A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-05-15 DOI:10.1038/s41429-024-00737-z

Yuta Awano, Ryoya Ishii, Yume Takahashi, Hayama Tsutsumi, Yoshihiro Watanabe, Masaaki Sonoda, Rei Hokari, Masato Iwatsuki, Yuki Inahashi

引用次数: 0

Abstract

A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin.

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由链霉菌 K22-0017 产生的一种新型多烯大环内酯类抗生素--马奇达霉素。

通过理化筛选，从链霉菌 K22-0017 的培养液中获得了一种新的多烯大环内酯类化合物 Machidamycin (1) 和一种已知化合物 YS-822A (2)。通过质谱和一维/二维核磁共振分析阐明了这两种化合物的结构。化合物 1 对白色念珠菌和粘孢子菌具有较弱的抗真菌活性。此外，1 号化合物比现有药物 paromomycin 显示出更强的抗利什曼病活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.