Journal of Cranio-Maxillofacial Surgery最新文献_第3页

The impact of COVID-19 on complications and long-term outcomes in maxillofacial trauma: A retrospective multicentre analysis. COVID-19对颌面部创伤并发症和长期预后的影响：一项回顾性多中心分析

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-09-03 DOI: 10.1016/j.jcms.2025.08.019

Ladislav Czako, Mária Janickova, Branislav Borza, Kristian Simko, Sarah Kalmanova, Rastislav Juricek, Marek Sovis, Klaudia Uvegesova, Anna Kobyliakova, Peter Kizek

{"title":"The impact of COVID-19 on complications and long-term outcomes in maxillofacial trauma: A retrospective multicentre analysis.","authors":"Ladislav Czako, Mária Janickova, Branislav Borza, Kristian Simko, Sarah Kalmanova, Rastislav Juricek, Marek Sovis, Klaudia Uvegesova, Anna Kobyliakova, Peter Kizek","doi":"10.1016/j.jcms.2025.08.019","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.08.019","url":null,"abstract":"<p><p>The COVID-19 pandemic significantly impacted global healthcare, including patterns of maxillofacial trauma. This multicentre retrospective study analysed 3954 patients treated from January 2018 to December 2023 at hospitals in Bratislava, Martin, and Kosice, covering three periods: pre-COVID, during COVID, and post-COVID. Data included patient demographics, trauma causes, treatment methods, and complication rates. While short-term complication rates remained consistent across the periods, statistical analysis showed a strong association between fracture type and complications (p < 0.001). Mandibular, alveolar process, and naso-orbito-ethmoidal (NOE) fractures had the highest short-term complication rates (9.8 %, 11.8 %, and 16.4 %, respectively). Long-term outcomes were significantly affected by fracture type and injury cause, with blow-in fractures resulting in persistent issues in 50 % of cases. The COVID-19 period showed slightly fewer short-term complications, but worse long-term outcomes, likely due to delayed care and limited follow-up. Post-COVID outcomes improved compared to pre-COVID levels. The findings underscore the importance of resilient and adaptable healthcare systems in managing trauma effectively during public health crises, offering key lessons for future protocols in trauma care. © The Author(s) 2025.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sagittal split ramus osteotomy-enhanced mandibular distraction osteogenesis: A biomechanically superior approach for three-dimensional reconstruction in severe micrognathia. 矢状分叉支截骨术增强下颌牵张成骨：一种生物力学上优越的方法用于严重小颌畸形的三维重建。

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-09-03 DOI: 10.1016/j.jcms.2025.08.005

Xiang Li, Tianyu Zhao, Zhuoga Baima, Kan Li, Siyong Gao, Huanzhong Ji, Wei Sun, Xiang Gao, Guangsen Zheng, Guiqing Liao

{"title":"Sagittal split ramus osteotomy-enhanced mandibular distraction osteogenesis: A biomechanically superior approach for three-dimensional reconstruction in severe micrognathia.","authors":"Xiang Li, Tianyu Zhao, Zhuoga Baima, Kan Li, Siyong Gao, Huanzhong Ji, Wei Sun, Xiang Gao, Guangsen Zheng, Guiqing Liao","doi":"10.1016/j.jcms.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.08.005","url":null,"abstract":"<p><strong>Background: </strong>Mandibular distraction osteogenesis (MDO) remains essential for severe micrognathia correction. The clinical adoption of conventional osteotomy techniques has been constrained by complications including non-union, inferior alveolar nerve injury, and dental germ damage, compounded by suboptimal occlusal relationships and compromised facial aesthetics. Critical considerations in MDO execution encompass neural structure preservation, osteotomy gap integrity, and achieving three-dimensional skeletal augmentation to enhance both functional stability and craniofacial proportions.</p><p><strong>Methods: </strong>Between January 2020 and September 2024, ten patients with severe micrognathia underwent MDO via sagittal split ramus osteotomy (SSRO) or vertical transversal osteotomy (VTO). A subset of patients subsequently underwent staged orthognathic procedures to optimize facial balance.</p><p><strong>Results: </strong>SSRO-based MDO (SSRO-DO) demonstrated superior clinical outcomes relative to VTO-DO, evidenced by 3-fold greater osteotomy surface area (p < 0.01) and thus 33 % superior central ossification area ratio (COAR) (p = 0.02). Postoperative enhance was confirmed with SSRO, achieving significant transverse expansion of mandibular body (p = 0.02). SSRO-DO group demonstrated significant improvement in sagittal advancement of mandibular body as well as facial contour against VTO-DO group.</p><p><strong>Conclusions: </strong>SSRO-DO demonstrates potential advantages over current VTO-DO. This technique facilitates primary deformity correction and preserves anatomical foundations for subsequent orthognathic refinement. Further studies and long-term follow-up are needed.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Head and neck free flap reconstruction: A prospective case series with the Symani® surgical system. 头颈部自由皮瓣重建：Symani®手术系统的前瞻性病例系列。

