Nutrition Research Reviews最新文献

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Nutritional considerations in major depressive disorder: current evidence and functional testing for clinical practice. 重度抑郁障碍的营养考虑:临床实践的现有证据和功能测试。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-11-15 DOI: 10.1017/S0954422423000276
Kathryn Khiroya, Eric Sekyere, Bradley McEwen, Jessica Bayes
{"title":"Nutritional considerations in major depressive disorder: current evidence and functional testing for clinical practice.","authors":"Kathryn Khiroya, Eric Sekyere, Bradley McEwen, Jessica Bayes","doi":"10.1017/S0954422423000276","DOIUrl":"10.1017/S0954422423000276","url":null,"abstract":"<p><p>Depression is a multifaceted condition with diverse underlying causes. Several contributing and inter-related factors such as genetic, nutritional, neurological, physiological, gut-brain-axis, metabolic and psychological stress factors play a role in the pathophysiology of depression. This review aims to highlight the role that nutritional factors play in the aetiology of depression. Secondly, we discuss the biomedical and functional pathology tests which measure these factors, and the current evidence supporting their use. Lastly, we make recommendations on how practitioners can incorporate the latest evidence-based research findings into clinical practice. This review highlights that diet and nutrition greatly affect the pathophysiology of depression. Nutrients influence gene expression, with folate and vitamin B12 playing vital roles in methylation reactions and homocysteine regulation. Nutrients are also involved in the tryptophan/kynurenine pathway and the expression of brain-derived neurotrophic factor (BDNF). Additionally, diet influences the hypothalamic-pituitary-adrenal (HPA) response and the composition and diversity of the gut microbiome, both of which have been implicated in depression. A comprehensive dietary assessment, combined with appropriate evaluation of biochemistry and blood pathology, may help uncover contributing factors to depressive symptoms. By employing such an approach, a more targeted and personalised treatment strategy can be devised, ultimately leading to improved patient outcomes.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-12"},"PeriodicalIF":5.7,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep deprivation in development of obesity, effects on appetite regulation, energy metabolism, and dietary choices. 睡眠不足与肥胖的发展、对食欲调节、能量代谢和饮食选择的影响。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-10-31 DOI: 10.1017/S0954422423000264
Masoumeh Akhlaghi, Ali Kohanmoo
{"title":"Sleep deprivation in development of obesity, effects on appetite regulation, energy metabolism, and dietary choices.","authors":"Masoumeh Akhlaghi, Ali Kohanmoo","doi":"10.1017/S0954422423000264","DOIUrl":"10.1017/S0954422423000264","url":null,"abstract":"<p><p>Sleep deprivation, which is a decrease in duration and quality of sleep, is a common problem in today's life. Epidemiological and interventional investigations have suggested a link between sleep deprivation and overweight/obesity. Sleep deprivation affects homeostatic and non-homoeostatic regulation of appetite, with the food reward system playing a dominant role. Factors such as sex and weight status affect this regulation; men and individuals with excess weight seem to be more sensitive to reward-driven and hedonistic regulation of food intake. Sleep deprivation may also affect weight through affecting physical activity and energy expenditure. In addition, sleep deprivation influences food selection and eating behaviours, which are mainly managed by the food reward system. Sleep-deprived individuals mostly crave for palatable energy-dense foods and have low desire for fruit and vegetables. Consumption of meals may not change but energy intake from snacks increases. The individuals have more desire for snacks with high sugar and saturated fat content. The relationship between sleep and the diet is mutual, implying that diet and eating behaviours also affect sleep duration and quality. Consuming healthy diets containing fruit and vegetables and food sources of protein and unsaturated fats and low quantities of saturated fat and sugar may be used as a diet strategy to improve sleep. Since the effects of sleep deficiency differ between animals and humans, only evidence from human subject studies has been included, controversies are discussed and the need for future investigations is highlighted.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-21"},"PeriodicalIF":5.7,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myo-inositol: a potential prophylaxis against premature onset of labour and preterm birth. 肌醇:预防早产和早产的潜在方法。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2021-09-16 DOI: 10.1017/S0954422421000299
Neha Sharma, Oliver C Watkins, Anne H Y Chu, W Cutfield, Keith M Godfrey, Hannah E J Yong, Shiao-Yng Chan
