Journal of Heredity最新文献_第5页

Extreme male reproductive skew limits effective population size in American Standardbred horses. 极端的雄性生殖倾斜限制了美国标准种马的有效种群规模。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-08-13 DOI: 10.1093/jhered/esag062

Robin S Waples, Anas M Khanshour, E G Cothran

{"title":"Extreme male reproductive skew limits effective population size in American Standardbred horses.","authors":"Robin S Waples, Anas M Khanshour, E G Cothran","doi":"10.1093/jhered/esag062","DOIUrl":"https://doi.org/10.1093/jhered/esag062","url":null,"abstract":"Standardbred horses are widely used for harness racing in North America, Europe, Australia, and New Zealand. In the U.S., two gaits (Pacers and Trotters) are genetically differentiated at a level typical for different horse breeds. We used the complete pedigree for all registered American Standardbred foals born 1970-2014 (>200 K Trotters and > 500 K Pacers) to calculate annual and lifetime reproductive skew and its consequences for the effective number of breeders per year (Nb) and effective size per generation (Ne). With rare exceptions, females can only produce 0 or 1 foal per year, which limits annual and lifetime variance in offspring number. These constraints do not apply to males: with humans (rather than horses) deciding who breeds with whom, and how often, the most prolific stud regularly sires well over 100 foals each year and often over 1000 across its lifetime. Male reproductive skew increased over time in both gaits, with the most prolific studs producing 20% or more of all foals sired by members of their birth cohort. Although each gait in the U.S. is represented by tens of thousands of adult horses at any given time, male Ne is typically in the low hundreds, which drives the overall Ne/N ratio to or below 0.01-a value often considered to be \"tiny.\" Ne/N ratios this low have rarely been reported for large mammals and generally are thought to apply primarily to some marine species with very high fecundity. When Ne/N is this low, even large populations can experience substantial erosion of genetic diversity.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A chromosome scale reference genome of an arid adapted ungulate, Gazella subgutturosa. 干旱适应有蹄类Gazella subgutturrosa的染色体尺度参考基因组。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-08-13 DOI: 10.1093/jhered/esag064

Chao Yan, Qing-Gang Wei, Shamshidin Abduriyim

{"title":"A chromosome scale reference genome of an arid adapted ungulate, Gazella subgutturosa.","authors":"Chao Yan, Qing-Gang Wei, Shamshidin Abduriyim","doi":"10.1093/jhered/esag064","DOIUrl":"https://doi.org/10.1093/jhered/esag064","url":null,"abstract":"The goitered gazelle, Gazella subgutturosa, is a conservation priority globally, one of the important ungulates in the arid and semiarid ecosystem. We produced Illumina short reads, PacBio HiFi long reads and Hi-C sequencing data of a road-killed male individual of this species to assemble whole genome at the chromosome level. Consequently, the assembly is a 3.13 Gb in size, consisting of 16 pseudochromosomes (14 autosomes + X chromosome + partial Y chromosome), with a scaffold N50 length of 186.56Mb. The quality value and Benchmarking Universal Single-Copy Ortholog score were 47.6 and 99.3%, respectively, indicating that our genomes sequence is of high quality and completeness. A total of 20,896 protein-coding genes were predicted in the genome, with an average gene length of 38,012 bp and an average coding sequence length of 1,291 bp. Comparison with other Bovidae genome revealed that each of the pseudochromosome of G. subgutturosa corresponds to two chromosomes of Bovidae species, suggesting multiple whole chromosome fusions. Notably, the X chromosome corresponds to a fusion of the Bos taurus X chromosome and BTA5, consistent with a known X-autosomal translocation in the tribe Antilopini. However, the underlying molecular mechanism of this chromosome fusion has yet to be elucidated in future studies. In summary, the whole genome generated provides a high-quality reference for conservation genomics and genome evolution studies of Gazella species, especially of G. subgutturosa.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VAGILITY IN AN EPHEMERAL HABITAT SPECIALIST EXPLAINS PANMIXIA: A RECENT RANGE EXPANSION AND RETRACTION DO NOT. 在一个短暂的栖息地专家解释了混乱：最近的范围扩张和收缩不是。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-08-06 DOI: 10.1093/jhered/esag061

Amie E Settlecowski, Brant C Faircloth, Jeremy M Brown, James A Cox, Sabrina S Taylor

