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Nutrition knowledge assessment tools for older adults and their carers: a scoping review. 老年人及其照顾者的营养知识评估工具:范围审查。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-12-01 Epub Date: 2021-10-21 DOI: 10.1017/S0954422421000330
Shuyan Chin, Raymond Wong, Vasant Hirani, Fiona O'Leary
{"title":"Nutrition knowledge assessment tools for older adults and their carers: a scoping review.","authors":"Shuyan Chin, Raymond Wong, Vasant Hirani, Fiona O'Leary","doi":"10.1017/S0954422421000330","DOIUrl":"10.1017/S0954422421000330","url":null,"abstract":"<p><p>Poor nutritional intake is common among older adults. Given that nutrition knowledge is an important determinant of eating behaviour and nutritional status, understanding areas of inadequate knowledge can guide educational interventions to reduce risk of nutritional deficiencies and promote healthy ageing. This review investigated tools assessing general nutritional knowledge of older adults and their carers. Following the Joanna Briggs for Scoping Reviews guidelines, 4 databases (MEDLINE, CINAHL, Global Health and Embase) and grey literature were searched. Studies of any type containing general nutrition knowledge assessment tools for older adults or their carers were included. In total, 6934 articles were identified, of which 24 met the eligibility criteria, and 23 unique nutrition knowledge assessment tools were included. Of these tools, 14 were original, 6 were modified from other tools and 3 used dietary-related responses from national dietary survey questions. 6 tools were developed for carers (mostly nurses) and 17 tools for older adults. Tools had between 4 and 110 items. The most common topics for general nutrition knowledge questions were related to nutrients and roles, food sources of nutrients, and diet-disease relationships. 8 tools were developed prior to 2000. Most studies did not specify or assess psychometric properties of the tool, with only 9 (38 %) and 6 (26 %) studies testing for reliability and validity, respectively, and only 1 tool was considered reliable. Additional research for the development of reliable and validated tools or the validation of existing tools to assess nutrition knowledge of older adults and their carers is needed across different healthcare settings.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"216-231"},"PeriodicalIF":5.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9305901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial dysfunction and epigenetics underlying the link between early-life nutrition and non-alcoholic fatty liver disease. 线粒体功能障碍和表观遗传学在早期营养和非酒精性脂肪肝疾病之间的联系。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-12-01 Epub Date: 2022-01-24 DOI: 10.1017/S0954422422000038
Anabela La Colla, Carolina Anahí Cámara, Sabrina Campisano, Andrea Nancy Chisari
{"title":"Mitochondrial dysfunction and epigenetics underlying the link between early-life nutrition and non-alcoholic fatty liver disease.","authors":"Anabela La Colla, Carolina Anahí Cámara, Sabrina Campisano, Andrea Nancy Chisari","doi":"10.1017/S0954422422000038","DOIUrl":"10.1017/S0954422422000038","url":null,"abstract":"<p><p>Early-life malnutrition plays a critical role in foetal development and predisposes to metabolic diseases later in life, according to the concept of 'developmental programming'. Different types of early nutritional imbalance, including undernutrition, overnutrition and micronutrient deficiency, have been related to long-term metabolic disorders. Accumulating evidence has demonstrated that disturbances in nutrition during the period of preconception, pregnancy and primary infancy can affect mitochondrial function and epigenetic mechanisms. Moreover, even though multiple mechanisms underlying non-alcoholic fatty liver disease (NAFLD) have been described, in the past years, special attention has been given to mitochondrial dysfunction and epigenetic alterations. Mitochondria play a key role in cellular metabolic functions. Dysfunctional mitochondria contribute to oxidative stress, insulin resistance and inflammation. Epigenetic mechanisms have been related to alterations in genes involved in lipid metabolism, fibrogenesis, inflammation and tumorigenesis. In accordance, studies have reported that mitochondrial dysfunction and epigenetics linked to early-life nutrition can be important contributing factors in the pathogenesis of NAFLD. In this review, we summarise the current understanding of the interplay between mitochondrial dysfunction, epigenetics and nutrition during early life, which is relevant to developmental programming of NAFLD.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"281-294"},"PeriodicalIF":5.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9113985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Carotenoid metabolites, their tissue and blood concentrations in humans and further bioactivity via retinoid receptor-mediated signalling. 类胡萝卜素代谢物,其在人体组织和血液中的浓度以及通过类视黄受体介导的信号传导进一步的生物活性。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-12-01 Epub Date: 2022-11-16 DOI: 10.1017/S095442242200021X
Torsten Bohn, Angel R de Lera, Jean-Francois Landrier, Ralph Rühl
