Journal of Biomechanical Engineering-Transactions of the Asme最新文献

Variation in Layer-Specific Tear Properties of the Human Aorta Along Its Length and Circumference: Implications for Spatial Susceptibility to Dissection Initiation.

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-02-14 DOI: 10.1115/1.4067912

Dimitrios P Sokolis

{"title":"Variation in Layer-Specific Tear Properties of the Human Aorta Along Its Length and Circumference: Implications for Spatial Susceptibility to Dissection Initiation.","authors":"Dimitrios P Sokolis","doi":"10.1115/1.4067912","DOIUrl":"https://doi.org/10.1115/1.4067912","url":null,"abstract":"Hemodynamic variations influence the location of entry tears in aortic dissection. This study investigates whether variations in tear strength across the human aorta contribute to these clinical manifestations. Circumferential and axial strips were collected from nine axial and two circumferential sites along each autopsied aorta, yielding 1,188 samples (11 aortas × 18 sites × 2 directions × 3 layers per site). These samples underwent tear testing to assess tear strength and tear energy, constituting resistance to tear propagation. Adventitial tear parameters were significantly higher than those of the intima and media, with no significant differences between the latter two, supporting the observation that entry tears typically occur in the inner wall. Tear propagation angles were approximately 15 and 75 degrees for circumferential and axial medial strips, and 30 and 45 degrees for circumferential and axial strips of the intima and adventitia, with minimal variation along the aorta. These findings indicate that the media, and to a lesser extent the other layers, have higher resistance to axial tearing compared to circumferential tearing, aligning with the clinical observation of circumferentially directed tears. Intimal and adventitial tear parameters increased modestly along the aorta, while medial parameters varied less, explaining why entry tears rarely originate in the abdominal aorta. Tear parameters in inner and outer quadrants were similar at most axial locations, except for dissimilar tear propagation angles of the intima and adventitia in the proximal aorta (especially the arch), explaining why entry tears seldom involve the entire circumference.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-61"},"PeriodicalIF":1.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical Comparison of Human Walking Locomotion on Solid Ground and Sand.

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-02-10 DOI: 10.1115/1.4067842

Chunchu Zhu, Xunjie Chen, Jingang Yi

{"title":"Biomechanical Comparison of Human Walking Locomotion on Solid Ground and Sand.","authors":"Chunchu Zhu, Xunjie Chen, Jingang Yi","doi":"10.1115/1.4067842","DOIUrl":"https://doi.org/10.1115/1.4067842","url":null,"abstract":"Current studies on human locomotion focus mainly on solid ground walking conditions. In this paper, we present a biomechanic comparison of human walking locomotion on solid ground and sand. A novel dataset containing 3-dimensional motion and biomechanical data from 20 able-bodied adults for locomotion on solid ground and sand is collected. We present the data collection methods and report the sensor data along with the kinematic and kinetic profiles of joint biomechanics. The results reveal significant gait adaptations to the yielding terrain (i.e., sand), such as increased stance duration, reduced push-off force, and altered joint angles and moments. Specifically, the knee angle during the gait cycle on sand shows a delayed peak flexion and an increased overall magnitude, highlighting an adaptation to maintain stability on yielding terrain. These adjustments, including changes in joint timing and energy conservation mechanisms, provide insights into the motion control strategies humans adopt to navigate on yielding terrains. The dataset, containing synchronized ground reaction forces (GRFs) and kinematic data, offers a valuable resource for further exploration in foot-terrain interactions and human walking assistive devices development on yielding terrains.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Influence of Feature Selection Methods on a Random Forest Model for Gait Time Series Prediction using IMUs.

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-02-07 DOI: 10.1115/1.4067821

Shima/M Moghadam, Julie Choisne

{"title":"Exploring the Influence of Feature Selection Methods on a Random Forest Model for Gait Time Series Prediction using IMUs.","authors":"Shima/M Moghadam, Julie Choisne","doi":"10.1115/1.4067821","DOIUrl":"https://doi.org/10.1115/1.4067821","url":null,"abstract":"Despite the increasing use of IMUs and machine learning techniques for gait analysis, there remains a gap in which feature selection methods is best tailored for gait time series prediction. This study explores the impact of using various feature selection methods on the performance of a Random Forest (RF) model in predicting lower limb joints kinematics from two IMUs. This study primary objectives are: 1) Comparing eight feature selection methods based on their ability to identify more robust feature sets, time efficiency, and impact on RF models? performance, and 2) assessing the performance of RF models using generalized feature sets on a new dataset. Twenty-three typically developed children (ages 6 to 15) participated in data collection involving Optical Motion Capture, and IMUs. Joint kinematics were computed using OpenSim. By employing eight feature selection methods (four filter and four embedded methods), the study identified 30 important features for each target. These selected features were used to develop personalized and generalized RF models to predict lower limbs joints kinematics during gait. This study reveals that various feature selection methods have a minimal impact on the performance of personalized and generalized RF models. However, the RF and Mutual Information (MI) methods provided slightly lower errors and outliers. MI demonstrated remarkable robustness by consistently identifying the most common features across different participants. ElasticNet emerged as the fastest method. Overall, the study illuminated the robustness of RF models in predicting joint kinematics during gait in children, showcasing consistent performance across various feature selection methods.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-16"},"PeriodicalIF":1.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Force-Sensor-Less Approach for Rapid Young's Modulus Identification of Heterogeneous Soft Tissue.

