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Journal of Antibiotics最新文献

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Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima 基枝菌 Favolaschia minutissima 培养物中的抗疟 9-甲氧基石蒜碱衍生物。
IF 2.1 4区 医学
Journal of Antibiotics Pub Date : 2024-05-09 DOI: 10.1038/s41429-024-00733-3
Somporn Palasarn, Kitlada Srichomthong, Tuksaporn Thummarukcharoen, Chawanee Thongpanchang, Masahiko Isaka
{"title":"Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima","authors":"Somporn Palasarn, Kitlada Srichomthong, Tuksaporn Thummarukcharoen, Chawanee Thongpanchang, Masahiko Isaka","doi":"10.1038/s41429-024-00733-3","DOIUrl":"10.1038/s41429-024-00733-3","url":null,"abstract":"Investigation of cultures of the basidiomycete Favolaschia minutissima TBRC-BCC 19434 led to the isolation of two undescribed β-methoxyacrylate metabolites, 9-methoxystrobilurins R (1) and S (2), and a degraded aldehyde derivative, favodehyde E (3). 9-Methoxystrobilurin derivatives 1 and 2 exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC50 values of 0.12 and 0.21 μM, respectively.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 7","pages":"422-427"},"PeriodicalIF":2.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Miconazole and phenothiazine hinder the quorum sensing regulated virulence in Pseudomonas aeruginosa 咪康唑和吩噻嗪阻碍了铜绿假单胞菌的法定量传感毒力。
IF 2.1 4区 医学
Journal of Antibiotics Pub Date : 2024-05-09 DOI: 10.1038/s41429-024-00731-5
Amany I. Gad, Amira M. El-Ganiny, Ahmed G. Eissa, Nada A. Noureldin, Shaimaa I. Nazeih
{"title":"Miconazole and phenothiazine hinder the quorum sensing regulated virulence in Pseudomonas aeruginosa","authors":"Amany I. Gad, Amira M. El-Ganiny, Ahmed G. Eissa, Nada A. Noureldin, Shaimaa I. Nazeih","doi":"10.1038/s41429-024-00731-5","DOIUrl":"10.1038/s41429-024-00731-5","url":null,"abstract":"Antibiotic resistance is a major health problem worldwide. Pseudomonas aeruginosa is a Gram-negative pathogen with an arsenal of virulence factors and elevated antimicrobial resistance. It is a leading cause of nosocomial infections with high morbidity and mortality. The significant time and effort required to develop new antibiotics can be circumvented using alternative therapeutic strategies, including anti-virulence targets. This study aimed to investigate the anti-virulence activity of the FDA-approved drugs miconazole and phenothiazine against P. aeruginosa. The phenotypic effect of sub-inhibitory concentrations of miconazole and phenothiazine on biofilm, pyocyanin, protease, rhamnolipid and hemolysin activities in PAO1 strain was examined. qRT-PCR was used to assess the effect of drugs on quorum-sensing genes that regulate virulence. Further, the anti-virulence potential of miconazole and phenothiazine was evaluated in silico and in vivo. Miconazole showed significant inhibition of Pseudomonas virulence by reducing biofilm-formation approximately 45–48%, hemolytic-activity by 59%, pyocyanin-production by 47–49%, rhamnolipid-activity by approximately 42–47% and protease activity by 36–40%. While, phenothiazine showed lower anti-virulence activity, it inhibited biofilm (31–35%), pyocyanin (37–39%), protease (32–40%), rhamnolipid (35–40%) and hemolytic activity (47–56%). Similarly, there was significantly reduced expression of RhlR, PqsR, LasI and LasR following treatment with miconazole, but less so with phenothiazine. In-silico analysis revealed that miconazole had higher binding affinity than phenothiazine to LasR, RhlR, and PqsR QS-proteins. Furthermore, there was 100% survival in mice injected with PAO1 treated with miconazole. In conclusion, miconazole and phenothiazine are promising anti-virulence agents for P. aeruginosa.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 7","pages":"454-465"},"PeriodicalIF":2.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities 从海洋源真菌 Albifimbria verrucaria 的培养液中提取的三种新壬烯及其细胞毒性和抗病毒活性。
IF 2.1 4区 医学
Journal of Antibiotics Pub Date : 2024-05-09 DOI: 10.1038/s41429-024-00735-1
Young-Hee Kim, Dae-Cheol Choi, Dae-Won Ki, Yeong-Seon Won, Seung-Jae Lee, Ji-Yul Kim, In-Kyoung Lee, Bong-Sik Yun
{"title":"Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities","authors":"Young-Hee Kim, Dae-Cheol Choi, Dae-Won Ki, Yeong-Seon Won, Seung-Jae Lee, Ji-Yul Kim, In-Kyoung Lee, Bong-Sik Yun","doi":"10.1038/s41429-024-00735-1","DOIUrl":"10.1038/s41429-024-00735-1","url":null,"abstract":"Three new nonenes, verrucanonenes A‒C (1‒3), were isolated from culture broth of marine-derived fungus Albifimbria verrucaria. These compounds were isolated using silica gel column chromatography, reversed-phase medium pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined using a spectroscopic method. Cytotoxicities of these isolated compounds to A549, DU145, HCT116, and HT1080 cancer cell lines were assessed. Compounds 1‒3 exhibited cytotoxicities to DU145 cancer cell line, with IC50 values of 23.4, 28.6, and 20.1 µM, respectively. Compound 2 decreased H1N1-induced cytopathic effects on MDCK cells in a dose-dependent manner.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 7","pages":"466-470"},"PeriodicalIF":2.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The twin challenges of longevity and climate change in controlling antimicrobial resistance 在控制抗菌药耐药性方面，寿命和气候变化是双重挑战。
