COPD与间质性肺病患者6分钟步行试验后心肺恢复时间的临床相关性及预后意义

IF 2.6 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart & Lung Pub Date : 2025-06-20 DOI:10.1016/j.hrtlng.2025.06.001

Elif Yıldırım, Nisanur Tutuş, Yagmur Aydogdu, Ipek Ozmen

{"title":"COPD与间质性肺病患者6分钟步行试验后心肺恢复时间的临床相关性及预后意义","authors":"Elif Yıldırım, Nisanur Tutuş, Yagmur Aydogdu, Ipek Ozmen","doi":"10.1016/j.hrtlng.2025.06.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Cardiopulmonary recovery time after 6-min walk test (6MWT) is a novel and easily interpretable marker of clinical outcomes, which has not been studied yet in the setting of chronic obstructive pulmonary disease (COPD) versus interstitial lung disease (ILD).</div></div><div><h3>Objectives</h3><div>This study aimed to investigate clinical correlates and prognostic significance of cardiopulmonary recovery time after 6MWT in COPD versus ILD patients.</div></div><div><h3>Methods</h3><div>A total of 117 patients with COPD (<em>n</em> = 52) or ILD (<em>n</em> = 65) were evaluated in terms of pulmonary function, disease impact and 6MWT parameters including 6-min walk distance (6MWD) and cardiopulmonary recovery time. Predictors of adverse clinical outcomes (emergency admissions, hospitalizations, mortality) were also evaluated via multivariate logistic regression analysis.</div></div><div><h3>Results</h3><div>The 6MWD was significantly shorter in the COPD group than in the ILD group (median(min-max) 389.5(84.0597.0) vs. 476.0(120.0635.0) m, <em>p</em> < 0.001). SpO2 recovery time (<em>r</em>=-0.370, <em>p</em> = 0.037) and HRR time (<em>r</em>=-0.425, <em>p</em> = 0.017) were negatively correlated with DLCO in the ILD group. Increase in SpO2 recovery time predicted increased risk of overall adverse clinical outcomes in the ILD group (OR 1.009, <em>p</em> = 0.040). HRR time had no significant role in predicting the risk of adverse clinical outcomes in COPD and ILD groups.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that SpO2 recovery time during 6MWT may be a simple and practical novel marker to determine risk for future emergency admissions, hospitalizations and mortality in ILD patients but not in COPD patients. HRR time had no significant role in predicting adverse clinical outcomes in both COPD and ILD groups.</div></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":"74 ","pages":"Pages 19-26"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical correlates and prognostic significance of cardiopulmonary recovery time after 6-minute walk test in COPD versus interstitial lung disease patients\",\"authors\":\"Elif Yıldırım, Nisanur Tutuş, Yagmur Aydogdu, Ipek Ozmen\",\"doi\":\"10.1016/j.hrtlng.2025.06.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Cardiopulmonary recovery time after 6-min walk test (6MWT) is a novel and easily interpretable marker of clinical outcomes, which has not been studied yet in the setting of chronic obstructive pulmonary disease (COPD) versus interstitial lung disease (ILD).</div></div><div><h3>Objectives</h3><div>This study aimed to investigate clinical correlates and prognostic significance of cardiopulmonary recovery time after 6MWT in COPD versus ILD patients.</div></div><div><h3>Methods</h3><div>A total of 117 patients with COPD (<em>n</em> = 52) or ILD (<em>n</em> = 65) were evaluated in terms of pulmonary function, disease impact and 6MWT parameters including 6-min walk distance (6MWD) and cardiopulmonary recovery time. Predictors of adverse clinical outcomes (emergency admissions, hospitalizations, mortality) were also evaluated via multivariate logistic regression analysis.</div></div><div><h3>Results</h3><div>The 6MWD was significantly shorter in the COPD group than in the ILD group (median(min-max) 389.5(84.0597.0) vs. 476.0(120.0635.0) m, <em>p</em> < 0.001). SpO2 recovery time (<em>r</em>=-0.370, <em>p</em> = 0.037) and HRR time (<em>r</em>=-0.425, <em>p</em> = 0.017) were negatively correlated with DLCO in the ILD group. Increase in SpO2 recovery time predicted increased risk of overall adverse clinical outcomes in the ILD group (OR 1.009, <em>p</em> = 0.040). HRR time had no significant role in predicting the risk of adverse clinical outcomes in COPD and ILD groups.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that SpO2 recovery time during 6MWT may be a simple and practical novel marker to determine risk for future emergency admissions, hospitalizations and mortality in ILD patients but not in COPD patients. HRR time had no significant role in predicting adverse clinical outcomes in both COPD and ILD groups.</div></div>\",\"PeriodicalId\":55064,\"journal\":{\"name\":\"Heart & Lung\",\"volume\":\"74 \",\"pages\":\"Pages 19-26\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Heart & Lung\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0147956325001396\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart & Lung","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0147956325001396","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