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-09-03 DOI: 10.1016/j.jcms.2025.08.009

Johannes Spille, Jörg Wiltfang, Henning Wieker

{"title":"Head and neck free flap reconstruction: A prospective case series with the Symani® surgical system.","authors":"Johannes Spille, Jörg Wiltfang, Henning Wieker","doi":"10.1016/j.jcms.2025.08.009","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.08.009","url":null,"abstract":"<p><p>Robotic surgery has undergone steady evolution in recent years. Until now, there has been no suitable robotic system for plastic reconstruction. With the Symani Surgical System, anastomoses of free flaps in the head and neck region can be performed efficiently and accurately. This prospective single-centre study aims to describe and investigate the use of robotic reconstructions in the head and neck region by oral and maxillofacial surgeons for the first time. 93 patients after ablative tumor surgery who required a free flap for reconstruction in the head and neck region were included in the study; 73 had oral squamous cell carcinoma (78.5 %). Radial forearm flap 28 (30.1 %), ulnar forearm flap 28 (30.1 %), and fibula flap 22 (23.7 %) were used most frequently. Three revision surgeries were performed, and one free flap was lost. Robotic microsurgery has a steep learning curve and can be used effectively to perform anastomoses in free flap reconstructions. The surgical spectrum of microsurgical techniques has not yet been fully explored and should be further investigated. Supermicrosurgery could benefit from the Symani robotic system in the long term.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The molecular mechanism of human beta-defensin 1 in inhibiting the progression of head and neck squamous cell carcinoma: The role of the IL-17B/IL-17RB/TRAF6/NF-κB signaling axis. 人β -防御素1抑制头颈部鳞状细胞癌进展的分子机制：IL-17B/IL-17RB/TRAF6/NF-κB信号轴的作用

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-09-03 DOI: 10.1016/j.jcms.2025.08.016

Shaonan Hu, Simin Li, Wenhao Chen, Guangqin Dai, Xiuhong Huang, Tao Tian, Yaxin Rao, Wanchen Ning, Xin Deng, Prabhakar Mujagund, Deborah Kreher, Gerhard Schmalz, Shaohong Huang, Chufeng Liu

