Journal of Biomechanical Engineering-Transactions of the Asme最新文献

Heart Scar-In-A-Dish: Tissue Culture Platform to Study Myocardial Injury and Mechanics In Vitro. 心脏Scar-In-A-Dish：体外心肌损伤及力学研究的组织培养平台。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-10-13 DOI: 10.1115/1.4070123

Michael Potter, Jonathan Heywood, Sam Coeyman, Will Richardson

{"title":"Heart Scar-In-A-Dish: Tissue Culture Platform to Study Myocardial Injury and Mechanics In Vitro.","authors":"Michael Potter, Jonathan Heywood, Sam Coeyman, Will Richardson","doi":"10.1115/1.4070123","DOIUrl":"https://doi.org/10.1115/1.4070123","url":null,"abstract":"Myocardial Infarction (MI) occurs when blood flow is blocked to a portion of the left ventricle and leads to necrosis and scar formation. Many therapies are under development to improve infarct healing, and 3-dimensional engineered heart tissues (EHTs) offer an in vitro drug screening option to help reduce, refine, and potentially replace animal testing. Unfortunately, existing EHTs over-simplify cardiac mechanics and neglect the spatial variations of the infarcted ventricle in vivo, wherein the passive infarct zone is cyclically stretched under tension as the remote zone cyclically contracts with every heartbeat. We present an in vitro 3-dimensional tissue culture platform focused on mimicking the heterogeneous mechanical environment of post-infarct myocardium. Herein, EHTs were subjected to a cryo-wound injury to induce localized cell death in a central portion of beating tissues composed of neonatal rat cardiomyocytes and fibroblasts. After injury, the remote zone continued to contract (i.e., negative strains) while the wounded zone was cyclically stretched (i.e., positive tensile strains) with intermediate strains in the border zone. We also observed increased tissue stiffnesses in the wounded zone and border zone following injury, while the remote zone did not show the same stiffening. Collectively, this work establishes a novel in vitro platform for characterizing myocardial mechanics after injury with both spatial and temporal resolution, contributing to a deeper understanding of MI and offering insights for potential therapeutic approaches.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-15"},"PeriodicalIF":1.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretching the Limits: From Planar-Biaxial Stress-Stretch to Arterial Pressure-Diameter. 拉伸极限：从平面-双轴应力-拉伸到动脉压力-直径。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-10-13 DOI: 10.1115/1.4070124

Thibault Vervenne, Nic Vermeeren, Nele Demeersseman, Heleen Fehervary, Mathias Peirlinck, Ellen Kuhl, Nele Famaey

{"title":"Stretching the Limits: From Planar-Biaxial Stress-Stretch to Arterial Pressure-Diameter.","authors":"Thibault Vervenne, Nic Vermeeren, Nele Demeersseman, Heleen Fehervary, Mathias Peirlinck, Ellen Kuhl, Nele Famaey","doi":"10.1115/1.4070124","DOIUrl":"https://doi.org/10.1115/1.4070124","url":null,"abstract":"Understanding the physiological condition of the vascular system is critical to explain, treat, and manage vascular disease. Numerous experimental and computational studies characterize the mechanical behavior of arterial tissue under controlled laboratory conditions. However, translating this knowledge into physiologically realistic conditions remains challenging. Key difficulties include selecting suitable and relevant test methods, minimizing uncertainty, and ensuring robust model validation. We present a novel integrative approach to translate laboratory experiments on arterial samples into clinically relevant pressure-diameter behavior. We perform controlled planar-biaxial tests on carotid arteries under three stretch ratios and generate axial and circumferential stress?stretch data to calibrate a fiber-reinforced soft tissue model. Using an analytical thick-walled cylindrical model, we predict subject-specific pressure-diameter behavior, informed by arterial prestretches from ring opening experiments. We systematically compare predictions against extension-inflation experiments on tubes from the same artery by applying controlled pairs of axial stretch and inner pressure, while recording outer diameter. We quantify prediction error in absolute and relative stretch regimes and evaluate the importance of the load-free reference dimensions. Results show how planar-biaxial tests probe different stretch regimes compared to extension-inflation deformations, leading to extrapolation of model predictions. We demonstrate how the constitutive material parameters can be fitted to different biomechanical loading conditions and assess the sensitivity of the simulations to axial stretch and circumferential prestretch. Only when key model parameters are accurately captured and their uncertainty propagated, planar-biaxial stress-stretch data can reliably predict arterial pressure?diameter behavior.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-33"},"PeriodicalIF":1.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro-Poro-Mechanical Modeling of The Lung Parenchyma: Theoretical Modeling and Parameters Identification. 肺实质的微孔力学建模：理论建模和参数识别。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-10-04 DOI: 10.1115/1.4070036

