Nutrition Research Reviews最新文献

The impact of whey protein on plasma branched-chain amino acids and glycaemic control in humans. A narrative review. 乳清蛋白对人血浆支链氨基酸和血糖控制的影响。叙述性评论

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-07-10 DOI: 10.1017/S0954422425100140

Hannah L Bell, Kim G Jackson, Les A Crompton, David I Givens, Julie A Lovegrove

{"title":"The impact of whey protein on plasma branched-chain amino acids and glycaemic control in humans. A narrative review.","authors":"Hannah L Bell, Kim G Jackson, Les A Crompton, David I Givens, Julie A Lovegrove","doi":"10.1017/S0954422425100140","DOIUrl":"https://doi.org/10.1017/S0954422425100140","url":null,"abstract":"Impaired glycaemic control is a major risk factor for developing type 2 diabetes (T2D), a worldwide health epidemic intrinsically linked to diet and obesity. Whey proteins (WP) are increasingly popular supplements that are a rich source of branched-chain amino acids (BCAA), essential for muscle protein synthesis and metabolic regulation. In humans, fasting plasma concentrations of BCAA are maintained around 350 µM but become chronically elevated by 10-25% in persons with T2D. Little is known about whether BCAA from WP impacts circulating BCAA concentrations and contributes to this phenomenon. This narrative review used a systematic search approach with relevant keywords to identify evidence from randomised controlled trials in normoglycaemic humans and those with insulin resistance or T2D, on the effects of WP intake on plasma BCAA and glycaemic control. This review is, to the authors' knowledge, the first to specifically examine the effects of WP intake on plasma BCAA concentrations in relation to glycaemic control. Whilst the majority of acute studies identified (n=6) reported that WP consumption between 10 to 50 g significantly elevates postprandial BCAA and insulin responses (as evidenced by peak concentration and/or area under the curve), evidence from chronic studies (n=3) report inconsistent findings on the impact of 9 to 51g of WP per day on fasting BCAA and glycaemic control (e.g., fasting glucose and insulin, insulin clearance). Findings from this literature review highlight the need for further studies that investigate the relationship between WP consumption with BCAA and glycaemic control, and to determine underlying mechanisms of action.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-35"},"PeriodicalIF":5.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manganese in health and disease. 锰在健康和疾病。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-17 DOI: 10.1017/S0954422425100139

Yingchen Wang, Jinyou Li, Jing Zhuang, Yinhang Wu, Jiang Liu, Shuwen Han

引用次数: 0

From plant to brain: flavonoids in the management of obesity-associated cognitive dysfunction. 从植物到大脑：黄酮类化合物在肥胖相关认知功能障碍管理中的作用。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-13 DOI: 10.1017/S0954422425100085

Patrícia Berilli, Paulo Roberto de Araujo Berni, Laís Zandoná, Levi Nascimento Bellinazzi, Mario Roberto Maróstica Junior

{"title":"From plant to brain: flavonoids in the management of obesity-associated cognitive dysfunction.","authors":"Patrícia Berilli, Paulo Roberto de Araujo Berni, Laís Zandoná, Levi Nascimento Bellinazzi, Mario Roberto Maróstica Junior","doi":"10.1017/S0954422425100085","DOIUrl":"10.1017/S0954422425100085","url":null,"abstract":"Obesity pathophysiological conditions and obesogenic diet compounds may influence brain function and structure and, ultimately, cognitive processes. Animal models of diet-induced obesity suggest that long-term dietary high fat and/or high sugar may compromise cognitive performance through concomitant peripheral and central disturbances. Some indicated mechanisms underlying this relationship are discussed here: adiposity, dyslipidaemia, inflammatory and oxidative status, insulin resistance, hormonal imbalance, altered gut microbiota and integrity, blood–brain barrier dysfunction, apoptosis/autophagy dysregulation, mitochondrial dysfunction, vascular disturbances, cerebral protein aggregates, impaired neuroplasticity, abnormal neuronal network activity and neuronal loss. Mechanistic insights are vital for identifying potential preventive and therapeutic targets. In this sense, flavonoids have gained attention due to their abundant presence in vegetable and other natural sources, their comparatively negligible adverse effects and their capacity to cross the blood–brain barrier promptly. In recent years, interventions with flavonoid sources have proven to be efficient in restoring cognitive impairment related to obesity. Its modulatory effects occur directly and indirectly into the brain, and three fronts of action are highlighted here: (1) restoring physiological processes altered in obesity; (2) promoting additional neuroprotection to the endogenous system; and (3) improving neuroplasticity mechanisms that improve cognitive performance itself. Therefore, flavonoid consumption is a promising alternative tool for managing brain health and obesity-related cognitive impairment.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-25"},"PeriodicalIF":5.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals. 探索对伴侣动物补充omega-3的功效和最佳剂量。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-11 DOI: 10.1017/S0954422425100115