{"title":"<i>Myo</i>-inositol: a potential prophylaxis against premature onset of labour and preterm birth.","authors":"Neha Sharma, Oliver C Watkins, Anne H Y Chu, W Cutfield, Keith M Godfrey, Hannah E J Yong, Shiao-Yng Chan","doi":"10.1017/S0954422421000299","DOIUrl":"10.1017/S0954422421000299","url":null,"abstract":"<p><p>The incidence of preterm birth (PTB), delivery before 37 completed weeks of gestation, is rising in most countries. Several recent small clinical trials of <i>myo</i>-inositol supplementation in pregnancy, which were primarily aimed at preventing gestational diabetes, have suggested an effect on reducing the incidence of PTB as a secondary outcome, highlighting the potential role of <i>myo</i>-inositol as a preventive agent. However, the underlying molecular mechanisms by which <i>myo</i>-inositol might be able to do so remain unknown; these may occur through directly influencing the onset and progress of labour, or by suppressing stimuli that trigger or promote labour. This paper presents hypotheses outlining the potential role of uteroplacental <i>myo</i>-inositol in human parturition and explains possible underlying molecular mechanisms by which <i>myo</i>-inositol might modulate the uteroplacental environment and inhibit preterm labour onset. We suggest that a physiological decline in uteroplacental inositol levels to a critical threshold with advancing gestation, in concert with an increasingly pro-inflammatory uteroplacental environment, permits spontaneous membrane rupture and labour onset. A higher uteroplacental inositol level, potentially promoted by maternal <i>myo</i>-inositol supplementation, might affect lipid metabolism, eicosanoid production and secretion of pro-inflammatory chemocytokines that overall dampen the pro-labour uteroplacental environment responsible for labour onset and progress, thus reducing the risk of PTB. Understanding how and when inositol may act to reduce PTB risk would facilitate the design of future clinical trials of maternal <i>myo</i>-inositol supplementation and definitively address the efficacy of <i>myo</i>-inositol prophylaxis against PTB.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"60-68"},"PeriodicalIF":5.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9447557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Current perspectives on global sugar consumption: definitions, recommendations, population intakes, challenges and future direction. 全球食糖消费现状:定义、建议、人口摄入量、挑战和未来方向。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2021-08-09 DOI: 10.1017/S095442242100024X
Janette Walton, Haley Bell, Roberta Re, Anne P Nugent
{"title":"Current perspectives on global sugar consumption: definitions, recommendations, population intakes, challenges and future direction.","authors":"Janette Walton, Haley Bell, Roberta Re, Anne P Nugent","doi":"10.1017/S095442242100024X","DOIUrl":"10.1017/S095442242100024X","url":null,"abstract":"<p><p>Currently, there is considerable emphasis on the relationship between dietary sugar consumption and various health outcomes, with some countries and regions implementing national sugar reduction campaigns. This has resulted in significant efforts to quantify dietary sugar intakes, to agree on terms to describe dietary sugars and to establish associated recommendations. However, this information is infrequently collated on a global basis and in a regularised manner. The present review provides context regarding sugar definitions and recommendations. It provides a global review of the available data regarding dietary sugar intake, considering forms such as total, free and added sugars. A comprehensive breakdown of intakes is provided by age group, country and sugar form. This analysis shows that free sugar intakes as a percentage of total energy (%E) are the highest for children and adolescents (12-14%E) and the lowest for older adults (8%E). This trend across lifecycle stages has also been observed for added sugars. The available data also suggest that, while some reductions in sugar intake are observed in a few individual studies, overall intakes of free/added sugars remain above recommendations. However, any wider conclusions are hampered by a lack of detailed high-quality data on sugar intake, especially in developing countries. Furthermore, there is a need for harmonisation of terms describing sugars (ideally driven by public health objectives) and for collaborative efforts to ensure that the most up-to-date food composition data are used to underpin recommendations and any estimates of intake or modelling scenarios.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"1-22"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9453011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrition interventions addressing structural racism: a scoping review. 解决结构性种族主义的营养干预:范围审查。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2022-01-13 DOI: 10.1017/S0954422422000014
Matthew Greene, Bailey Houghtaling, Claire Sadeghzadeh, Molly De Marco, De'Jerra Bryant, Randa Morgan, Denise Holston
{"title":"Nutrition interventions addressing structural racism: a scoping review.","authors":"Matthew Greene, Bailey Houghtaling, Claire Sadeghzadeh, Molly De Marco, De'Jerra Bryant, Randa Morgan, Denise Holston","doi":"10.1017/S0954422422000014","DOIUrl":"10.1017/S0954422422000014","url":null,"abstract":"<p><p>African Americans experience high rates of obesity and food insecurity in part due to structural racism, or overlapping discriminatory systems and practices in housing, education, employment, health care and other settings. Nutrition education and nutrition-focused policy, systems and environmental changes may be able to address structural racism in the food environment. This scoping review aimed to summarise the available literature regarding nutrition interventions for African Americans that address structural racism in the food environment and compare them with the 'Getting to Equity in Obesity Prevention' framework of suggested interventions. An electronic literature search was conducted with the assistance of a research librarian encompassing six