Nutrition Clinique et Metabolisme最新文献

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The relationship between coffee consumption and diarrhea: A cross-sectional study based on NHANES data 咖啡消费与腹泻之间的关系:基于NHANES数据的横断面研究
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2026-03-01 Epub Date: 2025-12-13 DOI: 10.1016/j.nupar.2025.11.004
Xiaoyang Zhang , Xiaomin Lin , Yahui Sun , Qingfeng Zeng , Yurong Liang , Wenfei Zha , Na Mi , Weijie Gu
{"title":"The relationship between coffee consumption and diarrhea: A cross-sectional study based on NHANES data","authors":"Xiaoyang Zhang ,&nbsp;Xiaomin Lin ,&nbsp;Yahui Sun ,&nbsp;Qingfeng Zeng ,&nbsp;Yurong Liang ,&nbsp;Wenfei Zha ,&nbsp;Na Mi ,&nbsp;Weijie Gu","doi":"10.1016/j.nupar.2025.11.004","DOIUrl":"10.1016/j.nupar.2025.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Coffee, one of the most globally consumed beverages with annual trade volumes exceeding $10<!--> <!-->billion USD, has been epidemiologically associated with gastrointestinal effects due to its bioactive constituents, particularly caffeine. While previous studies have suggested potential impacts of coffee consumption on digestive physiology, the precise mechanisms and dose-response relationships remain poorly characterized. This cross-sectional investigation utilizes nationally representative data from the National Health and Nutrition Examination Survey (NHANES) to systematically examine the association between coffee intake patterns and diarrheal incidence in the U.S. adult population.</div></div><div><h3>Methods</h3><div>This study conducted a cross-sectional analysis of self-reported diarrhea and coffee intake from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models and restricted cubic splines (RCS) were employed to assess the association between coffee consumption and diarrhea, with results presented as odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>In this observational study, a total of 9544 eligible participants were included. After adjusting for potential confounding variables, higher coffee consumption was associated with an increased risk of diarrhea compared to lower coffee consumption, regardless of whether intake was measured in grams (<em>P</em> overall<!--> <!-->=<!--> <!-->0.01) or cups (<em>P</em> overall<!--> <!-->=<!--> <!-->0.04). Furthermore, a restricted cubic spline (RCS) analysis revealed a statistically significant linear positive correlation between coffee intake and diarrhea risk (<em>P</em> for nonlinearity<!--> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>This population-based study demonstrates a statistically significant association between coffee intake and the incidence of diarrhea, regardless of whether consumption is measured in grams or cups. Therefore, individuals prone to gastrointestinal discomfort may benefit from moderating their coffee intake to reduce the risk of diarrhea.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103020"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of nutritional support on postoperative well-being and quality of life in gynecologic oncology patients 营养支持对妇科肿瘤患者术后幸福感和生活质量的影响
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2026-03-01 Epub Date: 2025-11-26 DOI: 10.1016/j.nupar.2025.11.003
Fazıl Avcı , Belma Gözde Özdemir , Memduha Aydın , Ahmet Bilgi , Çetin Çelik
{"title":"The effect of nutritional support on postoperative well-being and quality of life in gynecologic oncology patients","authors":"Fazıl Avcı ,&nbsp;Belma Gözde Özdemir ,&nbsp;Memduha Aydın ,&nbsp;Ahmet Bilgi ,&nbsp;Çetin Çelik","doi":"10.1016/j.nupar.2025.11.003","DOIUrl":"10.1016/j.nupar.2025.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>The effect of nutritional support on postoperative well-being and quality of life in gynecologic oncology patients was investigated.</div></div><div><h3>Material and methods</h3><div>Patients who underwent surgery for gynecologic oncologic reasons between August 2022 and December 2023 were included in the study. Those who received preoperative nutritional support were referred to as group 1 and those who did not were referred to as group 2. Demographic data, Quality of Life Form (EORTC QLQ-C30), Nutritional Risk Index score (NSR 2002), Hospital Anxiety and Depression Scale, surgical characteristics, and perioperative laboratory results were evaluated.