Journal of Biomechanical Engineering-Transactions of the Asme最新文献_第7页

Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber. 加强吸入给药：新型阀式容纳腔的比较研究与优化设计

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064436

Shahab Azimi, Siamak Arzanpour

{"title":"Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber.","authors":"Shahab Azimi, Siamak Arzanpour","doi":"10.1115/1.4064436","DOIUrl":"10.1115/1.4064436","url":null,"abstract":"This paper presents an innovative approach to the design optimization of valved holding chambers (VHCs), crucial devices for aerosol drug delivery. We present the design of an optimal cylindrical VHC body and introduce a novel valve based on particle impaction theory. The research combines computational simulations and physical experiments to assess the performance of various VHCs, with a special focus on the deposition patterns of medication particles within these devices. The methodology incorporates both experimental and simulation approaches to validate the reliability of the simulation. Emphasis is placed on the deposition patterns observed on the VHC walls and the classification of fine and large particles for salbutamol sulfate particles. The study reveals the superior efficacy of our valve design in separating particles compared to commercially available VHCs. In standard conditions, our valve design allows over 95% of particles under 7 μm to pass through while effectively filtering those larger than 8 μm. The optimized body design accomplishes a 60% particle mass flow fraction at the outlet and an average particle size reduction of 58.5%. When compared numerically in terms of size reduction, the optimal design outperforms the two commercially available VHCs selected. This study provides valuable insights into the optimization of VHC design, offering significant potential for improved aerosol drug delivery. Our findings demonstrate a new path forward for future studies, aiming to further optimize the design and performance of VHCs for enhanced pulmonary drug delivery.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systems Approach to Biomechanics, Mechanobiology, and Biotransport. 生物力学、机械生物学和生物传输的系统方法。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064547

Shayn M Peirce-Cottler, Edward A Sander, Matthew B Fisher, Alix C Deymier, John F LaDisa, Grace O'Connell, David T Corr, Bumsoo Han, Anita Singh, Sara E Wilson, Victor K Lai, Alisa Morss Clyne

{"title":"A Systems Approach to Biomechanics, Mechanobiology, and Biotransport.","authors":"Shayn M Peirce-Cottler, Edward A Sander, Matthew B Fisher, Alix C Deymier, John F LaDisa, Grace O'Connell, David T Corr, Bumsoo Han, Anita Singh, Sara E Wilson, Victor K Lai, Alisa Morss Clyne","doi":"10.1115/1.4064547","DOIUrl":"10.1115/1.4064547","url":null,"abstract":"The human body represents a collection of interacting systems that range in scale from nanometers to meters. Investigations from a systems perspective focus on how the parts work together to enact changes across spatial scales, and further our understanding of how systems function and fail. Here, we highlight systems approaches presented at the 2022 Summer Biomechanics, Bio-engineering, and Biotransport Conference in the areas of solid mechanics; fluid mechanics; tissue and cellular engineering; biotransport; and design, dynamics, and rehabilitation; and biomechanics education. Systems approaches are yielding new insights into human biology by leveraging state-of-the-art tools, which could ultimately lead to more informed design of therapies and medical devices for preventing and treating disease as well as rehabilitating patients using strategies that are uniquely optimized for each patient. Educational approaches can also be designed to foster a foundation of systems-level thinking.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow Rate and Wall Shear Stress Characterization of a Biomimetic Aerosol Exposure System. 仿生气溶胶曝露系统的流速和壁面剪切应力特征。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064549