Thiago H A Vendramini, Pedro H Marchi, Rodrigo F G Olivindo, Vivian Pedrinelli, Andressa R Amaral, Mariana S de Miranda, Leonardo A Príncipe, Cinthia G L Cesar, Rafael V A Zafalon, Mariana P Perini, Laís O C Lima, Júlio C C Balieiro, Marcio A Brunetto

{"title":"Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals.","authors":"Thiago H A Vendramini, Pedro H Marchi, Rodrigo F G Olivindo, Vivian Pedrinelli, Andressa R Amaral, Mariana S de Miranda, Leonardo A Príncipe, Cinthia G L Cesar, Rafael V A Zafalon, Mariana P Perini, Laís O C Lima, Júlio C C Balieiro, Marcio A Brunetto","doi":"10.1017/S0954422425100115","DOIUrl":"https://doi.org/10.1017/S0954422425100115","url":null,"abstract":"This review summarizes findings from studies in companion animals with chronic diseases receiving omega-3 supplementation. Investigated conditions included dermatopathies (dogs n=7), osteoarthritis (dogs n=7, cats n=2), cardiovascular diseases (dogs n=7), dyslipidaemias (dogs n=1), gastroenteropathies (dogs n=2), chronic kidney disease (dogs n=2, cats n=3), cognitive impairment (dogs n=4, cats n=1), and behavioural disorders (dogs n=3). When possible, dosages were standardized to mg/kg using available data on food intake and EPA/DHA concentrations. The minimum and maximum ranges of EPA and DHA, along with their ratios, were as follows: for dermatology 0.99-43 mg/kg EPA and 0.66-30 mg/kg DHA (ratio 1.4-3.4); for osteoarthritis 48-100 mg/kg EPA and 20-32 mg/kg DHA (ratio 1.5-3.4); cardiology 27-54.2 mg/kg EPA and 18-40.6 mg/kg DHA (ratio 1.3-1.5); dyslipidaemia 58.8 mg/kg EPA and 45.4 mg/kg DHA (ratio 1.3); cognition (1/5 studies) 225 mg/kg EPA and 90 mg/kg DHA (ratio 2.5); behaviour (1/3) 31 mg/kg EPA and 45 mg/kg DHA (ratio 0.7). Nephrology and oncology studies lacked sufficient data for calculation. Gastrointestinal diseases do not appear to benefit from omega-3 supplementation, likely due to inflammation-related malabsorption, although few adverse effects were reported in dogs. Other enteropathy studies were low-quality (case reports/series). The lowest omega-6/omega-3 ratio with anti-inflammatory effect was 1:3.75; the highest was 5.5:1. In conclusion, the reviewed EPA and DHA doses appear effective for atopic dermatitis, osteoarthritis, cardiac disease, hyperlipidaemia, and cognitive and behavioural disorders. Further research is needed to clarify efficacy in gastrointestinal and oncological conditions.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-47"},"PeriodicalIF":5.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What diet to recommend before pregnancy to reduce the risk of gestational diabetes and during pregnancy to affect its course and improve perinatal outcomes? A review of the current evidence. 怀孕前推荐什么饮食来降低妊娠糖尿病的风险，怀孕期间推荐什么饮食来影响其病程并改善围产期结局？对现有证据的回顾。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-03 DOI: 10.1017/S0954422425100103

