Journal of Biomechanical Engineering-Transactions of the Asme最新文献_第2页

Personalized Tibial Strain Prediction: Feasibility of a Novel Approach Using Markerless Motion Capture and Statistical Shape Models. 个性化胫骨应变预测：使用无标记运动捕捉和统计形状模型的新方法的可行性。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-17 DOI: 10.1115/1.4069774

Vivek Kote, Anup Pant, Ty Templin, Lance Frazer, Travis Eliason, Daniel/P Nicolella

{"title":"Personalized Tibial Strain Prediction: Feasibility of a Novel Approach Using Markerless Motion Capture and Statistical Shape Models.","authors":"Vivek Kote, Anup Pant, Ty Templin, Lance Frazer, Travis Eliason, Daniel/P Nicolella","doi":"10.1115/1.4069774","DOIUrl":"https://doi.org/10.1115/1.4069774","url":null,"abstract":"This study introduces a novel framework for generating personalized musculoskeletal models to predict tibial strains from video data. By integrating a statistical shape model (SSM) with markerless motion capture, this approach enables strain prediction without requiring medical scans or marker-based data collection, making it particularly useful in settings like Basic Combat Training. Additionally, we evaluate the impact of using single versus multiple principal components in estimating musculoskeletal injury risk indicators, such as tibial strains. Data from seven participants performing a one-legged hop were used to evaluate this framework. To determine the impact of using single versus multiple PCs on tibial strain predictions, the same loading profile was applied to the personalized models. Based on the observed effects, we selected the appropriate number of PCs and applied personalized loading profiles to the corresponding finite element (FE) models to predict tibial strains. Our findings indicate that using only the first PC to develop FE musculoskeletal models leads to differences in strain predictions compared to models incorporating multiple PCs, as the latter capture subtle morphological variations. The first PC primarily accounts for variability in overall size and relying solely on it may result in similar strain predictions for subjects of comparable stature. This study highlights the importance of incorporating higher-order PCs to better capture morphological differences, ultimately influencing strain distribution and injury risk assessment. The approach presented in this study offers a scalable, efficient solution for personalized biomechanical modeling, with applications in both individual and population-level injury risk analysis.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-21"},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulation of Pelvic Organ Prolapse Repair Surgery Using Computational Models of Biodegradable Implants Mimicking Uterosacral Ligaments. 利用模拟子宫骶韧带的可生物降解植入物的计算模型模拟盆腔器官脱垂修复手术。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-11 DOI: 10.1115/1.4069708

Ana Telma Silva, Nuno Miguel Ferreira, Francisca Vaz, Marco Parente, António A Fernandes, Maria Elisabete Silva

{"title":"Simulation of Pelvic Organ Prolapse Repair Surgery Using Computational Models of Biodegradable Implants Mimicking Uterosacral Ligaments.","authors":"Ana Telma Silva, Nuno Miguel Ferreira, Francisca Vaz, Marco Parente, António A Fernandes, Maria Elisabete Silva","doi":"10.1115/1.4069708","DOIUrl":"https://doi.org/10.1115/1.4069708","url":null,"abstract":"Pelvic Organ Prolapse (POP) is a common pelvic floor disorder resulting from weakened supportive muscles and ligaments. Although the demand for surgeries involving surgical meshes is expected to increase, current options remain limited. In 2019, the Food and Drug Administration (FDA) banned polypropylene mesh for transvaginal anterior compartment prolapse due to safety concerns. This study aimed to develop and evaluate computational models of biodegradable implants made of polycaprolactone, designed to replicate the mechanical behavior of the uterosacral ligaments (USLs) and mitigate complications associated with traditional synthetic meshes. The goal was to assess whether such implants could effectively restore pelvic support under varying degrees of USLs damage. Sacrocolpopexy was simulated using two distinct implant geometries: three square and one sinusoidal configuration. These were integrated into a pelvic cavity computational model to evaluate performance during the Valsalva maneuver under conditions of 50% and 90% damage, as well as total rupture of the USLs. The model, established without implants, demonstrated that complete USL rupture led to an approximate 41% increase in vaginal displacement when contrasted with the healthy model. All implants demonstrated a beneficial effect, decreasing vaginal displacement. Some of these implants successfully reversed the damage-induced displacement, nearing the level of a healthy vaginal model. While further clinical and in vivo validation is essential, these findings illustrate a promising direction and contribute to the growing evidence supporting the potential of biodegradable meshes in POP surgery. However, current outcomes are derived from computational models and serve primarily as a biomechanical proof of concept.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-20"},"PeriodicalIF":1.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Johnson-Cook model parameters for human cortical bone using inverse finite element method to practice and rehearse surgical operations. 用逆有限元法识别人类皮质骨的Johnson-Cook模型参数，以练习和排练外科手术。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-11 DOI: 10.1115/1.4069709

