Journal of Biomechanical Engineering-Transactions of the Asme最新文献

{"title":"Multiscale Architecture Governs Stability in Suction-Actuated Variable Stiffness Catheters.","authors":"DeVaughn Rucker, Sheridan Lee, Michael Qiu, Yuxuan Huang, Juan Becerra-García, Hanxun Jin, Charles Suskin, Michelle Connor, Sophia R Pyeatte, Josh Osbun, Mohamed Zayed, Guy Genin","doi":"10.1115/1.4071866","DOIUrl":"https://doi.org/10.1115/1.4071866","url":null,"abstract":"<p><p>Endovascular procedures require devices with widely varying mechanical properties: flexibility for navigating tortuous vessels, and rigidity for stable therapeutic delivery. Suction-actuated variable stiffness sheaths attempt to address this challenge by incorporating axial wire string arrays that couple mechanically under suction to increase flexural rigidity. However, prototype devices achieve stiffening ratios well below theoretical predictions, suggesting that string array positioning and interlayer mechanics require optimization. We therefore investigated whether interweaving expanded polytetrafluoroethylene (PTFE) tape within the string array can enhance flexural rigidity modulation and improve bending uniformity along the catheter length. Prototypes with varying PTFE wrap configurations were fabricated and evaluated using three complementary approaches. First, flexural testing revealed that flexural rigidity in the actuated and unactuated states was largely unaffected by wrapping for small deformations. Second, curvature stability testing revealed that deformation through acute simulated vascular bends was higher than expected due to two failure mechanisms: slip, in which string arrays migrate after overcoming wrap-imposed friction, and buckling, in which arrays become locally pinned and deflect against the outer lumen. Finally, a mathematical model characterized stability limits as functions of the wrapping architecture and device mechanical properties, revealing criteria for which device performance improved. Results suggest design principles for intra-catheter wrapping that can narrow the gap between theoretical and achieved flexural rigidity ratios, potentially contributing to the development of endovascular devices capable of single-sheath navigation and intervention.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-43"},"PeriodicalIF":1.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special Issue: Challenges in the Evaluation and Identification of Tissue Biomechanical Properties and Parameters.","authors":"Babak N Safa, Brianne K Connizzo","doi":"10.1115/1.4071547","DOIUrl":"10.1115/1.4071547","url":null,"abstract":"","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the \"Art\" in Modeling and Simulation of the Knee Joint: Model Benchmarking.","authors":"Maryam Nazem, Thor E Andreassen, Nancy Kim, Kate Moyle, Thor F Besier, Jason P Halloran, Carl W Imhauser, Snehal Chokhandre, Marco T Y Schneider, Shady Elmasry, William Zaylor, Kevin B Shelburne, Ahmet Erdemir, Peter J Laz","doi":"10.1115/1.4070823","DOIUrl":"10.1115/1.4070823","url":null,"abstract":"<p><p>Given the strong ties to data sharing and the responsible use of resources, reproducibility of modeling and simulation practice is of paramount importance in science. Computational models in orthopedics provide insight into healthy and injured joint mechanics and can inform clinical decision-making. The KneeHub project investigated the influence of modelers' decisions and thus their \"art\" in simulation and modeling; five teams developed and calibrated knee models using the same experimental data. Model benchmarking evaluated the predictive ability of the models under loading scenarios that were not considered in the development and calibration process. The objective of this study was to evaluate the accuracy of predictions of knee-specific joint biomechanics for benchmark scenarios of simulating a resected anterior cruciate ligament (ACL) using models of one knee and a combined pivot shift loading using models of another knee. The models predicted the major trends in kinematics and kinetics; however, differences were observed in comparison to experimental data and between teams. Model-to-experiment root-mean-square (RMS) errors were up to 6.6±2.4 mm in anterior-posterior (AP) translation, 13.5±12.9 deg in internal-external (IE) rotation, and 5.3±3.4 deg in varus-valgus (VV) rotation; errors were largest in internal-external rotation, and standard deviations reflected differences between teams. While calibrated models were tuned to a similar set of conditions (albeit with different decisions), the optimized stiffness and reference length/strain of ligament structures may not fully reproduce the contributions of these structures to joint kinematics that were measured experimentally in the benchmark scenarios. As researchers often extend models beyond the conditions used to calibrate them, quantifying model accuracy and limitations with benchmarking represents a crucial step toward reproducibility and can help establish best practices for credible modeling in our community.