Journal of Biomechanical Engineering-Transactions of the Asme最新文献

Macrophage-Epithelial Interactions Modulate Epithelial Cell Injury During Airway Reopening. 巨噬细胞-上皮相互作用调节气道重开过程中上皮细胞损伤。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-29 DOI: 10.1115/1.4068790

Tricia Oyster, Vasudha C Shukla, Yuji Tomizawa, Joshua Englert, Megan Ballinger, Samir N Ghadiali

{"title":"Macrophage-Epithelial Interactions Modulate Epithelial Cell Injury During Airway Reopening.","authors":"Tricia Oyster, Vasudha C Shukla, Yuji Tomizawa, Joshua Englert, Megan Ballinger, Samir N Ghadiali","doi":"10.1115/1.4068790","DOIUrl":"https://doi.org/10.1115/1.4068790","url":null,"abstract":"During the acute respiratory distress syndrome (ARDS), bacterial/viral infections, including COVID-19, lead to significant pulmonary edema and severe hypoxia. Although ARDS patients often require mechanical ventilation (MV), the biophysical forces generated during MV are known to exacerbate lung injury resulting in ventilation-induced lung injury (VILI). During VILI, the complex biomechanical forces generated during the reopening of fluid-occluded airway/alveoli (atelectrauma) causes plasma membrane rupture and epithelial cell death. However, it is not known how the interaction of immune cells, including alveolar macrophages, with epithelial cells alters the degree of atelectrauma. We used in-vitro modeling techniques to investigate how co-culture of both monocyte derived macrophages and primary human alveolar macrophages with lung epithelial cells alter the degree of cell injury during airway reopening. Co-culture of epithelial cells with macrophages led to a significant increase in epithelial cell death/plasma membrane rupture during airway reopening and this increased injury was not due to soluble factors secreted by macrophages. Inhibiting macrophage-epithelial gap junction interactions decreased epithelial cell injury during airway reopening. Morphological and cell biomechanical measurements indicate that epithelial cells in co-culture with macrophages have a lower height-to-width aspect ratio, a lower instantaneous elastic modulus, and a lower power-law exponent. Since lower aspect ratios have been associate with reduced atelectrauma, our data indicate that the reduced stiffness (lower elastic modulus) and increased elasticity (lower power-law exponent) is the biomechanical mechanism by which macrophages exacerbate epithelial cell injury during airway reopening.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-27"},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Student Paper Competition of the 2024 Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C). 2024年夏季生物力学、生物工程和生物运输会议（SB3C）学生论文竞赛。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-23 DOI: 10.1115/1.4068758

Megan L Killian

引用次数: 0

Annual Special Issue: 2024 in Review. 年度特刊：2024年回顾。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-21 DOI: 10.1115/1.4068745

Thao Vicky Nguyen, C Ross Ethier

引用次数: 0

Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations. 评估运动引起的主动脉缩窄压降的实验和模拟。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-17 DOI: 10.1115/1.4068716

Priya J Nair, Emanuele Perra, Doff B McElhinney, Alison Marsden, Daniel B Ennis, Seraina Dual

{"title":"Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations.","authors":"Priya J Nair, Emanuele Perra, Doff B McElhinney, Alison Marsden, Daniel B Ennis, Seraina Dual","doi":"10.1115/1.4068716","DOIUrl":"https://doi.org/10.1115/1.4068716","url":null,"abstract":"Blood pressure gradient (ΔP) across an aortic coarctation (CoA) is an important measurement to diagnose CoA severity and guide treatment. While invasive cardiac catheterization is the clinical gold-standard for measuring ΔP, it requires anesthesia and does not capture the effects of daily activity or exercise, potentially underestimating the disease's functional burden. This study aimed to identify patients with functionally significant CoA by evaluating exercise-induced ΔP using a hybrid mock circulatory loop (HMCL). Patient-specific aorta geometries (N=5) of patients with CoA were generated from 4D-Flow magnetic resonance imaging (MRI) scans, then 3D-printed to create compliant aortic phantoms. The phantoms were incorporated into an HMCL with flow and pressure waveforms tuned to patient-specific rest and exercise states. Matched fluid-structure interaction (FSI) simulations were performed using SimVascular for comparison. Results showed that mean ΔP increased non-linearly with cardiac output (CO), with trends differing between patients. HMCL and FSI simulations exhibited excellent agreement in trends of ΔP change with CO, with minimal error of 1.6 +/- 1.1 mmHg. This study emphasizes the need for assessing exercise CoA hemodynamics beyond resting ΔP measurements. Overall, HMCLs and FSI simulations enable assessment of patient-specific hemodynamic response to exercise unattainable in clinical practice, thereby facilitating a comprehensive non-invasive assessment of CoA severity. Further, the excellent agreement between HMCL and FSI results indicates that our validated FSI approach can be used independently to assess exercise CoA hemodynamics hereafter, eliminating the need for repeated complex HMCL experiments.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bubbler system design for regulating media oxygen levels in an open testing environment. 起泡器系统设计用于在开放测试环境中调节介质氧水平。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-09 DOI: 10.1115/1.4068635