Syed Naveed Ul Meiraj, Pandithevan Ponnusamy, Roger Narayan

{"title":"Identification of Johnson-Cook model parameters for human cortical bone using inverse finite element method to practice and rehearse surgical operations.","authors":"Syed Naveed Ul Meiraj, Pandithevan Ponnusamy, Roger Narayan","doi":"10.1115/1.4069709","DOIUrl":"https://doi.org/10.1115/1.4069709","url":null,"abstract":"Constitutive models are used to predict material-specific relationships, such as stress and strain, through computer simulation. Although constitutive models, such as Johnson-Cook, Cowper-Symonds, modified Johnson-Cook, and Arrhenius were used to simulate the behavior of animal bones and surrogate materials, the outcomes predicted from such models cannot be directly applied to human bone, as they were developed from animal and bone surrogate materials. Therefore, this is the first study to identify the Johnson-Cook model parameters for human cortical bone using the inverse finite element method. As a procedure, the initial value with upper and lower bounds for each of the parameters involved in the Johnson-Cook model was assigned for the simulation, and then the parameter values that could best represent the human cortical bone were determined using the Levenberg-Marquardt optimization algorithm. To evaluate the results, tensile test simulations were carried out at various strain rates (0.00001/s ~ 1/s); the results obtained from the simulations were shown to agree well with the experiments. A case study to demonstrate the orthogonal bone cutting was also conducted, which justified the demand for the Johnson-Cook model parameters of the human cortical bone. The findings of this study could be used to simulate complex surgical operations, and thus, the surgical rehearsal and practice could be carried out in silico without conducting experiments on human or animal bones.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-41"},"PeriodicalIF":1.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Phantoms to Enhance Mechanical Knowledge about Aortic Aneurysms: A Systematic Review. 利用幻影增强主动脉瘤的力学知识：系统综述。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-11 DOI: 10.1115/1.4069710

Louise Koskas, Steeve Doizi, Emma Parmentier, Farid Bakir, Jean-Michel Davaine

{"title":"Use of Phantoms to Enhance Mechanical Knowledge about Aortic Aneurysms: A Systematic Review.","authors":"Louise Koskas, Steeve Doizi, Emma Parmentier, Farid Bakir, Jean-Michel Davaine","doi":"10.1115/1.4069710","DOIUrl":"https://doi.org/10.1115/1.4069710","url":null,"abstract":"Purpose - Aortic aneurysms represent a major public health issue, whose growth and rupture are driven by complex interactions between hemodynamics, wall mechanics, and biochemical factors. While the biological understanding of the arterial network has advanced, its mechanical behavior remains less explored. Experimental simulations, particularly those using arterial phantoms, are essential for approximating physiological conditions and improving biomechanical understanding, which may ultimately support a shift from statistical to individualized risk assessment. This systematic review aims to identify key parameters and evaluate advances in the phantom-based experimental research on aortic aneurysms. Methods - A systematic review was conducted in July 2025 following PRISMA guidelines, using the Medline database, without time or language restrictions. Studies were included if they focused on experimental research with aortic aneurysm phantoms. Computational studies, aortic dissections, and non-research applications were excluded. A narrative synthesis was applied due to outcome heterogeneity. Results - From 2 332 records, 68 studies were included: 21 investigated isolated arterial phantoms, and 47 used phantoms within circulatory loops. Conclusions - Arterial modeling is challenging due to the difficulty of reproducing both the wall mechanics and blood flow. Current models often emphasize certain features at the expense of overall bio-similarity. Future efforts should focus on integrating patient-specific geometries, realistic materials, and advanced circulatory systems to deepen the biomechanical understanding of aneurysms. This foundational work may ultimately inform more personalized strategies for monitoring and treatment.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-44"},"PeriodicalIF":1.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanics of manual-bent versus patient-specific mandibular implants. 人工弯曲与患者特异性下颌种植体的生物力学对比。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-06 DOI: 10.1115/1.4069665