Mahdi Manoochertayebi, Martin Genet, Aline Bel-Brunon

{"title":"Micro-Poro-Mechanical Modeling of The Lung Parenchyma: Theoretical Modeling and Parameters Identification.","authors":"Mahdi Manoochertayebi, Martin Genet, Aline Bel-Brunon","doi":"10.1115/1.4070036","DOIUrl":"https://doi.org/10.1115/1.4070036","url":null,"abstract":"Micro-poro-mechanical approaches can be employed to simulate the behavior of porous media, such as lung parenchyma, with respect to their microscopic morphological and mechanical features. In this work, we propose a general micromechanical framework to describe the behavior of a porous hyperelastic material in large strains, including surface tension, and adapt its parameters to reproduce lung parenchyma behavior. We illustrate the method on a 2D periodic microstructure. The modeling framework is adaptable to any microstructure and any combination of stress, strain and pressure loadings.The identification of the model parameters in the context of lung parenchyma, based on existing experimental morphological and pressure-volume data, is performed sequentially. 12 parameters related to morphology, alveolar wall constitutive behavior and surface tension are calibrated to reproduce pressure-volume curves in various conditions, for a porosity in the unloaded state set to Φf0 =63%. The calibrated alveolar diameter is Dalv = 54 μm. The identifiability of the Neohookean and Ogden-Ciarlet-Geymonat hyperelastic potential parameters is studied; their values are β1 = 94.3 Pa, β2 = 16.9 Pa, β3 = 619 Pa and α = 3.154. The hysteretic response of lung to pressure is reproduced thanks to the formulation of a surface-dependent surface tension. This work paves the way for a better understanding of the relationship between microscopic features and the macroscopic response of lung, in healthy and pathological conditions. Further experimental investigations could help confirming the ranges of parameters obtained in this study.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-31"},"PeriodicalIF":1.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating muscle forces in patients with cerebral palsy during walking using static optimization and computed muscle control. 使用静态优化和计算肌肉控制估计脑瘫患者行走时的肌肉力量。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-10-04 DOI: 10.1115/1.4070037

Alina Nawab Kidwai, Kerim Atmaca, Ergin Tönük, Yunus Ziya Arslan

{"title":"Estimating muscle forces in patients with cerebral palsy during walking using static optimization and computed muscle control.","authors":"Alina Nawab Kidwai, Kerim Atmaca, Ergin Tönük, Yunus Ziya Arslan","doi":"10.1115/1.4070037","DOIUrl":"https://doi.org/10.1115/1.4070037","url":null,"abstract":"Cerebral palsy (CP) is a group of neurological disorders that presents significant challenges for clinical rehabilitation. While muscle forces could aid clinical decision-making, direct in-vivo measurement is infeasible and ethically questionable. Consequently, model-based methods such as static optimization (SO) and computed muscle control (CMC) have gained attention. Although SO and CMC have been compared for healthy individuals, it remains uncertain whether one approach yields more accurate predictions across varying severities of crouch gait in CP. We evaluated SO and CMC using OpenSim to estimate muscle forces and activations from an openly available dataset with delineations based on crouch severity. Predicted muscle activations were validated against experimental EMG data using Spearman's rank correlation coefficients (ρ) and root-mean-squared error (RMSE), while joint moment tracking was assessed using reserve moments. A sensitivity analysis was conducted to examine the influence of tendon slack length on force predictions. Results showed that while CMC predicted generally higher muscle forces than SO, both methods yielded variable ρ values (-0.7 to 0.9) and RMSEs (0.14 to 0.7) across muscle groups and crouch severities. ρSO was significantly higher than ?CMC for the medial hamstrings, and crouch severity significantly influenced the ρ difference between methods for the lateral hamstrings and rectus femoris. However, RMSEs did not consistently reflect these trends. CMC was more sensitive to tendon slack length variations. Overall, neither method currently provides sufficiently validated muscle force estimates for clinical application in CP, emphasizing the need for further methodological refinement.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-53"},"PeriodicalIF":1.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital twin-based investigation of seismocardiogram sensitivity to tissue mechanics and myocardial motion. 基于数字孪生的地震心动图对组织力学和心肌运动敏感性的研究。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-10-04 DOI: 10.1115/1.4070038

