Journal of Biomechanical Engineering-Transactions of the Asme最新文献_第2页

Four-Dimensional Visualization of Topological Fixed Points in Pulsatile Cardiovascular Flows. 脉动性心血管血流拓扑不动点的4D可视化。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068078

Thangam Natarajan, Zainab Husain, Peter W Coppin, David A Steinman

{"title":"Four-Dimensional Visualization of Topological Fixed Points in Pulsatile Cardiovascular Flows.","authors":"Thangam Natarajan, Zainab Husain, Peter W Coppin, David A Steinman","doi":"10.1115/1.4068078","DOIUrl":"10.1115/1.4068078","url":null,"abstract":"Topological features of time-dependent, three-dimensional (3D) vector flow fields, such as wall shear stress (WSS) fixed points, are considered surrogates of pathological blood flow dynamics in cardiovascular diseases. Fixed-point visualizations are typically constrained to two-dimensional (2D) spaces, yet they aim to display complex spatiotemporal (four-dimensional (4D)) dynamics. There is a need for visualization strategies to reduce occlusion and reliance on animations to allow the detection of holistic flow patterns. Using intracranial aneurysms as a use case, we present the fixed-point carousel, a novel approach to visually depicting the \"4D\" nature of WSS fixed points via (1) topographic mapping of the 3D aneurysm sac to overcome occlusion while preserving fixed-point distances and sac morphological features; and (2) arranging these into a carousel model to present with temporal dimension holistically. Examples are presented for image-based computational fluid dynamic (CFD) models of intracranial aneurysms, illuminating the intricate and distinct fixed-point trajectories and interactions, a necessary step toward understanding the volumetric flow manifolds that drive them for this and other cardiovascular-and potentially nonbiomedical-fluid dynamics applications.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemodynamic Evaluation of Norwood Aortic Arch Geometry Compared to Native Arch Controls. 诺伍德主动脉弓几何形状与原生弓对照的血流动力学评价。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068009

Aloma Blanch-Granada, John F LaDisa, Margaret M Samyn, Joseph R Cava, Stephanie S Handler, Jennifer F Gerardin, Benjamin Goot, Mehdi Maadooliat, Viktor Hraška

{"title":"Hemodynamic Evaluation of Norwood Aortic Arch Geometry Compared to Native Arch Controls.","authors":"Aloma Blanch-Granada, John F LaDisa, Margaret M Samyn, Joseph R Cava, Stephanie S Handler, Jennifer F Gerardin, Benjamin Goot, Mehdi Maadooliat, Viktor Hraška","doi":"10.1115/1.4068009","DOIUrl":"10.1115/1.4068009","url":null,"abstract":"The Norwood procedure creates a reconstructed neo-aorta to provide unobstructed systemic cardiac output for hypoplastic left heart syndrome patients. We used patient-specific computational fluid dynamics (CFD) simulations incorporating physiologic boundary conditions to quantify hemodynamics for reconstructed aortic arch geometries versus native aortic arches from a control group of single ventricle patients. We hypothesized that reconstructed arches from Norwood patients (n = 5) would experience significant differences in time-averaged wall shear stress normalized to body surface area (TAWSSnBSA), oscillatory shear index (OSI), energy efficiency (Eeff), and energy loss (EL) versus controls (n = 3). CFD simulations were conducted using 3 T cardiac magnetic resonance imaging, blood flow, and pressure data. Simulations incorporated downstream vascular resistance and compliance to replicate patient physiology. TAWSSnBSA and OSI were quantified axially and circumferentially. Global differences in Eeff and EL were compared. Significance was assessed by Mann-Whitney U test. Norwood patients had higher TAWSSnBSA distal to the transverse arch at locations of residual narrowing presenting following coarctation correction, as well as higher OSI within ascending aorta and transverse arch regions (p < 0.05). EL correlated with patient features including cardiac output (r = 0.9) and BT-shunt resistance (r = -0.63) but did not correlate with arch measurements or morphology. These results indicate reconstructed arches from Norwood patients are exposed to altered wall shear stress and energy indices linked to cellular proliferation and inefficiency in prior studies. These results may help clinicians further understand what constitutes an optimally reconstructed arch after confirmation in larger studies.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical Shape Modeling and Prediction of Lumbar Spine Morphology in Patients With Adolescent Idiopathic Scoliosis. 青少年特发性脊柱侧凸患者腰椎形态的统计形状建模和预测。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068010