Shengping Zhong, Yi Zhang, Qimin Shi, Jeroen Van Dessel, Joris Geusens, Sam Coppieters, Bart Van Meerbeek, Constantinus Politis, Shoufeng Yang, Yi Sun

引用次数: 0

An Image-Based Computational Framework to Evaluate the Material Stiffness of Arterial Tissue With High-Resolution Magnetic Resonance Imaging. 基于图像的计算框架评估动脉组织的材料特性与高分辨率磁共振成像。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-09-01 DOI: 10.1115/1.4069209

Y F Jack Wang, Jacopo Ferruzzi, Stewart Yeoh, Samer S Merchant, Steve A Maas, Jeffrey A Weiss, Edward W Hsu, Lucas H Timmins

{"title":"An Image-Based Computational Framework to Evaluate the Material Stiffness of Arterial Tissue With High-Resolution Magnetic Resonance Imaging.","authors":"Y F Jack Wang, Jacopo Ferruzzi, Stewart Yeoh, Samer S Merchant, Steve A Maas, Jeffrey A Weiss, Edward W Hsu, Lucas H Timmins","doi":"10.1115/1.4069209","DOIUrl":"10.1115/1.4069209","url":null,"abstract":"Atherosclerotic plaque rupture is the precipitating event in most acute coronary syndromes. As rupture results from the material failure of arterial tissue under mechanical loading, in vivo image-based techniques that can accurately characterize arterial material stiffness offer potential in risk-stratifying lesions. This study developed and validated a novel magnetic resonance (MR) image-based computational framework to evaluate the material stiffness of vascular tissue. Porcine carotid arteries (n = 4) were subjected to biaxial mechanical testing, followed by MR image acquisition under controlled loading. Best-fit material parameters for an anisotropic material model were estimated via regression analysis on the biaxial data. A deformable image registration technique, termed hyperelastic warping, was utilized to derive strain fields from the MR images and integrated with an inverse parameter estimation algorithm to identify the parameters for the same constitutive model. Experimentally and warping-estimated material stiffness values (tangent moduli) were not significantly different at physiologic lumen pressures of 80 (0.36 ± 0.15 and 0.48 ± 0.20 MPa; p = 0.14) and 120 mmHg (0.64 ± 0.27 and 0.73 ± 0.36 MPa; p = 0.60). The warping-directed inverse modeling framework identified subtle, but observable variations in material stiffness within a sample and accurately illustrated the physical influence of loading conditions on those properties. Collectively, these results demonstrated the robustness of an innovative approach to characterize nonlinear, hyperelastic behaviors of arterial tissue and quantify material stiffness directly from image data.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating imaging and invasive pressure data into a multi-scale whole-heart model. 将成像和有创压力数据整合到多尺度全心模型中。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-08-23 DOI: 10.1115/1.4069497

Marina Strocchi, Christoph M Augustin, Matthias A F Gsell, Christopher A Rinaldi, Edward J Vigmond, Gernot Plank, Chris J Oates, Richard D Wilkinson, Steven A Niederer