</div></div><div><h3>Results</h3><div>A total of 215 patients were evaluated, 99 in group 1 and 116 in group 2. Group 1 was associated with shorter wound healing time (<em>P</em> <!-->=<!--> <!-->0.020) and shorter hospital stay (<em>P</em> <!-->=<!--> <!-->0.025), higher postoperative hemoglobulin (<em>P</em> <!-->=<!--> <!-->0.001), higher ferritin (<em>P</em> <!-->=<!--> <!-->0.001), lower CRP (<em>P</em> <!-->=<!--> <!-->0.044), and albumin (<em>P</em> <!-->=<!--> <!-->0.001), lower depression (<em>P</em> <!-->=<!--> <!-->0.001) and anxiety (<em>P</em> <!-->=<!--> <!-->0.001) and higher functional status and lower symptom scores than group 2 (<em>P</em> <!-->=<!--> <!-->0.001).</div></div><div><h3>Conclusion</h3><div>Nutritional support in gynecologic oncology has a positive effect on postoperative well-being and quality of life, especially in patients with high Nutritional Risk Index.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103019"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of vitamin D supplementation on COVID-19 mortality: A systematic review and meta-analysis 补充维生素D对COVID-19死亡率的影响:系统综述和荟萃分析
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2026-03-01 Epub Date: 2025-12-26 DOI: 10.1016/j.nupar.2025.12.001
Azam Doustmohammadian , Maryam Amini , Bahareh Nikooyeh , Maryam Hajigholam-Saryazdi , Sepideh Alibeyk , Melika Hajjar
{"title":"Impact of vitamin D supplementation on COVID-19 mortality: A systematic review and meta-analysis","authors":"Azam Doustmohammadian ,&nbsp;Maryam Amini ,&nbsp;Bahareh Nikooyeh ,&nbsp;Maryam Hajigholam-Saryazdi ,&nbsp;Sepideh Alibeyk ,&nbsp;Melika Hajjar","doi":"10.1016/j.nupar.2025.12.001","DOIUrl":"10.1016/j.nupar.2025.12.001","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study aimed to synthesize available evidence on the impact of vitamin D supplementation on COVID-19-related mortality through a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>We systematically searched major databases for randomized controlled trials (RCTs), quasi-RCTs, and cluster-randomized trials published between October 1, 2019, and December 14, 2024, evaluating vitamin D supplementation in adult patients with laboratory-confirmed COVID-19. Studies were included if they reported mortality outcomes and compared vitamin D with placebo, standard care, or no intervention. Risk of bias was assessed using the Cochrane tool. Pooled odds ratios (ORs) were calculated using a random-effects model. Subgroup analyses were performed by age and sex composition. Publication bias was assessed via funnel plot symmetry and Egger's test.</div></div><div><h3>Results</h3><div>A total of 24 studies encompassing diverse populations across hospital, ICU, and community settings were included. Sample sizes ranged from 32 to 6200 participants, and intervention durations from 5 to 180<!--> <!-->days. A pooled analysis revealed that vitamin D supplementation was associated with a significant 33% reduction in COVID-19 mortality (OR<!--> <!-->=<!--> <!-->0.67; 95% CI: 0.46–0.98; <em>P</em> <!-->=<!--> <!-->0.04), with moderate heterogeneity (I<sup>2</sup> <!-->=<!--> <!-->48.2%). Subgroup analysis revealed a greater benefit among patients aged 65<!--> <!-->years or older (minimal heterogeneity; I<sup>2</sup> <!-->=<!--> <!-->4.3%) and among studies with more than 50% female participants (OR<!--> <!-->=<!--> <!-->0.47; <em>P</em> <!-->=<!--> <!-->0.01). No significant publication bias was detected.</div></div><div><h3>Conclusions</h3><div>Vitamin D may confer a protective effect against COVID-19 mortality, particularly among older adults and women. It represents a promising adjunctive strategy in COVID-19 management.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103022"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of the Persian version of the Leeds Food Preference Questionnaire (LFPQ-IR): A reliable tool for assessing food rewards and preferences in adults 波斯语版利兹食物偏好问卷(LFPQ-IR)的开发和验证:一个评估成人食物奖励和偏好的可靠工具
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2026-03-01 Epub Date: 2025-11-19 DOI: 10.1016/j.nupar.2025.11.002
Faezeh Nematolahi , Nasrin Sharifi , Habibollah Rahimi , Graham Finlayson , Abbas Mohtashamian