Tianyi Zhang, Xuelian Gu, Hai Li, Chenchen Wu, Niuniu Zhao, Xin Peng

{"title":"Statistical Shape Modeling and Prediction of Lumbar Spine Morphology in Patients With Adolescent Idiopathic Scoliosis.","authors":"Tianyi Zhang, Xuelian Gu, Hai Li, Chenchen Wu, Niuniu Zhao, Xin Peng","doi":"10.1115/1.4068010","DOIUrl":"10.1115/1.4068010","url":null,"abstract":"A lumbar spine statistical shape model (SSM) was developed to explain morphological differences in a population with adolescent idiopathic scoliosis (AIS). Computed tomography (CT) was used to collect data on the lumbar spine vertebrae and curvature of 49 subjects. The CT data were processed by segmentation, landmark identification, and template mesh mapping, and then SSMs of the individual vertebrae and entire lumbar spine were established using generalized Procrustes analysis and principal component analysis (PCA). Scaling was the most prevalent variation pattern. The weight coefficient was optimized using the Levenberg-Marquardt (LM) algorithm, and multiple regression analysis was used to establish a prediction model for age, sex, height, and body mass index (BMI). The effectiveness of the SSM and prediction model was quantified based on the root-mean-square error (RMSE). An automatic measurement method was developed to measure the anatomical parameters of the geometric model. The lumbar vertebrae size was significantly affected by height, sex, BMI, and age, with men having lower vertebral height than women. The trends in anatomical parameters were consistent with previous studies. The vertebral SSMs characterized the shape changes in the processes, while the lumbar spine SSM described alignment changes associated with translatory shifts, kyphosis, and scoliosis. Quantifying anatomical variation with SSMs can inform implant design and assist clinicians in diagnosing pathology and screening patients. Lumbar spine SSMs can also support biomechanical simulations of populations with AIS.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standard of Care Cervical Spine Flexion/Extension Radiograph Measurements Do Not Predict Multiplanar Intervertebral Motion. 颈椎屈伸x线片测量不能预测多平面椎间运动。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068076

Christopher J Como, Clarissa M LeVasseur, Anthony A Oyekan, Samuel Pitcairn, Aditya Padmanabhan, Noah Makowicz, Stephen R Chen, Jeremy D Shaw, William F Donaldson, Joon Y Lee, William J Anderst

{"title":"Standard of Care Cervical Spine Flexion/Extension Radiograph Measurements Do Not Predict Multiplanar Intervertebral Motion.","authors":"Christopher J Como, Clarissa M LeVasseur, Anthony A Oyekan, Samuel Pitcairn, Aditya Padmanabhan, Noah Makowicz, Stephen R Chen, Jeremy D Shaw, William F Donaldson, Joon Y Lee, William J Anderst","doi":"10.1115/1.4068076","DOIUrl":"10.1115/1.4068076","url":null,"abstract":"Evaluation of patients with neck pain often relies on end-range flexion and extension radiographs that do not capture mid-range or multiplanar motion. The purpose of this study was to determine if end-range flexion/extension range of motion (ROM) predicts axial rotation ROM or mid-range ROM during either flexion/extension or axial rotation in patients with neck pain or in asymptomatic controls. It was hypothesized that end-range flexion/extension ROM would predict mid-range flexion/extension ROM, but not mid-range or end-range axial rotation ROM. Dynamic flexion/extension and axial rotation were performed by 75 patients prior to surgery and 71 asymptomatic controls, while synchronized biplane radiographs were collected at 30 images per second. Intervertebral motion from C2 to C7 was tracked using a validated volumetric model-based tracking process that matched subject-specific computed tomography (CT)-based bone models to the radiographs. The main findings were that intervertebral end-range flexion/extension ROM is a strong to very strong predictor of mid-range flexion/extension at all subaxial motion segments of the cervical spine (all r = 0.61 to 0.91), but, in general, a weak to moderate predictor of axial rotation mid-range (all ρ = 0.002 to 0.50) and end-range (all r = 0.2 to 0.68) ROM. This study suggests that the current standard of care end-range flexion/extension ROM is not sufficient to characterize the multiplanar motion that occurs in the cervical spine during activities of daily living.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Location-Dependent Biomechanical Characterization of the Human Achilles Tendon in Diabetic and Nondiabetic Patients. 糖尿病和非糖尿病患者跟腱的位置依赖性生物力学特征。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068015