IF 2.1 4区 医学
Journal of Antibiotics Pub Date : 2024-05-09 DOI: 10.1038/s41429-024-00730-6
Maryam Shafaati, Mohammadreza Salehi, Maryam Zare
{"title":"The twin challenges of longevity and climate change in controlling antimicrobial resistance","authors":"Maryam Shafaati, Mohammadreza Salehi, Maryam Zare","doi":"10.1038/s41429-024-00730-6","DOIUrl":"10.1038/s41429-024-00730-6","url":null,"abstract":"Antimicrobial resistance (AMR) is one of the global health challenges of the 21st century that is faced with the twin threats of global climate change and greater longevity, which pose a synergistic risk to the management of AMR. Antimicrobial agents are in high demand due to the challenges faced by increasing life expectancy and the dynamic changes in disease ecology prompted by climate change. In light of global aging and climate change, the complexity and importance of addressing antibiotic resistance are further highlighted by this interplay of issues.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 7","pages":"399-402"},"PeriodicalIF":2.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41429-024-00730-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro activity of plazomicin and other aminoglycosides against Klebsiella pneumoniae multidrug-resistant strains 普拉唑霉素和其他氨基糖苷类药物对肺炎克雷伯氏菌耐多药菌株的体外活性
IF 2.1 4区 医学
Journal of Antibiotics Pub Date : 2024-05-08 DOI: 10.1038/s41429-024-00734-2
Alicja Sękowska
{"title":"In vitro activity of plazomicin and other aminoglycosides against Klebsiella pneumoniae multidrug-resistant strains","authors":"Alicja Sękowska","doi":"10.1038/s41429-024-00734-2","DOIUrl":"10.1038/s41429-024-00734-2","url":null,"abstract":"Plazomicin is a new aminoglycoside with broad-spectrum activity against multidrug-resistant strains. The aim of this study was to assess the susceptibility of the K. pneumoniae strains to plazomicin and other aminoglycosides. The activity of plazomicin in combination with ceftazidim-avibactam or meropenem with selected strains was evaluated. The study involved 60 ESβL-positive K. pneumoniae isolates and 50 carbapenemase-positive. The susceptibility to aminoglycosides was tested using the gradient strip. The in vitro activities of plazomicin and ceftazidim-avibactam or meropenem were evaluated using the MTSTM cross synergy method. Plazomicin exhibited high activity against K. pneumoniae with MICs ranging from 0.19 to 4 µg ml−1 for ESβL-positive strains and from 0.25 to 256 µg ml−1 for carbapenemase-positive strains. No antagonism was identified with any combinations. Plazomicin demonstrated excellent in vitro activity against analyzed strains, suggesting that this antibiotic may be an effective therapeutic option in the treatment of infections caused by MDR K. pneumoniae strains.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 8","pages":"548-551"},"PeriodicalIF":2.1,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140885240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model 由链霉菌 TMPU-20A065 产生的新型脂质霉素同系物--在家蚕感染模型中具有疗效的抗分枝杆菌复合制剂
IF 2.1 4区 医学
Journal of Antibiotics Pub Date : 2024-05-08 DOI: 10.1038/s41429-024-00724-4
Akiho Yagi, Mayu Fujiwara, Mayu Sato, Yuzu Abe, Ryuji Uchida
{"title":"New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model","authors":"Akiho Yagi, Mayu Fujiwara, Mayu Sato, Yuzu Abe, Ryuji Uchida","doi":"10.1038/s41429-024-00724-4","DOIUrl":"10.1038/s41429-024-00724-4","url":null,"abstract":"Three new liposidomycin congeners (1, 2, and 4), together with 14 known liposidomycins (3 and 5–17), were isolated from the culture broth of Streptomyces sp. TMPU-20A065 as anti-Mycobacterium avium complex agents. The structures of liposidomycins were elucidated by spectroscopic analyses, including NMR and MS. Compounds 1, 2, and 4 belong to type-I liposidomycin-containing sulfate groups and methylglutaric acid, each with a different acyl side chain in the structure. Compounds 1–17 exhibited in vitro anti-M. avium and M. intracellulare activities with MIC values ranging between 2.0 and 64 μg ml−1. Furthermore, 1–17 exerted potent therapeutic effects in an in vivo-mimic silkworm infection model with ED50 values ranging between 0.12 and 3.7 μg larva−1 g−1.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 7","pages":"412-421"},"PeriodicalIF":2.1,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41429-024-00724-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140885014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384 贝那斯汀 K，一种来自链霉菌 HGTA384 的氯化贝那斯汀相关抗生素。