{"title":"VAGILITY IN AN EPHEMERAL HABITAT SPECIALIST EXPLAINS PANMIXIA: A RECENT RANGE EXPANSION AND RETRACTION DO NOT.","authors":"Amie E Settlecowski, Brant C Faircloth, Jeremy M Brown, James A Cox, Sabrina S Taylor","doi":"10.1093/jhered/esag061","DOIUrl":"https://doi.org/10.1093/jhered/esag061","url":null,"abstract":"Use of ephemeral habitats may lead to high vagility and an increase in gene flow and panmixia across a species' range. Range expansions associated with habitat alterations may also spur connectivity among previously isolated habitats and reduce genetic diversity at the colonization front. A century and a half of historical and modern single nucleotide polymorphism (SNP) data for Bachman's Sparrow (Peucaea aestivalis) demonstrate that panmixia is characteristic of this ephemeral habitat specialist, not a byproduct of a recent range expansion or retraction. Furthermore, high vagility has apparently dampened expected genetic signatures at the colonization front where no consistent signal of lower genetic diversity was observed in the extralimital region compared to other regions during expansion or retraction. Overall, our data support an emerging pattern of limited genetic structure for a species associated with ephemeral habitats, for which high vagility may have evolved to help individuals locate transient habitat across large spatial scales. Nevertheless, extensive habitat loss and fragmentation in recent decades have begun to influence genetic variation in P. aestivalis with small but significant increases in genetic structure. If this exceptionally vagile ephemeral habitat specialist is unable to reach remaining isolated habitat fragments, it is likely that barriers to its dispersal are limiting gene flow in other species, even those thought to be capable of traversing long distances.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing genetic diversity and population structure of gray fox (Urocyon cinereoargenteus) in the eastern U.S. using 2bRAD sequencing data. 利用2bRAD测序数据分析美国东部灰狐（Urocyon cinereogenteus）的遗传多样性和种群结构。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-07-31 DOI: 10.1093/jhered/esag060

Adam L Koller, Jesús E Maldonado, William R Clark, Jeff Beringer, Geriann Albers, Tim L Hiller, Dawn M Reding

{"title":"Characterizing genetic diversity and population structure of gray fox (Urocyon cinereoargenteus) in the eastern U.S. using 2bRAD sequencing data.","authors":"Adam L Koller, Jesús E Maldonado, William R Clark, Jeff Beringer, Geriann Albers, Tim L Hiller, Dawn M Reding","doi":"10.1093/jhered/esag060","DOIUrl":"https://doi.org/10.1093/jhered/esag060","url":null,"abstract":"Concerns about declining gray fox (Urocyon cinereoargenteus) populations in the Midwest, USA, prompted a petition to list the prairie gray fox subspecies (U. c. ocythous) under the U.S. Endangered Species Act. Although previous studies identified a deep phylogenetic break between eastern and western lineages of the gray fox at the Great Plains Suture Zone, population structure within the Midwest remains poorly understood, complicating subspecies classification. To address this, we genotyped 339 individuals from the eastern lineage of the gray fox using SNPs generated from 2bRAD genomic sequencing to assess genetic diversity and structure. Bayesian clustering and PCA supported three genetic clusters (K = 3), revealing a cryptic break within Missouri that subdivides the morphologically defined range of U. c. ocythous and a secondary break coinciding with the Mississippi River and the currently accepted subspecies boundary. However, low pairwise FST values and admixture indicate weak overall genetic differentiation with ongoing gene flow, whereas declining genetic diversity at northern latitudes is reflective of founder effects from post-glacial population expansion. Consistent with prior mtDNA results, nuclear SNP data suggest that U. c. ocythous and U. c. cinereoargenteus are unlikely to represent distinct evolutionary units. However, because 2bRAD detects primarily neutral variation, whole-genome sequencing will be needed to test for adaptive divergence that might persist despite gene flow. Our findings provide an important step toward a comprehensive understanding of population structure and refining subspecies boundaries within the eastern lineage of the gray fox.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Jinsha-Yalong River Divide: A Core Floristic Boundary Shaping Asymmetric Nuclear-Chloroplast Genetic Differentiation in Allium macranthum. 金沙-雅砻江分水岭：形成葱核-叶绿体不对称遗传分化的核心区系边界。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-07-26 DOI: 10.1093/jhered/esag057

