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Can ferroptosis be a target for reproductive health? 铁下垂能成为生殖健康的目标吗？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-12-19 DOI: 10.1016/j.tem.2024.11.011
Mengchun Hu, Yingying Qin, Xue Jiao
{"title":"Can ferroptosis be a target for reproductive health?","authors":"Mengchun Hu, Yingying Qin, Xue Jiao","doi":"10.1016/j.tem.2024.11.011","DOIUrl":"10.1016/j.tem.2024.11.011","url":null,"abstract":"<p><p>Ferroptosis has been implicated in several reproductive disorders, but the underlying mechanisms remain unknown; thus, interventions targeting this pathway are lacking. Here we summarize the emerging findings on ferroptosis in reproductive biology and corresponding disorders, and highlight perspectives and challenges on future ferroptosis research with potential clinical applications.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"398-402"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new clinical age of aging research. 老龄化研究的临床新时代。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-09-02 DOI: 10.1016/j.tem.2024.08.004
Zhen Zhang, Renlei Yang, Zhike Zi, Baohua Liu
{"title":"A new clinical age of aging research.","authors":"Zhen Zhang, Renlei Yang, Zhike Zi, Baohua Liu","doi":"10.1016/j.tem.2024.08.004","DOIUrl":"10.1016/j.tem.2024.08.004","url":null,"abstract":"<p><p>Aging is a major risk factor for a variety of diseases, thus, translation of aging research into practical applications is driven by the unmet need for existing clinical therapeutic options. Basic and translational research efforts are converging at a critical stage, yielding insights into how fundamental aging mechanisms are used to identify promising geroprotectors or therapeutics. This review highlights several research areas from a clinical perspective, including senescent cell targeting, alleviation of inflammaging, and optimization of metabolism with endogenous metabolites or precursors. Refining our understanding of these key areas, especially from the clinical angle, may help us to better understand and attenuate aging processes and improve overall health outcomes.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"440-458"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shared metabolic and stress pathways to neonatal adiposity. 新生儿肥胖的共同代谢和应激途径。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-12-18 DOI: 10.1016/j.tem.2024.11.012
Sonja Entringer, Gernot Desoye
{"title":"Shared metabolic and stress pathways to neonatal adiposity.","authors":"Sonja Entringer, Gernot Desoye","doi":"10.1016/j.tem.2024.11.012","DOIUrl":"10.1016/j.tem.2024.11.012","url":null,"abstract":"<p><p>Perceived stress levels, prevalence of pregnancies complicated by metabolic disorders, and childhood obesity have been increasing steadily. We here propose a pathway integrating stress-responsive biological systems into the established effects of maternal diabetes and obesity during pregnancy, overall exerting a combined contribution to offspring adiposity risk.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"392-394"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How purine metabolites impact reproduction. 嘌呤代谢物如何影响生殖。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-09-12 DOI: 10.1016/j.tem.2024.08.010
Sifan Rong, Yixuan Fu, Yue Zhao, Wencheng Zhu, Liangshan Mu
{"title":"How purine metabolites impact reproduction.","authors":"Sifan Rong, Yixuan Fu, Yue Zhao, Wencheng Zhu, Liangshan Mu","doi":"10.1016/j.tem.2024.08.010","DOIUrl":"10.1016/j.tem.2024.08.010","url":null,"abstract":"<p><p>Purine metabolism is one of the core biochemical processes essential for cell survival and function. During development, purines are involved in germ cell development, ovarian function, and pregnancy outcomes. Here, we discuss the relationships between purine metabolism and reproductive health, offering insights into the future directions of the field.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"395-397"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hallmarks of ovarian aging. 卵巢衰老的标志
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2025-02-24 DOI: 10.1016/j.tem.2025.01.005
Chuqing Wu, Dan Chen, Michael B Stout, Meng Wu, Shixuan Wang
{"title":"Hallmarks of ovarian aging.","authors":"Chuqing Wu, Dan Chen, Michael B Stout, Meng Wu, Shixuan Wang","doi":"10.1016/j.tem.2025.01.005","DOIUrl":"10.1016/j.tem.2025.01.005","url":null,"abstract":"<p><p>Ovarian aging is considered to be the pacemaker of female aging, and is linked to various comorbidities such as osteoporosis, cardiovascular diseases, and cognitive decline. Many efforts have been made to determine the mechanisms underlying ovarian aging, but their potential to act as hallmarks to predict and intervene in this process currently remains unclear. In this review we propose nine hallmarks as common features of ovarian aging: genomic instability, telomere attrition, epigenetic alterations, impaired autophagy, cellular senescence, deregulated nutrient-sensing, mitochondrial dysfunction, oxidative stress, and chronic inflammation. Understanding the interaction between these hallmarks poses a significant challenge but may also pave the way to the identification of pharmaceutical targets that can attenuate ovarian aging.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"418-439"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143505964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The paternal contribution to shaping the health of future generations. 父亲对塑造后代健康的贡献。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-11-18 DOI: 10.1016/j.tem.2024.10.007
Christopher Casciaro, Hirotaka Hamada, Enrrico Bloise, Stephen G Matthews
