Martin Hashemi, Philip Fransson, Mikael Korduner, Martin Bengtsson
{"title":"Analysis of correlations between health-related quality of life and clinical measures after arthroscopic lysis and lavage of the temporomandibular joint.","authors":"Martin Hashemi, Philip Fransson, Mikael Korduner, Martin Bengtsson","doi":"10.1016/j.jcms.2025.01.021","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.01.021","url":null,"abstract":"<p><p>How well patient perceived outcome reflects clinical measurements after arthroscopic lysis and lavage of the temporomandibular joint (TMJ) is not fully understood. The purpose of this study was to detect any correlation between patient reported outcome measures (PROM) and clinical follow-up measurements. Patients with internal derangement of the TMJ treated with arthroscopic lysis and lavage 2014-2019 were consented for review of medical records and a follow-up PROM-questionnaire. The predictor was maximal mouth opening (MMO) and presence of pain. The main outcome variable was a PROM-score. Secondary outcome variables were time from treatment to follow-up, gender, and age. Student's T-test and Pearson's correlation test were used. Out of 127 patients eligible for inclusion 62, 14 men and 48 women, with a mean age of 43.58 years accepted participation. The mean follow-up time was 76.02 months (44-109 months). A correlation was observed between PROM-score and postoperative MMO, r = -0.34 (p = 0.01) and between PROM-score and the progression of MMO, r = -0.17 (p = 0.21). In conclusion, outcome measures after arthroscopic treatment of internal derangement of the TMJ showed conformity between clinical and PROM measures.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3D face reconstruction for maxillofacial surgery based on morphable models and neural networks: A preliminary assessment for anthropometry accuracy.","authors":"Zhewei Chen, Binghang Li, Bowen Lei, Yehong Zhong, Qinghua Huang, Tiecheng Sun, Hengyuan Ma","doi":"10.1016/j.jcms.2025.01.030","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.01.030","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the anthropometric accuracy of 3D face reconstruction based on neural networks (3DFRBN) using 2D images, including the assessment of global errors and landmarks, as well as linear and angular measurements.</p><p><strong>Methods: </strong>Thirty healthy volunteers were recruited in this study. For each volunteer, five standard photos were taken, capturing anterior, 45° to left and right, and 90° to left and right views. These 2D images were then imported into the 3DFRBN program for generating 3D facial models. Accuracy of landmarks on these models was analyzed in comparison with 3dMD-captured models, as well as global error, and linear and angular measurements.</p><p><strong>Results: </strong>The average root mean square error of the 3DFRBN-generated models was 1.52 ± 0.23 mm. Euclidean distance for landmark deviation on 3DFRBN-generated models was 1.87 ± 0.13 mm, ranging from 1.21 mm to 2.17 mm. 13 out of 16 measurements had ICCs over 0.90. The average errors for linear and angular measurements were 0.67 mm and 3.25°, respectively.</p><p><strong>Conclusions: </strong>This study introduced a novel, convenient, and accurate approach for both prospective and retrospective 3D facial data acquirement. Its great potential for retrospective 3D facial data acquisition can greatly benefit trauma and oncological reconstruction, as well as retrospective studies.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Onur Odabaşi, Mehmet Fatih Şentürk, Mehmet Emrah Polat, Halil İbrahim Durmuş
{"title":"Intraoperative comparison of Y-shape cannula and concentric needle techniques in single-puncture temporomandibular joint arthrocentesis.","authors":"Onur Odabaşi, Mehmet Fatih Şentürk, Mehmet Emrah Polat, Halil İbrahim Durmuş","doi":"10.1016/j.jcms.2025.01.031","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.01.031","url":null,"abstract":"<p><p>This study aims to compare two different single-puncture arthrocentesis (SPA) Type 2 techniques, the Y-shaped cannula and the concentric needle methods, in terms of intraoperative parameters. In the study, data from 32 unilateral temporomandibular joint (TMJ) arthrocentesis procedures, including procedure duration (seconds), the number of cannula relocations, and procedural difficulty (evaluated using a visual analog scale), were retrospectively analyzed. The Y-shaped cannula technique was found to significantly reduce procedure duration (284.81 ± 74.6 s vs. 649.50 ± 118.9 s, p < 0.001). Although there were no significant differences between the groups in the number of cannula relocations or procedural difficulty, analysis of covariance (ANCOVA) showed that the Y-shaped cannula technique made the procedure less difficult (p = 0.018). These results suggest that the Y-shaped cannula may offer advantages, particularly in busy clinical settings, by shortening procedure duration and facilitating ease of operation.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yong June Chang, Jungrae Cho, Byungeun Shon, Kang Young Choi, Sungmoon Jeong, Jeong Yeop Ryu
