Journal of Biomechanical Engineering-Transactions of the Asme最新文献

Characterization of Flow Structure and Wall Shear Stress in Patient-Specific Abdominal Aortic Aneurysm Phantom using Particle Image Velocimetry. 使用粒子图像测速技术表征患者特异性腹主动脉瘤幻象的流动结构和壁面剪切应力。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-08-02 DOI: 10.1115/1.4069296

Mehmet Anil Susar, Oguzhan Yilmaz, Amirhossein Fathipour, Onur Mutlu, Noaman Mazhar, Ayman El-Menyar, Hassan Al-Thani, Hüseyin Çagatay Yalçin, Mehmet Metin Yavuz

{"title":"Characterization of Flow Structure and Wall Shear Stress in Patient-Specific Abdominal Aortic Aneurysm Phantom using Particle Image Velocimetry.","authors":"Mehmet Anil Susar, Oguzhan Yilmaz, Amirhossein Fathipour, Onur Mutlu, Noaman Mazhar, Ayman El-Menyar, Hassan Al-Thani, Hüseyin Çagatay Yalçin, Mehmet Metin Yavuz","doi":"10.1115/1.4069296","DOIUrl":"https://doi.org/10.1115/1.4069296","url":null,"abstract":"Abdominal Aortic Aneurysm (AAA) is an irreversible dilation of the abdominal aorta that carries significant risk of rupture if not adequately screened and treated. This condition poses severe threat, with mortality rate exceeding 80% in certain age groups. The enlargement of abdominal aorta leads to notable hemodynamic alterations in AAAs, characterized by flow separation and vortical structures. Current understanding acknowledges a correlation between growth and rupture mechanisms of AAA and disturbed hemodynamics, emphasizing metrics such as time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), endothelial cell activation potential (ECAP), and relative residence time (RRT). In this study, we utilized a quantitative velocity measurement technique, particle image velocimetry (PIV), to characterize the flow structure and wall shear stress in a patient-specific aneurysmal abdominal aorta phantom. Phase-averaged flow fields for 12 phases of physiological flow are investigated, constructing velocity contours, streamline patterns, vorticity contours, and swirling strength contours in AAA at three different PIV planes. In addition, a method previously developed and validated to extract wall shear stress from PIV measurements is applied to obtain shear stress indexes, including TAWSS, OSI, ECAP, and RRT. The progression of vortex structures in the bulge along with flow separation and reattachment zones in relation to the shear stress indexes are presented and discussed in detail. Here we present in detail generating AAA phantoms from patient CT images, and PIV based flow examination through the phantom, which will contribute to experimental investigations for understanding the influence of disturbed hemodynamics on AAA biomechanics.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-21"},"PeriodicalIF":1.7,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Turbulence Models for Accurate Prediction of Airflow Structure in a Subject-Specific Upper Airway Geometry. 评估湍流模型，以准确预测特定受试者上呼吸道的气流结构。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-07-30 DOI: 10.1115/1.4069231

Alek Nino, Yu Feng

{"title":"Evaluation of Turbulence Models for Accurate Prediction of Airflow Structure in a Subject-Specific Upper Airway Geometry.","authors":"Alek Nino, Yu Feng","doi":"10.1115/1.4069231","DOIUrl":"https://doi.org/10.1115/1.4069231","url":null,"abstract":"Accurate prediction of complex airflow fields in the human upper airway is crucial for precise quantifications of aerosol transport and the optimization of inhalation therapy. While Large Eddy Simulation (LES) has been widely validated for capturing more detailed turbulence features, its high computational cost limits widespread applications. Reynolds-Averaged Navier-Stokes (RANS) models are more computationally efficient but cannot resolve key flow features (i.e., the random fluctuation terms) in anatomically complex airway geometries. Recently, hybrid models such as Stress-Blended Eddy Simulation (SBES) have emerged as promising alternatives, yet their performance in airways remains underexplored. This study is a research effort to address the knowledge gap by evaluating the computational accuracy and efficiency of LES, RANS, and SBES in simulating the airflow field through a subject-specific mouth-to-trachea geometry. The experimentally validated in-house LES results served as the benchmark for assessing the RANS and SBES models in predicting velocity distributions, secondary vortex structures, and turbulent kinetic energy (TKE). Compared with LES results, the realizable k-e model significantly underpredicted secondary flow structures and TKE due to excessive numerical diffusion and inherent model limitations, although it completed simulations in less than 1% of the time required by LES. The SBES model demonstrated excellent agreement with LES in capturing localized flow features. Computational efficiency-wise, although SBES required roughly 25% more overall CPU time than LES, SBES achieved a reduction in average CPU time per iteration of approximately 7% compared to LES.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-35"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surfactant-Depleted Rat Lungs: A Characterization Of Organ- And Tissue-Level Mechanics Under Negative And Positive Pressure Ventilation. 表面活性剂耗竭大鼠肺：负压和正压通气下器官和组织水平力学的表征。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-07-16 DOI: 10.1115/1.4069142