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Triggering in Tagged Magnetic Resonance Imaging for in vivo Characterization of Brain Biomechanics During Head Rotation.","authors":"Yuan-Chiao Lu, Joy Mojumder, Ahmed Alshareef, Wen-Tung Wang, Jerry L Prince, Philip Bayly, John A Butman, Dzung L Pham","doi":"10.1115/1.4071580","DOIUrl":"10.1115/1.4071580","url":null,"abstract":"<p><p>Tagged magnetic resonance imaging (MRI) has been successfully applied for noninvasive quantification of in vivo brain deformation, enabling characterization of strain distributions under mild, noninjurious loading conditions. Previously, the double trigger (DT) method was proposed to improve temporal consistency, where an initial trigger initiates the MRI tagging pulse and a second trigger initiates image acquisition. However, this approach has two disadvantages: (1) the initial trigger was mechanical and susceptible to misalignment during connection to a fiber optic cable; (2) the time history of the tagged MRI acquisition was constrained to the interval between the initial and second triggers, thereby limiting the overall acquisition duration. In this work, a late trigger (LT) approach is proposed to eliminate mechanical triggering and the use of a fiber optic cable, reduce tag fading, and enable a longer duration time history. Gel phantom experiments demonstrate that both DT and LT approaches yield consistent strain patterns and angular kinematics. Similarly, angular motion and in-plane strain measured using in vivo two-dimensional (2D) tagged MRI show strong agreement between the DT and LT approaches; nonetheless, LT consistently provides improved tag contrast, signal-to-noise ratio (SNR), and anatomical delineation. In in vivo three-dimensional (3D) testing, LT method produces 95th percentile maximum principal strain (MPS95) strain values that closely align with those of the DT method across multiple brain regions. Collectively, the LT method demonstrates performance comparable to DT in both phantom and in vivo experiments, highlighting its potential as a physiologically robust and technically advantageous strategy for measuring brain deformation.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distortion Energy Drives Cellular and Mechanical Changes in Fibroblast-Seeded Collagen Scaffolds Under Cyclic Loading.","authors":"Amevi M Semodji, Dalia DeLaCruz, Anamaria G Zavala, Sean M Howard, Shaughnessy Murphy, Katherine J Fors, Zachary Pinkley, Gunes Uzer, Julia Thom Oxford, Trevor J Lujan","doi":"10.1115/1.4071132","DOIUrl":"10.1115/1.4071132","url":null,"abstract":"<p><p>Fibroblast activity in soft tissues is highly regulated by the mechanical environment of the extracellular matrix. Physical thresholds that regulate fibroblast-mediated remodeling have been previously identified using stress or strain invariants, but these thresholds depend on loading configuration, precluding the formulation of a unifying theory to predict cell response across loading environments. An alternative approach for predicting matrix remodeling is to use distortion energy, a scalar measure of deformation that accounts for both stress and strain. Here we explore whether distortion energy can predict cellular and mechanical changes across three cyclic loading configurations: uniaxial tension, uniaxial compression, and biaxial tension-compression. Collagen scaffolds were seeded with murine fibroblasts and mechano-stimulated for 7 days with a multi-axial bioreactor that cyclically applied approximately 40 J/m3 of strain energy for all loading types (error < 1%). We measured the mechanical properties of the cell-seeded constructs, before and after stimulation, and quantified cell density and fiber alignment using confocal microscopy. Multiple regression analysis revealed that changes in cell density across loading configurations had the greatest correlation with distortion energy (partial r = 0.85, p = 0.001), rather than traditional stress and strain invariants (e.g., first principal, von Mises). Distortion energy also had strong positive correlations with tensile stiffness, but not compressive properties. Overall, this study found distortion energy to be the best predictor of cellular and mechanical changes across simple and complex loads, suggesting that distortion energy may be a key physical driver for fibroblast activity and matrix remodeling.