Nutrition Clinique et Metabolisme最新文献

{"title":"High-carbohydrate diet-induced central obesity in gerbils: 20-hydroxyecdysone effects on adrenal zona fasciculata histology","authors":"Zineb Bellahreche,&nbsp;Ouahiba Sihali-Beloui,&nbsp;Nesrine Semiane,&nbsp;Aicha Mallek,&nbsp;Yasmina Dahmani","doi":"10.1016/j.nupar.2025.07.002","DOIUrl":"10.1016/j.nupar.2025.07.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Excessive consumption of carbohydrates often leads to central obesity, endocrine metabolic alterations, and adrenal dysfunctions. Phytoecdysteroids, a class of active natural compounds, have shown promising effects on the physiological functions of vertebrates. In this study, we investigated the impact of 20-hydroxyecdysone (20E), a specific phytoecdysteroid, on the adrenal zona fasciculata of the obese gerbil species <em>Gerbillus tarabuli</em>.</div></div><div><h3>Materials and methods</h3><div>Gerbils were fed a high-carbohydrate diet (HCD) for a period of 3 months, followed by an additional 2-month period on the same diet, with and without supplementation with 20E (50<!--> <!-->mg/kg body weight). At the end of the experimental period, we recorded body and organ weights, assessed biochemical and hormonal parameters, and analyzed the adrenal glands through histological and ultrastructural examinations.</div></div><div><h3>Results</h3><div>The HCD regimen elevated both body weight and abdominal adipose tissue in <em>Gerbillus tarabuli</em>, accompanied by hyperactivation of the HPA axis. Significantly increased levels of plasma glucose, insulin, and adrenal cortisol were also observed. Histological and ultrastructural analyses of the adrenal glands revealed important alterations, characterized by zona fasciculata disorganization, inflammatory cell infiltration, and collagen deposition. Conversely, administration of 20E led to improvements in biochemical and hormonal parameters, including significant reductions in insulin, glucose, HOMA-IR, cholesterol, and plasma adrenocorticotropic hormone levels. Although no significant changes were observed in body weight, mesenteric or subcutaneous fat mass or relative adrenal weight, we noted a significant reduction in perigonadal adipose tissue weight, underscoring its selective impact on fat distribution.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 292-301"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolic promise of intermittent fasting in obesity intervention: Insights from human clinical studies","authors":"Pınar Unaldi-Daldeviren,&nbsp;Seda Ciftci","doi":"10.1016/j.nupar.2025.07.003","DOIUrl":"10.1016/j.nupar.2025.07.003","url":null,"abstract":"<div><h3>Purpose of review</h3><div>Obesity is a multifaceted condition that significantly increases the risk of metabolic disorders, including type 2 diabetes, cardiovascular diseases, hypertension, stroke, and certain cancers. Traditional dietary interventions emphasize continuous caloric restriction; however, intermittent fasting (IF) has emerged as an alternative approach that prioritizes meal timing over sustained calorie reduction. This review examines the effectiveness of IF in obesity management, highlighting its potential benefits, mechanisms of action, and clinical implications. Notably, the focus is on evidence from human clinical studies, excluding data from animal models.</div></div><div><h3>Recent findings</h3><div>IF, which includes protocols such as alternate-day fasting (ADF), modified alternate-day fasting (MADF), the 5:2 diet, and time-restricted feeding (TRF), has demonstrated efficacy in promoting weight loss, improving metabolic health, and optimizing body composition. Studies indicate that a 5–10% reduction in body weight within six months can enhance glycemic control, blood pressure, and lipid profiles, thereby reducing obesity-related complications. IF provides a sustainable approach to dietary regulation without necessitating the elimination of specific food groups. Emerging clinical evidence also suggests that beyond weight loss, IF can improve insulin sensitivity, lower blood pressure, modulate appetite-regulating hormones (e.g., leptin and adiponectin), and even reduce liver fat and enzymes associated with non-alcoholic fatty liver disease.</div></div><div><h3>Summary</h3><div>IF represents a promising dietary strategy for obesity management, offering metabolic benefits beyond weight loss. While accumulating evidence supports its effectiveness, further research is required to determine its long-term effects, optimal implementation strategies, and broader impact on metabolic health.