{"title":"The molecular mechanism of human beta-defensin 1 in inhibiting the progression of head and neck squamous cell carcinoma: The role of the IL-17B/IL-17RB/TRAF6/NF-κB signaling axis.","authors":"Shaonan Hu, Simin Li, Wenhao Chen, Guangqin Dai, Xiuhong Huang, Tao Tian, Yaxin Rao, Wanchen Ning, Xin Deng, Prabhakar Mujagund, Deborah Kreher, Gerhard Schmalz, Shaohong Huang, Chufeng Liu","doi":"10.1016/j.jcms.2025.08.016","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.08.016","url":null,"abstract":"<p><p>The present study aimed to investigate the regulatory functions and mechanisms of human β-defensin 1 (hBD-1) in head and neck squamous cell carcinoma (HNSCC) through comprehensive bioinformatics analyses and experimental validation. Comprehensive bioinformatics analyses of TCGA database samples were performed, including DEFB1 expression profiling, clinical correlation analysis, prognostic evaluation, and pathway enrichment studies. The results demonstrated that DEFB1/hBD-1 expression was significantly downregulated in tumor tissues and negatively correlated with key genes in the IL-17 signaling pathway, while being associated with reduced lymph node metastasis and improved overall survival. Immunohistochemical validation confirmed low hBD-1 protein expression in HNSCC tissues. Assessment of hBD-1 expression across multiple HNSCC cell lines revealed consistently downregulated hBD-1 mRNA and protein levels. Functional experiments using stable hBD-1-overexpressing cell models demonstrated that hBD-1 overexpression significantly inhibited cell metabolic activity, clone formation, invasion, and migration while effectively inducing apoptosis. Mechanistic studies revealed that hBD-1 suppressed the IL-17B/IL-17RB/TRAF6/NF-κB signaling pathway by downregulating IL-17B and IL-17RB expression, inhibiting TRAF6 ubiquitination, and decreasing NF-κB pathway protein phosphorylation levels. In vivo xenograft experiments validated that hBD-1 overexpression significantly reduced tumor growth, volume, cell proliferation, and increased apoptosis. These findings collectively demonstrate that DEFB1/hBD-1 functions as a tumor suppressor in HNSCC through suppression of the IL-17B/IL-17RB/TRAF6/NF-κB axis, positioning it as a potential prognostic biomarker and therapeutic target for HNSCC management.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and radiographic outcomes of dynamic navigation-assisted and freehand zygomatic implant surgery: a retrospective study with an average follow-up of 5 years. 动态导航辅助和徒手颧植入手术的临床和影像学结果：一项平均随访5年的回顾性研究。

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-09-03 DOI: 10.1016/j.jcms.2025.08.017

Houzuo Guo, Donghao Wei, Tiziano Testori, Ping Di, Xi Jiang, Ye Lin

{"title":"Clinical and radiographic outcomes of dynamic navigation-assisted and freehand zygomatic implant surgery: a retrospective study with an average follow-up of 5 years.","authors":"Houzuo Guo, Donghao Wei, Tiziano Testori, Ping Di, Xi Jiang, Ye Lin","doi":"10.1016/j.jcms.2025.08.017","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.08.017","url":null,"abstract":"<p><p>Little evidence was available regarding the long-term clinical outcomes of zygomatic implants placed with dynamic navigation assistance compared to freehand zygomatic implants placement. The study aimed to evaluate the clinical and radiographic outcomes of dynamic navigation-assisted and freehand zygomatic implant placement over an average observation period of 5 years. Zygomatic implants were placed in patients with dynamic navigation assistance or by freehand. Immediate provisionalization was completed within 24 h postoperatively. Permanent restorations were placed for all patients 6-12 months after surgery. Subsequently, annual follow-ups were conducted. Implant survival, mechanical and biological complications, and patient-reported outcomes (PROs) were recorded. Meanwhile, the area of bone-to-implant contact (A-BIC), the implant angle, the implant exit section, the distances to the infraorbital margin (DIO), and the distances to the infratemporal fossa (DIT) were measured on postoperative radiographic images. A total of 28 patients with 52 zygomatic implants completed an average follow-up period of 60.29 ± 11.16 months. The implant survival rates were 96.15 % in both groups. The incidence of paresthesia was significantly higher in the freehand group (11.54 %) compared to the dynamic navigation group (3.85 %). Statistically differences were found between the groups in A-BIC, implant angle, and DIO (p = 0.007, p = 0.011, and p = 0.032). In the freehand group, 3 zygomatic implants (11.54 %) exited to the infratemporal fossa, while no implants in the dynamic navigation group did. The PROs of the two groups showed comparable results. Zygomatic implants exhibited promising long-term survival rates. Limited by a retrospective study design, dynamic navigation-assisted surgery offered potential advantages including significantly reduced complications for patients and a greater bone-to-implant contact area.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selegiline as an innovative drug for the treatment of inferior alveolar nerve injury: a randomized clinical trial. 塞来吉兰作为治疗下肺泡神经损伤的创新药物：一项随机临床试验。