{"title":"Integrating imaging and invasive pressure data into a multi-scale whole-heart model.","authors":"Marina Strocchi, Christoph M Augustin, Matthias A F Gsell, Christopher A Rinaldi, Edward J Vigmond, Gernot Plank, Chris J Oates, Richard D Wilkinson, Steven A Niederer","doi":"10.1115/1.4069497","DOIUrl":"https://doi.org/10.1115/1.4069497","url":null,"abstract":"Cardiovascular diseases are the leading cause of death. Clinical data used to decide treatment are hard to integrate and interpret, making optimal treatment selection difficult. Personalised models can be used to integrate clinical data into a physics and physiology-constrained framework, but their clinical application faces limitations due to complex calibration and validation. In this study, we present a novel systematic calibration method for a whole-heart, multi-scale, electromechanics model using emulators, sensitivity analysis and history matching. Using cardiac motion derived from ECG-gated computed tomography (CT) and invasive left ventricular (LV) pressure data, we calibrated 25 model parameters to match the LV end-diastolic (ED) and peak pressure, ED and end-systolic (ES) volumes (EDV and ESV), right ventricle EDV, and the left atrium EDV, ESV and the maximum volume during venous return. After calibration, all features were fit within [0.8, 10.8]% of the mean target value, and fell within 1.4 experimental standard deviations from the target values. We validated the model by comparing CT-derived and simulated atrioventricular plane displacement (8.2 vs 8.1mm) and the ED and ES configurations against the CT images. The model replicated the measured acute haemodynamic response to biventricular pacing (simulated: 222mmHg/s vs clinical: 213+/-65mmHg/s). This study provides a systematic method to integrate clinical data into a whole-heart, multiscale electromechanics framework. The validation shows that the model replicates local heart motion and response to therapy, demonstrating potential in assisting clinical decision-making.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-52"},"PeriodicalIF":1.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable Tensiometry for Measuring Achilles and Patellar Tendon Loading While Walking on Various Terrains and Stairs. 可穿戴式张力测量仪，用于测量在各种地形和楼梯上行走时跟腱和髌骨肌腱的负荷。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-08-01 DOI: 10.1115/1.4068545

Alex J Reiter, Elizabeth A Schmida, Yiteng Ma, Peter G Adamczyk, Darryl G Thelen

{"title":"Wearable Tensiometry for Measuring Achilles and Patellar Tendon Loading While Walking on Various Terrains and Stairs.","authors":"Alex J Reiter, Elizabeth A Schmida, Yiteng Ma, Peter G Adamczyk, Darryl G Thelen","doi":"10.1115/1.4068545","DOIUrl":"10.1115/1.4068545","url":null,"abstract":"Assessing movement biomechanics is important for understanding healthy locomotion, injury or disease progression, and recovery. However, laboratory- or clinic-based studies fail to capture the ecological factors of real-world activity. Advancements in wearable sensors provide an opportunity to capture movement biomechanics in these settings. This study demonstrates the capacity of a wearable system to measure patellar and Achilles tendon kinetics via tensiometry as well as knee and ankle kinematics via inertial measurement units (IMUs) while walking across varied terrains, including level ground, sloped pavement, and stairs. The wearable system successfully captured time-varying tendon loading over the walking gait cycle. Both patellar and Achilles tendon loading showed distinct sensitivities to changes in slope and stairs. Importantly, these tendon loading patterns correspond well with prior measurements of knee extension and ankle plantarflexion moment profiles obtained via traditional motion analysis. This represents a significant advancement over studies that relied on traditional complex, immobile equipment to obtain comparable results. The portability of the wearable system may allow for objective assessments of human performance, injury risk, functional adaptation due to injury, and treatment response in real-world environments.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Modeling of Human Skin Deformation and Growth During Tissue Expansion in Postmastectomy Breast Reconstruction. 乳房切除术后乳房重建中组织扩张过程中人体皮肤变形和生长的预测模型。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-07-01 DOI: 10.1115/1.4068370

Joel Laudo, Tianhong Han, Joanna Ledwon, Ariel E Figueroa, Arun K Gosain, Taeksang Lee, Adrian Buganza Tepole