Mahmut Pekedis, Firat Ozan, Muhammed Melez

{"title":"Location-Dependent Biomechanical Characterization of the Human Achilles Tendon in Diabetic and Nondiabetic Patients.","authors":"Mahmut Pekedis, Firat Ozan, Muhammed Melez","doi":"10.1115/1.4068015","DOIUrl":"10.1115/1.4068015","url":null,"abstract":"Although diabetes is associated with alterations in the structural and functional properties of soft tissue, the response of the human Achilles tendon to location-dependent variations in both quasi-static and dynamic loading is unclear. This study aimed to characterize the elastic, viscoelastic, hysteresis, and failure properties of the distal, midsubstance, and proximal Achilles tendons in diabetic and nondiabetic patients and to investigate the relationship between biomechanical and clinical observations. Tendons were obtained from patients who underwent above- or below-knee amputation. Dumbbell-shaped specimens were harvested from the three sites. Relaxation tests were performed to determine viscoelastic characteristics. Cyclic loading tests at various frequencies were deployed to determine the dynamic modulus and phase angles. Incremental cyclic loading tests were carried out to investigate the backbone curve and energy dissipation due to hysteresis. Additionally, monotonic loading tests were performed to determine the elastic and failure properties. The results show that biomechanical parameters are not significantly different among the three sites. However, the midsubstance site exhibits significantly higher energy dissipation compared to other sites. Additionally, an increase in cyclic frequency enhances the phase angle, indicating that higher energy dissipation may protect the tendon from high loading rates. Furthermore, an increase in body mass index (BMI) and hemoglobin A1c (HbA1c) is significantly and negatively correlated with stiffness and viscoelasticity, suggesting that improving metabolic health may prevent tendon impairment. These findings may assist in creating more effective therapeutic strategies for tendon repair.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Evaluation of the Primary Stability of Acetabular Revision Cups: Standard Versus Locking Screws. 髋臼翻修杯初步稳定性的计算机评价：标准与锁定螺钉。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068226

Federico Andrea Bologna, Nicholas Elena, Davide Bentivoglio, Alessandro Aprato, Mara Terzini, Cristina Bignardi, Stefano Giaretta, Alberto Momoli

{"title":"In Silico Evaluation of the Primary Stability of Acetabular Revision Cups: Standard Versus Locking Screws.","authors":"Federico Andrea Bologna, Nicholas Elena, Davide Bentivoglio, Alessandro Aprato, Mara Terzini, Cristina Bignardi, Stefano Giaretta, Alberto Momoli","doi":"10.1115/1.4068226","DOIUrl":"10.1115/1.4068226","url":null,"abstract":"Given the increasing complexity of revision total hip arthroplasty, ensuring optimal stability of acetabular revision cups (ARCs) is crucial, especially in cases of bone stock loss. In this study, the primary stability of ARCs was investigated by modeling various configurations of screw placements, including all standard, all locking, and mixed setups, under different load scenarios. Finite element (FE) models were implemented to evaluate the stress distribution and micromotions at the bone-prosthesis interface, simulating three primary load cases: \"walking,\" \"stairs-down,\" and \"stand-up.\" The results indicated that the stairs-down load case generated the highest von Mises stresses and sliding distances, marking it as the most critical load scenario. Configurations using all standard screws showed higher peak stresses and reduced stable areas, compared to those utilizing locking screws. While the locking screws provided a stiffer connection, the mixed screw configuration offered a balanced performance by combining the compression benefits of standard screws with the rigid fixation of locking screws. Configurations with a single standard screw complemented by locking screws showed enhanced stability, suggesting this combination could be advantageous in clinical applications. This study underscores the importance of screw type and placement in ensuring the primary stability of ARCs. Locking screws are recommended for use when feasible. For ARCs allowing both screw types, a mixed configuration starting with a standard compression screw followed by locking screws appears optimal. Future research should further explore various combinations of screw geometries and lengths to refine these findings and enhance surgical outcomes in acetabular revisions.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical Strain Responses in the Sclera, Choroid, and Retina in Glaucoma Patients After Intraocular Pressure Lowering. 眼压降低后青光眼患者巩膜、脉络膜和视网膜的生物力学应变反应。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068155