{"title":"The paternal contribution to shaping the health of future generations.","authors":"Christopher Casciaro, Hirotaka Hamada, Enrrico Bloise, Stephen G Matthews","doi":"10.1016/j.tem.2024.10.007","DOIUrl":"10.1016/j.tem.2024.10.007","url":null,"abstract":"<p><p>Paternal health and exposure to adverse environments in the period prior to conception have a profound impact on future generations. Adversities such as stress, diet, and toxicants influence offspring health. Emerging evidence indicates that epigenetic mechanisms including noncoding RNA, DNA methylation, and chromatin remodelling mediate these effects. Preclinical studies have contributed to advancing mechanistic understanding in the field; however, human research is limited and primarily observational. Here, we discuss the evidence linking paternal to offspring health and advocate for further research in this area, which may ultimately inform policy and healthcare guidelines to improve paternal preconception health and offspring outcomes.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"459-471"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gonadotropin-releasing hormone. 促性腺激素释放激素。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-11-01 DOI: 10.1016/j.tem.2024.10.003
Miguel Ruiz-Cruz, Juan Roa, Manuel Tena-Sempere
{"title":"Gonadotropin-releasing hormone.","authors":"Miguel Ruiz-Cruz, Juan Roa, Manuel Tena-Sempere","doi":"10.1016/j.tem.2024.10.003","DOIUrl":"10.1016/j.tem.2024.10.003","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"495-496"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing diabetes across female reproductive stages. 管理女性生育阶段的糖尿病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1016/j.tem.2025.02.003
Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal
{"title":"Managing diabetes across female reproductive stages.","authors":"Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal","doi":"10.1016/j.tem.2025.02.003","DOIUrl":"10.1016/j.tem.2025.02.003","url":null,"abstract":"<p><p>Hormonal fluctuations across the female reproductive lifespan lead to physiological adjustments that impact insulin sensitivity and glucose metabolism, generating unique challenges in diabetes management. Although current guidelines focus primarily on diabetes care during pregnancy, they lack tailored recommendations for addressing glycaemic variability associated with menstrual cycles, contraceptive needs, and menopause. Low rates of prepregnancy counselling, limited contraceptive guidance, and underuse of hormone replacement therapy further complicate care for women with diabetes. Here we examine these care gaps, identify unmet needs across reproductive stages, and suggest research directions to develop comprehensive, stage-specific management strategies that better support women's health and improve diabetes outcomes throughout the reproductive years.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"403-417"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic inheritance of PCOS by developmental programming and germline transmission. 多囊卵巢综合征的发育规划和种系遗传。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-12-27 DOI: 10.1016/j.tem.2024.12.002
Elisabet Stener-Victorin, Qiaolin Deng
{"title":"Epigenetic inheritance of PCOS by developmental programming and germline transmission.","authors":"Elisabet Stener-Victorin, Qiaolin Deng","doi":"10.1016/j.tem.2024.12.002","DOIUrl":"10.1016/j.tem.2024.12.002","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder, affecting approximately 11-13% of women of reproductive age. Women with PCOS experience a higher prevalence of infertility, pregnancy complications, and cardiometabolic disorders such as obesity, insulin resistance, and type 2 diabetes mellitus. Furthermore, psychiatric comorbidities, including depression and anxiety, significantly impact the quality of life in this population. Although obesity exacerbates these health risks, the exact etiology and pathophysiology of PCOS remain complex and only partially understood. Emerging research suggests potential transgenerational inheritance through genetic and epigenetic mechanisms, highlighting the possibility of PCOS-related risks affecting subsequent generations, including sons. This review synthesizes recent findings on PCOS inheritance patterns and underscores areas for future clinical and research exploration.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"472-481"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses. 妊娠诱导的新陈代谢重编程和对促衰老压力的再生反应。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-08-08 DOI: 10.1016/j.tem.2024.07.011
Dainan Yu, Lanfang Luo, Hongmei Wang, Ng Shyh-Chang
{"title":"Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses.","authors":"Dainan Yu, Lanfang Luo, Hongmei Wang, Ng Shyh-Chang","doi":"10.1016/j.tem.2024.07.011","DOIUrl":"10.1016/j.tem.2024.07.011","url":null,"abstract":"<p><p>Pregnancy is associated with physiological adaptations that affect virtually all organs, enabling the mother to support the growing fetus and placenta while withstanding the demands of pregnancy. As a result, mammalian pregnancy is a unique state that exerts paradoxical effects on maternal health. On one hand, the metabolic stress induced by pregnancy can accelerate aging and functional decline in organs. On the other hand, pregnancy activates metabolic programming and tissue regenerative responses that can reverse age-related impairments. In this sense, the oocyte-to-blastocyst transition is not the only physiological reprogramming event in the mammalian body, as pregnancy-induced regeneration could constitute a second physiological reprogramming event. Here, we review findings on how pregnancy dualistically leads to aging and rejuvenation in the maternal body.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"482-494"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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