Margaret Capalbo, Spencer Szczesny

引用次数: 0

Deformation Response of the Human Lamina Cribrosa to Intracranial Pressure Lowering. 人筛板对颅内压降低的变形响应。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-09 DOI: 10.1115/1.4068633

Kelly Clingo, Cameron A Czerpak, Sara G Ho, Megha Patel, Crystal Favorito, Anny Zheng, Abhay Moghekar, Harry A Quigley, Thao Vicky Nguyen

{"title":"Deformation Response of the Human Lamina Cribrosa to Intracranial Pressure Lowering.","authors":"Kelly Clingo, Cameron A Czerpak, Sara G Ho, Megha Patel, Crystal Favorito, Anny Zheng, Abhay Moghekar, Harry A Quigley, Thao Vicky Nguyen","doi":"10.1115/1.4068633","DOIUrl":"https://doi.org/10.1115/1.4068633","url":null,"abstract":"The optic nerve head (ONH) is subjected to both intraocular pressure (IOP) and intracranial pressure (ICP), which act in opposing directions at the lamina cribrosa (LC). The translaminar pressure difference (TLPD) is defined as the difference between IOP and ICP. A change in TLPD, whether from changes in IOP or ICP, could subject the LC to altered deformation, potentially damaging the axons, activating the mechanosensitive glial cells, and promoting remodeling of the connective tissue structures in the ONH. In this study, we applied spectral domain optical coherence tomography (SD-OCT) and digital volume correlation to calculate the deformation response of the LC in 7 eyes of 7 patients with normal pressure hydrocephalus. Radial SD-OCT scans centered on the ONH were acquired prior to and after therapeutic extended cerebrospinal fluid (CSF) drainage. IOP was measured immediately before imaging, and ICP was measured at the beginning and end of the drainage procedure. The procedure led to a mean ICP decrease of 11.24±1.84 mmHg and a small, nonsignificant mean IOP increase of 0.67±2.56 mmHg. ICP lowering produced a significant Ezz = -0.50%±0.47%, Err = 0.53%±0.48%, and Eqz = 0.35%±0.21% (p ≤ 0.031). A larger compressive Ezz was associated with a larger ICP decrease (p = 0.007). Larger Err, Erq , maximum principal strain, Emax, and maximum shear strain, Smax, in the plane of the radial scans were associated with a larger increase in a calculated TLPD change (p ≤ 0.035).","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-36"},"PeriodicalIF":1.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis and Implications of Compliance On Joint Biomechanics Measurements In Superposition Testing. 叠加试验中关节生物力学测量的顺应性分析及意义。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-09 DOI: 10.1115/1.4068634

Callan M Gillespie, Nicholas/J Haas, Tara Nagle, Robb Colbrunn

{"title":"Analysis and Implications of Compliance On Joint Biomechanics Measurements In Superposition Testing.","authors":"Callan M Gillespie, Nicholas/J Haas, Tara Nagle, Robb Colbrunn","doi":"10.1115/1.4068634","DOIUrl":"https://doi.org/10.1115/1.4068634","url":null,"abstract":"To quantify the contributions of specific ligaments to overall joint movement, the principle of superposition has been used for nearly 30 years. This principle relies on using a robotic test system to move a biological joint to the same position before and after transecting a specific ligament. The resulting difference in joint forces is assumed to be the transected ligament's tension. However, the robotic test system's ability to accurately return the joint to the commanded pose is dependent on the compliance of the system's various components, which is often neglected. Accordingly, there were three objectives in this manuscript: 1) Explain the influence of system compliance on positioning error in superposition testing with a mathematical model, 2) Quantify the compliance of components within the robotic test system and 3) Provide a framework to evaluate uncertainty in published superposition based in situ force measurements and demonstrate their implications on published Anterior Cruciate Ligament forces. A system stiffness model was derived to explain that compliance of test system components will cause the superposition method to underestimate ligament tension and stiffness. Based on typical test system component and joint stiffness ranges measured in this study, it was determined that with decreasing robot and/or bone stiffness, or increasing joint stiffness values, ligament load error could increase to values greater than 50%. Results indicate that experimentalists should 1) maximize test system component stiffness relative to joint stiffness and/or 2) compensate for compliance induced deflection of the test system components.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-46"},"PeriodicalIF":1.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Headform Pose on The Blunt Impact Performance of American Football Helmets. 头部姿势对美式橄榄球头盔钝冲击性能的影响。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-09 DOI: 10.1115/1.4068632

Mark Jesunathadas, Elizabeth Edwards, Tiffany Landry, Scott Piland, Trenton Gould, Thomas Plaisted