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 240-250"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue contents","authors":"","doi":"10.1016/S0985-0562(25)00084-6","DOIUrl":"10.1016/S0985-0562(25)00084-6","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Page e1"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composition of fatty acids in lipid emulsions and clinical outcomes in non-surgical critically ill patients: A systematic review and meta-analysis of randomized controlled trials","authors":"Melika Hajimohammadebrahim-Ketabforoush ,&nbsp;Amene Saghazadeh ,&nbsp;Maryam Behfar ,&nbsp;Amir Ali Hamidieh ,&nbsp;Zahra Vahdat Shariatpanahi","doi":"10.1016/j.nupar.2025.06.006","DOIUrl":"10.1016/j.nupar.2025.06.006","url":null,"abstract":"<div><h3>Background &amp; objectives</h3><div>Increasing evidence has demonstrated that lipid emulsions are an essential part of nutrition therapy for critically-ill patients who are candidates for parenteral nutrition (PN). Meanwhile, determining the optimal lipid composition remains challenging, especially in non-surgical critically-ill patients. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing fatty acids in lipid emulsions and clinical outcomes in these patients.</div></div><div><h3>Methods</h3><div>Based on our predefined search strategy, PubMed, Cochrane, and Web of Science were searched for RCTs published up to 18 October 2023. The interventions included fish oil (FO), olive oil (OO), medium-chain triglyceride (MCT), and soybean oil (SO) or their mixture and were compared with traditional emulsions mostly based on 100% SO. The clinical outcomes evaluated included infections, mechanical ventilation, intensive care unit (ICU) length of stay (LOS), hospital LOS, ICU mortality, in-hospital mortality, and long-term mortality.</div></div><div><h3>Results</h3><div>A total of 802 articles were retrieved in the first stage of our search. Based on our predefined inclusion criteria, 9 articles were eligible for entering this meta-analysis. The studies had a low to moderate risk of bias. Hospital LOS was the only statistically significant outcome with a lower value in the treatment groups compared with the controls (Hedges's g −0.45; 95% CI −0.69, −0.20; <em>P</em> <!-->=<!--> <!-->0.00; I² <!-->=<!--> <!-->8.90%). Infection was identified as another statistically significant variable (Log odds-ratio 0.77; 95% CI 0.13, 1.42; <em>P</em> <!-->=<!--> <!-->0.02; I² <!-->=<!--> <!-->0%); however, only 2 articles in this regard were included in the meta-analysis.</div></div><div><h3>Conclusion</h3><div>The results of our meta-analysis highlighted a decrease in hospital LOS and infections. However, particularly regarding infections, more future studies are required. In accordance with previous meta-analyses, this findings highlight the superiority of mixed lipid emulsions consisting of FO/OO/MCT/SO, especially based on FO, over the traditional ones mostly based on SO, in non-surgical critically-ill patients who are candidates for PN.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 230-239"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’éditorial de la présidente de la SNFCM","authors":"Francisca Joly","doi":"10.1016/j.nupar.2025.10.001","DOIUrl":"10.1016/j.nupar.2025.10.001","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Page 229"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What diet is optimal in adults with metabolic dysfunction-associated steatotic liver disease? A systematic review and network meta-analysis","authors":"Zi Zeng ,&nbsp;Hua Wei ,&nbsp;Yuejuan Dong ,&nbsp;Sijin Sun ,&nbsp;Zhuoma Sunu","doi":"10.1016/j.nupar.2025.08.004","DOIUrl":"10.1016/j.nupar.2025.08.004","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effects of various dietary regimens on adult patients with metabolic dysfunction-associated steatotic liver disease.</div></div><div><h3>Methods</h3><div>Randomized controlled trials of various dietary regimens in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), published up to October 6th, 2024, were included in this study. The Cochrane Collaboration tool was employed to assess the risk of bias for quality evaluation. STATA 17.0 software was utilized for both pairwise meta-analysis and a series of network meta-analyses (NMA).</div></div><div><h3>Results</h3><div>A total of 19 randomized controlled trials (RCTs) from 22 studies involving 1288 patients were included, focusing on 12 different dietary approaches. The findings indicated that the recommended diet varied based on different outcome measures. The very low-calorie ketogenic diet (VLCKD) was found to be the most effective for reducing body weight, body mass index (BMI), and waist circumference. In contrast, the Dietary Approaches to Stop Hypertension (DASH) was more effective in lowering blood lipid levels. Regarding liver enzyme indicators, the results were inconsistent, leading to no specific recommendations. Additionally, the low free sugar diet (LFSD) demonstrated greater benefits in improving glucose metabolism indicators.</div></div><div><h3>Conclusions</h3><div>The VLCKD is more effective for improving anthropometric indicators, while the DASH diet is more suitable for enhancing lipid indicators. There is currently no standardized dietary recommendation for alleviating liver enzyme indicators. The LFSD has proven to be more effective for parameters related to glucose metabolism indicators. Clinical applications should be tailored to the individual circumstances of each patient.