Janusz Krzymien, Dariusz Wlodarek, Piotr Ladyzynski

{"title":"What diet to recommend before pregnancy to reduce the risk of gestational diabetes and during pregnancy to affect its course and improve perinatal outcomes? A review of the current evidence.","authors":"Janusz Krzymien, Dariusz Wlodarek, Piotr Ladyzynski","doi":"10.1017/S0954422425100103","DOIUrl":"10.1017/S0954422425100103","url":null,"abstract":"Several dietary strategies are designed to achieve optimal glycaemic control in managing gestational diabetes mellitus (GDM), considering factors such as energy needs, the glycaemic index, high fibre content and the reduction or exclusion of sugary foods and drinks. However, in achieving therapeutic goals, there is a lack of consensus in the formulation of uniform recommendations. This article reviews the literature to assess the impact of dietary interventions on GDM risk - measured by the percentage of at-risk women who develop GDM - and on the progression of GDM pregnancies, including weight gain, hyperglycaemia severity, insulin requirements and perinatal outcomes such as macrosomia, hypertensive disorders, caesarean delivery and neonatal size. We conducted a thorough search of PubMed and the Cochrane Library, focusing on randomised controlled trials, cohort studies, systematic reviews and meta-analyses involving women either at risk of or diagnosed with GDM. These search criteria yielded 2800 articles, whose titles and abstracts were reviewed to determine their relevance to the research objective. In the initial search, 192 relevant articles met the inclusion criteria. The comprehensive analysis of these studies highlights the current uncertainty regarding the long-term consequences of recommended diets during pregnancy, especially among women with GDM. While the available literature is substantial, conclusions drawn from various methodologies and study populations have not yielded a consensus on the most effective diet for reducing perinatal complications. Nonetheless, it is reasonable to advocate for the early initiation of dietary interventions, particularly during pregnancy planning, especially among women exhibiting risk factors for GDM.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-18"},"PeriodicalIF":5.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable and available sources of omega-3 fatty acids for health: are the current dietary recommendations, food sources and legislation fit for purpose? 可持续和可用的omega-3脂肪酸来源对健康：目前的饮食建议、食物来源和立法是否符合目的？

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-03 DOI: 10.1017/S0954422425100127

Eva Lewis, Simon Steenson, Richard P Haslam, Emma McDonald, Matthew Sharman, Maria Traka, Alice Stanton, Johnathan A Napier, Anna Sweeting, Rasha N M Saleh, Michael Hornberger, Ian Givens, Philip C Calder, Anne M Minihane

{"title":"Sustainable and available sources of omega-3 fatty acids for health: are the current dietary recommendations, food sources and legislation fit for purpose?","authors":"Eva Lewis, Simon Steenson, Richard P Haslam, Emma McDonald, Matthew Sharman, Maria Traka, Alice Stanton, Johnathan A Napier, Anna Sweeting, Rasha N M Saleh, Michael Hornberger, Ian Givens, Philip C Calder, Anne M Minihane","doi":"10.1017/S0954422425100127","DOIUrl":"10.1017/S0954422425100127","url":null,"abstract":"The health benefits of the long-chain omega-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been known for over 50 years and underpin the UK population recommendation to consume >450 mg EPA + DHA per day. These recommendations, last revised in 2004, are based mainly on epidemiological evidence. Much research has been conducted in the interim. Most randomised controlled trials (RCT) use doses of EPA + DHA of 840 mg/d or more. For anti-inflammatory, triacylglycerol-lowering and anti-hypertensive effects, >1.5 g EPA + DHA per day is needed. Cognitive benefits are also likely to require these higher intakes. Farmed salmon now contains considerably less EPA + DHA relative to farmed fish of 20 years ago, meaning one portion per week will no longer provide the equivalent of 450 mg EPA + DHA per day. Oily fish alone can only provide a fraction of the EPA + DHA required to meet global needs. Furthermore, there is low global oily fish consumption, with typical intakes of <200 mg EPA + DHA per day, and limited intakes in vegans and vegetarians. Therefore, there is an urgent need for affordable, acceptable, alternative EPA + DHA sources, including vegan/vegetarian friendly options, such as bio-enriched poultry, red meat and milk products; fortified foods; enriched oilseeds (for example, genetically modified Camelina sativa); algae and algal oils; and approaches which enhance endogenous EPA/DHA synthesis. In this narrative review, we suggest that current EPA + DHA intake recommendations are too low, consider EPA/DHA from a holistic health-sustainability perspective and identify research, policy and knowledge mobilisation areas which need attention.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-16"},"PeriodicalIF":5.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep deprivation in development of obesity, effects on appetite regulation, energy metabolism, and dietary choices. 睡眠不足与肥胖的发展、对食欲调节、能量代谢和饮食选择的影响。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2023-10-31 DOI: 10.1017/S0954422423000264