{"title":"Development and validation of the Persian version of the Leeds Food Preference Questionnaire (LFPQ-IR): A reliable tool for assessing food rewards and preferences in adults","authors":"Faezeh Nematolahi ,&nbsp;Nasrin Sharifi ,&nbsp;Habibollah Rahimi ,&nbsp;Graham Finlayson ,&nbsp;Abbas Mohtashamian","doi":"10.1016/j.nupar.2025.11.002","DOIUrl":"10.1016/j.nupar.2025.11.002","url":null,"abstract":"<div><h3>Objectives</h3><div>The Leeds Food Preference Questionnaire (LFPQ) is a computer-based task assessing “liking” and “wanting” as distinct psychological components of food reward. This study aimed to adapt LFPQ for Iranian adults (LFPQ-IR) and examine its validity, sensitivity, and reliability in fasted and fed states.</div></div><div><h3>Methods</h3><div>LFPQ-IR was developed through cultural adaptation of food images and clustering based on taste and fat content. Validation was conducted in 81 adults (41 females, 40 males; 18–33 years; BMI: 23.6<!--> <!-->±<!--> <!-->3.7<!--> <!-->kg/m<sup>2</sup>). They participated in identical test and retest trials one week apart, when they completed LFPQ-IR while fasting and again after consuming a standardized test meal. Changes in outcomes between conditions were assessed using repeated measures ANOVA, while test–retest reliability was evaluated via interclass correlation coefficients (ICC) and Bland-Altman plots.</div></div><div><h3>Results</h3><div>After the standardized meal, implicit wanting shifted toward lower fat, higher sweet foods. Explicit liking and wanting for both savory and sweet foods decreased significantly post-meal (<em>P</em> <!-->&lt;<!--> <!-->0.001), with a greater reduction for savory foods. BMI showed a weak association with explicit liking for high versus low-fat foods in the fed state (<em>r</em> <!-->=<!--> <!-->0.22, <em>P</em> <!-->&lt;<!--> <!-->0.05). Gender differences emerged: men preferred sweet foods when fasted and savory foods when fed, whereas women displayed stronger preferences for sweet foods in the fed state. Moreover, most ICC values exceeded 0.75, demonstrating excellent reliability.</div></div><div><h3>Conclusion</h3><div>LFPQ-IR is a culturally adapted, valid, sensitive, and reliable tool for assessing food preferences and reward processes in Iranian adults, suitable for use in nutritional and behavioral research.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103018"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between emotional eating, depressive symptoms, and body weight: A comparative cross-sectional study 情绪性进食、抑郁症状和体重之间的关系:一项比较横断面研究
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2026-03-01 Epub Date: 2025-12-04 DOI: 10.1016/j.nupar.2025.11.005
Serap Balaban Barta , Gizem Helvacı , Aslı Uçar
{"title":"Association between emotional eating, depressive symptoms, and body weight: A comparative cross-sectional study","authors":"Serap Balaban Barta ,&nbsp;Gizem Helvacı ,&nbsp;Aslı Uçar","doi":"10.1016/j.nupar.2025.11.005","DOIUrl":"10.1016/j.nupar.2025.11.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Emotional eating, influenced by emotional states, depression, and stress, is associated with weight gain and obesity. This study aimed to evaluate the association between emotional eating and body mass index (BMI) in individuals with normal body weight and those with obesity and to assess the mediating role of emotional eating in the relationship between depressive symptoms and BMI.</div></div><div><h3>Material and methods</h3><div>In this comparative cross-sectional study, 300 individuals aged 20–65 years (150 obese and 150 with normal body weight) were assessed using validated questionnaires: Emotional Appetite Questionnaire (EMAQ), Beck Depression Inventory (BDI), Three-Factor Eating Questionnaire-Revised-18 (TFEQ-R18), and the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Anthropometric measurements were collected, and multiple linear regression and logistic regression analyses were performed to identify factors influencing emotional eating and obesity.</div></div><div><h3>Results</h3><div>Obese individuals showed significantly higher scores in emotional eating, hunger sensitivity, and negative emotional responses compared to those with normal weight (<em>P</em> <!-->&lt;<!--> <!