Journal of Biomechanical Engineering-Transactions of the Asme最新文献

Regulatory Role of Collagen XI in the Establishment of Mechanical Properties of Tendons and Ligaments in Mice is Tissue Dependent. 胶原蛋白 XI 在建立小鼠肌腱和韧带机械性能中的调节作用取决于组织。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-19 DOI: 10.1115/1.4066570

Yaping Ye, Snehal Shetye, David Birk, Louis J Soslowsky

{"title":"Regulatory Role of Collagen XI in the Establishment of Mechanical Properties of Tendons and Ligaments in Mice is Tissue Dependent.","authors":"Yaping Ye, Snehal Shetye, David Birk, Louis J Soslowsky","doi":"10.1115/1.4066570","DOIUrl":"https://doi.org/10.1115/1.4066570","url":null,"abstract":"Collagen XI is ubiquitous in tissues such as joint cartilage, cancellous bone, muscles, and tendons and is an important contributor during a crucial part in fibrillogenesis. The COL11A1 gene encodes one of three alpha chains of collagen XI. The present study elucidates the role of collagen XI in the establishment of mechanical properties of tendons and ligaments. We investigated the mechanical response of three tendons and one ligament tissues from wild type and a targeted mouse model null for collagen XI: Achilles tendon (ACH), , the flexor digitorum longus tendon (FDL), the supraspinatus tendon (SST), and the anterior cruciate ligament (ACL). Area was substantially lower in Col11a1?Ten/?Ten ACH, FDL and SST. Maximum load and maximum stress were significantly lower in Col11a1?Ten/?Ten ACH and FDL. Stiffness was lower in Col11a1?Ten/?Ten ACH, FDL and SST. Modulus was reduced in Col11a1?Ten/?Ten FDL and SST (both insertion site and midsubstance). Collagen fiber distributions were more aligned under load in both WT group and Col11a1?Ten/?Ten groups. Results also revealed that the effect of collagen XI knockout on collagen fiber realignment is tendon dependent and location dependent (insertion versus midsubstance). In summary, this study clearly shows that the regulatory role of collagen XI on tendon and ligament is tissue specific and that joint hypermobility in type II Stickler?s Syndrome may in part be due to suboptimal mechanical response of the soft tissues surrounding joints.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenomenological Muscle Constitutive Model with Actin-Titin Binding for Simulating Active Stretching. 用于模拟主动拉伸的肌动蛋白-岩丁结合现象学肌肉构成模型

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-13 DOI: 10.1115/1.4066564

Manuel Lucas Sampaio de Oliveira, Thomas K Uchida

{"title":"Phenomenological Muscle Constitutive Model with Actin-Titin Binding for Simulating Active Stretching.","authors":"Manuel Lucas Sampaio de Oliveira, Thomas K Uchida","doi":"10.1115/1.4066564","DOIUrl":"https://doi.org/10.1115/1.4066564","url":null,"abstract":"The force produced by a muscle depends on its contractile history, yet human movement simulations typically employ muscle models that define the force-length relationship from measurements of fiber force during isometric contractions. In these muscle models, the total force-length curve can have a negative slope at fiber lengths greater than the fiber length at which peak isometric force is produced. This region of negative stiffness can cause numerical instability in simulations. Experiments have found that the steady-state force in a muscle fiber following active stretching is greater than the force produced during a purely isometric contraction. This behaviour is called residual force enhancement. We present a constitutive model that exhibits force enhancement, implemented as a hyperelastic material in the FEBio finite element software. There is no consensus on the mechanisms responsible for force enhancement; we adopt the assumption that the passive fiber force depends on the sarcomere length at the instant that the muscle is activated above a threshold. We demonstrate the numerical stability of our model using an eigenvalue analysis and by simulating a muscle whose fibers are of different lengths. We then use a 3D muscle geometry to verify the effect of force enhancement on the development of stress and the distribution of fiber lengths. Our proposed muscle material model is one of the few models available that exhibits force enhancement and is suitable for simulations of active lengthening. We provide our implementation in FEBio so that others can reproduce and extend our results.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image-Based Estimation of Left Ventricular Myocardial Stiffness. 基于图像的左心室心肌僵硬度估计

