Journal of Biomechanical Engineering-Transactions of the Asme最新文献_第10页

Special Issue: Education in Biomechanics and Bioengineering Ever Evolving, Ever Learning. 社论：生物力学和生物工程教育--不断发展，不断学习。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-05-01 DOI: 10.1115/1.4064987

Debanjan Mukherjee, Victor Lai

引用次数: 0

Numerical Analysis of Non-Fourier Model-Based Bio-Heat Transfer in the Laser-irradiated Axisymmetric Living Tissue. 基于非傅里叶模型的激光照射轴对称活组织生物传热数值分析

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-26 DOI: 10.1115/1.4065400

Pankaj Kishore, Sumit Kumar

{"title":"Numerical Analysis of Non-Fourier Model-Based Bio-Heat Transfer in the Laser-irradiated Axisymmetric Living Tissue.","authors":"Pankaj Kishore, Sumit Kumar","doi":"10.1115/1.4065400","DOIUrl":"https://doi.org/10.1115/1.4065400","url":null,"abstract":"The current work is related to the numerical investigation of non-Fourier heat transfer inside the short-pulsed laser-irradiated axisymmetric soft tissue phantom. It utilizes the modified discrete ordinate method to solve the transient radiative transfer equation (TRTE) for determining the intensity field. The laser energy absorbed by the soft tissue phantom behaves like a source in the Fourier/non-Fourier heat conduction model based-bio-heat transfer equation (BHTE), which is solved by employing the finite volume method (FVM) to determine the temperature distribution. Despite the prevalent use of non-Fourier BHTE for this purpose, a second law analysis is considered crucial to detect any potential anomalies. Equilibrium entropy production rates (EPR) are initially computed based on classical irreversible thermodynamics (CIT), which may yield negative values, possibly contravening the second law. Consequently, the EPR based on CIT is adjusted using the extended irreversible thermodynamics (EIT) hypothesis to ensure positivity. After that, the current research findings are compared with the results from the literature, and found good agreement between them. Then, the independent study is performed to select the optimum grid size, control angle size, and time step. A comparative analysis of results between the traditional Fourier and non-Fourier models has been performed. The impact of different parameters on the temperature fields and EPRs, is discussed. The effect of the optical properties of the inhomogeneity on the temperature distribution has been investigated. This study may help to enhance the effectiveness of the laser-based photo-thermal therapy.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":"1-33"},"PeriodicalIF":1.7,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Biomechanical Response Curves for the Calibration of Biofidelic Measuring Devices Used in Robot Collision Testing. 开发生物力学响应曲线，用于校准机器人碰撞测试中使用的生物保真度测量设备。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064448

Roland Behrens, Jan Zimmermann, Zechang Wang, Sebastian Herbster, Norbert Elkmann

{"title":"Development of Biomechanical Response Curves for the Calibration of Biofidelic Measuring Devices Used in Robot Collision Testing.","authors":"Roland Behrens, Jan Zimmermann, Zechang Wang, Sebastian Herbster, Norbert Elkmann","doi":"10.1115/1.4064448","DOIUrl":"10.1115/1.4064448","url":null,"abstract":"Collaborative robots (cobots) can be employed in close proximity to human workers without safety fences. The operation mode Power and Force Limiting requires that cobots not exceed the biomechanical limits of ISO/TS 15066 to ensure protection against injuries caused by collisions with them. Collision tests must be performed to prove that cobots cannot exceed the biomechanical limits. Such tests are performed with a biofidelic measuring device that measures contact forces and replicates the biomechanics of the human body. Biomechanical response curves serve as a reference for the calibration of such devices. In order to be able to compare measurements and limits correctly and reliably, the limits and response curves for calibration must be obtained from the same data with the same methodology. In this article, we present a new technique for developing biomechanical response curves, which employs a statistical model we used to calculate biomechanical limits for cobots in a previous study. This technique's development process entails normalizing the data over force, resampling them and then fitting the newly obtained samples to a log-normal distribution. The statistical model makes it possible to produce response curves for the same quantile we used for the limits. Our technique adds a confidence region around each response curve to express the sufficiency of the available data. We have produced response curves for 24 different body locations for which we have calculated limits. These curves will enable manufacturers of cobot testing equipment to calibrate their measuring devices precisely.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":"146 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139577189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Integrated Experimental-Computational Study of Vocal Fold Vibration in Type I Thyroplasty. I 型甲状腺成形术中声带褶皱振动的综合实验-计算研究

