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Lipids guide T cell antitumor immunity by shaping their metabolic and functional fitness. 脂质通过塑造T细胞的代谢和功能适应性来引导T细胞抗肿瘤免疫。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-31 DOI: 10.1016/j.tem.2024.11.014
Letizia Rumiano, Teresa Manzo
{"title":"Lipids guide T cell antitumor immunity by shaping their metabolic and functional fitness.","authors":"Letizia Rumiano, Teresa Manzo","doi":"10.1016/j.tem.2024.11.014","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.014","url":null,"abstract":"<p><p>Lipids are metabolic messengers essential for energy production, membrane structure, and signal transduction. Beyond their recognized role, lipids have emerged as metabolic rheostats of T cell responses, with distinct species differentially modulating CD8+ T cell (CTL) fate and function. Indeed, lipids can influence T cell signaling by altering their membrane composition; in addition, they can affect the differentiation path of T cells through cellular metabolism. This Review discusses the ability of lipids to shape T cell phenotypes and functions. Based on this link between lipid metabolism, metabolic fitness and immunosurveillance, we suggest that lipid could be rationally integrated in the context of immunotherapies to fine-tune fitness and function of adoptive T cell therapy (ACT) products.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian disruption and its impact on the cardiovascular system. 昼夜节律紊乱及其对心血管系统的影响。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-19 DOI: 10.1016/j.tem.2024.11.010
Morag J Young, Seamus Heanue, Monica Kanki, Kegan J Moneghetti
{"title":"Circadian disruption and its impact on the cardiovascular system.","authors":"Morag J Young, Seamus Heanue, Monica Kanki, Kegan J Moneghetti","doi":"10.1016/j.tem.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.010","url":null,"abstract":"<p><p>Circadian rhythms are highly conserved biorhythms of ~24 h that govern many fundamental biological processes, including cardiovascular (CV) homeostasis. Disrupting the timing of cellular oscillators promotes cellular stress, and induction of pathogenic pathways underpins the pathogenesis of many CV diseases (CVDs). Thus, shift work, late eating, sleep disturbances, and other disruptors can result in an elevated risk of heart disease and increased incidence of adverse CV events. Here, we discuss the importance of circadian rhythms for CV homeostasis, recent developments in understanding the impact of disrupted circadian rhythms on CV health and disease progression, and how understanding the interactions between circadian and CV physiology is crucial for improving interventions to mitigate CVD, especially in populations impacted by disrupted circadian rhythms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shared metabolic and stress pathways to neonatal adiposity. 新生儿肥胖的共同代谢和应激途径。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-18 DOI: 10.1016/j.tem.2024.11.012
Sonja Entringer, Gernot Desoye
{"title":"Shared metabolic and stress pathways to neonatal adiposity.","authors":"Sonja Entringer, Gernot Desoye","doi":"10.1016/j.tem.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.012","url":null,"abstract":"<p><p>Perceived stress levels, prevalence of pregnancies complicated by metabolic disorders, and childhood obesity have been increasing steadily. We here propose a pathway integrating stress-responsive biological systems into the established effects of maternal diabetes and obesity during pregnancy, overall exerting a combined contribution to offspring adiposity risk.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More than carriers, orosomucoids are key metabolic modulators. 与载体相比，orosomucoids是关键的代谢调节剂。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-18 DOI: 10.1016/j.tem.2024.11.015
Mi Jeong Heo, Inyoung Cheon, Kang Ho Kim
{"title":"More than carriers, orosomucoids are key metabolic modulators.","authors":"Mi Jeong Heo, Inyoung Cheon, Kang Ho Kim","doi":"10.1016/j.tem.2024.11.015","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.015","url":null,"abstract":"<p><p>Orosomucoids (ORMs) have historically been considered as carriers involved in drug and lipid delivery. However, recent studies indicate ORM2 as a hepatokine involved in metabolic regulation. Here, we highlight the functions of ORM2 in controlling metabolic health and disease, focusing on its newly discovered regulatory mechanisms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring tryptophan metabolism in cardiometabolic diseases. 探索色氨酸在心脏代谢疾病中的代谢。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-17 DOI: 10.1016/j.tem.2024.11.009
Nirmala Mouttoulingam, Soraya Taleb
{"title":"Exploring tryptophan metabolism in cardiometabolic diseases.","authors":"Nirmala Mouttoulingam, Soraya Taleb","doi":"10.1016/j.tem.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.009","url":null,"abstract":"<p><p>Tryptophan (Trp) metabolism is linked to health and disease, with indoleamine 2,3-dioxygenase 1 (IDO) being a key enzyme in its breakdown outside the liver. This process produces metabolites that influence metabolic and inflammatory responses. A distinctive feature of the gut is its involvement in three major Trp catabolic pathways: the IDO-driven kynurenine pathway, bacteria-produced indoles, and serotonin. Dysregulation of these pathways is associated with gastrointestinal and chronic inflammatory diseases. Understanding these mechanisms could reveal how gut function affects overall systemic health and disease susceptibility. Here, we review current insights into Trp metabolism, its impact on host physiology and cardiometabolic diseases, and its role in the gut-periphery connection, highlighting its relevance for therapeutic innovation.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter-organ communication is a critical machinery to regulate metabolism and aging. 器官间通讯是调节新陈代谢和衰老的重要机制。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-17 DOI: 10.1016/j.tem.2024.11.013