Matthew Shankel, Arif Badrou, Talyah Nelson, Mona Eskandari

{"title":"Surfactant-Depleted Rat Lungs: A Characterization Of Organ- And Tissue-Level Mechanics Under Negative And Positive Pressure Ventilation.","authors":"Matthew Shankel, Arif Badrou, Talyah Nelson, Mona Eskandari","doi":"10.1115/1.4069142","DOIUrl":"https://doi.org/10.1115/1.4069142","url":null,"abstract":"Multiple types of lung diseases damage epithelial cell layers producing pulmonary surfactant, a substance vital for decreasing lung surface tension, and therefore increase the risk of ventilator induced lung injury (VILI). VILI may be exacerbated by positive pressure ventilation (PPV; standard clinical method) compared to negative pressure ventilation (NPV; diaphragm physiological loading), warranting investigations of the comparative effect of PPV and NPV on surfactant-depleted lungs. Surfactant depletion was induced using ex-vivo rat lungs via saline wash. An electromechanical ventilator imposed PPV or NPV, where digital image correlation technology continuously measured the associated inflation deformations simultaneously; both bulk-level pressure-volume measures and local tissue-level strain values were used to compare the two ventilation modes. For PPV, compared to control counterparts, the surfactant-depleted lungs showed decreased starting compliance, increased hysteresis, and decreased skewness of major strain distribution at maximum inflation, known to be associated with increased VILI risk ; these same measures were not significantly different between NPV controls and surfactant-depleted specimens. For surfactant-depleted lungs, NPV showed a pressure-time curve fit closer to one (associated with the clinical stress index, less pressure inhomogeneities, and safer ventilation), and lower regional and 75th percentile compliance values at maximum inflation compared to PPV. The negative impact of surfactant depletion is suggested to be ameliorated under NPV via a more gradual initial pressure increase and resulting lower local compliance values compared to PPV. For lungs with surfactant loss, findings indicate NPV supports safer mechanical ventilation in contrast to PPV.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-34"},"PeriodicalIF":1.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictions of Atelectasis-Induced Micro-Volutrauma: a Key Pathway to Ventilator-Induced Lung Injury. 预测肺不张诱发的微容量损伤：呼吸机诱发肺损伤的关键途径。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-07-04 DOI: 10.1115/1.4069073

Hideki Fujioka, David Halpern, Donald Gaver

{"title":"Predictions of Atelectasis-Induced Micro-Volutrauma: a Key Pathway to Ventilator-Induced Lung Injury.","authors":"Hideki Fujioka, David Halpern, Donald Gaver","doi":"10.1115/1.4069073","DOIUrl":"https://doi.org/10.1115/1.4069073","url":null,"abstract":"This study presents a full three-dimensional multi-scale computational model of lung parenchyma to investigate how heterogeneous alveolar ventilation generates regions of high stress. The model integrates elastin and collagen fiber mechanics at the alveolar level to capture microstructural interactions. Simulations of non-uniform alveolar pressure, particularly in the presence of atelectasis (collapsed lung regions), reveal significant localized distortions in adjacent normal parenchyma, especially along the atelectatic boundary. Results demonstrate that heterogeneous ventilation induces substantial stress concentrations in surrounding healthy tissue, which may contribute to lung injury and disease progression in acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI). A reduced-dimension periacinar pressure model is introduced to provide a simplified yet effective framework for analyzing these mechanical interactions. Notably, the model shows that even under seemingly normal transmural pressures, alveolar collagen fibers near atelectatic regions experience extreme tensile stresses, which could be misinterpreted as micro-volutrauma despite originating from atelectasis. These findings underscore the critical role of heterogeneous ventilation in driving injurious mechanical forces within the lung, highlighting the need for ventilation strategies that minimize airway closure or alveolar derecruitment.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-24"},"PeriodicalIF":1.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Modeling of Human Skin Deformation and Growth During Tissue Expansion in Postmastectomy Breast Reconstruction. 乳房切除术后乳房重建中组织扩张过程中人体皮肤变形和生长的预测模型。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-07-01 DOI: 10.1115/1.4068370

Joel Laudo, Tianhong Han, Joanna Ledwon, Ariel E Figueroa, Arun K Gosain, Taeksang Lee, Adrian Buganza Tepole