databases: MEDLINE, PyscINFO, Agricola, ERIC, SocINDEX and ProQuest Dissertations & Theses. A total of thirty sources were identified detailing interventions addressing structural barriers to healthy eating. The majority of nutrition interventions addressing structural racism consisted of policy, systems and/or environmental changes in combination with nutrition education, strategies focused on proximal causes of racial health disparities. Only two articles each targeted the 'reduce deterrents' and 'improve social and economic resources' aspects of the framework, interventions which may be better suited to addressing structural racism in the food environment. Because African Americans experience high rates of obesity and food insecurity and encounter structural barriers to healthy eating in the food environment, researchers and public health professionals should address this gap in the literature.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"155-174"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9447567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence. 健康老年人的膳食蛋白质需求量和建议:对科学证据的批判性叙述回顾。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2021-10-20 DOI: 10.1017/S0954422421000329
Yusuke Nishimura, Grith Højfeldt, Leigh Breen, Inge Tetens, Lars Holm
{"title":"Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence.","authors":"Yusuke Nishimura, Grith Højfeldt, Leigh Breen, Inge Tetens, Lars Holm","doi":"10.1017/S0954422421000329","DOIUrl":"10.1017/S0954422421000329","url":null,"abstract":"<p><p>Adequate protein intake is essential for the maintenance of whole-body protein mass. Different methodological approaches are used to substantiate the evidence for the current protein recommendations, and it is continuously debated whether older adults require more protein to counteract the age-dependent loss of muscle mass, sarcopenia. Thus, the purpose of this critical narrative review is to outline and discuss differences in the approaches and methodologies assessing the protein requirements and, hence, resulting in controversies in current protein recommendations for healthy older adults. Through a literature search, this narrative review first summarises the historical development of the Food and Agriculture Organization/World Health Organization/United Nations University setting of protein requirements and recommendations for healthy older adults. Hereafter, we describe the various types of studies (epidemiological studies and protein turnover kinetic measurements) and applied methodological approaches founding the basis and the different recommendations with focus on healthy older adults. Finally, we discuss important factors to be considered in future studies to obtain evidence for international agreement on protein requirements and recommendations for healthy older adults. We conclude by proposing future directions to determine 'true' protein requirements and recommendations for healthy older adults.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"69-85"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence - CORRIGENDUM. 健康老年人的膳食蛋白质需求量和建议:科学证据的批判性叙述回顾 - CORRIGENDUM。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 Epub Date: 2021-12-17 DOI: 10.1017/S0954422421000408
Yusuke Nishimura, Grith Højfeldt, Leigh Breen, Inge Tetens, Lars Holm
{"title":"Dietary protein requirements and recommendations for healthy older adults: a critical narrative review of the scientific evidence - CORRIGENDUM.","authors":"Yusuke Nishimura, Grith Højfeldt, Leigh Breen, Inge Tetens, Lars Holm","doi":"10.1017/S0954422421000408","DOIUrl":"10.1017/S0954422421000408","url":null,"abstract":"","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"175"},"PeriodicalIF":5.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NAFLD and vitamin D: Evidence for intersection of microRNA-regulated pathways. NAFLD和维生素D: microrna调控通路交叉的证据。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 DOI: 10.1017/S095442242100038X
Zixuan Zhang, Rachel Moon, James L Thorne, J Bernadette Moore
{"title":"NAFLD and vitamin D: Evidence for intersection of microRNA-regulated pathways.","authors":"Zixuan Zhang,&nbsp;Rachel Moon,&nbsp;James L Thorne,&nbsp;J Bernadette Moore","doi":"10.1017/S095442242100038X","DOIUrl":"https://doi.org/10.1017/S095442242100038X","url":null,"abstract":"<p><p>Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease, worldwide. The molecular pathogenesis of NAFLD is complex, involving numerous signalling molecules, including microRNAs (miRNAs). Dysregulation of miRNA expression is associated with hepatic inflammation, fibrosis and hepatocellular carcinoma. Although miRNAs are also critical to the cellular response to vitamin D, mediating regulation of the vitamin D receptor and vitamin D's anti-cancer effects, the role of vitamin-D-regulated miRNAs in NAFLD pathogenesis has been relatively unexplored. Therefore, this review aims to critically assess the evidence for a potential subset of miRNAs that are both dysregulated in NAFLD and modulated by vitamin D. Comprehensive review of eighty-nine human studies identified twenty-five miRNAs found dysregulated in more than one NAFLD study. In contrast, only seventeen studies, including a protocol for a trial in NAFLD, had examined miRNAs in relation to vitamin D status, response to supplementation, or vitamin D in the context of the liver. This paper summarises these data and reviews the biological roles of six miRNAs (miR-21, miR-30, miR-34, miR-122, miR-146, miR-200) found dysregulated in multiple independent NAFLD studies. While modulation of miRNAs by vitamin D has been understudied, integration of the data suggests seven vitamin-D-modulated miRNAs (miR-27, miR-125, miR-155, miR-192, miR-223, miR-375, miR-378) potentially relevant to NAFLD pathogenesis. Our summary tables provide a significant resource to underpin future hypothesis-driven research, and we conclude that the measurement of serum and hepatic miRNAs in response to vitamin D supplementation in larger trials is warranted.