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-13 DOI: 10.1115/1.4066525

Tarek Shazly, Logan Eads, Mia Kazel, Francesco Yigamawano, Juliana Guest, Traci Jones, Ahmed Alshareef, Kurt Barringhaus, FrancisG Spinale

引用次数: 0

Study of the Mechanism of Perceived Rotational Acceleration of a Bionic Semicircular Canal on the Basis of the "Circular Geometry Hypothesis". 基于 "圆形几何假说 "的仿生半规管感知旋转加速度机制研究。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-13 DOI: 10.1115/1.4066526

Yixiang Bian, Wujie Liu, Junjie Dai, Xianhua Wen, Yani Jiang

引用次数: 0

Sex-Based Differences and Asymmetry in Hip Kinematics During Unilateral Extension from Deep Hip Flexion. 从髋关节深屈开始单侧伸展时髋关节运动学的性别差异和不对称。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-12 DOI: 10.1115/1.4066466

Camille Johnson, Ethan Ruh, Naomi Frankston, Shaquille Charles, Michael McClincy, William Anderst

{"title":"Sex-Based Differences and Asymmetry in Hip Kinematics During Unilateral Extension from Deep Hip Flexion.","authors":"Camille Johnson, Ethan Ruh, Naomi Frankston, Shaquille Charles, Michael McClincy, William Anderst","doi":"10.1115/1.4066466","DOIUrl":"https://doi.org/10.1115/1.4066466","url":null,"abstract":"The purpose of this study was to identify side-to-side and sex-based differences in hip kinematics during a unilateral step-up from deep flexion. Twelve (8 men, 4 women) asymptomatic young adults performed a step ascent motion while synchronized biplane radiographs of the hip were collected at 50 images per second. Femur and pelvis position were determined using a validated volumetric model-based tracking technique that matched digitally reconstructed radiographs created from subject-specific computed tomography (CT) bone models to each pair of synchronized radiographs. Hip kinematics and side-to-side differences were calculated and a linear mixed effects model evaluated sex-based differences. Women were on average 10.2° more abducted and 0.2mm more medially translated than men across the step up motion (p<0.001). Asymmetry between hips was up to 14.1 ± 12.1° in internal rotation and 1.3 ± 1.4mm in translation. This dataset demonstrates the inherent asymmetry during movements involving unilateral hip extension from deep flexion and may be used provide context for observed kinematics differences following surgery or rehabilitation. Previously reported kinematic differences between total hip arthroplasty and contralateral hips may be well within the natural side-to-side differences that exist in asymptomatic native hips.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Structure and Wearing Modes on The Protective Performance of Industrial Safety Helmet. 结构和佩戴方式对工业安全帽防护性能的影响

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-12 DOI: 10.1115/1.4066467

Tian-Cheng Li, Hua Zhao, Bin Zhang, Cheng-Fei Du

引用次数: 0

Evaluation of an Inverse Method for Quantifying Spatially Variable Mechanics. 评估用于量化空间可变力学的逆方法。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-06 DOI: 10.1115/1.4066434

