{"title":"Aconitate decarboxylase (ACOD1) has found a disease.","authors":"Fakhar H Waqas, Chutao Chen, Frank Pessler","doi":"10.1016/j.tem.2024.04.003","DOIUrl":"10.1016/j.tem.2024.04.003","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":"35 7","pages":"561-562"},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The big picture.","authors":"Salvatore Fabbiano","doi":"10.1016/j.tem.2024.06.001","DOIUrl":"10.1016/j.tem.2024.06.001","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"559-560"},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chemical chaperones in metabolic fitness beyond protein folding.","authors":"Ester Zito, Alain Lescure, Nica Borgese","doi":"10.1016/j.tem.2024.04.006","DOIUrl":"10.1016/j.tem.2024.04.006","url":null,"abstract":"<p><p>Chemical chaperones are small molecules that improve protein folding, alleviating aberrant pathological phenotypes due to protein misfolding. Recent reports suggest that, in parallel with their role in relieving endoplasmic reticulum (ER) stress, chemical chaperones rescue mitochondrial function and insulin signaling. These effects may underlie their pharmacological action on metabolically demanding tissues.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"572-575"},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metabolic dysregulation of lymphocytes in autoimmune diseases.","authors":"Shuyi Wang, Niansheng Yang, Hui Zhang","doi":"10.1016/j.tem.2024.01.005","DOIUrl":"10.1016/j.tem.2024.01.005","url":null,"abstract":"<p><p>Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic reprogramming determines the autoreactive and proinflammatory nature of lymphocytes in SLE and RA, unraveling molecular mechanisms and providing therapeutic targets for human autoimmune diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"624-637"},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Armando Jesús Pérez-Díaz, María Ángeles Núñez-Sánchez, Bruno Ramos-Molina
{"title":"Revisiting liver metabolism through acetyl-CoA carboxylase inhibition.","authors":"Armando Jesús Pérez-Díaz, María Ángeles Núñez-Sánchez, Bruno Ramos-Molina","doi":"10.1016/j.tem.2024.04.010","DOIUrl":"10.1016/j.tem.2024.04.010","url":null,"abstract":"<p><p>Liver-targeted acetyl-coenzyme A (CoA) carboxylase (ACC) inhibitors in metabolic dysfunction-associated steatotic liver disease (MASLD) trials reveal notable secondary effects: hypertriglyceridemia and altered glucose metabolism, paradoxically with reduced hepatic steatosis. In their study, Deja et al. explored how hepatic ACC influences metabolism using different pharmacological and genetic methods, coupled with targeted metabolomics and stable isotope-based tracing techniques.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"563-565"},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dan Ye, Pu Wang, Lei-Lei Chen, Kun-Liang Guan, Yue Xiong
{"title":"Itaconate in host inflammation and defense.","authors":"Dan Ye, Pu Wang, Lei-Lei Chen, Kun-Liang Guan, Yue Xiong","doi":"10.1016/j.tem.2024.02.004","DOIUrl":"10.1016/j.tem.2024.02.004","url":null,"abstract":"<p><p>Immune cells undergo rapid and extensive metabolic changes during inflammation. In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling molecules. Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory conditions. This metabolite binds to and regulates the function of diverse proteins intracellularly to influence metabolism, oxidative response, epigenetic modification, and gene expression and to signal extracellularly through binding the G protein-coupled receptor (GPCR). Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances antitumor immunity in preclinical models. In this article, we review ITA metabolism and its regulation, discuss its target proteins and mechanisms, and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases and cancer.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"586-606"},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ifene David Festus, Jeri Spilberg, Martin E Young, Sean Cain, Sepideh Khoshnevis, Michael H Smolensky, Fariya Zaheer, Giannina Descalzi, Tami A Martino
{"title":"Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health.","authors":"Ifene David Festus, Jeri Spilberg, Martin E Young, Sean Cain, Sepideh Khoshnevis, Michael H Smolensky, Fariya Zaheer, Giannina Descalzi, Tami A Martino","doi":"10.1016/j.tem.2024.02.011","DOIUrl":"10.1016/j.tem.2024.02.011","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, light, and meal timing) with potential to enhance cardiovascular care. We also highlight pioneering research in the new field of rest, the gut microbiome, novel chronotherapies for hypertension, pain management, and small molecules that targeting the circadian mechanism.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"607-623"},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gong Feng, Yu Han, Wah Yang, Scott Shikora, Kamal Mahawar, Tan To Cheung, Giovanni Targher, Christopher D Byrne, Virginia Hernandez-Gea, Herbert Tilg, Ming-Hua Zheng