Masoumeh Akhlaghi, Ali Kohanmoo

{"title":"Sleep deprivation in development of obesity, effects on appetite regulation, energy metabolism, and dietary choices.","authors":"Masoumeh Akhlaghi, Ali Kohanmoo","doi":"10.1017/S0954422423000264","DOIUrl":"10.1017/S0954422423000264","url":null,"abstract":"Sleep deprivation, which is a decrease in duration and quality of sleep, is a common problem in today's life. Epidemiological and interventional investigations have suggested a link between sleep deprivation and overweight/obesity. Sleep deprivation affects homeostatic and non-homoeostatic regulation of appetite, with the food reward system playing a dominant role. Factors such as sex and weight status affect this regulation; men and individuals with excess weight seem to be more sensitive to reward-driven and hedonistic regulation of food intake. Sleep deprivation may also affect weight through affecting physical activity and energy expenditure. In addition, sleep deprivation influences food selection and eating behaviours, which are mainly managed by the food reward system. Sleep-deprived individuals mostly crave for palatable energy-dense foods and have low desire for fruit and vegetables. Consumption of meals may not change but energy intake from snacks increases. The individuals have more desire for snacks with high sugar and saturated fat content. The relationship between sleep and the diet is mutual, implying that diet and eating behaviours also affect sleep duration and quality. Consuming healthy diets containing fruit and vegetables and food sources of protein and unsaturated fats and low quantities of saturated fat and sugar may be used as a diet strategy to improve sleep. Since the effects of sleep deficiency differ between animals and humans, only evidence from human subject studies has been included, controversies are discussed and the need for future investigations is highlighted.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"4-24"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional considerations in major depressive disorder: current evidence and functional testing for clinical practice. 重度抑郁障碍的营养考虑:临床实践的现有证据和功能测试。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2023-11-15 DOI: 10.1017/S0954422423000276

Kathryn Khiroya, Eric Sekyere, Bradley McEwen, Jessica Bayes

{"title":"Nutritional considerations in major depressive disorder: current evidence and functional testing for clinical practice.","authors":"Kathryn Khiroya, Eric Sekyere, Bradley McEwen, Jessica Bayes","doi":"10.1017/S0954422423000276","DOIUrl":"10.1017/S0954422423000276","url":null,"abstract":"Depression is a multifaceted condition with diverse underlying causes. Several contributing and inter-related factors such as genetic, nutritional, neurological, physiological, gut-brain-axis, metabolic and psychological stress factors play a role in the pathophysiology of depression. This review aims to highlight the role that nutritional factors play in the aetiology of depression. Secondly, we discuss the biomedical and functional pathology tests which measure these factors, and the current evidence supporting their use. Lastly, we make recommendations on how practitioners can incorporate the latest evidence-based research findings into clinical practice. This review highlights that diet and nutrition greatly affect the pathophysiology of depression. Nutrients influence gene expression, with folate and vitamin B12 playing vital roles in methylation reactions and homocysteine regulation. Nutrients are also involved in the tryptophan/kynurenine pathway and the expression of brain-derived neurotrophic factor (BDNF). Additionally, diet influences the hypothalamic-pituitary-adrenal (HPA) response and the composition and diversity of the gut microbiome, both of which have been implicated in depression. A comprehensive dietary assessment, combined with appropriate evaluation of biochemistry and blood pathology, may help uncover contributing factors to depressive symptoms. By employing such an approach, a more targeted and personalised treatment strategy can be devised, ultimately leading to improved patient outcomes.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"25-36"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Military rations: Nutritional, sensorial and technological quality and their effects on military physical exercise in extreme environments. 军用口粮：营养、感官和技术质量及其对极端环境下军事体育锻炼的影响。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-09-26 DOI: 10.1017/S0954422424000246

