Journal of Biomechanical Engineering-Transactions of the Asme最新文献

{"title":"Effects of Aging and Early-Onset Menopause on Intraocular Pressure (IOP) and Aqueous Humor Conventional Outflow Facility.","authors":"Nina Sara Fraticelli-Guzmán, Dennis Jiang, Beam Yongphiphatwong, Joseph van Batenburg-Sherwood, Andrew Feola","doi":"10.1115/1.4072763","DOIUrl":"https://doi.org/10.1115/1.4072763","url":null,"abstract":"<p><p>Biomechanical factors play a crucial role in glaucoma development, the world-leading cause of irreversible blindness. Although age is known to affect the tissues? biomechanical properties, early-onset menopause has recently been associated with the risk of developing glaucoma, and the effects of aging relative to early-onset menopause on eye?s biomechanical factors remain underexplored. This work?s goals were to study the effects of aging and early-onset menopause on intraocular pressure (IOP), aqueous humor outflow facility, and ocular compliance. Female Brown Norway rats underwent Sham or surgical menopause (ovariectomy; OVX) at 3-4 months of age and were split into young (5-6 months) or middle-aged groups (9-10 months). We monitored IOP until the established aging time points and performed ex vivo biomechanical measurements via the iPerfusion system. IOP was higher for the middle-aged Sham and OVX animals by 25% and 35%, respectively (p<0.001), when compared to their respective initial IOPs. Furthermore, middle-aged OVX animals had a 11% higher IOP compared to Sham animals (p=0.005), and a 20% lower outflow facility (p=0.031). Ocular compliance decreased with age in the Sham (24.9%, p=0.011) and OVX (24.5%, p=0.005) cohorts and by 24.1% independent of cohort (p=0.0001). Elucidating the effects of age and early-onset menopause on biomechanical factors that contribute to glaucoma pathology is necessary to help move the field forward and preserve the eyesight of millions of patients.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-33"},"PeriodicalIF":1.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Emerging Role of Cellular Mechanical Memory In Aqueous Humor Outflow Dysfunction In Glaucoma.","authors":"Samuel Herberg","doi":"10.1115/1.4072760","DOIUrl":"10.1115/1.4072760","url":null,"abstract":"<p><p>Emerging evidence suggests that cells can retain information about previous mechanical environments and subsequently exhibit altered phenotypes even after the original mechanical stimulus is removed. This phenomenon is known as cellular mechanical memory that occurs in three phases: memory acquisition, storage, and recall. The literature supports a model in which mechanical experiences become encoded through interconnected cytoskeletal, nuclear, metabolic, and epigenetic mechanisms. Mechanical memory is increasingly recognized as a central regulator of cell fate and tissue remodeling, as well as a fundamental principle in development, aging, fibrosis, cancer, and regenerative medicine. We here give a concise overview of the historical origins and defining features of mechanical memory, discuss the emergence of mechanical memory in aqueous humor outflow dysfunction in glaucoma, summarize key unanswered questions, and close with a discussion of the clinical relevance of targeting mechanical memory for therapeutic purposes.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-26"},"PeriodicalIF":1.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear Stress Regulates C-type Natriuretic Peptide Gene Expression by Valvular Endothelial Cells in a Sex-Dependent Manner.","authors":"Rachel Adams, Maria Zena Miranda, Craig Simmons","doi":"10.1115/1.4072753","DOIUrl":"https://doi.org/10.1115/1.4072753","url":null,"abstract":"<p><p>Aortic valve disease initiates on the fibrosa (aorta-facing) side of the valve leaflets, whereas the ventricularis side is disease-protected. Spatially predictable disease correlates with side-specific hemodynamics and gene expression: fibrosa-side valvular endothelial cells (VECs) experience low magnitude, oscillatory shear stress and have lower expression of pathological inhibitors, whereas ventricularis VECs experience higher magnitude shear stress and have a more protective phenotype. Among the protective genes higher expressed on the ventricular side, C-type natriuretic peptide (CNP) stands out as an endogenous inhibitor of fibrotic differentiation of aortic valve interstitial cells and valvular disease in vivo. However, shear stress regulation of CNP in aortic valves has not been characterized. To this end, porcine VECs were subjected to prescribed shear stresses in vitro. Steady, high magnitude shear stress and ventricular side-specific shear stress waveforms upregulated CNP gene (NPPC) expression in a KLF2-dependent manner. NPPC was upregulated by shear stress in VECs isolated from both the fibrosa and ventricularis sides, but with greater sensitivity in fibrosa-side cells. Notably, while KLF2 expression was upregulated with shear stress in both male and female VECs, NPPC was upregulated only in male VECs. Side- and sex-specific CNP expression patterns observed in vitro were also observed in immunohistochemically-stained human aortic valves. This work positions CNP as a biomechanically regulated factor in aortic valve homeostasis and pathogenesis, and provides insights into the factors regulating sex differences in valvular disease.