impact of low-dose amiodarone prophylaxis against POAF in high-risk patients undergoing OPCAB procedures.</div></div><div><h3>Methods</h3><div>This IRB-approved prospective study included all adult inpatients undergoing isolated OPCAB procedures at a single tertiary care facility between June 2018-June 2021 identified as high risk for POAF (preoperative CHA₂DS₂VASc score <u>&gt;</u> 2). Patients treated with amiodarone prophylaxis were compared to a retrospective historical control group which underwent similar OPCAB procedures in the same center prior to the implementation of amiodarone prophylaxis. Preoperative hospitalized inpatients received a weight-adjusted dose of oral amiodarone on each preoperative day until the day prior to surgery. Patients who were inadequately loaded (&lt;1 g) received 150 mg of amiodarone intravenously in the operating room. Patients with intraoperative symptomatic bradycardia received temporary prophylactic epicardial pacing wires. Postoperatively, all patients received an amiodarone regimen of 200 mg orally twice daily, continued for 15 doses or until discharge. Multivariate logistic models were used to determine the effect of low-dose oral amiodarone prophylaxis on new-onset POAF.</div></div><div><h3>Results</h3><div>A 10.7 % reduction in incidence of POAF requiring treatment was noted in the study group (OR=0.4; 95 % CI [0.167–0.958], <em>p</em> = 0.04), as well as a 12 % decrease in patients requiring AF treatment at discharge (<em>p</em> = 0.017), and significantly reduced time to extubation. All baseline characteristics and safety parameters were similar between groups.</div></div><div><h3>Conclusions</h3><div>The use of a low-dose amiodarone prophylaxis regimen led to significant reduction in new POAF, without apparent adverse effects. This regimen may be considered safe, effective, and feasible for implementation in high-risk OPCAB patients. Further studies in on-pump CABG and valvular patients are needed.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"72 ","pages":"Pages 85-94"},"PeriodicalIF":2.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The association between posttraumatic stress symptoms and hope following intensive care unit discharge: Findings from a longitudinal cohort study” [Heart & Lung Volume 70, MarchApril 2025, Pages 223-229]","authors":"Klara Friberg MSc, RN, CCN ,&nbsp;Kristin Hofsø PhD, RN, CCN ,&nbsp;Tone Rustøen PhD, RN ,&nbsp;Johan Ræder PhD, MD ,&nbsp;Milada Hagen PhD ,&nbsp;Kathleen Puntillo PhD, RN, FCCM ,&nbsp;Brita Fosser Olsen PhD, RN, CCN","doi":"10.1016/j.hrtlng.2025.04.001","DOIUrl":"10.1016/j.hrtlng.2025.04.001","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"72 ","pages":"Pages 83-84"},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}