{"title":"Predictive Modeling of Human Skin Deformation and Growth During Tissue Expansion in Postmastectomy Breast Reconstruction.","authors":"Joel Laudo, Tianhong Han, Joanna Ledwon, Ariel E Figueroa, Arun K Gosain, Taeksang Lee, Adrian Buganza Tepole","doi":"10.1115/1.4068370","DOIUrl":"10.1115/1.4068370","url":null,"abstract":"Breast reconstruction using tissue expanders is the primary treatment option following mastectomy. Although skin growth in response to chronic supra-physiological stretch is well-established, individual patient factors such as breast shape, volume, skin prestrain, and mechanical properties, create unique deformation and growth patterns. The inability to predict skin growth and deformation prior to treatment often leads to complications and suboptimal esthetic outcomes. Personalized predictive simulations offer a promising solution to these challenges. We present a pipeline for predictive computational models of skin growth in tissue expansion. At the start of treatment, we collect three-dimensional (3D) photos and create an initial finite element model. Our framework accounts for uncertainties in treatment protocols, mechanical properties, and biological parameters. These uncertainties are informed by surgeon input, existing literature on mechanical properties, and prior research on porcine models for biological parameters. By collecting 3D photos longitudinally during treatment, and integrating the data through a Bayesian framework, we can systematically reduce uncertainty in the predictions. Calibrated personalized models are sampled using Monte Carlo methods, which require thousands of model evaluations. To overcome the computational limitations of directly evaluating the finite element model, we use Gaussian process surrogate models. We anticipate that this pipeline can be used to guide patient treatment in the near future.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Numerical Simulation of Central Airway Gas Flow Dynamics During Conventional and Multi-Frequency Ventilation. 常规与多频通气时中央气道气流动力学的数值模拟。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-06-28 DOI: 10.1115/1.4069032

Bing Han, Emmanuel Akor, Andrea Fonseca da Cruz, Mingchao Cai, David W Kaczka

{"title":"Numerical Simulation of Central Airway Gas Flow Dynamics During Conventional and Multi-Frequency Ventilation.","authors":"Bing Han, Emmanuel Akor, Andrea Fonseca da Cruz, Mingchao Cai, David W Kaczka","doi":"10.1115/1.4069032","DOIUrl":"https://doi.org/10.1115/1.4069032","url":null,"abstract":"Patients with acute respiratory failure often require supportive mechanical ventilation to maintain adequate gas exchange. Recent studies have shown that multi-frequency ventilation (MFV), the technique of presenting multiple simultaneous frequencies in flow or pressure at the airway opening, may provide more uniform ventilation distribution and parenchymal strain throughout the mechanically heterogeneous lung. In this study, we simulated gas flow within a porcine central airway tree, from the trachea to the fifth generation, with dynamic boundary conditions during volume-controlled conventional mechanical ventilation (CMV) cycled at 0.27 Hz (16.2 min-1), as well as MFV waveforms comprised of two fast sinusoidal components (i.e., 3.5 Hz and 7.0 Hz) superimposed on the 0.27 Hz CMV waveform. By using forced gas flows at the airway opening of the computational lung model, dynamic pressures at various airway segments were predicted, based on the interactions of internal flow with the downstream elastances and peripheral airway resistances. Internal airflows were simulated and analyzed in both time- and frequency-domains. The results indicate that MFV resulted in stronger asymmetric flow (i.e., \"pendelluft\") at end-inspiration and end-expiration. MFV also appeared to augment inlet-outlet phase differences for both pressure and flow compared with CMV, suggesting that MFV may enhance gas mixing, thus facilitating more efficient ventilation.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-35"},"PeriodicalIF":1.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Modelling of Pulmonary Surfactant Dynamics from Alveolus to Whole Lung. 肺表面活性物质从肺泡到全肺动态的计算机模拟。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-06-28 DOI: 10.1115/1.4069033

Ruobing Li, Alys Clark, Merryn Tawhai, Kelly Burrowes

{"title":"In Silico Modelling of Pulmonary Surfactant Dynamics from Alveolus to Whole Lung.","authors":"Ruobing Li, Alys Clark, Merryn Tawhai, Kelly Burrowes","doi":"10.1115/1.4069033","DOIUrl":"https://doi.org/10.1115/1.4069033","url":null,"abstract":"Surfactant plays a crucial role in maintaining lung mechanics by reducing alveolar surface tension and preventing alveolar collapse. Deficiencies or alterations in surfactant properties can lead to significant changes in lung mechanics and impairments in lung function. However, understanding how changes in surfactant concentration and properties impact on lung function remains challenging. In this study, we integrated a previously published model of alveolar surfactant dynamics [Otis et al., 1994] into a computational model that links acinar mechanics with ventilation of the full conducting airway tree. This approach allowed us to explore the regional and global effects of surfactant on lung function under different ventilation conditions. Simulations mimicking saline filled, lavaged, and air-filled lungs demonstrated the well-known effect of surfactant on reducing surface tension at the air-liquid interface and establishing the hysteresis observed during inhalation and exhalation. Increased hysteresis was observed during ventilation with higher tidal volumes, while increasing breathing frequency led to increased heterogeneity in surfactant distribution and acinar compliance. These findings demonstrate that reductions in surfactant concentration impair alveolar expansion and ventilation efficiency, influencing lung function under varying mechanical ventilation strategies. By integrating surfactant dynamics with acinar mechanics, this computational model has the potential to predict how surfactant depletion, as seen in neonatal respiratory distress syndrome and acute lung injury, leads to alveolar instability and ventilation heterogeneity. The framework provides a tool to assess surfactant-related lung dysfunction and optimize mechanical ventilation strategies to improve alveolar recruitment and gas exchange in patients with surfactant deficiencies.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Material characterization of ovine lung parenchyma at pressures representing the breathing cycle. 在代表呼吸循环的压力下，绵羊肺实质的物质特性。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-06-06 DOI: 10.1115/1.4068872