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-37"},"PeriodicalIF":1.6,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear Stress and Pressure Homeostasis in the Eye's Aqueous Outflow Pathway.","authors":"Mark Johnson, C Ross Ethier","doi":"10.1115/1.4072751","DOIUrl":"https://doi.org/10.1115/1.4072751","url":null,"abstract":"<p><p>Glaucoma is the most common cause of irreversible blindness. Many patients with glaucoma suffer from elevated intraocular pressure (IOP), due to impaired drainage of aqueous humor fluid from the eye, and all current treatments are designed to lower IOP, implicating dysregulation of IOP as an important clinical problem. Because IOP is maintained within a narrow range over a lifetime in a healthy eye, it is thought that mechanically-driven feedback loops within the eye maintain IOP homeostasis, and in fact, good evidence for such loops now exists. Here we revisit the fluid mechanics of aqueous humor flow in the eye to estimate fluid shear stresses in relevant aqueous drainage tissues, in order to identify mechanical signals that may be involved in IOP homeostatic feedback loops. We find that shear stresses within the juxtacanalicular tissue are likely too small to play a significant role, except perhaps in the very immediate vicinity of the inner wall of Schlemm's canal. We estimate that the basement membrane underlying the inner wall of Schlemm's canal is exposed to very high shear stresses. Furthermore, we find remarkably large shear stresses acting on pores passing through the inner wall of Schlemm's canal. Finally, the inner wall of Schlemm's canal is exposed to moderate shear stresses that, unlike other locations in the outflow pathway, increase as IOP increases. Thus, the inner wall endothelial cells of Schlemm's canal are well-suited to participate in a shear stress-driven IOP homeostatic feedback loop.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-21"},"PeriodicalIF":1.6,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Uncertainty Quantification into Computational Fluid Dynamics Models of Coronary Arteries Under Steady Flow.","authors":"Muhammad Usman, Peter N Castillo, Akil Narayan, Lucas H Timmins","doi":"10.1115/1.4071773","DOIUrl":"10.1115/1.4071773","url":null,"abstract":"<p><p>Computational fluid dynamics (CFD) simulations are increasingly being integrated into clinical medicine, where they have the potential to support clinicians in disease diagnosis, prognosis, and treatment. However, these models frequently use deterministic approaches, neglecting inherent variability (or uncertainty) in input parameters, thereby undermining model credibility and limiting clinical adoption. Herein, we integrate modern and certifiable uncertainty quantification techniques to characterize and quantify the variability in coronary artery wall shear stress (WSS) under steady-flow conditions due to intrinsic uncertainty in model-dependent quantities. Univariate probability distributions were fitted to hemodynamic parameters (density, pressure, radius, velocity, and viscosity), and sampled parameter ensembles were applied to an analytical solution (Poiseuille flow) and a patient-specific coronary artery model. Results from the analytical solution demonstrated that variability in input parameters propagated into uncertainty in WSS values, with uncertainty in velocity accounting for the majority (∼81%) of WSS variability. In the patient-specific model, spatial medians in WSS varied by ∼50% due to input parameter uncertainties, with viscosity (∼59%) and velocity (∼40%) emerging as the dominant contributors to WSS variability. Across each use case, unary interactions dominated (i.e., first-order Sobol indices accounted for the majority of the variance), contributing to ∼93% and ∼99% of the total WSS variance in the analytical and patient-specific model, respectively. Collectively, this study establishes an uncertainty-aware framework to strengthen computational biomechanics model credibility, aligning with emerging regulatory guidance and enabling more trustworthy modeling-based decision support in the management of coronary artery disease.