Vitor Andre Silva Vidal, Ida-Johanne Jensen, Øyvind Sandbakk, Pål Haugnes, Martin Winge Austeen, Rune Gjeldnes, Birger Svihus, Jørgen Lerfall

{"title":"Military rations: Nutritional, sensorial and technological quality and their effects on military physical exercise in extreme environments.","authors":"Vitor Andre Silva Vidal, Ida-Johanne Jensen, Øyvind Sandbakk, Pål Haugnes, Martin Winge Austeen, Rune Gjeldnes, Birger Svihus, Jørgen Lerfall","doi":"10.1017/S0954422424000246","DOIUrl":"10.1017/S0954422424000246","url":null,"abstract":"In recent years, many countries have significantly increased military spending, mainly due to geopolitical instability in several regions and the potential risk of armed conflicts spreading worldwide. In this context, understanding the nutritional needs of soldiers in different climates (warm, cold and high altitude) is important and directly impacts the performance and health of soldiers, especially in extreme environments. The amount of liquids, calories, and macro- and micronutrients contained in military rations must be determined considering the type of exercise, duration and environment. Military rations, in addition to being nutritionally adequate, must be practical, sustainable and easy to consume at any temperature and situation. Given these considerations, this study aimed to review scientific knowledge regarding the convenience, sensory attributes and nutritional components of military rations. Furthermore, this review studied the factors influencing soldiers' appetite, gut microbiota and nutritional needs during training or combat in extreme environments (warm, cold and high altitude). This exploration further advances our understanding of contemporary nutritional strategies for military personnel, contributing to future research and highlighting areas that must be developed.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"324-337"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of nutritional factors in the aetiopathogenesis of myocardial fibrosis in great apes. 类人猿心肌纤维化发病机制中的营养因素概述。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-02-12 DOI: 10.1017/S0954422424000076

Laurens Van Mulders, Laurent Locquet, Christine Kaandorp, Geert P J Janssens

{"title":"An overview of nutritional factors in the aetiopathogenesis of myocardial fibrosis in great apes.","authors":"Laurens Van Mulders, Laurent Locquet, Christine Kaandorp, Geert P J Janssens","doi":"10.1017/S0954422424000076","DOIUrl":"10.1017/S0954422424000076","url":null,"abstract":"The main cause of mortality in great apes in zoological settings is cardiovascular disease (CVD), affecting all four taxa: chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla spp.) and orangutan (Pongo spp.). Myocardial fibrosis, the most typical histological characterisation of CVD in great apes, is non-specific, making it challenging to understand the aetiopathogenesis. A multifactorial origin of disease is assumed whereby many potential causative factors are directly or indirectly related to the diet, which in wild-living great apes mainly consists of high-fibre, low-carbohydrate and very low-sodium components. Diets of great apes housed in zoological settings are often different compared with the situation in the wild. Moreover, low circulating vitamin D levels have recently been recognised in great apes housed in more northern regions. Evaluation of current supplementation guidelines shows that, despite implementation of different dietary strategies, animals stay vitamin D insufficient. Therefore, recent hypotheses designate vitamin D deficiency as a potential underlying factor in the pathogenesis of myocardial fibrosis. The aim of this literature review is to: (i) examine important differences in nutritional factors between zoological and wild great ape populations; (ii) explain the potential detrimental effects of the highlighted dietary discrepancies on cardiovascular function in great apes; and (iii) elucidate specific nutrition-related pathophysiological mechanisms that may underlie the development of myocardial fibrosis. This information may contribute to understanding the aetiopathogenesis of myocardial fibrosis in great apes and pave the way for future clinical studies and a more preventive approach to great ape CVD management.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"37-52"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0