Patricia K Thomas, Eugene Ablordeppey, Grace Liverett, Olivia Rutherford, Tyler Roy, Philip Brown, F Scott Gayzik

{"title":"Material characterization of ovine lung parenchyma at pressures representing the breathing cycle.","authors":"Patricia K Thomas, Eugene Ablordeppey, Grace Liverett, Olivia Rutherford, Tyler Roy, Philip Brown, F Scott Gayzik","doi":"10.1115/1.4068872","DOIUrl":"https://doi.org/10.1115/1.4068872","url":null,"abstract":"Lung tissue behavior at different physiological pressures has not been well studied. The objectives of this study therefore were to characterize lung tissue at different physiologically relevant pressures within the breathing cycle, quantifying how the tissue deforms, and determining associated shear moduli. We utilized fresh ovine lungs harvested and tested within 8 hours of sacrifice, using spherical indentation and digital image correlation (DIC). Tests were conducted at three different pressures - 0, 4, and 10 cmH2O. Lungs from a total of ten animals were tested. The resulting instantaneous shear modulus, relaxed shear modulus, and shear modulus ratio were used for statistical analyses, via a mixed effect model. The instantaneous shear modulus had trending differences between pressures (0.05 0.1). The modulus ratio was considered significantly different, as p < 0.05. When comparing pressurized (4 and 10 cm H20 together) to non-pressurized, both instantaneous and relaxed shear moduli were significantly lower than the ambient pressure state.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-25"},"PeriodicalIF":1.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 2025 Richard Skalak Award and Editors' Choice Papers. 2025年理查德·斯卡拉克奖和编辑之选论文。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-06-04 DOI: 10.1115/1.4068823

Thao Vicky Nguyen, C Ross Ethier

引用次数: 0

Design and Validation of a Cable-Driven Joint Actuator for Pediatric Knee Orthoses. 儿童膝关节矫形器缆索驱动关节驱动器的设计与验证。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-06-01 DOI: 10.1115/1.4068369

Jason J Wiebrecht, Jacob A Strick, Ryan J Farris, Jerzy T Sawicki

{"title":"Design and Validation of a Cable-Driven Joint Actuator for Pediatric Knee Orthoses.","authors":"Jason J Wiebrecht, Jacob A Strick, Ryan J Farris, Jerzy T Sawicki","doi":"10.1115/1.4068369","DOIUrl":"10.1115/1.4068369","url":null,"abstract":"Robot-assisted gait rehabilitation is an increasingly common therapeutic intervention for enhancing locomotion and improving quality of life for children with lower-limb mobility impairments. However, there are few systems specifically designed for pediatric use, and those that do exist are largely cumbersome, bulky, and noncustom devices that ultimately reduce therapy effectiveness. This paper introduces the Cable-Driven Joint System (CDJS), a novel approach for pediatric gait rehabilitation that addresses these shortcomings in a lightweight and compact robotic device using the patient's professionally fitted orthosis. The CDJS consists of a 2.1 kg actuation unit that is held by a clinician which delivers assistive torques through a Bowden cable transmission to a 0.3 kg joint mounted to user-custom bracing. This work details an actuator benchtop evaluation, demonstrating a peak torque of 20 N·m, peak velocity of 7.2 rad/s, bandwidth of 9.7 Hz, and a mass moment of inertia of 58.38 kg cm2. An actuator model was developed and evaluated in simulation, showing a strong correlation with the experimental torque data (R-squared = 0.95) and indicating a transmission efficiency of 72%. In-air gait tracking experiments on an emulated subject showed that the CDJS assisted the subject to track a nominal knee trajectory with an average root-mean-squared error of 2.56 deg at a continuous torque of 1.37 N·m. These results suggest that the cable-driven actuator meets the design requirements for use in pediatric gait rehabilitation and is ready for implementation in clinical device trials.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0