Hao Li, Chuan Xie, Binzhong Wang, Xingjin He, Dengfeng Xie

{"title":"The Jinsha-Yalong River Divide: A Core Floristic Boundary Shaping Asymmetric Nuclear-Chloroplast Genetic Differentiation in Allium macranthum.","authors":"Hao Li, Chuan Xie, Binzhong Wang, Xingjin He, Dengfeng Xie","doi":"10.1093/jhered/esag057","DOIUrl":"https://doi.org/10.1093/jhered/esag057","url":null,"abstract":"The hypothesis that mountain uplift creates riverine barriers to alpine plant gene flow is widely accepted in biogeography, yet how these barriers drive species genetic differentiation remains poorly understood. Here, we tested this hypothesis using Allium macranthum (section Bromatorrhiza), a diploid-tetraploid alpine herb endemic to southwest China with a core distribution in the Jinsha-Yalong River basin. We genotyped 280 individuals from 22 range-wide populations (including sympatric cytotypes) using nuclear ITS and two chloroplast (cpDNA) fragments (trnL-F and rps16). Population karyotypic characteristics were investigated, and population genetic structure, differentiation and divergence time were estimated, with biogeographical history investigated. Our results reveal striking asymmetric genetic diversity, with biparentally inherited ITS showed far higher haplotype diversity (Hd = 0.95) than cpDNA markers (trnL-F: Hd = 0.54; rps16: Hd = 0.48). Meanwhile, significant population differentiation were revealed, with three deeply divergent phylogenetic clades detected, which corresponding to different geographic regions: the internal Hengduan Mountains between the Jinsha and Yalong Rivers (I), the external Hengduan Mountains (E), and Qinling Mountains (Q). Karyotypic analyses demonstrated that A. macranthumis characterized by pronounced polyploidy (coexisting diploid and tetraploid forms), and the tetraploid populations exhibited a significantly high level of karyotype asymmetry.Divergent time estimation showed that the intraspecific differentiation of A. macranthum was approximate at 6.72-1.91 Ma, coinciding with the intense uplift of the HMR and formation of the Jinsha-Yalong drainage system. Our findings suggest that Early Pleistocene mountain building might promote river incision, expediting the differentiation of A. macranthum, while riverine barriers, ploidy variation, and reproductive shifts may have synergistically shaped the observed asymmetric differentiation.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A chromosome-level genome assembly of the bluethroat (Luscinia s. svecica; Linnaeus, 1758) uncovers the complex MHC region. 蓝喉鱼（Luscinia s.s ivecica; Linnaeus, 1758）的染色体水平基因组组装揭示了复杂的MHC区域。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-07-22 DOI: 10.1093/jhered/esag058

Marius A Strand, Emily L G Enevoldsen, Ole K Tørresen, Morten Skage, Giada Ferrari, Ave Tooming-Klunderud, Erica H Leder, Jan T Lifjeld, Arild Johnsen, Kjetill S Jakobsen

{"title":"A chromosome-level genome assembly of the bluethroat (Luscinia s. svecica; Linnaeus, 1758) uncovers the complex MHC region.","authors":"Marius A Strand, Emily L G Enevoldsen, Ole K Tørresen, Morten Skage, Giada Ferrari, Ave Tooming-Klunderud, Erica H Leder, Jan T Lifjeld, Arild Johnsen, Kjetill S Jakobsen","doi":"10.1093/jhered/esag058","DOIUrl":"https://doi.org/10.1093/jhered/esag058","url":null,"abstract":"We describe a chromosome-level, pseudo-haplotype-resolved genome assembly from a female bluethroat (Luscinia s. svecica). The assembly comprises two pseudo-haplotypes of 1461 Mb and 1171 Mb, with 77.4% and 88.4% scaffolded into 40 autosomal chromosomes and the W and Z sex chromosomes in pseudo-haplotype one. Assembly completeness is high (BUSCO 99.2% and 94.9%), with 22,462 and 18,769 annotated protein-coding genes for pseudo-haplotypes one and two, respectively. The use of Oxford Nanopore Technologies sequencing enables resolution of genomic regions that are often fragmented in genome assemblies, including the hypervariable Major Histocompatibility Complex (MHC). We find that MHC loci include both the canonical organization of tandemly duplicated MHCIIβ genes with a single MHCIIα, and a distinct arrangement in which MHCI and MHCIIβ loci are interspersed. Substantial structural differences between the two assembled chromosome 35 homologs are resolved across the MHC region.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A river runs through it: Causal graphs capture rivers' complex control on the genetic structure of populations. 一条河流穿过它：因果图捕捉到了河流对种群遗传结构的复杂控制。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-07-14 DOI: 10.1093/jhered/esag056