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"120-139"},"PeriodicalIF":5.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9449402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Functional properties of edible insects: a systematic review. 食用昆虫的功能特性:系统综述。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 DOI: 10.1017/S0954422421000366
V D'Antonio, N Battista, G Sacchetti, C Di Mattia, M Serafini
{"title":"Functional properties of edible insects: a systematic review.","authors":"V D'Antonio,&nbsp;N Battista,&nbsp;G Sacchetti,&nbsp;C Di Mattia,&nbsp;M Serafini","doi":"10.1017/S0954422421000366","DOIUrl":"https://doi.org/10.1017/S0954422421000366","url":null,"abstract":"<p><p>Consumption of edible insects has been widely suggested as an environmentally sustainable substitute for meat to reduce greenhouse gas emissions. However, the novel research field for edible insects relies on the content of bioactive ingredients and on the ability to induce a functional effect in humans. The goal of this manuscript is to review the available body of evidence on the properties of edible insects in modulating oxidative and inflammatory stress, platelet aggregation, lipid and glucose metabolism and weight control. A search for literature investigating the functional role of edible insects was carried out in the PubMed database using specific keywords. A total of 55 studies, meeting inclusion criteria after screening, were divided on the basis of the experimental approach: <i>in vitro</i> studies, cellular models/<i>ex vivo</i> studies or <i>in vivo</i> studies. In the majority of the studies, insects demonstrated the ability to reduce oxidative stress, modulate antioxidant status, restore the impaired activity of antioxidant enzymes and reduce markers of oxidative damage. Edible insects displayed anti-inflammatory activity reducing cytokines and modulating specific transcription factors. Results from animal studies suggest that edible insects can modulate lipid and glucose metabolism. The limited number of studies focused on the assessment of anti-coagulation activity of edible insects makes it difficult to draw conclusions. More evidence from dietary intervention studies in humans is needed to support the promising evidence from <i>in vitro</i> and animal models about the functional role of edible insect consumption.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"98-119"},"PeriodicalIF":5.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9453020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Efficacy of resveratrol in male urogenital tract dysfunctions: an evaluation of pre-clinical data. 白藜芦醇治疗男性泌尿生殖道功能障碍的疗效:临床前数据的评估。
IF 5.7 2区 医学
Nutrition Research Reviews Pub Date : 2023-06-01 DOI: 10.1017/S0954422421000354
F B Calmasini, F H Silva, E C Alexandre, E Antunes
{"title":"Efficacy of resveratrol in male urogenital tract dysfunctions: an evaluation of pre-clinical data.","authors":"F B Calmasini,&nbsp;F H Silva,&nbsp;E C Alexandre,&nbsp;E Antunes","doi":"10.1017/S0954422421000354","DOIUrl":"https://doi.org/10.1017/S0954422421000354","url":null,"abstract":"<p><p>Resveratrol is a polyphenol found naturally in fruits and plants. Recently, studies in humans and animal models have suggested beneficial properties of this polyphenol, such as improvements to metabolic and lipid profiles, along with antioxidant, anti-inflammatory and anti-proliferative effects. In the urogenital tract (UGT), resveratrol has also been tested clinically and experimentally as a therapeutic drug in several diseases; however, the translational efficacy of resveratrol, especially in UGT, is still a matter of debate. In the present review, we address the pre-clinical efficacy of resveratrol in UGT-related dysfunctions, focusing on lower urinary tract symptoms, non-cancerous prostatic disease (benign prostatic hyperplasia and prostatitis) and erectile dysfunction. <i>In vitro</i> studies indicate that resveratrol reduces inflammatory markers and oxidative stress, and improves endothelial function in UGT organs and cells isolated from humans and animals. Despite displaying low oral bioavailability, <i>in vivo</i> administration of resveratrol largely improves erectile dysfunction, benign prostatic hyperplasia, prostatitis and voiding impairments, as evidenced in different animal models. Resveratrol also acts as a microbiota modulator, which may explain some of its beneficial effects <i>in vivo</i>. In contrast to the large amount of pre-clinical data, there are insufficient clinical trials to establish resveratrol treatment efficacy in human UGT-related diseases. In summary, we provide an overview of the <i>in vivo</i> and <i>in vitro</i> efficacy of resveratrol in animal and human UGT dysfunctions, which may support future clinical trials.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"36 1","pages":"86-97"},"PeriodicalIF":5.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9449398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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