{"title":"A novel clinical investigation using deep learning and human-in-the-loop approach in orbital volume measurement.","authors":"Yong June Chang, Jungrae Cho, Byungeun Shon, Kang Young Choi, Sungmoon Jeong, Jeong Yeop Ryu","doi":"10.1016/j.jcms.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.01.007","url":null,"abstract":"<p><p>Orbital volume assessment is crucial for surgical planning. Traditional methods lack efficiency and accuracy. Recent studies explore AI-driven techniques, but research on their clinical effectiveness is limited. This study included 349 patients aged 19 years and above, who underwent three-dimensional facial computed tomography (3DCT) without orbital trauma or congenital anomalies. To construct an AI training dataset, manual segmentation was performed on 178 patients' 3DCT using 3D Slicer. The remaining data of 171 patients underwent human-in-the-loop method, resulting in a dataset of 349 annotated samples. Comparative analysis of Dice coefficients and execution speeds was performed between manual and semi-automated segmentations. Comparing AI-assisted semi-automated segmentation with manual segmentation, all six annotators demonstrated lower average inference times without a significant difference in Dice coefficients (90.31% vs. 88.72%). For 178 patients' 3DCT, a high average Dice coefficient of 89.9% was observed, and a 38.42-ms inference time was recorded. For the full dataset, the AI model achieved a high average Dice coefficient of 94.1% and a fast average inference time of 32.55 ms per axial slice. This study demonstrates the potential of AI for maintaining high accuracy and time-efficiency in orbital region segmentation, with wide clinical applications.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marius Heitzer, Annemarie Breitenstein, Mark Ooms, Philipp Winnand, Anna Bock, Florian Peters, Frank Hölzle, Ali Modabber
{"title":"Impact of segment length on bony changes following microvascular jaw reconstruction using virtually planned fibula flaps - A retrospective study.","authors":"Marius Heitzer, Annemarie Breitenstein, Mark Ooms, Philipp Winnand, Anna Bock, Florian Peters, Frank Hölzle, Ali Modabber","doi":"10.1016/j.jcms.2024.12.021","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.021","url":null,"abstract":"<p><p>Postoperative bone resorption within the first year after a free fibular flap is a common problem and poses major challenges for subsequent therapies. Due to the concerns of increased bone resorption, short segments in particular, i.e. ≤ 20 mm long, are considered unfavorable despite insufficient data in the literature. Therefore, the aim of this retrospective study was to analyze the changes in bone volume (BV), cortical thickness (cTh) and cortical density of especially short fibula segments one year after microvascular jaw reconstruction. Eighty-six fibula segments were included in this study, of which 30 segments were ≤25 mm and 16 segments were ≤20 mm long. The longer fibula segments served as a comparison for bone remodeling. After 15.10 ± 5.60 months, the changes in total bone volume (BV), cTh and cortical density of the fibula segments were determined from analyses of three-dimensional radiological images, and the percentage bone loss rates were assessed in relation to different segment lengths. All fibula segments showed loss of bone volume (BV) regardless of segment length, with no difference in the relative changes in BV as a function of segment length. While the volume changes were smaller in the shorter segments, the longer segments (average length: 26.50 mm) showed a higher bone loss of up to 25%. Although the total BV of the small segments (≤20 mm) did not change at follow-up, the loss of cortical density was substantial. Based on our findings that the largest bony changes were associated with segments of 25 mm in length, the current clinical practice that fibula segments should not be smaller than 20 mm should be critically reconsidered.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olina Rios, Robin Pradel, Jonathan Pradel, Barbara Lerhe, Charles Savoldelli
{"title":"Jawline improvement using patient-specific angle implants with virtual planning in orthognathic surgery.","authors":"Olina Rios, Robin Pradel, Jonathan Pradel, Barbara Lerhe, Charles Savoldelli","doi":"10.1016/j.jcms.2025.01.024","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.01.024","url":null,"abstract":"<p><p>There has been a recent increase in the global demand for jawline augmentation. Managing angle definition in patients undergoing orthognathic surgery remains challenging owing to the characteristics of classic mandibular osteotomy, which mostly allows sagittal mandibular movements but cannot modify the ramus height. The advent of computer-assisted surgical planning and computer-aided design/computer-aided manufacturing techniques for patient-specific implant fabrication has introduced new methods for jawline management. In this study, we aimed to assess jawline improvement using patient-specific angle implants in 18 patients undergoing orthognathic surgery with standard