Garett L Maag, Austin R Biddy, Maya F Stokes, Greer A Dolby

{"title":"A river runs through it: Causal graphs capture rivers' complex control on the genetic structure of populations.","authors":"Garett L Maag, Austin R Biddy, Maya F Stokes, Greer A Dolby","doi":"10.1093/jhered/esag056","DOIUrl":"https://doi.org/10.1093/jhered/esag056","url":null,"abstract":"Earth's physiographic features shape the genetic evolution of organisms, but understanding how such features act as barriers to gene flow requires quantifying characteristics of both the barrier and the organism. Many barrier characteristics, however, are interdependent and not fully captured by traditional multivariate statistics. Here, we evaluate the use of directed acyclic (causal) graphs and structural equation modeling (SEM) to test the Riverine Barrier Hypothesis using 27 river-spanning population genomic datasets of terrestrial plants and animals associated with 24 rivers across the contiguous United States. These data were paired with seasonality, river width, and river discharge data. SEM analysis revealed patterns not captured by standard approaches. River width had a strong effect on population differentiation, with distinct direct and indirect effects for high and low dispersers. Results suggest a negative width-Fst relationship for low dispersers, which we interpret to be due to topographic context of higher elevation or bedrock-incised rivers. In contrast, high dispersers had a positive relationship, indicating wider rivers present a greater barrier to dispersal. The total effect of river discharge was negligible because its direct effects on population differentiation were canceled out by indirect effects on other river features. Overall, the best-fitting SEM explained 52% of population differentiation for low dispersers and 13% for high dispersers, consistent with the idea that high-dispersing species are less impacted from river barrier effects. This proof of concept shows the utility of causal graphs and SEM at modeling complex relationships between Earth's physiographic features and the organisms that evolve with them.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosome-level genome assemblies of Southern pygmy perch (Nannoperca australis) and Yarra pygmy perch (N. obscura) reveal several miniaturization genes. 南方侏儒鲈（Nannoperca australis）和亚拉侏儒鲈（N. obscura）的染色体水平基因组组装揭示了几个小型化基因。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-07-10 DOI: 10.1093/jhered/esag054

Jonathan Sandoval-Castillo, Luciano B Beheregaray

{"title":"Chromosome-level genome assemblies of Southern pygmy perch (Nannoperca australis) and Yarra pygmy perch (N. obscura) reveal several miniaturization genes.","authors":"Jonathan Sandoval-Castillo, Luciano B Beheregaray","doi":"10.1093/jhered/esag054","DOIUrl":"https://doi.org/10.1093/jhered/esag054","url":null,"abstract":"Freshwater biodiversity is declining at alarming rates, and the biological characteristics of small freshwater fishes make them particularly vulnerable to habitat degradation and fragmentation. Pygmy perches are small Australian fishes whose populations have recently undergone rapid declines due to human-induced pressures. They also exhibit paedomorphic miniaturization, an evolutionary phenomenon whose consequences for the persistence and diversification of freshwater fishes remain unclear. Genomic resources for pygmy perches would significantly enhance both conservation efforts and evolutionary research. Here, we describe chromosome-level genome assemblies for the Southern Pygmy Perch (Nannoperca australis) and the Yarra Pygmy Perch (N. obscura). We provide evidence for high synteny among percichthyid genomes and for positive selection on size- and growth-related genes in the pygmy perch lineage. The N. australis and N. obscura assemblies are 675.7 and 653.9 Mbp in length, with scaffold N50 values of 26.98 and 26.22 Mbp, respectively. Each assembly comprises 24 pseudo-chromosomes and 890 or 1,476 contigs, with repeat contents of 22.3% and 28.1%. We predicted 26,390 and 24,654 protein-coding genes, and BUSCO completeness scores for Teleostei genes were 96.9% and 96.5%, respectively for N. australis and N. obscura. Their genomes are comparable in quality to the best currently available percichthyid assemblies. These genomic resources will support conservation management efforts and provide a foundation for comparative studies on the adaptive significance of miniaturization.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triploidy in a pair of hybridizing salamanders at the far end of the speciation continuum. 在物种形成连续体的远端一对杂交蝾螈的三倍体。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-07-02 DOI: 10.1093/jhered/esag006