{"title":"Carotenoid metabolites, their tissue and blood concentrations in humans and further bioactivity via retinoid receptor-mediated signalling.","authors":"Torsten Bohn, Angel R de Lera, Jean-Francois Landrier, Ralph Rühl","doi":"10.1017/S095442242200021X","DOIUrl":"10.1017/S095442242200021X","url":null,"abstract":"<p><p>Many epidemiological studies have emphasised the relation between carotenoid dietary intake and their circulating concentrations and beneficial health effects, such as lower risk of cardiometabolic diseases and cancer. However, there is dispute as to whether the attributed health benefits are due to native carotenoids or whether they are instead induced by their metabolites. Several categories of metabolites have been reported, most notably involving (a) modifications at the cyclohexenyl ring or the polyene chain, such as epoxides and geometric isomers, (b) excentric cleavage metabolites with alcohol-, aldehyde- or carboxylic acid-functional groups or (c) centric cleaved metabolites with additional hydroxyl, aldehyde or carboxyl functionalities, not counting their potential phase-II glucuronidated / sulphated derivatives. Of special interest are the apo-carotenoids, which originate in the intestine and other tissues from carotenoid cleavage by β-carotene oxygenases 1/2 in a symmetrical / non-symmetrical fashion. These are more water soluble and more electrophilic and, therefore, putative candidates for interactions with transcription factors such as NF-kB and Nrf2, as well as ligands for RAR-RXR nuclear receptor interactions. In this review, we discuss <i>in vivo</i> detected apo-carotenoids, their reported tissue concentrations, and potential associated health effects, focusing exclusively on the human situation and based on quantified / semi-quantified carotenoid metabolites proven to be present in humans.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"498-511"},"PeriodicalIF":5.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10351957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) from oral exposure into cow's milk - part II: toxicokinetic predictive models for risk assessment. 多氯二苯并对二恶英和二苯并呋喃(PCDD/Fs)和多氯联苯(PCBs)从口服接触转移到牛奶中——第二部分:用于风险评估的毒性动力学预测模型
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-12-01 Epub Date: 2022-11-08 DOI: 10.1017/S0954422422000208
Jan-Louis Moenning, Torsten Krause, Julika Lamp, Ronald Maul, Hans Schenkel, Peter Fürst, Robert Pieper, Jorge Numata
{"title":"Transfer of polychlorinated dibenzo-<i>p</i>-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) from oral exposure into cow's milk - part II: toxicokinetic predictive models for risk assessment.","authors":"Jan-Louis Moenning, Torsten Krause, Julika Lamp, Ronald Maul, Hans Schenkel, Peter Fürst, Robert Pieper, Jorge Numata","doi":"10.1017/S0954422422000208","DOIUrl":"10.1017/S0954422422000208","url":null,"abstract":"<p><p>Understanding the transfer of polychlorinated dibenzo-<i>p</i>-dioxins (PCDDs) and dibenzofurans (PCDFs) as well as polychlorinated biphenyls (PCBs) from oral exposure into cow's milk is not purely an experimental endeavour, as it has produced a large corpus of theoretical work. This work consists of a variety of predictive toxicokinetic models in the realms of health and environmental risk assessment and risk management. Their purpose is to provide mathematical predictive tools to organise and integrate knowledge on the absorption, distribution, metabolism and excretion processes. Toxicokinetic models are based on more than 50 years of transfer studies summarised in part I of this review series. Here in part II, several of these models are described and systematically classified with a focus on their applicability to risk analysis as well as their limitations. This part of the review highlights the opportunities and challenges along the way towards accurate, congener-specific predictive models applicable to changing animal breeds and husbandry conditions.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"484-497"},"PeriodicalIF":5.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10444370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current perspectives on global sugar consumption: definitions, recommendations, population intakes, challenges and future direction. 全球食糖消费现状:定义、建议、人口摄入量、挑战和未来方向。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2021-08-09 DOI: 10.1017/S095442242100024X
Janette Walton, Haley Bell, Roberta Re, Anne P Nugent
{"title":"Current perspectives on global sugar consumption: definitions, recommendations, population intakes, challenges and future direction.","authors":"Janette Walton, Haley Bell, Roberta Re, Anne P Nugent","doi":"10.1017/S095442242100024X","DOIUrl":"10.1017/S095442242100024X","url":null,"abstract":"<p><p>Currently, there is considerable emphasis on the relationship between dietary sugar consumption and various health outcomes, with some countries and regions implementing national sugar reduction campaigns. This has resulted in significant efforts to quantify dietary sugar intakes, to agree on terms to describe dietary sugars and to establish associated recommendations. However, this information is infrequently collated on a global basis and in a regularised manner. The present review provides context regarding sugar definitions and recommendations. It provides a global review of the available data regarding dietary sugar intake, considering forms such as total, free and added sugars. A comprehensive breakdown of intakes is provided by age group, country and sugar form. This analysis shows that free sugar intakes as a percentage of total energy (%E) are the highest for children and adolescents (12-14%E) and the lowest for older adults (8%E). This trend across lifecycle stages has also been observed for added sugars. The available data also suggest that, while some reductions in sugar intake are observed in a few individual studies, overall intakes of free/added sugars remain above recommendations. However, any wider conclusions are hampered by a lack of detailed high-quality data on sugar intake, especially in developing countries. Furthermore, there is a need for harmonisation of terms describing sugars (ideally driven by public health objectives) and for collaborative efforts to ensure that the most up-to-date food composition data are used to underpin recommendations and any estimates of intake or modelling scenarios.