S Emma Sarles, Edward C Hensel, Janessa Terry, Caleb Nuss, Risa J Robinson

{"title":"Flow Rate and Wall Shear Stress Characterization of a Biomimetic Aerosol Exposure System.","authors":"S Emma Sarles, Edward C Hensel, Janessa Terry, Caleb Nuss, Risa J Robinson","doi":"10.1115/1.4064549","DOIUrl":"10.1115/1.4064549","url":null,"abstract":"Current in vitro emissions and exposure systems lack biomimicry, use unrealistic flow conditions, produce unrealistic dose, and provide inaccurate biomechanical cues to cell cultures, limiting ability to correlate in vitro outcomes with in vivo health effects. A biomimetic in vitro system capable of puffing aerosol and clean air inhalation may empower researchers to investigate complex questions related to lung injury and disease. A biomimetic aerosol exposure system (BAES), including an electronic cigarette adapter, oral cavity module (OCM), and bifurcated exposure chamber (BEC) was designed and manufactured. The fraction of aerosol deposited in transit to a filter pad or lost as volatiles was 0.116±0.021 in a traditional emissions setup versus 0.098 ± 0.015 with the adapter. The observed flowrate was within 5% of programed flowrate for puffing (25 mL/s), puff-associated respiration (450 mL/s), and tidal inhalation (350 mL/s). The maximum flowrate observed in the fabricated BAES was 450 mL/s, exceeding the lower target nominal wall shear stress of 0.025 Pa upstream of the bifurcation and fell below the target of 0.02 Pa downstream. This in vitro system addresses several gaps observed in commercially available systems and may be used to study many inhaled aerosols. The current work illustrates how in silico models may be used to correlate results of an in vitro study to in vivo conditions, rather than attempting to design an in vitro system that performs exactly as the human respiratory tract.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling Running via Optimal Control for Shoe Design. 通过优化控制建立跑步模型，用于鞋类设计

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064405

Sarah C Fay, A E Hosoi

{"title":"Modeling Running via Optimal Control for Shoe Design.","authors":"Sarah C Fay, A E Hosoi","doi":"10.1115/1.4064405","DOIUrl":"10.1115/1.4064405","url":null,"abstract":"Shoe manufacturing technology is advancing faster than new shoe designs can viably be evaluated in human subject trials. To aid in the design process, this paper presents a model for estimating how new shoe properties will affect runner performance. This model assumes runners choose their gaits to optimize an intrinsic, unknown objective function. To learn this objective function, a simple two-dimensional mechanical model of runners was used to predict their gaits under different objectives, and the resulting gaits were compared to data from real running trials. The most realistic model gaits, i.e., the ones that best matched the data, were obtained when the model runners minimized the impulse they experience from the ground as well as the mechanical work done by their leg muscles. Using this objective function, the gait and thus performance of running under different shoe conditions can be predicted. The simple model is sufficiently sensitive to predict the difference in performance of shoes with disruptive designs but cannot distinguish between existing shoes whose properties are fairly similar. This model therefore is a viable tool for coarse-grain exploration of the design space and identifying promising behaviors of truly novel shoe materials and designs.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying the Influence of X-Ray Irradiation on Cell-Size-Scale Viscoelasticity of Collagen Type 1. 量化 X 射线辐照对细胞尺寸尺度的 1 型胶原蛋白粘弹性的影响

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064404

Väinö Mikael Mäntylä, Arttu Juhani Lehtonen, Vesa Korhonen, Linda Srbova, Juho Pokki

{"title":"Quantifying the Influence of X-Ray Irradiation on Cell-Size-Scale Viscoelasticity of Collagen Type 1.","authors":"Väinö Mikael Mäntylä, Arttu Juhani Lehtonen, Vesa Korhonen, Linda Srbova, Juho Pokki","doi":"10.1115/1.4064404","DOIUrl":"10.1115/1.4064404","url":null,"abstract":"X-rays are widely used in mammography and radiotherapy of breast cancer. The research has focused on the effects of X-rays on cells in breast tissues, instead of the tissues' nonliving material, extracellular matrix. It is unclear what the influence of X-ray irradiation is on the matrix's mechanical cues, known to regulate malignant cancer-cell behaviors. Here, we developed a technique based on magnetic microrheology that can quantify the influence of X-ray irradiation on matrix viscoelasticity--or (solid-like) elastic and (liquid-like) viscous characteristics--at cell-size scales. To model breast-tissue extracellular matrix, we used the primary component of the tissue matrix, collagen type 1, as it is for control, and as irradiated by X-rays (tube voltage 50 kV). We used a magnetic microrheometer to measure collagen matrices using 10-μm-diameter magnetic probes. In each matrix, the probes were nanomanipulated using controlled magnetic forces by the microrheometer while the probes' displacements were detected to measure the viscoelasticity. The collagen-matrix data involve with a typical spatial variation in viscoelasticity. We find that higher irradiation doses (320 Gy) locally reduce stiffness (soften) collagen matrices and increase their loss tangent, indicating an elevated liquid-like nature. For lower, clinically relevant irradiation doses (54 Gy), we find insignificant matrix-viscoelasticity changes. We provide this irradiation-related technique for detection, and modification, of matrix viscoelastic cues at cell-size scales. The technique enables enhanced characterization of irradiated tissue constituents in a variety of breast-cancer radiotherapy types.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Gait Event Detection Algorithm Using a Thigh-Worn Inertial Measurement Unit and Joint Angle Information. 利用大腿佩戴式惯性测量单元和关节角度信息的新型步态事件检测算法