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-01-28 DOI: 10.1115/1.4067735

Zhen Wang, Tian Xu, Mengruo Sheng, Yong Lei

{"title":"A Force-Sensor-Less Approach for Rapid Young's Modulus Identification of Heterogeneous Soft Tissue.","authors":"Zhen Wang, Tian Xu, Mengruo Sheng, Yong Lei","doi":"10.1115/1.4067735","DOIUrl":"https://doi.org/10.1115/1.4067735","url":null,"abstract":"Due to individual differences, accurate identification of tissue elastic parameters is essential for biomechanical modeling in surgical guidance for hepatic venous injections. This paper aims to acquire the absolute Young's modulus of heterogeneous soft tissues during endoscopic surgery with 2D ultrasound images. First, we introduced a force-sensor-less approach that utilizes a pre-calibrated soft patch with a known Young's modulus and its ultrasound images to calculate the external forces exerted by the probe on the tissue. Second, we introduced a Kriging-based inverse algorithm to identify the relative Young's modulus (RYM) between the inclusion and the background tissue. The RYM was estimated based on 2D plane strain approximation and mapped to the RYM of 3D soft tissue through a trained Kriging model. Finally, we developed a direct method to identify the background Young's modulus (BYM) based on calculated external forces and RYM. The simulation results demonstrate the high efficiency and robustness of the Kriging-based inverse algorithm in identifying RYM. Physical experiments on the three phantoms show that the errors of the identified BYM and RYM are all below 15%. The proposed methodology for Young's modulus identification is feasible and achieves satisfactory accuracy and computational efficiency in both simulations and physical experiments.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Combined Neurotoxicity of Amyloid Beta and Tau Oligomers in Alzheimer's Disease: A Novel Cellular-Level Criterion. 评估β淀粉样蛋白和Tau寡聚物在阿尔茨海默病中的联合神经毒性：一种新的细胞水平标准。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-01-22 DOI: 10.1115/1.4067701

Andrey Kuznetsov

{"title":"Evaluating the Combined Neurotoxicity of Amyloid Beta and Tau Oligomers in Alzheimer's Disease: A Novel Cellular-Level Criterion.","authors":"Andrey Kuznetsov","doi":"10.1115/1.4067701","DOIUrl":"https://doi.org/10.1115/1.4067701","url":null,"abstract":"A criterion characterizing the combined neurotoxicity of amyloid beta and tau oligomers is suggested. A mathematical model that makes it possible to calculate a value of this criterion during senile plaque and NFT formation is proposed. Computations show that for physiologically relevant parameter values, the value of the criterion increases approximately linearly as time increases. Once the formation of neurofibrillary tangles starts in addition to the senile plaque formation, the slope characterizing the rate at which the criterion increases becomes larger. The critical value of the criterion upon reaching which the neuron dies is estimated. Computations predict that unless the production rates of amyloid beta and tau monomers are very large, in order for the accumulated toxicity to reach the critical value, the degradation machinery responsible for the degradation of amyloid beta and tau must become dysfunctional. The value of the criterion after 20 years of the aggregation process is strongly influenced by deposition rates of amyloid beta and tau oligomers into senile plaques and NFTs. This suggests that deposition of amyloid beta and tau oligomers into senile plaques and NFTs may reduce accumulated toxicity by sequestering more toxic oligomeric species into less toxic insoluble aggregates.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-46"},"PeriodicalIF":1.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits of Using Functional Joint Coordinate Systems in In Vitro Knee Testing. 在体外膝关节测试中使用功能性关节坐标系统的好处。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-01-22 DOI: 10.1115/1.4067700

Tara Nagle, Jeremy G Loss, Robb Colbrunn

{"title":"Benefits of Using Functional Joint Coordinate Systems in In Vitro Knee Testing.","authors":"Tara Nagle, Jeremy G Loss, Robb Colbrunn","doi":"10.1115/1.4067700","DOIUrl":"https://doi.org/10.1115/1.4067700","url":null,"abstract":"To measure knee joint kinematics, coordinate systems (CS) must be assigned to the tibia and femur. Functional CS have been shown to be more reproducible than Anatomical. This study aims to quantify the benefits of using Functional CS in in vitro testing. Seven cadaveric knee joints were loaded in a 6-Degree of Freedom (DOF) joint simulator. Anatomical CS were established for each joint and Functional CS were calculated based on joint kinematics during passive motion. Loading profiles were applied to the knee joints using different CS definitions. Resulting kinematics and kinetics were obtained to quantify the 1) reduction in intra-knee kinematic response variation, 2) reduction in kinematic cross-talk, 3) reduction in inter-knee kinematic response variation, and 4) improvement in force control performance, when using Functional CS compared to Anatomical. Functional CS, compared to Anatomical, 1) significantly reduced intra-knee kinematic response variation across 12 combined loading conditions for nearly all DOF, 2) significantly reduced kinematic cross-talk during anterior-posterior, varus-valgus and internal-external rotation laxity testing across many DOF, 3) significantly reduced inter-knee kinematic response variation for all DOFs over a gait profile and combined loading conditions, and 4) significantly improved Anterior-Posterior and Varus-Valgus force/torque control performance during dynamic loading profiles. The advantage of using Functional CS for in vitro testing has been demonstrated across all considered domains. Functional CS should be used when performing in vitro knee joint testing.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-32"},"PeriodicalIF":1.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a Consistent Framework for Describing the Free Vibration Modes of the Brain. 迈向描述大脑自由振动模式的一致框架。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-01-22 DOI: 10.1115/1.4067699