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-09-03 DOI: 10.1016/j.jcms.2025.08.015

Bruno Silva Mesquita, Ana Cláudia Amorim Gomes, Belmiro Cavalcanti Egito Vasconcelos, Carlos Augusto Pereira Lago, João Luiz Monteiro, Emanuel Savio Souza Andrade

{"title":"Selegiline as an innovative drug for the treatment of inferior alveolar nerve injury: a randomized clinical trial.","authors":"Bruno Silva Mesquita, Ana Cláudia Amorim Gomes, Belmiro Cavalcanti Egito Vasconcelos, Carlos Augusto Pereira Lago, João Luiz Monteiro, Emanuel Savio Souza Andrade","doi":"10.1016/j.jcms.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.08.015","url":null,"abstract":"<p><strong>Background: </strong>Inferior alveolar nerve (IAN) injuries are common complications of mandibular orthognathic surgery. Selegiline has demonstrated neuroprotective effects in preclinical studies.</p><p><strong>Objective: </strong>To evaluate the effect of oral selegiline hydrochloride on neurosensory recovery following bilateral sagittal split osteotomy.</p><p><strong>Methods: </strong>A randomized, double-blind, controlled trial was conducted with 40 patients. Participants received either selegiline (5 mg/day for 30 days) or a combination of uridine 5'-triphosphate (UTP), cytidine-5'-monophosphate (CMP), and hydroxycobalamin (three times daily). Neurosensory assessments included two-point discrimination, directional perception, and 1-point sensitivity, evaluated at six time points. Pain was assessed using a visual analog scale (VAS).</p><p><strong>Results: </strong>The selegiline group showed earlier improvement in some parameters, especially in 1-point tactile sensitivity of the lower lip at day 15 (p < 0.05). Differences in two-point discrimination and directional perception were not consistent. Pain scores were lower in the selegiline group at day 15 (p < 0.05). By day 90, both groups had similar recovery levels.</p><p><strong>Conclusion: </strong>Selegiline hydrochloride may contribute to early neurosensory recovery after IAN injury, particularly in the lower lip. However, these benefits were limited to specific parameters and time points. Further studies are needed to validate its therapeutic potential.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical note: Supine harvesting of subscapular system of flaps combined with the pull-through technique. 技术说明：仰卧位摘取肩胛下系统的皮瓣并结合拉穿技术。

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-09-01 DOI: 10.1016/j.jcms.2025.08.011

Kazuki Hasegawa, Hideo Miyamoto, Tomokazu Sawada, Yoshio Ohyama

{"title":"Technical note: Supine harvesting of subscapular system of flaps combined with the pull-through technique.","authors":"Kazuki Hasegawa, Hideo Miyamoto, Tomokazu Sawada, Yoshio Ohyama","doi":"10.1016/j.jcms.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.08.011","url":null,"abstract":"<p><p>Traditionally, tumor ablation and reconstruction using the subscapular system of flaps require two patient position changes. Consequently, ablation and harvesting cannot be performed simultaneously by two teams, which is a considerable disadvantage of the subscapular flap system. We harvested these flaps using the pull-through technique in the lateral decubitus position to decrease position changes. Even with this procedure, a positioning change was required. Following the 2004 report on supine flap elevation, we adopted a supine approach combined with the pull-through technique, eliminating the need for repositioning and repeated field preparation, and significantly reducing operative time. Overall, 121 subscapular system of flaps were harvested in the supine position employing the pull-through technique wherein flap elevation preceded tumor ablation. Tumor ablation and donor-site closure were then performed simultaneously by two surgical teams. During tumor ablation, the elevated flap remained vascularized by the subscapular vessels, minimizing the ischemic time and allowing continuous monitoring. The risks of patient repositioning under general anesthesia were eliminated. All flaps showed stable vascularity, and harvesting was uneventful. The combination of supine harvesting and the pull-through technique offered significant advantages in reconstructive procedures utilizing the subscapular system of flaps.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mandibular positioning using patient-specific guides and osteosynthesis implants in bimaxillary orthognathic surgery with maxilla-first approach. A 3D-analysis. 在上颌先入路的双颌正颌手术中，使用患者特异性导向器和骨合成种植体进行下颌定位。3 d-analysis。