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064435

Jacob A Strick, Ryan J Farris, Jerzy T Sawicki

{"title":"A Novel Gait Event Detection Algorithm Using a Thigh-Worn Inertial Measurement Unit and Joint Angle Information.","authors":"Jacob A Strick, Ryan J Farris, Jerzy T Sawicki","doi":"10.1115/1.4064435","DOIUrl":"10.1115/1.4064435","url":null,"abstract":"This paper describes the development and evaluation of a novel, threshold-based gait event detection algorithm utilizing only one thigh inertial measurement unit (IMU) and unilateral, sagittal plane hip and knee joint angles. The algorithm was designed to detect heel strike (HS) and toe off (TO) gait events, with the eventual goal of detection in a real-time exoskeletal control system. The data used in the development and evaluation of the algorithm were obtained from two gait databases, each containing synchronized IMU and ground reaction force (GRF) data. All database subjects were healthy individuals walking in either a level-ground, urban environment or a treadmill lab environment. Inertial measurements used were three-dimensional thigh accelerations and three-dimensional thigh angular velocities. Parameters for the TO algorithm were identified on a per-subject basis. The GRF data were utilized to validate the algorithm's timing accuracy and quantify the fidelity of the algorithm, measured by the F1-Score. Across all participants, the algorithm reported a mean timing error of -41±20 ms with an F1-Score of 0.988 for HS. For TO, the algorithm reported a mean timing error of -1.4±21 ms with an F1-Score of 0.991. The results of this evaluation suggest that this algorithm is a promising solution to inertial based gait event detection; however, further refinement and real-time evaluation are required for use in exoskeletal control.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variable Pivot Gait Based a Novel Dynamics Correction Method for Human Lower Limbs Model. 基于可变支点步态的新型人体下肢模型动态校正方法

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064548

Cunjin Ai, Jun Wei, Jianjun Zhang, Jingke Song, Weilin Lv, Chenglei Liu

{"title":"Variable Pivot Gait Based a Novel Dynamics Correction Method for Human Lower Limbs Model.","authors":"Cunjin Ai, Jun Wei, Jianjun Zhang, Jingke Song, Weilin Lv, Chenglei Liu","doi":"10.1115/1.4064548","DOIUrl":"10.1115/1.4064548","url":null,"abstract":"The rationality of gait analysis directly affects the dynamics of human lower limbs in the sagittal plane, and recent studies on gait stage redivision lack the stage when both feet are not in complete contact with the ground. This paper proposes a novel variable pivot gait, which includes the stage when the heel of one foot and the toe of the other are in contact with the ground and a dynamics correction method based on this gait. First, the relative motion data between the foot and the ground are measured by motion capture experiments, and then a variable pivot gait is proposed in terms of the pivot transformation between the foot and the ground. Second, the dynamics modeling is conducted based on the principle of mechanisms of human lower limbs in each stage of the variable pivot gait. Third, a dynamics correction method is proposed to correct the foot dynamics when the foot is not in complete contact with the ground. The experiment and simulation show that the variable pivot gait is consistent with the actual motion of the foot relative to the ground. The effectiveness of the dynamics correction method is proved by comparing dynamics results (hip, knee, and ankle moments) with previous studies. The variable pivot gait and the dynamics correction method can be applied to the human lower limbs and lower-limb robots, providing a new avenue.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

simMACT, a Software Demonstrator to Improve Maximum Actuation Joint Torques Simulation for Ergonomics Assessment. simMACT，用于改进人体工程学评估最大启动关节扭矩模拟的软件演示器。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064661