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Active Backpack Loading Patterns to Improve the Walking Performance for Individuals With a Unilateral Transtibial Amputation.","authors":"Mila M Wetz, Glenn K Klute, Richard R Neptune","doi":"10.1115/1.4071641","DOIUrl":"10.1115/1.4071641","url":null,"abstract":"<p><p>Individuals with unilateral transtibial amputation (TTA) often demonstrate asymmetrical gait patterns, which are further exacerbated during load carriage as passive prostheses cannot modulate their mechanical stiffness to accommodate the increased demand. Load carriage also increases the loads on the intact limb that can lead to overuse injuries and is also associated with increased metabolic cost and decreased forward propulsion. While active and passive load-suspended backpacks have been studied in healthy populations, no studies have explored the use of active backpacks to improve the walking performance for individuals with TTA. Therefore, the purpose of this study was to identify active backpack loading patterns to improve the metabolic cost, forward propulsion, and knee joint loading of individuals with TTA using a musculoskeletal simulation-based optimization framework. Different loading patterns were simulated using a time-varying actuator force applied to an active backpack over the gait cycle. The magnitude and timing of the actuator force were optimized for each performance criterion that resulted in a unique actuation pattern for each biomechanical measure. Interestingly, similar improvements relative to a passive backpack were observed across all actuation patterns, regardless of the optimization criteria. With all active backpacks, the force impulse experienced by the body from the dynamic load decreased, which resulted in increased forward propulsion, decreased intact knee joint loading, and improved metabolic cost. This suggests that active backpacks have the potential to improve walking performance during load carriage for individuals with TTA.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":"148 8","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remodeling-Mediated Changes in Left Ventricular Mechanics Under Settings of Chronic Pressure Overload and Exercise.","authors":"Francesco K Yigamawano, Ricky Ruiz, Conner E Johnson, Alexander Barnette, Lisa Freeburg, Kurt G Barringhaus, Francis G Spinale, Tarek Shazly","doi":"10.1115/1.4071665","DOIUrl":"10.1115/1.4071665","url":null,"abstract":"<p><p>Left ventricular (LV) remodeling, whether occurring with somatic growth or as a chronic response to a sustained stimulus, is a primary factor underlying cardiac mechanical function. Although LV remodeling is a complex process that can be described at several levels, response variables that govern cardiac mechanics include changes in LV wall and chamber geometry, the mechanical properties of the LV myocardium, and LV structural mechanical properties such as LV chamber stiffness. We leverage two-dimensional speckle-tracking echocardiography (STE) to serially monitor key LV remodeling response variables in porcine models of LV pressure overload (LVPO), chronic exercise (CE), and the superposition of both settings (CE+LVPO), and compare changes to those occurring in age-matched referent control (RC) animals. Our findings show that over 28-days, LVPO and CE both induce hypertrophy, but passive LV myocardial stiffness increases with the former and decreases with the latter. As a net effect of geometrical and mechanical property changes, these settings induce divergent changes in LV chamber stiffness, namely, an elevation with LVPO and reduction with CE. In the CE+LVPO cohort, exercise was found to attenuate the LVPO-induced increase in LV myocardial and LV chamber stiffnesses. Data obtained were used to identify a phenomenological model of LV chamber stiffness and develop a predictive mathematical model of late changes in LV chamber stiffness based on early remodeling response variables irrespective of stimulus. Our findings support exercise in cardiac therapy and the use of STE to predict cardiac disease risk/progression.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fascicular Elastin Modulates Recovery of Mechanical Properties Following Subfailure Repetitive Loading.","authors":"Shawn N Pavey, Nathan Xu, Spencer P Lake","doi":"10.1115/1.4072061","DOIUrl":"10.1115/1.4072061","url":null,"abstract":"<p><p>While fascicular elastic fibers have been shown to significantly affect mechanical properties of tendon in stress relaxation and ramp to failure testing, the contribution of elastin to fatigue properties has only recently been investigated. This study expanded upon recent fatigue-to-failure data in wild-type and limb-specific elastin knockdown mice (Prx1Cre+;Elnfl/fl) by halting tests at 50% of cyclic fatigue (based on normalized strain) instead of completing tests to full tissue failure. Following 50% fatigue loading, Achilles (AT) and tibialis anterior (TB) tendons were subjected to subsequent stress relaxation and ramp to failure testing, enabling comparison to prior properties of nondamaged tendons to determine the effects of subfailure fatigue. Indeed, multiple properties (e.g., ultimate stress and linear modulus) were decreased following fatigue loading, especially in elastin-deficient tendons, and genotype-dependent differences in stress relaxation properties were observed. Quantitative metrics of damage (i.e., collagen denaturation and fiber kinking) were not different between wild-type and elastin knockdown tendons as observed previously following fatigue-induced failure, suggesting that tendon damage develops later in the fatigue lifecycle. In addition, results suggest that elastin mediates collagen fiber alignment more in ATs than TBs, providing evidence that the different effects of elastin on tendon mechanics rely on microstructural mechanisms that vary by tendon type. Clinically, results of this study suggest that individuals with deficient or depleted elastin may experience impaired recovery following repetitive tendon loading, which could have downstream effects on subsequent damage accumulation and tissue remodeling that should be investigated further in future studies.