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"1-22"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9453011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrition interventions addressing structural racism: a scoping review. 解决结构性种族主义的营养干预:范围审查。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2022-01-13 DOI: 10.1017/S0954422422000014
Matthew Greene, Bailey Houghtaling, Claire Sadeghzadeh, Molly De Marco, De'Jerra Bryant, Randa Morgan, Denise Holston
{"title":"Nutrition interventions addressing structural racism: a scoping review.","authors":"Matthew Greene, Bailey Houghtaling, Claire Sadeghzadeh, Molly De Marco, De'Jerra Bryant, Randa Morgan, Denise Holston","doi":"10.1017/S0954422422000014","DOIUrl":"10.1017/S0954422422000014","url":null,"abstract":"<p><p>African Americans experience high rates of obesity and food insecurity in part due to structural racism, or overlapping discriminatory systems and practices in housing, education, employment, health care and other settings. Nutrition education and nutrition-focused policy, systems and environmental changes may be able to address structural racism in the food environment. This scoping review aimed to summarise the available literature regarding nutrition interventions for African Americans that address structural racism in the food environment and compare them with the 'Getting to Equity in Obesity Prevention' framework of suggested interventions. An electronic literature search was conducted with the assistance of a research librarian encompassing six databases: MEDLINE, PyscINFO, Agricola, ERIC, SocINDEX and ProQuest Dissertations & Theses. A total of thirty sources were identified detailing interventions addressing structural barriers to healthy eating. The majority of nutrition interventions addressing structural racism consisted of policy, systems and/or environmental changes in combination with nutrition education, strategies focused on proximal causes of racial health disparities. Only two articles each targeted the 'reduce deterrents' and 'improve social and economic resources' aspects of the framework, interventions which may be better suited to addressing structural racism in the food environment. Because African Americans experience high rates of obesity and food insecurity and encounter structural barriers to healthy eating in the food environment, researchers and public health professionals should address this gap in the literature.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"155-174"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9447567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myo-inositol: a potential prophylaxis against premature onset of labour and preterm birth. 肌醇:预防早产和早产的潜在方法。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2021-09-16 DOI: 10.1017/S0954422421000299
Neha Sharma, Oliver C Watkins, Anne H Y Chu, W Cutfield, Keith M Godfrey, Hannah E J Yong, Shiao-Yng Chan
{"title":"<i>Myo</i>-inositol: a potential prophylaxis against premature onset of labour and preterm birth.","authors":"Neha Sharma, Oliver C Watkins, Anne H Y Chu, W Cutfield, Keith M Godfrey, Hannah E J Yong, Shiao-Yng Chan","doi":"10.1017/S0954422421000299","DOIUrl":"10.1017/S0954422421000299","url":null,"abstract":"<p><p>The incidence of preterm birth (PTB), delivery before 37 completed weeks of gestation, is rising in most countries. Several recent small clinical trials of <i>myo</i>-inositol supplementation in pregnancy, which were primarily aimed at preventing gestational diabetes, have suggested an effect on reducing the incidence of PTB as a secondary outcome, highlighting the potential role of <i>myo</i>-inositol as a preventive agent. However, the underlying molecular mechanisms by which <i>myo</i>-inositol might be able to do so remain unknown; these may occur through directly influencing the onset and progress of labour, or by suppressing stimuli that trigger or promote labour. This paper presents hypotheses outlining the potential role of uteroplacental <i>myo</i>-inositol in human parturition and explains possible underlying molecular mechanisms by which <i>myo</i>-inositol might modulate the uteroplacental environment and inhibit preterm labour onset. We suggest that a physiological decline in uteroplacental inositol levels to a critical threshold with advancing gestation, in concert with an increasingly pro-inflammatory uteroplacental environment, permits spontaneous membrane rupture and labour onset. A higher uteroplacental inositol level, potentially promoted by maternal <i>myo</i>-inositol supplementation, might affect lipid metabolism, eicosanoid production and secretion of pro-inflammatory chemocytokines that overall dampen the pro-labour uteroplacental environment responsible for labour onset and progress, thus reducing the risk of PTB. Understanding how and when inositol may act to reduce PTB risk would facilitate the design of future clinical trials of maternal <i>myo</i>-inositol supplementation and definitively address the efficacy of <i>myo</i>-inositol prophylaxis against PTB.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"60-68"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9447557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence. 健康老年人的膳食蛋白质需求量和建议:对科学证据的批判性叙述回顾。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2021-10-20 DOI: 10.1017/S0954422421000329