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 319-333"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of optimized nosocomial infection management model combined with nutritional support on the incidence of nosocomial infections and indoor bacterial count in surgical room patients","authors":"Runmei Pan ,&nbsp;Liangmei Ouyang ,&nbsp;Xiying Zhang,&nbsp;Jimei Huang,&nbsp;Yan Xiao ,&nbsp;Yingfang Chen","doi":"10.1016/j.nupar.2025.08.002","DOIUrl":"10.1016/j.nupar.2025.08.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the impact of optimizing nosocomial infection management plus nutritional support on the incidence of nosocomial infections and the quantity of indoor bacteria in surgical patients.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 400 surgical patients, rolled into Group A (<em>n</em> <!-->=<!--> <!-->100, traditional nosocomial infection management<!--> <!-->+<!--> <!-->simple nutritional support), Group B (<em>n</em> <!-->=<!--> <!-->100, traditional nosocomial infection management<!--> <!-->+<!--> <!-->complex nutritional support), Group C (<em>n</em> <!-->=<!--> <!-->100, optimized nosocomial infection management<!--> <!-->+<!--> <!-->simple nutritional support), and Group D (<em>n</em> <!-->=<!--> <!-->100, optimized nosocomial infection management<!--> <!-->+<!--> <!-->complex nutritional support). The incidence of nosocomial infections, indoor bacterial counts, and patient satisfaction were analyzed among the four groups.</div></div><div><h3>Results</h3><div>The postoperative air and hand bacterial counts in Groups C and D were lower than those in Groups A and B (<em>P</em> <!-->&lt;<!--> <!-->0.05). The preoperative preparation time and surgical time in Groups C and D were shorter than those in Groups A and B (<em>P</em> <!-->&lt;<!--> <!-->0.05). Patients in Groups C and D exhibited higher scores in nosocomial infection management quality compared to Groups A and B (<em>P</em> <!-->&lt;<!--> <!-->0.05). The number of highly satisfied patients in Group D was higher than that in Groups A, B, and C (<em>P</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>Optimizing nosocomial infection management combined with complex nutritional support can reduce the counts of airborne and hand bacteria in surgical rooms, decrease the incidence of nosocomial infections, and demonstrate positive practical effects.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 302-309"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update on gut microbiota: Its interaction with nutrients and metabolic syndrome","authors":"Ijaz ul Haq ,&nbsp;Maham Saeed","doi":"10.1016/j.nupar.2025.08.001","DOIUrl":"10.1016/j.nupar.2025.08.001","url":null,"abstract":"<div><div>The intestinal microbiota has been identified as an important regulator of cellular metabolism and human health. The gut microbiota begins developing in infancy and is fully established by the age of three years. It has a strong connection with diet and food components, influencing general well-being, nutrition, and disease conditions. In this review, we examine the structural and functional composition of the intestinal microbiota, the various ways it affects metabolic activity, its complex interactions with food components, and its association with metabolic syndrome (MetS). Furthermore, we address the mechanisms by which intestinal microbes influence metabolic syndrome. We present a comprehensive body of research supporting the notion that gut microbiota-based therapies including probiotic and prebiotic supplementation, fecal microbiota transplantation (FMT), pharmacological modulation (e.g., metformin, liraglutide), and metabolic surgery, can be utilized to modify host metabolism and reduce MetS. Such approaches are likely to transition from the bench to the bedside in the near future.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 260-272"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’été, une parenthèse pour nourrir l’esprit","authors":"Francisca Joly","doi":"10.1016/j.nupar.2025.07.001","DOIUrl":"10.1016/j.nupar.2025.07.001","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Page 149"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Typologie des patients en situation d’obésité : place de l’outil numérique pour aider au phénotypage","authors":"Cyril Gauthier ,&nbsp;Clothilde Dumortier ,&nbsp;Marie-Claude Brindisi","doi":"10.1016/j.nupar.2025.04.006","DOIUrl":"10.1016/j.nupar.2025.04.006","url":null,"abstract":"<div><div>Today, obesity represents a major public health challenge. This pathology requires comprehensive, multi-professional, multimodal, adapted and exhaustive management, taking into account all associated co-morbidities. Precise phenotyping of patients suffering from obesity, based on the recommendations for good practice published in 2022, which goes far beyond BMI alone, is essential to adapt care and refer patients to the appropriate levels of care. This phenotyping can seem tedious. How can digital phenotyping overcome some of today's obstacles and help set up care pathways for obesity? That is what we’re going to discuss.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 3","pages":"Pages 219-224"},"PeriodicalIF":0.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}