-->0.001). Emotional eating was positively associated with BMI and negative emotions, and inversely related to positive emotions. Depression levels and physical activity did not significantly predict emotional eating. Logistic regression identified negative emotions (OR: 1.12, 95% CI: 1.06–1.19), total positive score (OR: 0.90, 95% CI: 0.82–0.99), emotional eating (OR: 1.52, 95% CI: 1.21–1.91), and hunger sensitivity (OR: 1.32, 95% CI: 1.07–1.62) as significant predictors of obesity (<em>P</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>Emotional eating is a key behavioral risk factor for obesity, influenced by both emotional situations and BMI. These findings underline the need for a multidisciplinary approach to obesity treatment that addresses emotional and psychological dimensions alongside dietary and physical activity interventions.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103021"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eosinophilic esophagitis; An updated review 嗜酸性食管炎;最新的评论
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2026-03-01 Epub Date: 2026-01-12 DOI: 10.1016/j.nupar.2025.12.002
Mohamed Guda , Aseel Almagrabi , Muhammed Zahri , Nada A. Alshaikh , Elsayed Ghoneem
{"title":"Eosinophilic esophagitis; An updated review","authors":"Mohamed Guda ,&nbsp;Aseel Almagrabi ,&nbsp;Muhammed Zahri ,&nbsp;Nada A. Alshaikh ,&nbsp;Elsayed Ghoneem","doi":"10.1016/j.nupar.2025.12.002","DOIUrl":"10.1016/j.nupar.2025.12.002","url":null,"abstract":"<div><div>Chronic inflammatory esophageal illness, also known as eosinophilic esophagitis (EoE), is mostly caused by immunological responses mediated by T-helper 2 (Th2) cells. Dysphagia, chest pain, and regurgitation are some of the symptoms that can be seen in both adults and children. Specific histological criteria usually lead to a diagnosis of the condition, which is marked by eosinophilic infiltration of the esophagus. It is more common in men, and the incidence and prevalence of EoE are on the rise, especially in high-income nations. The etiology of EoE is influenced by both hereditary and environmental factors. In order to manage EoE effectively, it is necessary to deal with the inflammatory and fibrostenotic components of the condition simultaneously. Efficacious dietary elimination programs, such as the 6-food elimination diet (6FED), are currently being used as therapies, along with proton pump inhibitors (PPIs) and topical corticosteroids. Dupilumab and other monoclonal antibodies that target the interleukin-4 receptor alpha are examples of biologic therapeutics that are showing promise as treatments, especially for patients who have not responded to conventional methods. Nevertheless, studies are still being conducted to determine the medicines’ long-term safety and effectiveness in various patient populations.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103023"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular crosstalk between nutrition and osteosarcopenia in chronic liver disease: Pathophysiology and therapeutic prospects 慢性肝病中营养与骨骼肌减少的分子串扰:病理生理学和治疗前景
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2025-12-01 Epub Date: 2025-10-17 DOI: 10.1016/j.nupar.2025.09.002
Omer Qutaiba B. Allela , Abdulkareem Shareef , Hayder Naji Sameer , Ahmed Yaseen , Zainab H. Athab , Mohaned Adil
{"title":"Molecular crosstalk between nutrition and osteosarcopenia in chronic liver disease: Pathophysiology and therapeutic prospects","authors":"Omer Qutaiba B. Allela ,&nbsp;Abdulkareem Shareef ,&nbsp;Hayder Naji Sameer ,&nbsp;Ahmed Yaseen ,&nbsp;Zainab H. Athab ,&nbsp;Mohaned Adil","doi":"10.1016/j.nupar.2025.09.002","DOIUrl":"10.1016/j.nupar.2025.09.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteosarcopenia, defined by the simultaneous loss of bone and muscle mass, is a growing complication in chronic liver disease (CLD) that worsens frailty, fracture risk, and clinical outcomes. However, its nutritional and molecular drivers remain poorly understood. This scoping review examines the prevalence and clinical impact of osteosarcopenia in CLD and explores underlying nutritional and metabolic pathways to identify modifiable dietary targets for prevention and treatment.