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064662

Amit Avhad, Azure Wilson, Lea Sayce, Zheng Li, Bernard Rousseau, James F Doyle, Haoxiang Luo

{"title":"An Integrated Experimental-Computational Study of Vocal Fold Vibration in Type I Thyroplasty.","authors":"Amit Avhad, Azure Wilson, Lea Sayce, Zheng Li, Bernard Rousseau, James F Doyle, Haoxiang Luo","doi":"10.1115/1.4064662","DOIUrl":"10.1115/1.4064662","url":null,"abstract":"Subject-specific computational modeling of vocal fold (VF) vibration was integrated with an ex vivo animal experiment of type 1 thyroplasty to study the effect of the implant on the vocal fold vibration. In the experiment, a rabbit larynx was used to simulate type 1 thyroplasty, where one side of the vocal fold was medialized with a trans-muscular suture while the other side was medialized with a silastic implant. Vocal fold vibration was then achieved by flowing air through the larynx and was filmed with a high-speed camera. The three-dimensional computational model was built upon the pre-operative scan of the laryngeal anatomy. This subject-specific model was used to simulate the vocal fold medialization and then the fluid-structure interaction (FSI) of the vocal fold. Model validation was done by comparing the vocal fold displacement with postoperative scan (for medialization), and by comparing the vibratory characteristics with the high-speed images (for vibration). These comparisons showed the computational model successfully captured the effect of the implant and thus has the potential for presurgical planning.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11005858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in Glenohumeral Joint Contact Forces Between Recovery Hand Patterns During Wheelchair Propulsion With and Without Shoulder Muscle Weakness: A Simulation Study. 有肩部肌肉无力和无肩部肌肉无力时，轮椅推进过程中恢复手型与盂肱关节接触力的差异：模拟研究。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064590

Shelby L Walford, Jeffery W Rankin, Sara J Mulroy, Richard R Neptune

{"title":"Differences in Glenohumeral Joint Contact Forces Between Recovery Hand Patterns During Wheelchair Propulsion With and Without Shoulder Muscle Weakness: A Simulation Study.","authors":"Shelby L Walford, Jeffery W Rankin, Sara J Mulroy, Richard R Neptune","doi":"10.1115/1.4064590","DOIUrl":"10.1115/1.4064590","url":null,"abstract":"The majority of manual wheelchair users (MWCU) develop shoulder pain or injuries, which is often caused by impingement. Because propulsion mechanics are influenced by the recovery hand pattern used, the pattern may affect shoulder loading and susceptibility to injury. Shoulder muscle weakness is also correlated with shoulder pain, but how shoulder loading changes with specific muscle group weakness is unknown. Musculoskeletal modeling and simulation were used to compare glenohumeral joint contact forces (GJCFs) across hand patterns and determine how GJCFs vary when primary shoulder muscle groups are weakened. Experimental data were analyzed to classify individuals into four hand pattern groups. A representative musculoskeletal model was then developed for each group and simulations generated to portray baseline strength and six muscle weakness conditions. Three-dimensional GJCF peaks and impulses were compared across hand patterns and muscle weakness conditions. The semicircular pattern consistently had lower shear (anterior-posterior and superior-inferior) GJCFs compared to other patterns. The double-loop pattern had the highest superior GJCFs, while the single-loop pattern had the highest anterior and posterior GJCFs. These results suggest that using the semicircular pattern may be less susceptible to shoulder injuries such as subacromial impingement. Weakening the internal rotators and external rotators resulted in the greatest increases in shear GJCFs and decreases in compressive GJCF, likely due to decreased force from rotator cuff muscles. These findings suggest that strengthening specific muscle groups, especially the rotator cuff, is critical for decreasing the risk of shoulder overuse injuries.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber. 加强吸入给药：新型阀式容纳腔的比较研究与优化设计