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-08-26 DOI: 10.1016/j.jcms.2025.08.002

Mario Scheurer, Johannes Schulze, Thomas Lins, Tobias Daut, Robin Kasper, Frank Wilde, Alexander Schramm, Marcel Ebeling, Andreas Sakkas

{"title":"Mandibular positioning using patient-specific guides and osteosynthesis implants in bimaxillary orthognathic surgery with maxilla-first approach. A 3D-analysis.","authors":"Mario Scheurer, Johannes Schulze, Thomas Lins, Tobias Daut, Robin Kasper, Frank Wilde, Alexander Schramm, Marcel Ebeling, Andreas Sakkas","doi":"10.1016/j.jcms.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.jcms.2025.08.002","url":null,"abstract":"<p><p>The aim of this study was to evaluate the accuracy of a fully 3D planned digital workflow for bimaxillary osteotomies, utilizing patient-specific osteotomy and drill guides (PSDOG) and osteosynthesis implants (PSOI), within a maxilla-first approach. Emphasis was placed on the accuracy of guided mandibular positioning. This retrospective study included 30 patients undergoing bimaxillary orthognathic surgery [bimaxillary PSDOG/PSOI (Group 1; n = 11) versus maxillary PSDOG/PSOI (Group 2; n = 19)]. 3D CT datasets were used for accuracy assessment. Primary outcome parameter was the accuracy of the intraoperative mandibular transfer evaluated on cephalometric landmarks. Secondary outcome parameter was the 3D accuracy of mandibular positioning. Cephalometric analysis revealed significant vertical undercorrections and lateral deviations in the positioning of proximal mandibular segments (adj. p < 0.05). 3D analysis revealed a trend towards lower maximal deviations at the left ascending ramus in Group 1 (p = 0.058). Moderate positional accuracy was observed, with the largest vector deviations occurring in the latero-inferior-anterior direction. Iatrogenic injuries and bad splits were lower in Group 1 (p ≥ 0.52). Duration of surgery did not differ significantly between groups (p = 0.21). Fully guided and patient-specific orthognathic procedures enable precise and reproducible mandibular repositioning and may contribute to a reduction in intraoperative complication rates. However, control of the proximal segments, particularly condylar positioning, remains limited.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D virtual surgical planning in patients with bilateral cleft lip and palate undergoing premaxilla osteotomy combined with secondary alveolar bone grafting: a retrospective accuracy analysis 双侧唇腭裂患者行上颌骨前截骨联合二次牙槽骨移植的三维虚拟手术计划：回顾性准确性分析。

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-08-22 DOI: 10.1016/j.jcms.2025.07.013

L.S. Klunder , B.B.J. Merema , A.Z. Matthews-Brzozowski , J. Jansma , S.E.C. Pichardo , J. Kraeima , J.M. Alberga