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Uncertainty Quantification into Computational Fluid Dynamics Models of Coronary Arteries Under Steady Flow.","authors":"Muhammad Usman, Peter Castillo, Akil Narayan, Lucas H Timmins","doi":"10.1115/1.4071773","DOIUrl":"10.1115/1.4071773","url":null,"abstract":"<p><p>Computational fluid dynamics simulations are increasingly being integrated into clinical medicine, where they have the potential to support clinicians in disease diagnosis, prognosis, and treatment. However, these models frequently use deterministic approaches, neglecting inherent variability (or uncertainty) in input parameters, thereby undermining model credibility and limiting clinical adoption. Herein, we integrate modern and certifiable uncertainty quantification (UQ) techniques to characterize and quantify the variability in coronary artery wall shear stress (WSS) under steady flow conditions due to intrinsic uncertainty in model-dependent quantities. Univariate probability distributions were fit to hemodynamic parameters (density, pressure, radius, velocity, viscosity), and sampled parameter ensembles were applied to an analytical solution (Poiseuille flow) and a patient-specific coronary artery model. Results from the analytical solution demonstrated that variability in input parameters propagated to uncertainty in WSS values, with uncertainty in velocity accounting for the majority (~79%) of WSS variability. In the patient-specific model, spatial medians in WSS varied by ~50% due to input parameter uncertainties, with viscosity (~59%) and velocity (~40%) emerging as the dominant contributors to WSS variability. Across each use case unary interactions dominated (i.e., first-order Sobol indices accounted for the majority of the variance), contributing to ~93% and ~99% of the total WSS variance in the analytical and patient-specific model, respectively. Collectively, this study establishes an uncertainty-aware framework to strengthen computational biomechanics model credibility, aligning with emerging regulatory guidance and enabling more trustworthy modeling-based decision support in the management of coronary artery disease.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-41"},"PeriodicalIF":1.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a Novel Dual-function Spacer Valve for Selective Aerosol Size Filtering and Measuring Peak Expiratory Flow Rate.","authors":"Shahab Azimi, Siamak Arzanpour","doi":"10.1115/1.4071666","DOIUrl":"https://doi.org/10.1115/1.4071666","url":null,"abstract":"<p><strong>Background: </strong>Variable inhalation flow rates reduce aerosol drug efficacy, while separate devices for therapy and monitoring hinder patient adherence. This study computationally designs a novel, dual-function valve to solve these issues. Operating on inertial impaction, the valve uses a nozzle to create an aerosol jet and a movable plate to force a sharp airflow turn. Larger, high-inertia particles impact the plate, while smaller therapeutic particles remain entrained.</p><p><strong>Methods: </strong>Building on an optimized geometry, a computational fluid dynamics (CFD) model characterized valve performance across clinically relevant conditions. The model simulated aerosol transport during low-flow therapeutic inhalation (10-60 L/min) and high-flow diagnostic peak expiratory flow rate (PEFR) exhalation (100-700 L/min). A custom \"Valve Efficacy\" metric quantified selective particle filtration based on aerodynamic diameter.</p><p><strong>Results: </strong>Filtration efficacy is highly dependent on inhalation flow rate and nozzle-to-plate distance. A high-performance therapeuticwindow was identified at 20-35 L/min, maintaining efficacy above 90%. A direct, linear relationship between aerodynamic drag on the plate and the optimal filtration distance was established. This enables a passive, self-regulating mechanism governed by a linear spring. Augmenting this with a second, stiffer spring in series allows the assembly to function as a PEFR meter.</p><p><strong>Conclusion: </strong>The computational results validate the feasibility of a single, inhalation- actuated valve that integrates selective therapeutic aerosol filtration with diagnostic PEFR monitoring. This design represents a significant step towards developing more personalized, effective, and user-friendly devices for managing chronic respiratory diseases.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-18"},"PeriodicalIF":1.