Yusuke Nishimura, Grith Højfeldt, Leigh Breen, Inge Tetens, Lars Holm
{"title":"Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence.","authors":"Yusuke Nishimura, Grith Højfeldt, Leigh Breen, Inge Tetens, Lars Holm","doi":"10.1017/S0954422421000329","DOIUrl":"10.1017/S0954422421000329","url":null,"abstract":"<p><p>Adequate protein intake is essential for the maintenance of whole-body protein mass. Different methodological approaches are used to substantiate the evidence for the current protein recommendations, and it is continuously debated whether older adults require more protein to counteract the age-dependent loss of muscle mass, sarcopenia. Thus, the purpose of this critical narrative review is to outline and discuss differences in the approaches and methodologies assessing the protein requirements and, hence, resulting in controversies in current protein recommendations for healthy older adults. Through a literature search, this narrative review first summarises the historical development of the Food and Agriculture Organization/World Health Organization/United Nations University setting of protein requirements and recommendations for healthy older adults. Hereafter, we describe the various types of studies (epidemiological studies and protein turnover kinetic measurements) and applied methodological approaches founding the basis and the different recommendations with focus on healthy older adults. Finally, we discuss important factors to be considered in future studies to obtain evidence for international agreement on protein requirements and recommendations for healthy older adults. We conclude by proposing future directions to determine 'true' protein requirements and recommendations for healthy older adults.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"69-85"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence - CORRIGENDUM. 健康老年人的膳食蛋白质需求量和建议:科学证据的批判性叙述回顾 - CORRIGENDUM。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2021-12-17 DOI: 10.1017/S0954422421000408
Yusuke Nishimura, Grith Højfeldt, Leigh Breen, Inge Tetens, Lars Holm
{"title":"Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence - CORRIGENDUM.","authors":"Yusuke Nishimura, Grith Højfeldt, Leigh Breen, Inge Tetens, Lars Holm","doi":"10.1017/S0954422421000408","DOIUrl":"10.1017/S0954422421000408","url":null,"abstract":"","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"175"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NAFLD and vitamin D: Evidence for intersection of microRNA-regulated pathways. NAFLD和维生素D: microrna调控通路交叉的证据。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 DOI: 10.1017/S095442242100038X
Zixuan Zhang, Rachel Moon, James L Thorne, J Bernadette Moore
{"title":"NAFLD and vitamin D: Evidence for intersection of microRNA-regulated pathways.","authors":"Zixuan Zhang,&nbsp;Rachel Moon,&nbsp;James L Thorne,&nbsp;J Bernadette Moore","doi":"10.1017/S095442242100038X","DOIUrl":"https://doi.org/10.1017/S095442242100038X","url":null,"abstract":"<p><p>Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease, worldwide. The molecular pathogenesis of NAFLD is complex, involving numerous signalling molecules, including microRNAs (miRNAs). Dysregulation of miRNA expression is associated with hepatic inflammation, fibrosis and hepatocellular carcinoma. Although miRNAs are also critical to the cellular response to vitamin D, mediating regulation of the vitamin D receptor and vitamin D's anti-cancer effects, the role of vitamin-D-regulated miRNAs in NAFLD pathogenesis has been relatively unexplored. Therefore, this review aims to critically assess the evidence for a potential subset of miRNAs that are both dysregulated in NAFLD and modulated by vitamin D. Comprehensive review of eighty-nine human studies identified twenty-five miRNAs found dysregulated in more than one NAFLD study. In contrast, only seventeen studies, including a protocol for a trial in NAFLD, had examined miRNAs in relation to vitamin D status, response to supplementation, or vitamin D in the context of the liver. This paper summarises these data and reviews the biological roles of six miRNAs (miR-21, miR-30, miR-34, miR-122, miR-146, miR-200) found dysregulated in multiple independent NAFLD studies. While modulation of miRNAs by vitamin D has been understudied, integration of the data suggests seven vitamin-D-modulated miRNAs (miR-27, miR-125, miR-155, miR-192, miR-223, miR-375, miR-378) potentially relevant to NAFLD pathogenesis. Our summary tables provide a significant resource to underpin future hypothesis-driven research, and we conclude that the measurement of serum and hepatic miRNAs in response to vitamin D supplementation in larger trials is warranted.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"120-139"},"PeriodicalIF":5.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9449402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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