Jan W Arntzen, Evan McCartney-Melstad, Spartak N Litvinchuk, Ben Wielstra

{"title":"Triploidy in a pair of hybridizing salamanders at the far end of the speciation continuum.","authors":"Jan W Arntzen, Evan McCartney-Melstad, Spartak N Litvinchuk, Ben Wielstra","doi":"10.1093/jhered/esag006","DOIUrl":"10.1093/jhered/esag006","url":null,"abstract":"Ecological and genetic interactions of species at the far end of the speciation continuum can often be studied in sympatry. Triturus cristatus (C) and Triturus marmoratus (M) are two deeply differentiated yet hybridizing salamander species that engage in a mosaic distribution over a wide zone of range overlap in the west of France. Interspecies hybrids are easy to distinguish from both parentals and occur at ca. 3% of the total breeding population. Most hybrids are thought to be F1 diploids (CM). We aim to identify triploid F1 hybrids with single nucleotide polymorphism (SNP) data and determine their frequency. Special attention to the genus Triturus is warranted because triploidy might in principle constitute an escape route to the enigmatic chromosome-1 syndrome that constitutes a long-term 50% genetic load. Species-specific signals for a panel of 30 SNPs, analyzed with metric multidimensional scaling, suggest that triploid frequency is one out of 26 (3.8%), although a frequency of 18% was found in a larger sampling (n = 100) that paid particular attention to aberrant hybrid phenotypes. Triploids with a CMM genetic configuration appear more frequent than the CCM counterpart. The triploid status could be confirmed for two CMM females, either by target capture or cellular morphometric data. One of these two triploid individuals relocated in the field showed a hybrid phenotype leaning towards T. marmoratus, an exceptional life span (17+ yrs), length (187 mm) and the frequent skipping of annual breeding opportunities. Future research on the T. cristatus-T. marmoratus system should consider the different classes of interspecies hybrids.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":"730-739"},"PeriodicalIF":2.2,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13326410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A chromosome-level genome of the lethal tapeworm Sparganum proliferum, with candidate genomic safe harbours for functional genetics. 致命绦虫增殖丝粒绦虫的染色体水平基因组，功能遗传学候选基因组安全港。

IF 2.2 2区生物学

Journal of Heredity Pub Date : 2026-07-02 DOI: 10.1093/jhered/esaf104

Atsushi Hikima, Simo Sun, Tetsuya Okino, Kensei Kinoshita, Akemi Yoshida, Yasunobu Maeda, Kenji Ishiwata, Hirotaka Kanuka, Taisei Kikuchi

{"title":"A chromosome-level genome of the lethal tapeworm Sparganum proliferum, with candidate genomic safe harbours for functional genetics.","authors":"Atsushi Hikima, Simo Sun, Tetsuya Okino, Kensei Kinoshita, Akemi Yoshida, Yasunobu Maeda, Kenji Ishiwata, Hirotaka Kanuka, Taisei Kikuchi","doi":"10.1093/jhered/esaf104","DOIUrl":"10.1093/jhered/esaf104","url":null,"abstract":"Sparganum proliferum is an enigmatic, highly proliferative cestode that causes fatal sparganosis. We present a 681 Mb chromosome-level genome assembled from Oxford Nanopore, PacBio HiFi, Illumina, and Hi-C data, yielding nine chromosome-length scaffolds consistent with 2n = 18. The assembly exhibits strong intra-chromosomal Hi-C contact signals and a repeat content of 55.8%, dominated by LINEs. We annotated 29 231 protein-coding genes, including 6316 transposable element-associated loci, with BUSCO completeness scores of 91% (eukaryota_odb10) and 73% (metazoa_odb10). Macrosynteny is well conserved with Echinococcus granulosus and Hymenolepis microstoma, moderately conserved with the trematode Schistosoma mansoni, but largely disrupted in the free-living flatworm Schmidtea mediterranea, revealing lineage-specific genome reorganization among flatworms. To enable functional genetics, we identified candidate genomic safe harbours-intergenic loci within transcriptionally active neighborhoods, separated from adjacent genes by 2-10 kb gene-free buffers, flanked by convergently oriented genes, and containing CRISPR/Cas9 PAM motifs (NGG)-and compiled housekeeping promoters for stable transgene expression. Together, these resources provide a reference framework for chromosome evolution and parasitic adaptation in Diphyllobothriidea and establish practical entry points for CRISPR-based functional studies in cestodes.","PeriodicalId":54811,"journal":{"name":"Journal of Heredity","volume":" ","pages":"927-934"},"PeriodicalIF":2.2,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0