Kyohei Tokizane, Shin-Ichiro Imai
{"title":"Inter-organ communication is a critical machinery to regulate metabolism and aging.","authors":"Kyohei Tokizane, Shin-Ichiro Imai","doi":"10.1016/j.tem.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.013","url":null,"abstract":"<p><p>Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks and examine their roles in regulating metabolism and aging. Given the role of the hypothalamus as a high-order control center for aging and longevity, we particularly emphasize the importance of its communication with peripheral organs and pave the way for a better understanding of this critical machinery in metabolism and aging.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skeletal muscle adaptations and post-exertional malaise in long COVID. 长期COVID的骨骼肌适应和运动后不适。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-17 DOI: 10.1016/j.tem.2024.11.008
Braeden T Charlton, Richie P Goulding, Richard T Jaspers, Brent Appelman, Michèle van Vugt, Rob C I Wüst
{"title":"Skeletal muscle adaptations and post-exertional malaise in long COVID.","authors":"Braeden T Charlton, Richie P Goulding, Richard T Jaspers, Brent Appelman, Michèle van Vugt, Rob C I Wüst","doi":"10.1016/j.tem.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.008","url":null,"abstract":"<p><p>When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional malaise (PEM), which is the worsening of symptoms following mental or physical exertion. There is little consensus on the pathophysiology of exercise-induced PEM and skeletal-muscle-related symptoms. In this opinion article we highlight intrinsic mitochondrial dysfunction, endothelial abnormalities, and a muscle fiber type shift towards a more glycolytic phenotype as main contributors to the reduced exercise capacity in long COVID. The mechanistic trigger for physical exercise to induce PEM is unknown, but rapid skeletal muscle tissue damage and intramuscular infiltration of immune cells contribute to PEM-related symptoms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracellular endothelial cell metabolism in vascular function and dysfunction. 细胞内内皮细胞代谢与血管功能障碍。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-12 DOI: 10.1016/j.tem.2024.11.004
Kathryn M Citrin, Balkrishna Chaube, Carlos Fernández-Hernando, Yajaira Suárez
{"title":"Intracellular endothelial cell metabolism in vascular function and dysfunction.","authors":"Kathryn M Citrin, Balkrishna Chaube, Carlos Fernández-Hernando, Yajaira Suárez","doi":"10.1016/j.tem.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.004","url":null,"abstract":"<p><p>Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular function and homeostasis. They regulate vascular tone, oxidative stress, and permeability. Dysfunction leads to increased permeability, leukocyte adhesion, and thrombosis. ECs undergo metabolic changes in conditions such as wound healing, cancer, atherosclerosis, and diabetes, and can influence disease progression. We discuss recent research that has revealed diverse intracellular metabolic pathways in ECs that are tailored to their functional needs, including lipid handling, glycolysis, and fatty acid oxidation (FAO). Understanding EC metabolic signatures in health and disease will be crucial not only for basic biology but can also be exploited when designing new therapies to target EC-related functions in different vascular diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholic acid. 胆酸
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-11 DOI: 10.1016/j.tem.2024.11.007
Xi Luo, Kai Wang, Changtao Jiang
{"title":"Cholic acid.","authors":"Xi Luo, Kai Wang, Changtao Jiang","doi":"10.1016/j.tem.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.007","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can brain neurons change identity? Lessons from obesity. 大脑神经元能改变身份吗？肥胖的教训。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-05 DOI: 10.1016/j.tem.2024.11.006
Jean Charles Nicolas, Thomas H Lee, Carmelo Quarta
{"title":"Can brain neurons change identity? Lessons from obesity.","authors":"Jean Charles Nicolas, Thomas H Lee, Carmelo Quarta","doi":"10.1016/j.tem.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.006","url":null,"abstract":"<p><p>It has long been thought that the functional identity of mammalian brain neurons is programmed during development and remains stable throughout adult life; however, certain populations of neurons continue to express active regulators of neuronal identity into adulthood. Prolonged exposure to diet-induced metabolic stress induces features of neuronal identity modification in adult mice, and maladaptive changes in neuronal identity maintenance have been linked to cognitive impairment in humans suffering from neurodegenerative diseases often associated with obesity. Here we discuss how, by unraveling the neurological roots of obesity, we may solve the puzzle of whether mammalian brain neurons retain identity plasticity into adulthood, while advancing knowledge of the pathogenic mechanisms at the interface of metabolic and neurodegenerative disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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