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Host metabolic inflammation fueled by bacterial DNA. 宿主代谢炎症由细菌DNA引起。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-27 DOI: 10.1016/j.tem.2024.11.003
Ke Wang, Karina Cunha E Rocha, Houji Qin, Zixuan Zeng, Wei Ying
{"title":"Host metabolic inflammation fueled by bacterial DNA.","authors":"Ke Wang, Karina Cunha E Rocha, Houji Qin, Zixuan Zeng, Wei Ying","doi":"10.1016/j.tem.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.003","url":null,"abstract":"<p><p>Metabolic diseases, characterized by chronic low-grade inflammation, exhibit a compromised gut barrier allowing the translocation of bacteria-derived products to bloodstream and distant metabolic organs. Bacterial DNA can be detected in metabolic tissues during the onset of these diseases, highlighting its role in the development of metabolic diseases. Extracellular vesicles (EVs) are involved in the delivery of bacterial DNA to the local tissues, and its sensing by the host triggers local and system inflammation. Understanding bacterial DNA translocation and its induced inflammation is crucial in deciphering metabolic disease pathways. Here, we delve into the mechanisms dictating the interaction between host physiology and bacterial DNA, focusing on its origin and delivery, host immune responses against it, and its roles in metabolic disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria as sensors of intracellular pathogens. 线粒体是细胞内病原体的传感器。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-22 DOI: 10.1016/j.tem.2024.10.009
Jose M Delgado, Lena Pernas
{"title":"Mitochondria as sensors of intracellular pathogens.","authors":"Jose M Delgado, Lena Pernas","doi":"10.1016/j.tem.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.009","url":null,"abstract":"<p><p>Mitochondria must sense their environment to enable cells and organisms to adapt to diverse environments and survive during stress. However, during microbial infection, an evolutionary pressure since the inception of the eukaryotic cell, these organelles are traditionally viewed as targets for microbes. In this opinion we consider the perspective that mitochondria are domesticated microbes that sense and guard their 'host' cell against pathogens. We explore potential mechanisms by which mitochondria detect intracellular pathogens and induce mitochondria-autonomous responses that activate cellular defenses.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The paternal contribution to shaping the health of future generations. 父亲对塑造后代健康的贡献。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-18 DOI: 10.1016/j.tem.2024.10.007
Christopher Casciaro, Hirotaka Hamada, Enrrico Bloise, Stephen G Matthews
{"title":"The paternal contribution to shaping the health of future generations.","authors":"Christopher Casciaro, Hirotaka Hamada, Enrrico Bloise, Stephen G Matthews","doi":"10.1016/j.tem.2024.10.007","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.007","url":null,"abstract":"<p><p>Paternal health and exposure to adverse environments in the period prior to conception have a profound impact on future generations. Adversities such as stress, diet, and toxicants influence offspring health. Emerging evidence indicates that epigenetic mechanisms including noncoding RNA, DNA methylation, and chromatin remodelling mediate these effects. Preclinical studies have contributed to advancing mechanistic understanding in the field; however, human research is limited and primarily observational. Here, we discuss the evidence linking paternal to offspring health and advocate for further research in this area, which may ultimately inform policy and healthcare guidelines to improve paternal preconception health and offspring outcomes.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of non-sugar sweeteners on metabolism beyond sweet taste perception. 非糖甜味剂对新陈代谢的影响超出了对甜味的感知。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-16 DOI: 10.1016/j.tem.2024.10.008
Herbert Herzog, Lei Zhang, Luigi Fontana, G Gregory Neely
{"title":"Impact of non-sugar sweeteners on metabolism beyond sweet taste perception.","authors":"Herbert Herzog, Lei Zhang, Luigi Fontana, G Gregory Neely","doi":"10.1016/j.tem.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.008","url":null,"abstract":"<p><p>Non-sugar sweeteners (NSS), low- or no-calorie alternatives to sugar, are marketed for weight loss and improved blood glucose control in people with diabetes. However, their health effects remain controversial. This review provides a brief overview of sweet taste perception and summarizes experimental findings of the impact of NSS on cardiometabolic health in animal models and humans. We also review evidence suggesting that many NSS are not metabolically inert, highlighting the challenges in related human studies. Given the conflicting and unclear data on health outcomes, additional mechanistic studies, particularly in animal models, are necessary to clarify how NSS influence feeding behaviors and energy homoeostasis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A three-layer perspective on miRNA regulation in β cell inflammation. 从三层视角看β细胞炎症中的 miRNA 调控。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-11 DOI: 10.1016/j.tem.2024.10.002
Stefano Auddino, Elena Aiello, Giuseppina Emanuela Grieco, Francesco Dotta, Guido Sebastiani