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148058355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Sterilization Method on Material Properties of 3D Printable Resins With Prolonged Exposure to Cell Culture Environments.","authors":"Ashlee S Liao, Michael J Bennington, Kevin Dai, Alaeddin Burak Irez, Anika Sun, Saul Schaffer, Bhavya Chopra, Ji Min Seok, Rebekah Adams, Yongjie Jessica Zhang, Victoria A Webster-Wood","doi":"10.1115/1.4071099","DOIUrl":"10.1115/1.4071099","url":null,"abstract":"<p><p>Low-cost 3D printing has become increasingly important in biomedical research, enabling rapid fabrication of custom cell culture devices, fixtures, and biohybrid robotic components. However, little is known about how common sterilization procedures and prolonged cell culture exposure impact the mechanical properties of commercially available resins. In this study, we analyzed five candidate 3D-printable resins-three rigid (Asiga DentaGUIDE, Liqcreate Bio-Med Clear, and Phrozen AquaGray 8K) and two elastomeric (Asiga DentaGUM and Formlabs Silicone 40A)-to evaluate the effects of ethanol/UV and autoclave sterilization on material properties in phosphate-buffered saline (PBS) at physiological conditions. Using stress-strain data from tensile and compressive mechanical tests, elastic moduli, ultimate tensile strength (UTS), and strain at break were compared across sterilization techniques. Results showed that sterilization significantly altered the mechanical properties of rigid resins, with Phrozen AquaGray 8K and Liqcreate Bio-Med Clear exhibiting large reductions in tensile stiffness and strength, while Asiga DentaGUIDE retained greater stability. In contrast, elastomeric resins were more robust: Asiga DentaGUM and Formlabs Silicone 40A demonstrated minimal or nonsignificant changes across sterilization methods, though post-treatment protocols influenced variability. Notably, several rigid resins also exhibited substantially lower moduli in PBS compared to manufacturer-reported values. These findings emphasize the need for experimental validation of 3D printed resin properties under intended use conditions and suggest that Asiga DentaGUIDE and Formlabs Silicone 40A are promising candidates for biohybrid applications. Overall, this work provides critical guidance for selecting sterilization-compatible materials for biomedical devices and biohybrid robotics.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Assessment of Associations Between Serum Estrogen to Progesterone Ratio and Anterior Cruciate Ligament Size, Biomechanics, and T2* Relaxation Time in the Porcine Model.","authors":"Jacob D Thompson, Danielle Howe, Emily H Griffith, Alan J Conley, Sandra J Shultz, Lauren V Schnabel, Jeffrey T Spang, Matthew B Fisher","doi":"10.1115/1.4071369","DOIUrl":"10.1115/1.4071369","url":null,"abstract":"<p><p>Adolescent females are at a higher risk of anterior cruciate ligament (ACL) injury than males. While prior studies have associated injury timing and menstrual cycle phase, these data are limited by indirect cycle tracking and lack of analysis on ACL structure, mechanics, or composition. Additionally, little is known about how female sex hormones influence the distinct ACL bundles. This exploratory study investigated associations between serum sex hormone concentrations and size, mechanics, and composition of the ACL and its bundles in a female adolescent pig model. Serum from nine adolescent female Yorkshire crossbreed pigs was collected pre-euthanasia and analyzed for levels of estradiol, progesterone, and testosterone. The ACL and its bundles were assessed for size via magnetic resonance imaging (MRI), mechanics via robotic testing, and composition via biochemical and histological analyses. While individual hormone levels and the estradiol-to-progesterone (E/P) ratio had no association with most metrics, the E/P ratio was significantly associated with ACL size and T2* relaxation time. Higher E/P ratios were negatively associated with anteromedial (AM) bundle cross-sectional area (CSA) (R2 = 0.44) and overall ACL volume (R2 = 0.49) and positively associated with posterolateral (PL) bundle T2* relaxation time (R2 = 0.69, p < 0.05). Serum E/P ratio was also positively associated with normalized ACL stiffness, but there were no associations observed for tissue composition. The results of this exploratory study indicate that the ACL may be responsive to exposure to the relative concentration of female sex hormone in a bundle-specific manner.</p>","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}