Zhuochen Yuan, Cameron A Czerpak, Michael Saheb Kashaf, Harry A Quigley, Thao D Nguyen

{"title":"Biomechanical Strain Responses in the Sclera, Choroid, and Retina in Glaucoma Patients After Intraocular Pressure Lowering.","authors":"Zhuochen Yuan, Cameron A Czerpak, Michael Saheb Kashaf, Harry A Quigley, Thao D Nguyen","doi":"10.1115/1.4068155","DOIUrl":"10.1115/1.4068155","url":null,"abstract":"This study measured the strain response to intraocular pressure (IOP) change in the sclera, choroid, and retina of glaucoma patients whose optic nerve head region was imaged by optical coherence tomography (OCT) before and after IOP-lowering by laser suturelysis following trabeculectomy surgery. The strain response was calculated from digital volume correlation of the prior and after images. The strain response of the sclera, choroid, and retina were compared to those previously published for the anterior lamina cribrosa (ALC). Mean strains were lowest in the retina and highest in the prelaminar neural tissue (PLNT). Maximum principal and maximum shear strains were significantly increased with greater IOP decrease in all five eye regions. Maximum principal and maximum shear strains in the anterior lamina cribrosa and the sclera were significantly related (p = 0.0094). Strain in the radial direction was negative in the ALC and PLNT, but positive in the sclera (p = 0.017). In conclusion, the strain response of the sclera, choroid, and retina is related to the magnitude of IOP change and is smaller than those of the ALC. The strain response of the ALC and sclera are significantly related to each other.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oversized Total Talar Prosthesis Enhances the Ankle Stability After Total Talus Replacement by Finite Element Analysis. 有限元分析表明，超大尺寸全距骨假体增强了全距骨置换术后踝关节的稳定性。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068008

Hao Li, Haitao Xie, Shujing Kang, Kuixue Xu, Meiming Xie, Haiqiong Xie, Xu Cai, Kai Wei

{"title":"Oversized Total Talar Prosthesis Enhances the Ankle Stability After Total Talus Replacement by Finite Element Analysis.","authors":"Hao Li, Haitao Xie, Shujing Kang, Kuixue Xu, Meiming Xie, Haiqiong Xie, Xu Cai, Kai Wei","doi":"10.1115/1.4068008","DOIUrl":"10.1115/1.4068008","url":null,"abstract":"Total talar replacement (TTR) with an additively manufactured personalized total talar prosthesis (TTP) is an emerging treatment for ankle disorders. However, how to enhance the ankle stability after TTR, which usually raises the ankle instability, has not been explored. This study constructed a set of specific numerical models to investigate the effects of TTR and oversized TTPs on the ankle stability, including inversion, eversion, and anterior stability. The oversized TTPs include TTP-FP1.5 and TTP-FP3 scaled the identical TTP0 by 1.5% and 3.0% along the frontal axis, and TTP-VP1.5 and TTP-VP3 scaled TTP0 by 1.5% and 3.0% along the vertical axis. The numerical results identify that under varus/valgus force, the TTP-FP1.5 and TTP-FP3 produce smaller talar tilt angles compared with that of TTP0, as the inversion and eversion stability are significantly enhanced. Furthermore, TTP-VP1.5 and TTP-VP3 can provide larger contact force to the tibia, providing better anterior stability under anterior drawer force. Additionally, the increased contact force of TTP-VP1.5 and TTP-VP3 with the tibial cartilage enhances the eversion stability. Besides, the increase of TTP size along the vertical axis will weaken the inversion stability under low loads, as this scaling might have compromised the stability of the subtalar joint. The present numerical study systematically investigates the effect of different ways of increasing TTP size on ankle stability after TTP.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bending Flexibility of Negative Poisson's Ratio Structural Vascular Stent. 负泊松比结构血管支架的弯曲柔韧性。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068156