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064436

Shahab Azimi, Siamak Arzanpour

{"title":"Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber.","authors":"Shahab Azimi, Siamak Arzanpour","doi":"10.1115/1.4064436","DOIUrl":"10.1115/1.4064436","url":null,"abstract":"This paper presents an innovative approach to the design optimization of valved holding chambers (VHCs), crucial devices for aerosol drug delivery. We present the design of an optimal cylindrical VHC body and introduce a novel valve based on particle impaction theory. The research combines computational simulations and physical experiments to assess the performance of various VHCs, with a special focus on the deposition patterns of medication particles within these devices. The methodology incorporates both experimental and simulation approaches to validate the reliability of the simulation. Emphasis is placed on the deposition patterns observed on the VHC walls and the classification of fine and large particles for salbutamol sulfate particles. The study reveals the superior efficacy of our valve design in separating particles compared to commercially available VHCs. In standard conditions, our valve design allows over 95% of particles under 7 μm to pass through while effectively filtering those larger than 8 μm. The optimized body design accomplishes a 60% particle mass flow fraction at the outlet and an average particle size reduction of 58.5%. When compared numerically in terms of size reduction, the optimal design outperforms the two commercially available VHCs selected. This study provides valuable insights into the optimization of VHC design, offering significant potential for improved aerosol drug delivery. Our findings demonstrate a new path forward for future studies, aiming to further optimize the design and performance of VHCs for enhanced pulmonary drug delivery.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systems Approach to Biomechanics, Mechanobiology, and Biotransport. 生物力学、机械生物学和生物传输的系统方法。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064547

Shayn M Peirce-Cottler, Edward A Sander, Matthew B Fisher, Alix C Deymier, John F LaDisa, Grace O'Connell, David T Corr, Bumsoo Han, Anita Singh, Sara E Wilson, Victor K Lai, Alisa Morss Clyne

{"title":"A Systems Approach to Biomechanics, Mechanobiology, and Biotransport.","authors":"Shayn M Peirce-Cottler, Edward A Sander, Matthew B Fisher, Alix C Deymier, John F LaDisa, Grace O'Connell, David T Corr, Bumsoo Han, Anita Singh, Sara E Wilson, Victor K Lai, Alisa Morss Clyne","doi":"10.1115/1.4064547","DOIUrl":"10.1115/1.4064547","url":null,"abstract":"The human body represents a collection of interacting systems that range in scale from nanometers to meters. Investigations from a systems perspective focus on how the parts work together to enact changes across spatial scales, and further our understanding of how systems function and fail. Here, we highlight systems approaches presented at the 2022 Summer Biomechanics, Bio-engineering, and Biotransport Conference in the areas of solid mechanics; fluid mechanics; tissue and cellular engineering; biotransport; and design, dynamics, and rehabilitation; and biomechanics education. Systems approaches are yielding new insights into human biology by leveraging state-of-the-art tools, which could ultimately lead to more informed design of therapies and medical devices for preventing and treating disease as well as rehabilitating patients using strategies that are uniquely optimized for each patient. Educational approaches can also be designed to foster a foundation of systems-level thinking.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling Running via Optimal Control for Shoe Design. 通过优化控制建立跑步模型，用于鞋类设计

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064405

Sarah C Fay, A E Hosoi

{"title":"Modeling Running via Optimal Control for Shoe Design.","authors":"Sarah C Fay, A E Hosoi","doi":"10.1115/1.4064405","DOIUrl":"10.1115/1.4064405","url":null,"abstract":"Shoe manufacturing technology is advancing faster than new shoe designs can viably be evaluated in human subject trials. To aid in the design process, this paper presents a model for estimating how new shoe properties will affect runner performance. This model assumes runners choose their gaits to optimize an intrinsic, unknown objective function. To learn this objective function, a simple two-dimensional mechanical model of runners was used to predict their gaits under different objectives, and the resulting gaits were compared to data from real running trials. The most realistic model gaits, i.e., the ones that best matched the data, were obtained when the model runners minimized the impulse they experience from the ground as well as the mechanical work done by their leg muscles. Using this objective function, the gait and thus performance of running under different shoe conditions can be predicted. The simple model is sufficiently sensitive to predict the difference in performance of shoes with disruptive designs but cannot distinguish between existing shoes whose properties are fairly similar. This model therefore is a viable tool for coarse-grain exploration of the design space and identifying promising behaviors of truly novel shoe materials and designs.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow Rate and Wall Shear Stress Characterization of a Biomimetic Aerosol Exposure System. 仿生气溶胶曝露系统的流速和壁面剪切应力特征。