Mohammadali Monfared, Bahram Kakavand, Peshala Thibbotuwawa Gamage, Amirtahà Taebi

{"title":"Digital twin-based investigation of seismocardiogram sensitivity to tissue mechanics and myocardial motion.","authors":"Mohammadali Monfared, Bahram Kakavand, Peshala Thibbotuwawa Gamage, Amirtahà Taebi","doi":"10.1115/1.4070038","DOIUrl":"https://doi.org/10.1115/1.4070038","url":null,"abstract":"Cardiovascular diseases remain the leading cause of mortality worldwide, underscoring the need for improved diagnostic tools. Seismocardiography (SCG), a noninvasive technique that records chest surface vibrations generated by cardiac activity, holds promise for such applications. However, the mechanistic origins of SCG waveforms, particularly under varying physiological conditions, remain insufficiently understood. This study presents a finite element modeling approach to simulate SCG signals by tracking the propagation of cardiac wall motion to the chest surface. The computational model, constructed from 4D CT scans of healthy adult subjects, incorporates the lungs, ribcage, muscles, and adipose tissue. Cardiac displacement boundary conditions were extracted using the Lucas-Kanade algorithm, and elastic properties were assigned to different tissues. The simulated SCG signals in the dorsoventral direction were compared to realistic SCG recordings, showing consistency in waveform morphology. Key cardiac events, such as mitral valve closure, aortic valve opening, and closure, were identified on the modeled SCG waveforms and validated with concurrent CT images and left ventricular volume changes. A systematic sensitivity analysis was also conducted to examine how variations in tissue properties, soft tissue thickness, and boundary conditions influence SCG signal characteristics. The results highlight the critical role of personalized anatomical modeling in accurately capturing SCG features, thereby improving the potential of SCG for individualized cardiovascular monitoring and diagnosis.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-48"},"PeriodicalIF":1.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Model for Aseptic Loosening Prediction in Cementless Hip Stems: A Design of Experiments. 无水泥髋干无菌性松动预测的计算机模型：实验设计。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-30 DOI: 10.1115/1.4070009

Sofia Baroni, Sara Oliviero, Marco Viceconti, Cristina Curreli

引用次数: 0

Bone Adaptation to Mechanical Loading is Disrupted by Inhibition of Endothelin Receptor a in ex vivo Human Trabecular Bone. 体外人小梁骨内皮素受体a的抑制破坏骨对机械负荷的适应。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-26 DOI: 10.1115/1.4069958

Luisa A Meyer, Caitlyn Collins, McKinley Van Klei, Alejandra Correa-Belloso, Mahsa Zojaji, Heidi-Lynn Ploeg