{"title":"The Influence of Headform Pose on The Blunt Impact Performance of American Football Helmets.","authors":"Mark Jesunathadas, Elizabeth Edwards, Tiffany Landry, Scott Piland, Trenton Gould, Thomas Plaisted","doi":"10.1115/1.4068632","DOIUrl":"https://doi.org/10.1115/1.4068632","url":null,"abstract":"The purpose of this research was to evaluate the influence of ATD head-neck system pose on the kinematic responses of an ATD donning football helmets during blunt impact tests. Specifically, for two American football helmets we aimed to determine if identical impact locations but with two different ATD head-neck poses resulted in differences in ATD headform kinematics. Eight Xenith Shadow and eight X2E+ American football helmets were fit to a medium NOCSAE ATD attached to a male 50th percentile Hybrid III neck. Each helmet was impacted at 6 m/s using a pneumatic linear ram 4 times at 4 sites on the helmet. One set (4) of the Shadow and (4) X2E+ helmets were impacted with the ATD head-neck in one type of pose, termed Flexion Pose. The other set (4 Shadow and 4 X2E+) were impacted with the ATD head-neck mount system rotated another type of pose, termed Lateral Bending Pose. Dependent measures included the difference (d) between the two poses (Flexion ? Lateral Bending) in peak linear acceleration (dPLA), peak angular acceleration (dPAA), and peak angular velocity (dPAV). A significant interaction between Helmet and Location was observed for dPLA (p < .001), dPAA (p < .001) and dPAV (p < .001). A main effect for helmet was also observed for dPLA (p < .001), dPAA (p =.025), and dPAV (p < .008). The effect of such results within the context of methodologies that rank helmets according to blunt impact performance is discussed.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors. 筛板缺氧对解剖学和血管因子变化的敏感性。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-02 DOI: 10.1115/1.4068577

Yuankai Lu, Yi Hua, Po-Yi Lee, Andrew Theophanous, Shaharoz Tahir, Qi Tian, Ian A Sigal

{"title":"Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors.","authors":"Yuankai Lu, Yi Hua, Po-Yi Lee, Andrew Theophanous, Shaharoz Tahir, Qi Tian, Ian A Sigal","doi":"10.1115/1.4068577","DOIUrl":"https://doi.org/10.1115/1.4068577","url":null,"abstract":"Insufficient oxygenation in the lamina cribrosa (LC) may contribute to axonal damage and glaucomatous vision loss. To understand the range of susceptibilities to glaucoma, we aimed to identify key factors influencing LC oxygenation and examine if these factors vary with anatomical differences between eyes. We reconstructed 3D, eye-specific LC vessel networks from histological sections of four healthy monkey eyes. For each network, we generated 125 models varying vessel radius, oxygen consumption rate, and arteriole perfusion pressure. Using hemodynamic and oxygen supply modeling, we predicted blood flow distribution and tissue oxygenation in the LC. ANOVA assessed the significance of each parameter. Our results showed that vessel radius had the greatest influence on LC oxygenation, followed by anatomical variations. Arteriole perfusion pressure and oxygen consumption rate were the third and fourth most influential factors, respectively. The LC regions are well perfused under baseline conditions. These findings highlight the importance of vessel radius and anatomical variation in LC oxygenation, providing insights into LC physiology and pathology. Pathologies affecting vessel radius may increase the risk of LC hypoxia, and anatomical variations could influence susceptibility. Conversely, increased oxygen consumption rates had minimal effects, suggesting that higher metabolic demands, such as those needed to maintain intracellular transport despite elevated intraocular pressure, have limited impact on LC oxygenation.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-34"},"PeriodicalIF":1.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inverse Uncertainty Quantification for Personalized Biomechanical Modeling: Application to Pulmonary Poromechanical Digital Twins. 个性化生物力学建模的逆不确定性量化：在肺孔隙力学数字双胞胎中的应用。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-02 DOI: 10.1115/1.4068578

Alice Peyraut, Martin Genet

{"title":"Inverse Uncertainty Quantification for Personalized Biomechanical Modeling: Application to Pulmonary Poromechanical Digital Twins.","authors":"Alice Peyraut, Martin Genet","doi":"10.1115/1.4068578","DOIUrl":"https://doi.org/10.1115/1.4068578","url":null,"abstract":"The development of personalized models is a key step for addressing various problems, especially in biomechanics. These models typically include many constants, introduced in the model material law or loading definition, and their estimation is crucial for the model personalization. However, performing solely the estimation does not yield any information on the estimation accuracy. Additionally, all parameters can typically not be estimated based only on clinical data: some parameters are identified, while others are fixed at generic values. The question of the identifiability of the parameters, along with the robustness of the estimation, notably to noise (measurement errors) and to bias (model errors), is therefore crucial and should be quantitatively addressed in parallel to the model development. In this paper, we propose a general uncertainty quantification pipeline based on the creation of synthetic data -for which the parameters ground-truth values are known-, generated for different noise and bias levels. Estimation is then performed for many realizations of the noise or bias, as well as parameter initializations, until convergence of the estimated parameters error distributions. This pipeline was applied to a poromechanical lung model for illustration and validation purposes. It provides quantitative information on the actual identifiability of the parameters, and any derived quantity of interest, in the clinical setting. In particular, it allows to retrieve a confidence interval for each estimated parameters, which represents valuable information for diagnosis or prognosis use of the estimated values. This work is therefore a step towards improving the reliability of digital twins pipelines.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-52"},"PeriodicalIF":1.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0