Daniel Pearce, Colleen Witzenburg

{"title":"Evaluation of an Inverse Method for Quantifying Spatially Variable Mechanics.","authors":"Daniel Pearce, Colleen Witzenburg","doi":"10.1115/1.4066434","DOIUrl":"https://doi.org/10.1115/1.4066434","url":null,"abstract":"Soft biological tissues often function as highly deformable membranes in vivo and exhibit impressive mechanical behavior effectively characterized by planar biaxial testing. The Generalized Anisotropic Inverse Mechanics (GAIM) method links full-field deformations and boundary forces from mechanical testing to quantify material properties of soft, anisotropic, heterogeneous tissues. In this study, we introduced an orthotropic constraint to GAIM to improve the quality and physical significance of its mechanical characterizations. We evaluated the updated GAIM method using simulated and experimental biaxial testing datasets obtained from soft tissue analogs (PDMS and TissueMend) with well-defined mechanical properties. GAIM produced stiffnesses (first Kelvin moduli, K1) that agreed well with previously published Young?s moduli of PDMS samples. It also matched the stiffness moduli determined via uniaxial testing for TissueMend, a collagen-rich patch intended for tendon repair. We then conducted the first biaxial testing of TissueMend and confirmed that the sample was mechanically anisotropic via a relative anisotropy metric produced by GAIM. Next, we demonstrated the benefits of full-field laser micrometry in distinguishing between spatial variations in thickness and stiffness. Finally, we conducted an analysis to verify that results were independent of partitioning scheme. The success of the newly implemented constraints on GAIM suggests notable potential for applying this tool to soft tissues, particularly following the onset of pathologies that induce mechanical and structural heterogeneities.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

We Will, We Will Shock You: Adaptive Versus Conventional Functional Electrical Stimulation in Individuals Post-Stroke. 我们会，我们会让你震惊：中风后患者的自适应功能性电刺激与传统功能性电刺激。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-03 DOI: 10.1115/1.4066419

Margo Donlin, Jill Higginson

{"title":"We Will, We Will Shock You: Adaptive Versus Conventional Functional Electrical Stimulation in Individuals Post-Stroke.","authors":"Margo Donlin, Jill Higginson","doi":"10.1115/1.4066419","DOIUrl":"https://doi.org/10.1115/1.4066419","url":null,"abstract":"Functional electrical stimulation (FES) is often used in post-stroke gait rehabilitation to address decreased walking speed, foot drop, and decreased forward propulsion. However, not all individuals experience clinically meaningful improvements in gait function with stimulation. Previous research has developed adaptive functional electrical stimulation (AFES) systems that adjust stimulation timing and amplitude at every stride to deliver optimal stimulation. The purpose of this work was to determine the effects of a novel AFES system on functional gait outcomes and compare them to the effects of the existing FES system. Twenty-four individuals with chronic post-stroke hemiparesis completed six four-minute walking trials on an adaptive and fixed-speed treadmill with no stimulation, stimulation from the existing FES system, and stimulation from the AFES system. There was no significant effect of stimulation condition on walking speed, peak dorsiflexion angle, or peak propulsive force. Walking speed was significantly faster and peak propulsive force was significantly larger on the adaptive treadmill than the fixed-speed treadmill (both p < 0.0001).Dorsiflexor stimulation timing was similar between stimulation conditions, but plantarflexor stimulation timing was significantly improved with the AFES system compared to the FES system (p = 0.0059). Variability between and within subjects was substantial, and some subjects experienced clinically meaningful improvements in walking speed, peak dorsiflexion angle, and peak propulsive force. However, not all subjects experienced benefits, suggesting that further research to characterize which subjects exhibit the best instantaneous response to FES is needed to optimize post-stroke gait rehabilitation using FES.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo Quantification of Ascending Thoracic Aortic Aneurysm Wall Stretch Using MRI: Relationship to Repair Threshold Diameter and Ex Vivo Wall Failure Behavior. 利用核磁共振成像对升胸主动脉瘤壁拉伸进行体内定量：与修复阈值直径和体内壁破坏行为的关系

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-03 DOI: 10.1115/1.4066430

Huiming Dong, Henrik Haraldsson, Joseph Leach, Ang Zhou, Megan Ballweber, Chengcheng Zhu, Yue Xuan, Zhongjie Wang, Michael Hope, Frederick Epstein, Liang Ge, David Saloner, Elaine Tseng, Dimitrios Mitsouras