{"title":"Bone Adaptation to Mechanical Loading is Disrupted by Inhibition of Endothelin Receptor a in ex vivo Human Trabecular Bone.","authors":"Luisa A Meyer, Caitlyn Collins, McKinley Van Klei, Alejandra Correa-Belloso, Mahsa Zojaji, Heidi-Lynn Ploeg","doi":"10.1115/1.4069958","DOIUrl":"https://doi.org/10.1115/1.4069958","url":null,"abstract":"Interactive effects among loading and biochemical signaling on the skeleton are incompletely understood. Endothelin-1 (ET1) is an essential potent autocrine/paracrine signaling molecule recognized for its role in bone mechanotransduction. Ex vivo experiments are a novel alternative method to investigate factors, like ET1, that otherwise would harm organism health. The hypothesis that antagonism of endothelin receptor A (EDNRA) would inhibit mechanotransduction pathways associated with mechanical load adaptation in human trabecular bone was tested in a four-week ex vivo study. Ex vivo trabecular bone cores (n=48, 5 mm x 10 mm) from hip heads donated by two hip arthroplasty patients were subjected to compressive loading in the presence or absence of EDNRA antagonist. Cores were allocated to four groups: control, blocked (10 μM/L BQ-123), loaded (-3000 μe), and loaded+blocked. Data were analyzed with Kruskal-Wallace tests with Dunn?s post hoc test, and Friedman analysis with repeated measures. Microstructural analyses were validated against physical measurements. Pan endothelin (ET) and prostaglandin E2 (PGE2) increased over time, for all groups. Pan ET was higher in blocked in comparison to loaded cores; whereas, PGE2 was higher in the loaded cores in comparison to controls. Percent change in apparent elastic modulus was highest in loaded (26%) and 56% lower in both blocked groups. EDNRA inhibition was found to interact with pathways that respond to mechanical load. This finding suggests that endothelin is required for transduction of mechanical cues into biochemical signals during the anabolic response of bone to mechanical load.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-39"},"PeriodicalIF":1.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalized Biomechanical Modeling of Pathologic Fracture: CTFEA Reveals Limitations of Traditional Fracture Risk Assessment in Benign Bone Tumors. 病理性骨折的个性化生物力学建模：CTFEA揭示了传统骨折风险评估在良性骨肿瘤中的局限性。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-23 DOI: 10.1115/1.4069925

Emily Cameron, Carla Winsor, Elise Laende, Jereme Outerleys, John F Rudan, Daniel Borschneck, Heidi-Lynn Ploeg

{"title":"Personalized Biomechanical Modeling of Pathologic Fracture: CTFEA Reveals Limitations of Traditional Fracture Risk Assessment in Benign Bone Tumors.","authors":"Emily Cameron, Carla Winsor, Elise Laende, Jereme Outerleys, John F Rudan, Daniel Borschneck, Heidi-Lynn Ploeg","doi":"10.1115/1.4069925","DOIUrl":"https://doi.org/10.1115/1.4069925","url":null,"abstract":"Benign bone tumors such as chondroblastoma, giant cell tumors, and aneurysmal bone cysts are rare but clinically significant lesions that frequently occur in the epiphyseal regions of long bones, particularly near load-bearing joints in children and young adults. These tumors compromise the structural integrity of bone, leading to an elevated risk of pathological fracture. Traditional methods for estimating fracture risk rely on simple geometric thresholds and volumetric ratios, but they fail to account for patient-specific differences in bone geometry, material heterogeneity, and physiological loading conditions. As a result, risk is often misclassified, which may lead to either overtreatment or missed prevention opportunities. To address this limitation, this study presents a novel alternative method (NAM); computational framework using patient-specific computed tomography (CT)-based finite element analysis (CTFEA) to evaluate fracture risk in four patients with benign knee tumors. Clinical CT imaging and motion capture-informed joint loading were used to develop anatomically accurate, mechanically calibrated models incorporating nonlinear bone behavior. CTFEA simulations focused on walking, jogging, and partial weight-bearing conditions captured localized stress and strain distributions and were benchmarked against clinical and volumetric assessment criteria. CTFEA outperformed traditional methods by revealing mechanical vulnerabilities, including in cases classified as low-risk clinically-through its ability to simulate individualized loading scenarios. These findings highlight the transformative potential of CTFEA as a non-invasive, patient-specific alternative to animal or oversimplified models, with direct implications for pre-operative planning and fracture risk stratification in orthopedic surgery.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-37"},"PeriodicalIF":1.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical Considerations for Patient-Specific Modeling Based on Observable State Variables. 基于可观察状态变量的患者特异性建模的理论考虑。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-23 DOI: 10.1115/1.4069924