osteotomies. Since jawline's shape is an aesthetic refinement of orthognathic surgery, it has to be assessed with the inclusion of the soft tissues. Therefore, this study focused on jawline improvement by comparing the preoperative and postoperative 3D-photographs of each patient's face using the VECTRA H2 Imaging System camera device and software. Quantitative analysis revealed that the mean volumetric angle expansion was 4.6 mm (males, 4.71 mm; females, 4.48 mm). Qualitative and quantitative analyses revealed that the jaw angle parameters were concordant with the ideal female and male jaw angle parameters proposed in the literature. Patient-specific titanium angle implants are a promising and safe method for jawline improvement in patients undergoing orthognathic surgery.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unleashing the potency of multi-segmental DCIA flap in mandibular reconstruction with the aid of virtual surgery- A retrospective cohort study.","authors":"Hao Lin, Weiwei Deng, Linzhou Zhang, Zhixiang Ge, Chunyue Ma, Tianfu Wu, Bing Liu","doi":"10.1016/j.jcms.2024.12.018","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.018","url":null,"abstract":"<p><p>Although the deep circumflex iliac artery (DCIA) flap is a mainstay in mandibular reconstruction, its multi-segmental utilization is infrequently reported, primarily due to concerns regarding the variable cutaneous component and potentially inadequate vascular supply to multi-block segments. This retrospective study analyzed the outcomes of 86 patients undergoing mandibular reconstruction with multi-segmental DCIA flaps, compared to 167 patients who received conventional single-segmental flaps. The survival rate for multi-segmental flaps was comparable to that of single-segmental flaps (100% vs. 98.2%, p = 0.553). Multi-segmental flaps were used to reconstruct longer bony defects (median: 9 cm vs. 6.5 cm, p < 0.001). Despite the longer operation times in the multi-segmental group (368.8 vs. 326.8 min, p < 0.001), there was no significant increase in the incidence of surgical complications. Furthermore, postoperative QoL and Harris Hip scores did not show significant differences, despite the increased graft lengths and segmentation in the multi-segmental group. The study underscores the underrecognized efficacy of multi-segmental DCIA flaps in complex mandibular reconstructions, particularly for specific types of defects such as Brown III, Brown I (Ic), and Brown II (IIc), which can be effectively and reliably reconstructed with the aid of virtual surgical techniques. This research also confirms that concerns regarding soft tissue management with multi-segmental DCIA flaps can be effectively addressed.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Flavia Bisconti, Marco Eva, Estelle Thevenet, Natalia Zamora-Martinez
{"title":"Comparison of efficacy between micro-osteoperforations and alveolar corticotomies on the rate of orthodontic tooth movement: A systematic review and meta-analysis.","authors":"Flavia Bisconti, Marco Eva, Estelle Thevenet, Natalia Zamora-Martinez","doi":"10.1016/j.jcms.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.01.013","url":null,"abstract":"<p><p>Micro-osteoperforations and corticotomies are two surgical techniques commonly used to increase the rate of tooth movement. The aim of this systematic review was to respond to the question: Which method used for accelerating orthodontic tooth movement, micro-osteoperforations or alveolar corticotomy, produces a higher rate of tooth movement and present less adverse effects? Searches were performed in the electronic databases of PubMed, Scopus, Cochrane CENTRAL, Web of Science, Lilacs and Science Direct, as well as grey literature (Opengrey), up to March 2024. All the included studies were controlled, randomized clinical trials, cohort, case-control, cross-sectional, and multicentre studies of patients treated with orthodontics and corticotomies or micro-osteoperforations. Cochrane Collaboration risk of bias tool was used for quality assessment. For the quantitative analysis, studies were analyzed with a mixed-effect (random effect) meta-regresion model, with beta coefficients and R2 values, with I2 index and with Q and Egger tests. 31 articles were included for the qualitative analysis and 17 for the quantitative analysis. The rate of tooth movement of the corticotomy was 0.539 mm per month (CI95%: 0.117,0.961) higher than with micro-osteoperforations, being the values statistically significant (p = 0.012) but in a context of strong heterogeneity (89.6%). Adverse effects such as pain, quality of life impact and swelling were reported to be longer and harder after corticotomies. After corticotomy a greater rate of tooth movement has been observed during canine retraction compared to micro-osteoperforations. However, more well-designed randomized clinical trials directly comparing both techniques are needed. REGISTRATION NUMBER: CRD42020156448.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maurice Y Mommaerts, Frederik Deman, Denis Verwilghen, Nikolas De Meurechy