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064549

S Emma Sarles, Edward C Hensel, Janessa Terry, Caleb Nuss, Risa J Robinson

{"title":"Flow Rate and Wall Shear Stress Characterization of a Biomimetic Aerosol Exposure System.","authors":"S Emma Sarles, Edward C Hensel, Janessa Terry, Caleb Nuss, Risa J Robinson","doi":"10.1115/1.4064549","DOIUrl":"10.1115/1.4064549","url":null,"abstract":"Current in vitro emissions and exposure systems lack biomimicry, use unrealistic flow conditions, produce unrealistic dose, and provide inaccurate biomechanical cues to cell cultures, limiting ability to correlate in vitro outcomes with in vivo health effects. A biomimetic in vitro system capable of puffing aerosol and clean air inhalation may empower researchers to investigate complex questions related to lung injury and disease. A biomimetic aerosol exposure system (BAES), including an electronic cigarette adapter, oral cavity module (OCM), and bifurcated exposure chamber (BEC) was designed and manufactured. The fraction of aerosol deposited in transit to a filter pad or lost as volatiles was 0.116±0.021 in a traditional emissions setup versus 0.098 ± 0.015 with the adapter. The observed flowrate was within 5% of programed flowrate for puffing (25 mL/s), puff-associated respiration (450 mL/s), and tidal inhalation (350 mL/s). The maximum flowrate observed in the fabricated BAES was 450 mL/s, exceeding the lower target nominal wall shear stress of 0.025 Pa upstream of the bifurcation and fell below the target of 0.02 Pa downstream. This in vitro system addresses several gaps observed in commercially available systems and may be used to study many inhaled aerosols. The current work illustrates how in silico models may be used to correlate results of an in vitro study to in vivo conditions, rather than attempting to design an in vitro system that performs exactly as the human respiratory tract.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying the Influence of X-Ray Irradiation on Cell-Size-Scale Viscoelasticity of Collagen Type 1. 量化 X 射线辐照对细胞尺寸尺度的 1 型胶原蛋白粘弹性的影响

IF 1.7 4区医学

Journal of Biomechanical Engineering-Transactions of the Asme Pub Date : 2024-04-01 DOI: 10.1115/1.4064404

Väinö Mikael Mäntylä, Arttu Juhani Lehtonen, Vesa Korhonen, Linda Srbova, Juho Pokki

{"title":"Quantifying the Influence of X-Ray Irradiation on Cell-Size-Scale Viscoelasticity of Collagen Type 1.","authors":"Väinö Mikael Mäntylä, Arttu Juhani Lehtonen, Vesa Korhonen, Linda Srbova, Juho Pokki","doi":"10.1115/1.4064404","DOIUrl":"10.1115/1.4064404","url":null,"abstract":"X-rays are widely used in mammography and radiotherapy of breast cancer. The research has focused on the effects of X-rays on cells in breast tissues, instead of the tissues' nonliving material, extracellular matrix. It is unclear what the influence of X-ray irradiation is on the matrix's mechanical cues, known to regulate malignant cancer-cell behaviors. Here, we developed a technique based on magnetic microrheology that can quantify the influence of X-ray irradiation on matrix viscoelasticity--or (solid-like) elastic and (liquid-like) viscous characteristics--at cell-size scales. To model breast-tissue extracellular matrix, we used the primary component of the tissue matrix, collagen type 1, as it is for control, and as irradiated by X-rays (tube voltage 50 kV). We used a magnetic microrheometer to measure collagen matrices using 10-μm-diameter magnetic probes. In each matrix, the probes were nanomanipulated using controlled magnetic forces by the microrheometer while the probes' displacements were detected to measure the viscoelasticity. The collagen-matrix data involve with a typical spatial variation in viscoelasticity. We find that higher irradiation doses (320 Gy) locally reduce stiffness (soften) collagen matrices and increase their loss tangent, indicating an elevated liquid-like nature. For lower, clinically relevant irradiation doses (54 Gy), we find insignificant matrix-viscoelasticity changes. We provide this irradiation-related technique for detection, and modification, of matrix viscoelastic cues at cell-size scales. The technique enables enhanced characterization of irradiated tissue constituents in a variety of breast-cancer radiotherapy types.","PeriodicalId":54871,"journal":{"name":"Journal of Biomechanical Engineering-Transactions of the Asme","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0