摘要

研究背景：步行6分钟后心肺恢复时间（6MWT）是一种新颖且易于解释的临床预后指标，但尚未在慢性阻塞性肺疾病（COPD）与间质性肺疾病（ILD）的对比中进行研究。目的探讨慢性阻塞性肺病患者与ILD患者6MWT后心肺恢复时间的临床相关性及预后意义。方法对117例COPD患者（52例）和ILD患者（65例）进行肺功能、疾病影响和6MWT参数（6 min步行距离（6MWD）和心肺恢复时间）评估。不良临床结果的预测因子（急诊入院、住院、死亡率）也通过多变量logistic回归分析进行评估。结果COPD组6MWD明显短于ILD组(中位（最小-最大）389.5(84.0 ~ 597.0)vs 476.0(120.0 ~ 635.0) m, p <；0.001)。ILD组SpO2恢复时间（r=-0.370, p = 0.037）、HRR时间（r=-0.425, p = 0.017）与DLCO呈负相关。在ILD组中，SpO2恢复时间的增加预示着总体不良临床结果的风险增加（OR 1.009, p = 0.040）。HRR时间在预测COPD组和ILD组不良临床结局风险方面无显著作用。结论我们的研究结果表明，6MWT期间SpO2恢复时间可能是确定ILD患者未来急诊入院、住院和死亡风险的简单实用的新指标，而不是COPD患者。HRR时间在预测COPD组和ILD组的不良临床结果方面没有显著作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Clinical correlates and prognostic significance of cardiopulmonary recovery time after 6-minute walk test in COPD versus interstitial lung disease patients

Background

Cardiopulmonary recovery time after 6-min walk test (6MWT) is a novel and easily interpretable marker of clinical outcomes, which has not been studied yet in the setting of chronic obstructive pulmonary disease (COPD) versus interstitial lung disease (ILD).

Objectives

This study aimed to investigate clinical correlates and prognostic significance of cardiopulmonary recovery time after 6MWT in COPD versus ILD patients.

Methods

A total of 117 patients with COPD (n = 52) or ILD (n = 65) were evaluated in terms of pulmonary function, disease impact and 6MWT parameters including 6-min walk distance (6MWD) and cardiopulmonary recovery time. Predictors of adverse clinical outcomes (emergency admissions, hospitalizations, mortality) were also evaluated via multivariate logistic regression analysis.

Results

The 6MWD was significantly shorter in the COPD group than in the ILD group (median(min-max) 389.5(84.0597.0) vs. 476.0(120.0635.0) m, p < 0.001). SpO2 recovery time (r=-0.370, p = 0.037) and HRR time (r=-0.425, p = 0.017) were negatively correlated with DLCO in the ILD group. Increase in SpO2 recovery time predicted increased risk of overall adverse clinical outcomes in the ILD group (OR 1.009, p = 0.040). HRR time had no significant role in predicting the risk of adverse clinical outcomes in COPD and ILD groups.

Conclusions

Our findings suggest that SpO2 recovery time during 6MWT may be a simple and practical novel marker to determine risk for future emergency admissions, hospitalizations and mortality in ILD patients but not in COPD patients. HRR time had no significant role in predicting adverse clinical outcomes in both COPD and ILD groups.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Heart & Lung 医学-呼吸系统

CiteScore

4.60

自引率

3.60%

发文量

184

审稿时长

35 days

期刊介绍： Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.