IF 2.1 4区 医学
Journal of Antibiotics Pub Date : 2024-04-25 DOI: 10.1038/s41429-024-00727-1
Teppei Kawahara, Kanako Saita, Rika Iwamoto, Mikiyo Wada
{"title":"Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384","authors":"Teppei Kawahara, Kanako Saita, Rika Iwamoto, Mikiyo Wada","doi":"10.1038/s41429-024-00727-1","DOIUrl":"10.1038/s41429-024-00727-1","url":null,"abstract":"Benastatin K (1), a new chlorinated benastatin derivative, was isolated from the culture broth of the actinomycete Streptomyces sp. HGTA384. The structure of 1 was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, as well as HRESI-MS, UV and IR, and comparison with data reported in the literature. Compound 1 and benastatins A and B exhibited inhibitory activity against Micrococcus luteus (MIC 7.8, 31.3, and 3.9 μM, respectively), and IgE-mediated β-hexosaminidase release in RBL-2H3 cells with IC50 values of 42, 79, and 19 μM, respectively.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 7","pages":"471-474"},"PeriodicalIF":2.1,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140658502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crowdsourcing for mining new fungal sources for addressing the need for novel antibiotics against multidrug resistant pathogens 众包挖掘新的真菌资源，满足对新型抗生素的需求，对抗耐多药病原体
IF 3.3 4区 医学
Journal of Antibiotics Pub Date : 2024-04-17 DOI: 10.1038/s41429-024-00723-5
T. S. Suryanarayanan
{"title":"Crowdsourcing for mining new fungal sources for addressing the need for novel antibiotics against multidrug resistant pathogens","authors":"T. S. Suryanarayanan","doi":"10.1038/s41429-024-00723-5","DOIUrl":"10.1038/s41429-024-00723-5","url":null,"abstract":"There are a limited number of new antibiotics to manage the health crisis caused by the evolution and spread of antimicrobial resistant (AMR) bacteria including multidrug resistant (MDR), extensively drug-resistant (XDR) and pan-drug-resistant (PDR) ones. Bioprospecting fungi of less studied and extreme environments using new and less used older approaches could reveal novel antibiotics to manage MDR pathogens. Furthermore, I posit a crowdsourcing model which could substantially increase the chances of discovering novel antibiotics as well as new chemotypes for other therapeutic areas and considerably reduce the cost and time of this exercise.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 6","pages":"335-337"},"PeriodicalIF":3.3,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41429-024-00723-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professor Teruhiko Beppu (March 9, 1934–November 10, 2023)—the path he had walked 别府照彦教授（1934 年 3 月 9 日-2023 年 11 月 10 日）--他走过的道路。
IF 3.3 4区 医学
Journal of Antibiotics Pub Date : 2024-04-10 DOI: 10.1038/s41429-024-00721-7
Kenji Ueda
{"title":"Professor Teruhiko Beppu (March 9, 1934–November 10, 2023)—the path he had walked","authors":"Kenji Ueda","doi":"10.1038/s41429-024-00721-7","DOIUrl":"10.1038/s41429-024-00721-7","url":null,"abstract":"","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 6","pages":"397-398"},"PeriodicalIF":3.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41429-024-00721-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential 来自全长链霉菌 RD068384 的一种新的多环四元大内酰胺：立体化学和抗真菌潜力
IF 3.3 4区 医学
Journal of Antibiotics Pub Date : 2024-04-09 DOI: 10.1038/s41429-024-00705-7
Marwa Elsbaey, Yuki Samaru, Engy Elekhnawy, Naoya Oku, Yasuhiro Igarashi
{"title":"A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential","authors":"Marwa Elsbaey, Yuki Samaru, Engy Elekhnawy, Naoya Oku, Yasuhiro Igarashi","doi":"10.1038/s41429-024-00705-7","DOIUrl":"10.1038/s41429-024-00705-7","url":null,"abstract":"A new polycyclic tetramate macrolactam designated allostreptamide (1), together with four known congeners, were isolated from the culture extract of Allostreptomyces RD068384. The planar structure of the new compound was elucidated through interpretation of NMR and MS data. The absolute configuration was determined through ROESY and ECD analyses. The isolated compounds revealed antifungal potential against fourteen Candida albicans isolates with minimum inhibitory concentrations (MICs) ranging from 64 to 2048 µg ml-1. Compound 3 showed antibiofilm action and considerably reduced the viability of five isolates (36%) in the formed biofilm. The qRT-PCR revealed that 3 downregulated the BCR1, PLB2, ALS1, and SAP5 biofilm related gene expression. Therefore, 3 could be a promising antifungal therapy for C. albicans infections.","PeriodicalId":54884,"journal":{"name":"Journal of Antibiotics","volume":"77 6","pages":"393-396"},"PeriodicalIF":3.3,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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