Turner Jennings, Rouzbeh Amini, Sinan Muftu

引用次数: 0

Multiscale Finite Element Modeling of Human Ear for Acoustic Wave Transmission into Cochlea and Hair Cells Fatigue Failure. 人耳声波传入耳蜗及毛细胞疲劳失效的多尺度有限元模拟。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-01-10 DOI: 10.1115/1.4067577

Yijie Jiang, John Bradshaw, Roshan Sharma, Rong Z Gan

{"title":"Multiscale Finite Element Modeling of Human Ear for Acoustic Wave Transmission into Cochlea and Hair Cells Fatigue Failure.","authors":"Yijie Jiang, John Bradshaw, Roshan Sharma, Rong Z Gan","doi":"10.1115/1.4067577","DOIUrl":"https://doi.org/10.1115/1.4067577","url":null,"abstract":"Hearing loss is highly related to acoustic injuries and mechanical damage of ear tissues. The mechanical responses of ear tissues are difficult to measure experimentally, especially cochlear hair cells within the organ of Corti (OC) at microscale. Finite element (FE) modeling has become an important tool for simulating acoustic wave transmission and studying cochlear mechanics. This study harnessed multiscale FE models to investigate the mechanical behaviors of ear tissues in response to acoustic wave and developed a fatigue mechanical model to describe the outer hair cells (OHCs) failure. The three-dimensional multiscale FE models consisted a macroscale model of the ear canal, middle ear, and 3-chambered cochlea and a microscale OC model on a representative basilar membrane section, including the hair cells, membranes, and supporting cells. Harmonic Acoustic mode was used in the FE models for simulating various acoustic pressures and frequencies. The cochlear basilar membrane and the cochlear pressure induced by acoustic pressures were derived from the macroscale model and used as inputs for microscale OC model. The OC model identified the stress and strain concentrations in the reticular lamina at the root of stereocilia hair bundles and in the Deiter's cells at the connecting ends with OHCs, indicating the potential mechanical damage sites. OHCs were under cyclic loading and the alternating stress was quantified by the FE model. A fatigue mechanism for OHCs was established based on modeling results and experimental data. This mechanism would be used for predicting fatigue failure and the resulting hearing loss.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-24"},"PeriodicalIF":1.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical Analysis for Enhanced Expulsion-proof Intervertebral Fusion Device. 增强型防排出椎间融合器的生物力学分析。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-01-10 DOI: 10.1115/1.4067574

Shaolong Tang, Dan Pan, Siyuan Chen, Hengyuan Li, Zhaoming Ye

{"title":"Biomechanical Analysis for Enhanced Expulsion-proof Intervertebral Fusion Device.","authors":"Shaolong Tang, Dan Pan, Siyuan Chen, Hengyuan Li, Zhaoming Ye","doi":"10.1115/1.4067574","DOIUrl":"https://doi.org/10.1115/1.4067574","url":null,"abstract":"This study aims to compare the sinking and shifting of an enhanced escape-proof intervertebral fusion device with a traditional TLIF intervertebral fusion device.Five specimens each of the improved escape-resistant intervertebral cage and the traditional TLIF cage were selected. Four types of mechanical tests were conducted on each cage, Furthermore, a blade-cutting torque test was performed on the escape-resistant cage, with the recording of load-displacement curves and mechanical values.In static axial compression performance testing and static subsidence testing and dynamic subsidence testing, the improved escape-resistant cage were similar to those of the traditional TLIF ccage. In static escape performance testing, the maximum escape force when the blade rotated out for the improved escape-resistant cage (534.02±21.24N) was higher than the maximum escape force when the blade did not rotate out (476.97±24.45N) (P=6.81E-04). The maximum escape force when the blade rotated out for the improved escape-resistant cage (534.02±21.24N) was significantly higher than that of the traditional TLIF cage (444.01±12.42N) (P=9.82E-05). The improved escape-resistant cage product effectively enhances the device's escape prevention and anti-subsidence performance, it demonstrates biomechanical advantages.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-17"},"PeriodicalIF":1.7,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image-Based Estimation of Left Ventricular Myocardial Stiffness. 基于图像的左心室心肌僵硬度估计

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-01-01 DOI: 10.1115/1.4066525

Tarek Shazly, Logan Eads, Mia Kazel, Francesco K Yigamawano, Juliana Guest, Traci L Jones, Ahmed A Alshareef, Kurt G Barringhaus, Francis G Spinale

引用次数: 0