</div></div><div><h3>Material and methods</h3><div>A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science up to May 2025. Twenty-six eligible studies were included: seven focused on prevalence and outcomes, and nineteen investigated nutrient-related mechanisms. Thematic synthesis was guided by PRISMA-ScR methodology.</div></div><div><h3>Results</h3><div>Osteosarcopenia affects up to 20% of individuals with CLD and is independently associated with increased frailty, fractures, and mortality. Pathophysiological drivers include amino acid depletion, vitamin D deficiency, bile acid-related malabsorption, and endocrine dysregulation (e.g., reduced IGF-1, elevated myostatin). Inflammatory and oxidative pathways mediated by TNF-α, IL-6, and NF-κB further promote musculoskeletal catabolism. Nutrients such as leucine, arginine, glutamine, vitamin D, omega-3 fatty acids, and gut-derived short-chain fatty acids modulate critical anabolic and anti-catabolic pathways, including the mTORC1, Wnt/β-catenin, SIRT1/PGC-1α, and Nrf2 pathways.</div></div><div><h3>Conclusion</h3><div>Osteosarcopenia in CLD is not merely a secondary consequence of malnutrition but a distinct, nutritionally modifiable syndrome driven by disrupted inter-organ crosstalk. Dietary interventions targeting gut-muscle-bone-liver axes could represent safe, scalable, and cost-effective strategies to mitigate musculoskeletal decline in CLD. Integrating nutrition into hepatology care is a critical priority to enhance patient resilience, independence, and survival.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 282-291"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of creatine supplementation on muscle protein synthesis in athletes: A review 补充肌酸对运动员肌肉蛋白质合成的影响:综述
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2025-12-01 Epub Date: 2025-09-23 DOI: 10.1016/j.nupar.2025.09.001
Mohammad Ali Izadi, Farhad Daryanoosh
{"title":"The effect of creatine supplementation on muscle protein synthesis in athletes: A review","authors":"Mohammad Ali Izadi,&nbsp;Farhad Daryanoosh","doi":"10.1016/j.nupar.2025.09.001","DOIUrl":"10.1016/j.nupar.2025.09.001","url":null,"abstract":"<div><div>Muscle mass is a key factor in the performance and health of athletes. Skeletal muscle mass is determined by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). One of the goals of strength athletes is to have more muscle mass through exercise, nutritional, and supplementation strategies. From a supplementation perspective, creatine supplementation, especially when combined with resistance training, is recognized as a strategy for increasing lean tissue mass and muscle strength. The mechanisms of action of creatine in skeletal muscle include increased energy availability, IGF-1 signaling, activation of the mTOR pathway, increased intracellular water, activation of satellite cells, reduced muscle damage, and improved recovery, which are discussed in this review. This article provides a comprehensive review of the current literature on creatine supplementation and its effects on MPS in athletes. We review the mechanisms through which creatine exerts its effects, its implications for different types of exercise training, and considerations for optimal dosing protocols.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 273-281"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Joint association of the triglyceride glucose and body roundness index with cardiovascular diseases among Chinese middle and old-aged adults with abnormal glucose metabolism: A nationwide prospective cohort study 甘油三酯葡萄糖和体圆度指数与中国中老年人糖代谢异常心血管疾病的联合关系:一项全国前瞻性队列研究
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2025-12-01 Epub Date: 2025-09-04 DOI: 10.1016/j.nupar.2025.08.003
Wangyang Bai , Yi Ling , Hangqi Chen , Xiaofei Ye , Jinfang Xu , Xiaojing Guo , Jia He