Mohan Yang, Yao Du, Dongmei Zhu, Xiaozheng Wu, Guoyong Liu

{"title":"Bending Flexibility of Negative Poisson's Ratio Structural Vascular Stent.","authors":"Mohan Yang, Yao Du, Dongmei Zhu, Xiaozheng Wu, Guoyong Liu","doi":"10.1115/1.4068156","DOIUrl":"10.1115/1.4068156","url":null,"abstract":"A negative Poisson's ratio structural vascular stent with arrow-shaped cell is proposed in the paper. In order to improve the bending flexibility of the stent, three shapes of connecting bars, namely, U-shaped, S-shaped, and linear, are designed. The influence of structural parameters of the stent connecting bars on the bending performance of the stent is studied using the finite element method and experimental method. The research results show that compared to S-shaped stents, U-shaped stents have better bending flexibility. In addition, the influence of the parameters of the connection bars of a U-shaped stent on its flexibility is also explored. The longer the length of the U-shaped connection bars, the lower the corresponding bending stiffness and better bending flexibility. The larger the width of the U-shaped connecting bar, the greater the bending stiffness of the stent, and the worse its bending flexibility. And some experiments are conducted using the four points bending method. The deformation of the S-shaped stent and U-shaped stent under bending is very similar, and the bending stiffness of the U-shaped stent is lower than that of the S-shaped bracket, which also verified the correctness of the finite element calculation.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Milk Flow Behavior in Human Lactating Breast: An Integrated Machine Learning and Computational Fluid Dynamics Approach. 预测人类哺乳乳房的乳汁流动行为：一种集成的机器学习和计算流体动力学方法。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2025-05-01 DOI: 10.1115/1.4068077

Abdullahi O Olapojoye, Shadi Zaheri, Aria Nostratinia, Fatemeh Hassanipour

{"title":"Predicting Milk Flow Behavior in Human Lactating Breast: An Integrated Machine Learning and Computational Fluid Dynamics Approach.","authors":"Abdullahi O Olapojoye, Shadi Zaheri, Aria Nostratinia, Fatemeh Hassanipour","doi":"10.1115/1.4068077","DOIUrl":"10.1115/1.4068077","url":null,"abstract":"This study develops a comprehensive framework that integrates computational fluid dynamics (CFD) and machine learning (ML) to predict milk flow behavior in lactating breasts. Utilizing CFD and other high-fidelity simulation techniques to tackle fluid flow challenges often entails significant computational resources and time investment. Artificial neural networks (ANNs) offer a promising avenue for grasping complex relationships among high-dimensional variables. This study leverages this potential to introduce an innovative data-driven approach to CFD. The initial step involved using CFD simulations to generate the necessary training and validation datasets. A machine learning pipeline was then crafted to train the ANN. Furthermore, various ANN architectures were explored, and their predictive performance was compared. The design of experiments method was also harnessed to identify the minimum number of simulations needed for precise predictions. This study underscores the synergy between CFD and ML methodologies, designated as ML-CFD. This novel integration enables a neural network to generate CFD-like results, resulting in significant savings in time and computational resources typically required for traditional CFD simulations. The models developed through this ML-CFD approach demonstrate remarkable efficiency and robustness, enabling faster exploration of milk flow behavior in individual lactating breasts compared to conventional CFD solvers.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0