{"title":"Predictive Modeling of Human Skin Deformation and Growth During Tissue Expansion in Postmastectomy Breast Reconstruction.","authors":"Joel Laudo, Tianhong Han, Joanna Ledwon, Ariel E Figueroa, Arun K Gosain, Taeksang Lee, Adrian Buganza Tepole","doi":"10.1115/1.4068370","DOIUrl":"10.1115/1.4068370","url":null,"abstract":"Breast reconstruction using tissue expanders is the primary treatment option following mastectomy. Although skin growth in response to chronic supra-physiological stretch is well-established, individual patient factors such as breast shape, volume, skin prestrain, and mechanical properties, create unique deformation and growth patterns. The inability to predict skin growth and deformation prior to treatment often leads to complications and suboptimal esthetic outcomes. Personalized predictive simulations offer a promising solution to these challenges. We present a pipeline for predictive computational models of skin growth in tissue expansion. At the start of treatment, we collect three-dimensional (3D) photos and create an initial finite element model. Our framework accounts for uncertainties in treatment protocols, mechanical properties, and biological parameters. These uncertainties are informed by surgeon input, existing literature on mechanical properties, and prior research on porcine models for biological parameters. By collecting 3D photos longitudinally during treatment, and integrating the data through a Bayesian framework, we can systematically reduce uncertainty in the predictions. Calibrated personalized models are sampled using Monte Carlo methods, which require thousands of model evaluations. To overcome the computational limitations of directly evaluating the finite element model, we use Gaussian process surrogate models. We anticipate that this pipeline can be used to guide patient treatment in the near future.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Rigidity Control for Supportive Sheaths in Endovascular Procedures. 血管内手术中支持鞘的动态刚度控制。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-07-01 DOI: 10.1115/1.4068225

Michael Y Qiu, Vinay Chandrasekaran, Chase M Hartquist, Halle R Lowe, Charles B Suskin, Sheridan Lee, Juan Becerra-Garcia, Jin Vivian Lee, DeVaughn B Rucker, Michelle R Connor, Sophia R Pyeatte, Mohamed S Zaghloul, Santiago Elizondo Benedetto, Eric C Leuthardt, Mohamed A Zayed, Joshua W Osbun, Guy M Genin

{"title":"Dynamic Rigidity Control for Supportive Sheaths in Endovascular Procedures.","authors":"Michael Y Qiu, Vinay Chandrasekaran, Chase M Hartquist, Halle R Lowe, Charles B Suskin, Sheridan Lee, Juan Becerra-Garcia, Jin Vivian Lee, DeVaughn B Rucker, Michelle R Connor, Sophia R Pyeatte, Mohamed S Zaghloul, Santiago Elizondo Benedetto, Eric C Leuthardt, Mohamed A Zayed, Joshua W Osbun, Guy M Genin","doi":"10.1115/1.4068225","DOIUrl":"10.1115/1.4068225","url":null,"abstract":"Endovascular procedures require sheaths with contradictory mechanical properties: flexibility for navigation through tortuous vessels, yet rigidity for device delivery. Current approaches rely on multiple device exchanges, increasing procedural time, and complication risks. Here we present a novel endovascular sheath design scheme with dynamically controllable flexural rigidity along its entire length. The device incorporates axially aligned metal string arrays between inner and outer lumens, enabling transition between flexible and rigid states through suction actuation. Three-point bend testing demonstrated that actuation increases flexural rigidity from the range associated with diagnostic catheters to that associated with support sheaths. In simulated contralateral access procedures, the device reduced access time to 1/3 of the time required when using conventional approaches. in vivo porcine studies validated the sheath's ability to navigate tortuous anatomy in its flexible state and successfully support advancement of increasingly rigid therapeutic devices when actuated. Technology enables single-sheath delivery of treatment, potentially reducing procedural complexity, decreasing complication rates, and improving patient outcomes across various endovascular interventions. This design represents a promising approach to combining catheter and sheath design that benefits both peripheral and neurovascular procedures.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0