Jonathan H Savin, Nasser Rezzoug

{"title":"simMACT, a Software Demonstrator to Improve Maximum Actuation Joint Torques Simulation for Ergonomics Assessment.","authors":"Jonathan H Savin, Nasser Rezzoug","doi":"10.1115/1.4064661","DOIUrl":"10.1115/1.4064661","url":null,"abstract":"The maximum actuation joint torques that operators can perform at the workplace are essential parameters for biomechanical risk assessment. However, workstation designers generally only have at their disposal the imprecise and sparse estimates of these quantities provided with digital manikin digital human model (DHM) software. For instance, such tools consider only static postures and ignore important specificities of the human musculoskeletal system such as interjoints couplings. To alleviate the weaknesses of existing approaches implemented in digital human modeling tools relying on torque databases, this paper describes a methodology based on a class of polytopes called zonotopes and musculoskeletal simulation to assess maximum actuation torques. It has two main advantages, the ability to estimate maximum joint torques for any posture and taking into account musculoskeletal specificities unlike existing digital human modeling tools. As a case study, it also compares simulated maximum actuation torques to those recorded during an experiment described in the literature, focusing on an isometric task of the upper limb. This simulation has led to similar or smaller errors than DHM software tools. Hence, this methodology may help in interpreting interjoint couplings, choosing appropriate mathematical models or design experimental protocols. It may also be implemented in DHM software to provide designers with more comprehensive and more reliable data.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of Machine Learning and Algorithmic Approaches to Automatically Identify the Yield Point in Normal and Aneurysmal Human Aortic Tissues. 自动识别正常和动脉瘤人体主动脉组织屈服点的机器学习和算法方法比较研究》（A Comparative Study of Machine Learning and Algorithm Approaches to Automatically Identify the Yield Point in Normal and Aneurysmal Human Aortic Tissues）。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064365

Timothy K Chung, Joseph Kim, Pete H Gueldner, David A Vorp, M L Raghavan

{"title":"A Comparative Study of Machine Learning and Algorithmic Approaches to Automatically Identify the Yield Point in Normal and Aneurysmal Human Aortic Tissues.","authors":"Timothy K Chung, Joseph Kim, Pete H Gueldner, David A Vorp, M L Raghavan","doi":"10.1115/1.4064365","DOIUrl":"10.1115/1.4064365","url":null,"abstract":"The stress-strain curve of biological soft tissues helps characterize their mechanical behavior. The yield point on this curve is when a specimen breaches its elastic range due to irreversible microstructural damage. The yield point is easily found using the offset yield method in traditional engineering materials. However, correctly identifying the yield point in soft tissues can be subjective due to its nonlinear material behavior. The typical method for yield point identification is visual inspection, which is investigator-dependent and does not lend itself to automation of the analysis pipeline. An automated algorithm to identify the yield point objectively assesses soft tissues' biomechanical properties. This study aimed to analyze data from uniaxial extension testing on biological soft tissue specimens and create a machine learning (ML) model to determine a tissue sample's yield point. We present a trained machine learning model from 279 uniaxial extension curves from testing aneurysmal/nonaneurysmal and longitudinal/circumferential oriented tissue specimens that multiple experts labeled through an adjudication process. The ML model showed a median error of 5% in its estimated yield stress compared to the expert picks. The study found that an ML model could accurately identify the yield point (as defined) in various aortic tissues. Future studies will be performed to validate this approach by visually inspecting when damage occurs and adjusting the model using the ML-based approach.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Material Properties of Fiber Bundles of the Superficial Medial Collateral Ligament of the Knee Joint. 膝关节浅内侧副韧带纤维束的材料特性

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-03-01 DOI: 10.1115/1.4064476

Wentao Chen, Qing Zhou, Jisi Tang

{"title":"Material Properties of Fiber Bundles of the Superficial Medial Collateral Ligament of the Knee Joint.","authors":"Wentao Chen, Qing Zhou, Jisi Tang","doi":"10.1115/1.4064476","DOIUrl":"10.1115/1.4064476","url":null,"abstract":"The superficial medial collateral ligament (sMCL) of the human knee joint has functionally separate anterior and posterior fiber bundles. The two bundles are alternatively loaded as the knee flexion angle changes during walking. To date, the two bundles are usually not distinguished in knee ligament simulations because there has been little information about their material properties. In this study, we conducted quasi-static tensile tests on the sMCL of matured porcine stifle joints and obtained the material properties of the anterior bundle (AB), posterior bundle (PB), and whole ligament (WL). AB and PB have similar failure stress but different threshold strain, modulus, and failure strain. As a result, we recommend assigning different material properties (i.e., modulus and failure strain) to the two fiber bundles to realize biofidelic ligament responses in human body models. However, it is often inconvenient to perform tensile tests on AB and PB. Hence, we proposed a microstructural model-based approach to predict the material properties of AB and PB from the test results of WL. Such obtained modulus values of AB and PB had an error of 2% and 0.3%, respectively, compared with those measured from the tests. This approach can reduce the experimental cost for acquiring the needed mechanical property data for simulations.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0