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remodeling-Mediated Changes in Left Ventricular Mechanics Under Settings of Chronic Pressure Overload and Exercise.","authors":"Francesco Yigamawano, Ricky Ruiz, Conner Johnson, Alexander Barnette, Lisa Freeburg, Kurt Barringhaus, Francis/G Spinale, Tarek Shazly","doi":"10.1115/1.4071665","DOIUrl":"10.1115/1.4071665","url":null,"abstract":"<p><p>Left ventricular (LV) remodeling, whether occurring with somatic growth or as a chronic response to a sustained stimulus, is a primary factor underlying cardiac mechanical function. Although LV remodeling is a complex process that can be described at several levels, response variables that govern cardiac mechanics include changes in LV wall and chamber geometry, the mechanical properties of the LV myocardium, and LV structural mechanical properties such as LV chamber stiffness. We leverage two-dimensional speckle-tracking echocardiography (STE) to serially monitor key LV remodeling response variables in porcine models of LV pressure overload (LVPO), chronic exercise (CE), and the superposition of both settings (CE+LVPO), and compare changes to those occurring in age-matched referent control (RC) animals. Our findings show that over 28-days, LVPO and CE both induce hypertrophy, but passive LV myocardial stiffness increases with the former and decreases with the latter. As a net effect of geometrical and mechanical property changes, these settings induce divergent changes in LV chamber stiffness, namely an elevation with LVPO and reduction with CE. In the CE+LVPO cohort, exercise was found to attenuate the LVPO-induced increase in LV myocardial and LV chamber stiffnesses. Data obtained were used to identify a phenomenological model of LV chamber stiffness and develop a predictive mathematical model of late changes in LV chamber stiffness based on early remodeling response variables irrespective of stimulus. Our findings support exercise in cardiac therapy and the use of STE to predict cardiac disease risk/progression.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-44"},"PeriodicalIF":1.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on Structural Optimization of Interventional Microaxial Blood Pump Based on Non-Dominated Sorting Genetic Algorithm-II.","authors":"Gang Cheng, Xuesong Geng, Jianying Ma, Ying Wang","doi":"10.1115/1.4071621","DOIUrl":"https://doi.org/10.1115/1.4071621","url":null,"abstract":"<p><p>This study presents an optimization approach for interventional microaxial blood pump, aimed at addressing the rising burden of cardiovascular diseases and the limited availability of heart transplant donors in China. The methodology integrates design of experiments (DOE), computational fluid dynamics (CFD) analysis, and response surface methodology (RSM), with the Non-dominated Sorting Genetic Algorithm-II (NSGA-II) multi-objective genetic algorithm employed to optimize impeller geometry. The primary objectives were to enhance hydraulic efficiency and improve hemocompatibility. The optimized blood pump model demonstrated notable performance improvements across various flow conditions: at a low flow rate of 1 L/min, the pump head increased by 2.97% and the hemolysis index decreased by 12.04%; at the design point, head improved by 5.22% while hemolysis was reduced by 11.71%; under high-flow conditions (4 L/min), head increased by 8.5% and hemolysis decreased by 12.57%. These enhancements contribute to higher energy efficiency and lower hemolytic risk, thereby improving the safety and reliability of the device in clinical applications. The findings provide a robust foundation for future advancements in blood pump design and optimization.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-49"},"PeriodicalIF":1.7,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Journal of Biomechanical Engineering Remains Committed to Supporting Scholarship Through the Promotion of Diversity, Equity, and Inclusion.","authors":"Darryl Dickerson, Spencer E Szczesny","doi":"10.1115/1.4070720","DOIUrl":"10.1115/1.4070720","url":null,"abstract":"<p><p>In light of the recent reprioritization of federal funding, the Journal of Biomechanical Engineering (JBME) reaffirms its commitment to reporting scientific excellence, advancements in knowledge, and technical innovations that benefit healthcare for everyone. Furthermore, we recognize that this commitment to excellent and rigorous science and engineering is supported by promoting diversity, equity, and inclusion, which ensures that advances in biomedical engineering address the distinct health needs of the broadest possible population. In this editorial, we highlight the recent actions that the journal has taken to support diversity and inclusion, including the appointment of Diversity Advocate positions, implementation of a double-blind review process, and publication of special issues on inclusive science and engineering. Finally, we present research and publication recommendations to the broader biomechanical engineering community that collectively embody the core principles of our field and that will lead to more equity and impact in biomechanical engineering.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}