{"title":"Lateral pterygoid muscle enthesis reconstruction in alloplastic total temporomandibular joint replacement: An animal experiment with histological verification.","authors":"Maurice Y Mommaerts, Frederik Deman, Denis Verwilghen, Nikolas De Meurechy","doi":"10.1016/j.jcms.2025.01.022","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.01.022","url":null,"abstract":"<p><p>In current alloplastic total temporomandibular joint replacements (TMJRs) typically the lateral pterygoid muscle (LPM) insertion is sacrificed, affecting joint function. This study assesses a novel additively manufactured TMJR (CADskills BV, Gent, Belgium) designed to enable LPM reinsertion through a scaffold feature on the implant. Thirteen TMJRs were implanted in Swifter crossbreed sheep, with follow-up CT scans after 288 days to evaluate LPM reintegration. Five specimens showed a close approximation between the LPM enthesis and the scaffold. Histological analysis with Masson-Goldner staining and microscopy revealed close bony enthesis alignment with the scaffold, although true bony ingrowth was not observed. One specimen could not be fully evaluated due to preparation issues, limiting conclusions on osseointegration. Random samples from the ramal scaffold showed good integration with the native mandible, with osteogenic activity noted, but no bony ingrowth from the reattached enthesis into the bone grafted titanium scaffold. Despite this, all samples displayed a continuous fibrotic attachment, suggesting functional restoration of the LPM. Findings indicate that while the TMJR design supports fibrotic attachment, further optimization of reattachment techniques, scaffold properties, and post-operative care may improve osseointegration and functional outcomes in future human TMJRs.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paolo Boffano, Francesca Neirotti, Matteo Brucoli, Muhammad Ruslin, Petia Pechalova, Nikolai Pavlov, Angel Sapundzhiev, Petar Uchikov, Juan Carlos de Vicente Rodríguez, Nerea Rodríguez Torres, Tania Rodríguez Santamarta, Christophe Meyer, Aurelien Louvrier, Alexandre Michel-Guillaneux, Eugenie Bertin, Thomas Starch-Jensen, Aleksandar Stamatoski, Ivana Mijatov, Branislav V Bajkin, Tadej Dovsak, Zan Garvas, Ana Durković, Marija Milosavljević, Vitomir Konstantinovic, Sara Degerholm, Johanna Snäll
{"title":"Clinical patterns and outcomes of patients affected by primary malignant melanoma of the oral mucosa: A European multicenter retrospective chart review.","authors":"Paolo Boffano, Francesca Neirotti, Matteo Brucoli, Muhammad Ruslin, Petia Pechalova, Nikolai Pavlov, Angel Sapundzhiev, Petar Uchikov, Juan Carlos de Vicente Rodríguez, Nerea Rodríguez Torres, Tania Rodríguez Santamarta, Christophe Meyer, Aurelien Louvrier, Alexandre Michel-Guillaneux, Eugenie Bertin, Thomas Starch-Jensen, Aleksandar Stamatoski, Ivana Mijatov, Branislav V Bajkin, Tadej Dovsak, Zan Garvas, Ana Durković, Marija Milosavljević, Vitomir Konstantinovic, Sara Degerholm, Johanna Snäll","doi":"10.1016/j.jcms.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.01.012","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this European multicenter study was to describe and assess the characteristics, diagnosis, management, and recurrence of oral malignant melanoma at different European oral and maxillofacial surgery centers.</p><p><strong>Materials and methods: </strong>This study was based on a systematic computer-assisted database that allowed the recording of data for all primary oral mucosal melanomas treated in the involved surgical units across Europe between January 1, 2003 and December 31, 2022. The following data were recorded for each patient: gender, age, site, TNM staging, metastases, symptoms, imaging features, histopathological features, treatment, complications, recurrence, follow up, and survival.</p><p><strong>Results: </strong>A total of 29 patients (15 females, 14 males) with a primary oral mucosal malignant melanoma fulfilled the inclusion criteria. The mean age was 64.4 years. The most frequent primary site was the vestibular and crestal maxillary gum. Nineteen patients had been diagnosed with a T3 oral melanoma, nine patients with a T4a oral melanoma, and one patient with a T4b neoplasm. Three patients had distant metastases at diagnosis. Clinically, the most frequently observed clinical features were hyperpigmentation, nodular appearance, ulceration, and hemorrhage. Among the 27 surgical cases, radical/clear margins were obtained in 24 cases, non-radical/invaded margins were obtained in two cases, while in one case a non-specific result of margin positivity was found. The overall 2-year survival was 62%. The 2-year disease-free survival was 52%.</p><p><strong>Conclusions: </strong>Oral mucosal melanoma is an aggressive and often asymptomatic malignancy. The overall long-term survival for patients with oral mucosal melanoma is poor, with a high rate of distant metastasis, independently from the performed treatment. Prevention and early diagnosis could be crucial to improving the disease-free survival of patients with oral mucosal melanomas.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}