{"title":"In Vivo Quantification of Ascending Thoracic Aortic Aneurysm Wall Stretch Using MRI: Relationship to Repair Threshold Diameter and Ex Vivo Wall Failure Behavior.","authors":"Huiming Dong, Henrik Haraldsson, Joseph Leach, Ang Zhou, Megan Ballweber, Chengcheng Zhu, Yue Xuan, Zhongjie Wang, Michael Hope, Frederick Epstein, Liang Ge, David Saloner, Elaine Tseng, Dimitrios Mitsouras","doi":"10.1115/1.4066430","DOIUrl":"https://doi.org/10.1115/1.4066430","url":null,"abstract":"Background Ascending thoracic aortic aneurysms (aTAA) can lead to life-threatening dissection and rupture. Recent studies highlighted aTAA mechanical properties as relevant factors associated with progression. The aim of this study was to quantify in vivo aortic wall stretch in healthy participants and aTAA patients using displacement encoding with stimulated echoes (DENSE) MRI. Moreover, aTAA wall stretch between surgical and non-surgical patients were investigated. Finally, DENSE measurements were compared to reference-standard mechanical testing on aTAA specimens from surgical repairs. Methods In total, 18 subjects were recruited, six healthy participants and 12 aTAA patients, for this prospective study. ECG-gated DENSE imaging was performed to measure systole-diastole wall stretch, as well as the ratio of aTAA stretch to unaffected descending thoracic aorta stretch. Free-breathing and breath-held DENSE protocols were used. Uniaxial tensile testing-measured indices were correlated to DENSE measurements in five specimens. Results In vivo aortic wall stretch was significantly lower in aTAA compared to healthy subjects (P=.0004). There was no correlation between stretch and maximum aTAA diameter. The ratio of aTAA to unaffected thoracic aorta wall stretch was significantly lower in surgical candidates compared to non-surgical candidates (P=.0442). Finally, in vivo aTAA wall stretch correlated to wall failure stress and peak modulus of the intima (P=.017 and P=.034, respectively), while the stretch ratio correlated to whole-wall thickness failure stretch and stress (P=.013 and P=.040, respectively). Conclusion Aortic DENSE has the potential to assess differences in aTAA mechanical properties and progressions.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulating the Growth of TAF15 Inclusions in Neuron Soma. 模拟神经元索质中 TAF15 包涵体的生长

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-09-02 DOI: 10.1115/1.4066386

Dr Andrey Kuznetsov

{"title":"Simulating the Growth of TAF15 Inclusions in Neuron Soma.","authors":"Dr Andrey Kuznetsov","doi":"10.1115/1.4066386","DOIUrl":"https://doi.org/10.1115/1.4066386","url":null,"abstract":"To the best of the author's knowledge, this paper presents the first attempt to develop a mathematical model of the formation and growth of inclusions containing misfolded TATA-box binding protein associated factor 15 (TAF15). It has recently been shown that TAF15 inclusions are involved in approximately 10% of cases of frontotemporal lobar degeneration (FTLD). FTLD is the second most common neurodegenerative disease after Alzheimer's disease (AD). It is characterized by a progressive loss of personality, behavioral changes, and a decline in language skills due to the degeneration of the frontal and anterior temporal lobes. The model simulates TAF15 monomer production, nucleation and autocatalytic growth of free TAF15 aggregates, and their deposition into TAF15 inclusions. The accuracy of the numerical solution of the model equations is validated by comparing it with analytical solutions available for limiting cases. Physiologically relevant parameter values were used to predict TAF15 inclusion growth. It is shown that the growth of TAF15 inclusions is influenced by two opposing mechanisms: the rate at which free TAF15 aggregates are deposited into inclusions and the rate of autocatalytic production of free TAF15 aggregates from monomers. A low deposition rate slows inclusion growth, while a high deposition rate hinders the autocatalytic production of new aggregates, thus also slowing inclusion growth. Consequently, the rate of inclusion growth is maximized at an intermediate deposition rate of free TAF15 aggregates into TAF15 inclusions.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0