Gerard A Ateshian, Sarah Deiters, Jeffrey A Weiss

{"title":"Theoretical Considerations for Patient-Specific Modeling Based on Observable State Variables.","authors":"Gerard A Ateshian, Sarah Deiters, Jeffrey A Weiss","doi":"10.1115/1.4069924","DOIUrl":"https://doi.org/10.1115/1.4069924","url":null,"abstract":"In this study, we address fundamental theoretical considerations that should guide biomedical engineers in the assessment of patient-specific risk of tissue failure, or the assesment of other material properties needed for patient-specific computational modeling, based on non-invasive imaging modalities. Upon reviewing theoretical concepts of mechanics, the primary conclusion is that patient-specific material properties, such as measures of tissue failure, cannot be observed directly, because material properties are dependent on non-observable functions of state. However, since functions of state may be formulated to depend on observable state variables, and since non-invasive imaging may be used to assess such variables, it behooves investigators to find strong correlations in vitro between the material property of interest and relevant observable state variables, such as measures of tissue morphology, transport characteristics, and composition. Once such univariate or multivariate correlations have been established experimentally in vitro, the next challenge is to relate imaging-based observable measures, acquired non-invasively (e.g., in vivo), to relevant material properties such as failure criteria. The uncertainty associated with these observation-derived material properties is, at best, equal to the uncertainty of the in vitro correlation.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-23"},"PeriodicalIF":1.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Ergomechanic markerless motion capture system for lower body kinematics during standing, squatting and walking. 对站立、下蹲和行走时下体运动学的人机力学无标记运动捕捉系统的评估。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-19 DOI: 10.1115/1.4069821

Simon Harrison, Raymond C Z Cohen, Scott Starkey, Jayan Greenwood, Ernest Cheong, Khoi Nguyen, Phu Trinh, Tomislav Bacek, Denny Oetomo

{"title":"Evaluation of the Ergomechanic markerless motion capture system for lower body kinematics during standing, squatting and walking.","authors":"Simon Harrison, Raymond C Z Cohen, Scott Starkey, Jayan Greenwood, Ernest Cheong, Khoi Nguyen, Phu Trinh, Tomislav Bacek, Denny Oetomo","doi":"10.1115/1.4069821","DOIUrl":"https://doi.org/10.1115/1.4069821","url":null,"abstract":"Markerless motion capture (MMC) shows promise for examining human movement across many domains because of its non-intrusive nature and negligible per-subject set up time. However published MMC systems typically require specific hardware. This validation study compared lower-body joint kinematics from Ergomechanic, a hardware-agnostic pose model-based MMC system, to an established marker-based motion capture (MBMC) system. Static trial data from eighteen people were used to register MMC keypoints within a widely used musculoskeletal model. The registered model was used to calculate joint kinematics for static pose, squatting, and walking trials. A novel perturbation analysis estimated the contributions to differences in MBMC and MMC approaches to measurement disparities. Very good (0.87 to 1.0) correlations between the systems were calculated for ankle, knee, and hip flexion-extension angles. Good (0.70-0.86) correlations were found for hip external-internal and abduction-adduction. Pelvis and lumbar spine angles had a wider range of correlation results (-0.06 to 0.95), likely due to the few MMC keypoints in these body regions. Relative contributions from the perturbation analysis were (i) 75% from variations in MMC data relative to MBMC; (ii) 8% because MMC keypoints (26) < MBMC markers (67); and (iii) 3% from differences in musculoskeletal model scaling. These results validate Ergomechanic for leg kinematics during standing, walking and squatting. Further, they suggest system improvements for pelvis and torso kinematics and provide new insights into the sources of known differences between MMC and MBMC measurements.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-40"},"PeriodicalIF":1.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0