{"title":"Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery.","authors":"Gong Feng, Yu Han, Wah Yang, Scott Shikora, Kamal Mahawar, Tan To Cheung, Giovanni Targher, Christopher D Byrne, Virginia Hernandez-Gea, Herbert Tilg, Ming-Hua Zheng","doi":"10.1016/j.tem.2024.05.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.05.009","url":null,"abstract":"<p><p>The prognosis of patients with decompensated cirrhosis is poor, with significantly increased liver-related mortality rates. With the rising tide of decompensated cirrhosis associated with metabolic dysfunction-associated steatotic liver disease (MASLD), the role of metabolic bariatric surgery (MBS) in achieving hepatic recompensation is garnering increasing attention. However, the complexity of preoperative assessment, the risk of postoperative disease recurrence, and the potential for patients to experience surgical complications of the MBS present challenges. In this opinion article we analyze the potential of MBS to induce recompensation in MASLD-related cirrhosis, discuss the mechanisms by which MBS may affect recompensation, and compare the characteristics of different MBS procedures; we highlight the therapeutic potential of MBS in MASLD-related cirrhosis recompensation and advocate for research in this complex area.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ines Foessl, Cheryl L Ackert-Bicknell, Erika Kague, Faidra Laskou, Franz Jakob, David Karasik, Barbara Obermayer-Pietsch, Nerea Alonso, Åshild Bjørnerem, Maria Luisa Brandi, Björn Busse, Ângelo Calado, Alper Han Cebi, Maria Christou, Kathleen M Curran, Jannie Dahl Hald, Maria Donatella Semeraro, Eleni Douni, Emma L Duncan, Ivan Duran, Melissa M Formosa, Yankel Gabet, Samuel Ghatan, Artemis Gkitakou, Eva Maria Hassler, Wolfgang Högler, Terhi J Heino, Gretl Hendrickx, Patricia Khashayar, Douglas P Kiel, Fjorda Koromani, Bente Langdahl, Philippe Lopes, Outi Mäkitie, Antonio Maurizi, Carolina Medina-Gomez, Evangelia Ntzani, Claes Ohlsson, Vid Prijatelj, Raquel Rabionet, Sjur Reppe, Fernando Rivadeneira, Gennady Roshchupkin, Neha Sharma, Kent Søe, Unnur Styrkarsdottir, Pavel Szulc, Anna Teti, Jon Tobias, Amina Valjevac, Jeroen van de Peppel, Bram van der Eerden, Bert van Rietbergen, Tatjana Zekic, M Carola Zillikens
{"title":"A perspective on muscle phenotyping in musculoskeletal research.","authors":"Ines Foessl, Cheryl L Ackert-Bicknell, Erika Kague, Faidra Laskou, Franz Jakob, David Karasik, Barbara Obermayer-Pietsch, Nerea Alonso, Åshild Bjørnerem, Maria Luisa Brandi, Björn Busse, Ângelo Calado, Alper Han Cebi, Maria Christou, Kathleen M Curran, Jannie Dahl Hald, Maria Donatella Semeraro, Eleni Douni, Emma L Duncan, Ivan Duran, Melissa M Formosa, Yankel Gabet, Samuel Ghatan, Artemis Gkitakou, Eva Maria Hassler, Wolfgang Högler, Terhi J Heino, Gretl Hendrickx, Patricia Khashayar, Douglas P Kiel, Fjorda Koromani, Bente Langdahl, Philippe Lopes, Outi Mäkitie, Antonio Maurizi, Carolina Medina-Gomez, Evangelia Ntzani, Claes Ohlsson, Vid Prijatelj, Raquel Rabionet, Sjur Reppe, Fernando Rivadeneira, Gennady Roshchupkin, Neha Sharma, Kent Søe, Unnur Styrkarsdottir, Pavel Szulc, Anna Teti, Jon Tobias, Amina Valjevac, Jeroen van de Peppel, Bram van der Eerden, Bert van Rietbergen, Tatjana Zekic, M Carola Zillikens","doi":"10.1016/j.tem.2024.01.004","DOIUrl":"10.1016/j.tem.2024.01.004","url":null,"abstract":"<p><p>Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genomics of MusculoSkeletal traits Translational Network' (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"478-489"},"PeriodicalIF":10.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endothelial lipid droplets drive atherosclerosis and arterial hypertension.","authors":"Suowen Xu, Stefan Offermanns","doi":"10.1016/j.tem.2024.02.014","DOIUrl":"10.1016/j.tem.2024.02.014","url":null,"abstract":"<p><p>Lipid droplets (LDs) are essential for cellular pathophysiology. In two recent reports, Kim et al. and Boutagy et al. show that accumulation of LDs in endothelial cells (ECs) elevates blood pressure and accelerates progression of atherosclerosis. These findings identify a novel mechanism of EC lipid metabolism which drives cardiometabolic diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"453-455"},"PeriodicalIF":10.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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