{"title":"A three-layer perspective on miRNA regulation in β cell inflammation.","authors":"Stefano Auddino, Elena Aiello, Giuseppina Emanuela Grieco, Francesco Dotta, Guido Sebastiani","doi":"10.1016/j.tem.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.002","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression post-transcriptionally and influence numerous biological processes. Aberrant miRNA expression is linked to diseases such as diabetes mellitus; indeed, miRNAs regulate pancreatic islet inflammation in both type 1 (T1D) and type 2 diabetes (T2D). Traditionally, miRNA research has focused on canonical sequences and offers a two-layer view - from expression to function. However, advances in RNA sequencing have revealed miRNA variants, called isomiRs, that arise from alternative processing or modifications of canonical sequences. This introduces a three-layer view - from expression, through sequence modifications, to function. We discuss the potential link between cellular stresses and isomiR biogenesis, and how this association could improve our knowledge of islet inflammation and dysfunction.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose tissue-gut microbiome crosstalk in inflammation and thermogenesis. 脂肪组织-肠道微生物组在炎症和产热过程中的相互影响
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-07 DOI: 10.1016/j.tem.2024.10.004
Erin E Mauney, Marsha C Wibowo, Yu-Hua Tseng, Aleksandar D Kostic
{"title":"Adipose tissue-gut microbiome crosstalk in inflammation and thermogenesis.","authors":"Erin E Mauney, Marsha C Wibowo, Yu-Hua Tseng, Aleksandar D Kostic","doi":"10.1016/j.tem.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.004","url":null,"abstract":"<p><p>Previously characterized as inert fat depots, adipocytes are now recognized as dynamic mediators of inflammatory tone, metabolic health, and nutrient homeostasis. As endocrine organs, specialized depots of adipose tissue engage in crosstalk between the gut, liver, pancreas, and brain to coordinate appetite, thermogenesis, and ultimately body weight. These functions are tightly linked to the inflammatory status of adipose tissue, which is in turn influenced by the health of the gut microbiome. Here, we review recent findings linking specific gut microbes and their secreted factors, including recently identified elements such as bacterial extracellular vesicles, to the functional status of adipocytes. We conclude that further study may generate novel approaches for treating obesity and metabolic disease.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is cardiovascular disease in PCOS driven by MASLD? 多囊卵巢综合征的心血管疾病是由 MASLD 引起的吗？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-07 DOI: 10.1016/j.tem.2024.10.005
Huadong Chen, Pomme I H G Simons, Martijn C G J Brouwers
{"title":"Is cardiovascular disease in PCOS driven by MASLD?","authors":"Huadong Chen, Pomme I H G Simons, Martijn C G J Brouwers","doi":"10.1016/j.tem.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.005","url":null,"abstract":"<p><p>Recent genetic studies have implicated an active role for intrahepatic lipid accumulation in the pathogenesis of both polycystic ovary syndrome (PCOS) and cardiovascular disease. These new insights may provide novel (non)pharmacological opportunities for the prevention and treatment of PCOS and cardiovascular disease at both the societal and clinical level.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ghrelin. 胃泌素
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI: 10.1016/j.tem.2024.07.002
Maria E R Garcia-Rendueles, Luis Varela, Tamas L Horvath
{"title":"Ghrelin.","authors":"Maria E R Garcia-Rendueles, Luis Varela, Tamas L Horvath","doi":"10.1016/j.tem.2024.07.002","DOIUrl":"10.1016/j.tem.2024.07.002","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1021-1022"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-carbon metabolism shapes T cell immunity in cancer. 一碳代谢影响癌症中的 T 细胞免疫。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-06-25 DOI: 10.1016/j.tem.2024.05.010
Yajing Qiu, Ermei Xie, Haipeng Xu, Hongcheng Cheng, Guideng Li
{"title":"One-carbon metabolism shapes T cell immunity in cancer.","authors":"Yajing Qiu, Ermei Xie, Haipeng Xu, Hongcheng Cheng, Guideng Li","doi":"10.1016/j.tem.2024.05.010","DOIUrl":"10.1016/j.tem.2024.05.010","url":null,"abstract":"<p><p>One-carbon metabolism (1CM), comprising folate metabolism and methionine metabolism, serves as an important mechanism for cellular energy provision and the production of vital signaling molecules, including single-carbon moieties. Its regulation is instrumental in sustaining the proliferation of cancer cells and facilitating metastasis; in addition, recent research has shed light on its impact on the efficacy of T cell-mediated immunotherapy. In this review, we consolidate current insights into how 1CM affects T cell activation, differentiation, and functionality. Furthermore, we delve into the strategies for modulating 1CM in both T cells and tumor cells to enhance the efficacy of adoptively transferred T cells, overcome metabolic challenges in the tumor microenvironment (TME), and maximize the benefits of T cell-mediated immunotherapy.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"967-980"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose stem cells drive T cell infiltration in obesity. 脂肪干细胞驱动肥胖症中的 T 细胞浸润。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-06-29 DOI: 10.1016/j.tem.2024.06.013
Aneta Balcerczyk, Assia Eljaafari, Luciano Pirola
{"title":"Adipose stem cells drive T cell infiltration in obesity.","authors":"Aneta Balcerczyk, Assia Eljaafari, Luciano Pirola","doi":"10.1016/j.tem.2024.06.013","DOIUrl":"10.1016/j.tem.2024.06.013","url":null,"abstract":"<p><p>Obesity is often associated with adipose tissue (AT) inflammation and immune cell infiltration. Writing recently in Cell Reports, Liao et al. investigated the mechanisms of T cell infiltration of AT using single cell (sc)RNA-sequencing (RNA-seq), transplantation studies, in vitro co-cultures, and knock-out mice. They highlighted the crucial role of C-C motif chemokine ligand 5 (CCL5)-secreting adipose stem cells (ASCs), offering insights for potential therapies.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"931-933"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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