{"title":"Joint association of the triglyceride glucose and body roundness index with cardiovascular diseases among Chinese middle and old-aged adults with abnormal glucose metabolism: A nationwide prospective cohort study","authors":"Wangyang Bai ,&nbsp;Yi Ling ,&nbsp;Hangqi Chen ,&nbsp;Xiaofei Ye ,&nbsp;Jinfang Xu ,&nbsp;Xiaojing Guo ,&nbsp;Jia He","doi":"10.1016/j.nupar.2025.08.003","DOIUrl":"10.1016/j.nupar.2025.08.003","url":null,"abstract":"<div><h3>Objectives</h3><div>It remains unclear whether the combined use of the triglyceride glucose index (TyG) and body roundness index (BRI), specifically the triglyceride glucose-body roundness index (TyG-BRI), is associated with the incidence of cardiovascular diseases (CVD). This study aimed to investigate the joint association of the TyG and BRI with CVD among middle-aged and elderly adults with abnormal glucose metabolism.</div></div><div><h3>Material and methods</h3><div>This study obtained four national waves data from China Health and Retirement Longitudinal Study. Patients age ≥<!--> <!-->45 years with abnormal glucose metabolism were included. The primary outcome was incident CVD. Multivariable-adjusted Cox proportional hazards regression models were employed to assess the joint association of the TyG, BRI and the TyG-BRI with outcomes.</div></div><div><h3>Results</h3><div>A total of 4805 Chinese adults with abnormal glucose metabolism were enrolled in this study. In the follow-up, 899 participants (18.7%) experienced CVD events. Compared to the first quartile of the index, the fourth quartile of TyG-BRI was associated with increased risk for CVD by 53.8% (HR, 1.538 [95% CI, 1.249–1.893]). Mediation effects analyses revealed that high TyG index significantly mediated 4.545% (<em>P</em> <!-->=<!--> <!-->0.016) of the association between a high BRI and CVD incidence, while BRI simultaneously mediated 14.583% (<em>P</em> <!-->&lt;<!--> <!-->0.001) of the association between high TyG index and CVD.</div></div><div><h3>Conclusions</h3><div>TyG, BRI, and the combined TyG-BRI index are independently associated with increased risks of CVD among middle-aged and older adults with abnormal glucose metabolism in China. These indicators are easy to obtain and can be implemented in resource-limited primary hospitals to assist clinical practitioners in early screening and assessment of cardiovascular disease risk in patients with abnormal glucose metabolism.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 310-318"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Canevas de structuration d’une unité transversale de nutrition institutionnelle 横向机构营养单位结构大纲
IF 0.4 4区 医学
Nutrition Clinique et Metabolisme Pub Date : 2025-12-01 Epub Date: 2025-08-11 DOI: 10.1016/j.nupar.2025.07.004
Frédéric V. Valla , Cécile Betry , Alexandra Aupetit , Dorothée Bedock , Cécile Bossu Estour , Caroline Dendoncker , Adam Jirka , Johann Morizot , Alexandre Morvan , Dominique Soupart , Bérénice Teulieres , Sophie Vandendorpe , Maggie Le Bourhis , Francisca Joly
{"title":"Canevas de structuration d’une unité transversale de nutrition institutionnelle","authors":"Frédéric V. Valla ,&nbsp;Cécile Betry ,&nbsp;Alexandra Aupetit ,&nbsp;Dorothée Bedock ,&nbsp;Cécile Bossu Estour ,&nbsp;Caroline Dendoncker ,&nbsp;Adam Jirka ,&nbsp;Johann Morizot ,&nbsp;Alexandre Morvan ,&nbsp;Dominique Soupart ,&nbsp;Bérénice Teulieres ,&nbsp;Sophie Vandendorpe ,&nbsp;Maggie Le Bourhis ,&nbsp;Francisca Joly","doi":"10.1016/j.nupar.2025.07.004","DOIUrl":"10.1016/j.nupar.2025.07.004","url":null,"abstract":"<div><div>In 2002, the French ministry of health encouraged the creation of organized and specialized healthcare professional teams dedicated to nutrition support within healthcare institutions. Since then, many institutions have implemented local nutrition support teams (NST), with locally defined objectives, scopes, missions and resources. However, only 17% of French and Belgian institutions have managed to do so and many others struggle to implement a local NST. A multidisciplinary group was set up, with 12 experts involved in a local NST, with the input of a hospital director and a health economist, to help design future local NST, through an NST Framework. Eleven questions were generated (NST scope of action, mission, institutional interaction and integration, composition, mandatory tools, rationale, health economic model, training, dietician and medical doctors’ collaboration, and resultant monitoring). Plans and strategies were conceived for each of the 11 questions, to facilitate local healthcare institutions to adapt this framework to their local context.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 251-259"},"PeriodicalIF":0.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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