{"title":"3D virtual surgical planning in patients with bilateral cleft lip and palate undergoing premaxilla osteotomy combined with secondary alveolar bone grafting: a retrospective accuracy analysis","authors":"L.S. Klunder , B.B.J. Merema , A.Z. Matthews-Brzozowski , J. Jansma , S.E.C. Pichardo , J. Kraeima , J.M. Alberga","doi":"10.1016/j.jcms.2025.07.013","DOIUrl":"10.1016/j.jcms.2025.07.013","url":null,"abstract":"<div><div>This retrospective study evaluates the surgical accuracy of 3D virtual planning and the use of computer-aided design/computer-aided manufacturing splints in premaxillary osteotomy combined with secondary alveolar bone grafting.</div><div>The study included all consecutive patients with bilateral cleft lip and palate undergoing a premaxillary osteotomy with secondary alveolar bone grafting treated by the Cleft Team North (the Netherlands) between 2016 and 2023. 3D virtual surgical planning was based on cone beam computed tomography scans and intraoral scans or plaster models. Surgical accuracy was assessed by comparing the planned and postoperative images of the premaxilla through three linear and three angular measurements. Eleven patients were included (mean age: 9.8 years). The mean Euclidean distance between the planned and postoperative outcomes was 1.57 ± 0.79 mm. Linear measurements showed mean differences of 0.74 ± 0.76 mm medio-laterally, 0.65 ± 0.53 mm caudo-cranially, and 0.89 ± 0.70 mm anteroposteriorly. Angular differences were 6.66 ± 5.12° for pitch, 5.09 ± 5.14° for yaw, and 4.61 ± 5.05° for roll. The intra-observer variability was 0.85 ± 0.58 mm and the intraclass correlation coefficient 0.99.</div><div>High surgical accuracy can be achieved using 3D virtual surgical planning and computer-aided design/computer-aided manufacturing splints in premaxillary osteotomy combined with secondary alveolar bone grafting.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 10","pages":"Pages 1904-1910"},"PeriodicalIF":2.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameloblastoma: The association of BRAF V600E expression with clinicopathological characteristics and treatment outcomes in a case series 成釉细胞瘤：BRAF V600E表达与临床病理特征和治疗结果的关系

IF 2.1 2区医学

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-08-22 DOI: 10.1016/j.jcms.2025.08.010

S. Crimi , S. Battaglia , R. Giudice , V. Ronsivalle , M. Cicciù , A. Bianchi

{"title":"Ameloblastoma: The association of BRAF V600E expression with clinicopathological characteristics and treatment outcomes in a case series","authors":"S. Crimi , S. Battaglia , R. Giudice , V. Ronsivalle , M. Cicciù , A. Bianchi","doi":"10.1016/j.jcms.2025.08.010","DOIUrl":"10.1016/j.jcms.2025.08.010","url":null,"abstract":"<div><h3>Objectives</h3><div>Ameloblastoma is a benign tumor with clinical significance due to its high incidence as well as high recurrence rate after surgical enucleation. Notably BRAF V600E pathogenic mutations have been reported in high rate of ameloblastoma. The aim of this study was investigating the association of BRAF V600E expression with clinicopathological characteristics, treatment outcomes and recurrence rates.</div></div><div><h3>Material and methods</h3><div>We have analyzed 10 patients with ameloblastoma followed by a three-year evaluation, to understand the pathogenesis and molecular mechanism underlying the tumorigenic. All samples were tested for genomic DNA to identify Esone 15 mutations (codon 600) by PCR and perkiness on rotorgene Q and Pyromark Q24, by the Pathological Anatomy Department.</div></div><div><h3>Results</h3><div>Positive BRAF V600E mutation was detected in 4 of the 10 ameloblastoma cases. Three of the patients with BRAF V600E mutation had a recurrence within 3 years from the first surgery. The fourth patient with mutation showed no signs of relapse during followup. In only one BRAF- patient we showed recurrence of disease, 14 years after the last surgery. Another significant finding from the study is the correlation between the presence of the mutation and the initial size of the lesion.</div></div><div><h3>Conclusions</h3><div>Ameloblastoma with BRAF V600E mutation has been observed with a higher recurrence rate and an increased initial volume of the lesion. The results obtained demonstrate an increased aggressiveness and invasiveness of BRAF + ameloblastomas.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 10","pages":"Pages 1911-1915"},"PeriodicalIF":2.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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