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Microbes put drugs in(action). 微生物让药物发挥作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-09-03 DOI: 10.1016/j.tem.2024.08.005
Jennifer van der Laan, Filipe Cabreiro
{"title":"Microbes put drugs in(action).","authors":"Jennifer van der Laan, Filipe Cabreiro","doi":"10.1016/j.tem.2024.08.005","DOIUrl":"10.1016/j.tem.2024.08.005","url":null,"abstract":"<p><p>Interactions between the gut microbiome, nutrients, drugs, and host physiology are inherently complex. Gut microbes contribute significantly towards host homeostasis and can modulate host-targeted drugs, affecting therapeutic outcomes. Finding ways to harness the gut microbiome to improve drug efficacy can be a promising strategy to advance precision medicine.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"7-10"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbial metabolites in cancer therapy. 癌症治疗中的肠道微生物代谢物
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-07-14 DOI: 10.1016/j.tem.2024.06.016
Panwei Song, Zhi Peng, Xiaohuan Guo
{"title":"Gut microbial metabolites in cancer therapy.","authors":"Panwei Song, Zhi Peng, Xiaohuan Guo","doi":"10.1016/j.tem.2024.06.016","DOIUrl":"10.1016/j.tem.2024.06.016","url":null,"abstract":"<p><p>The gut microbiota plays a crucial role in maintaining homeostasis and promoting health. A growing number of studies have indicated that gut microbiota can affect cancer development, prognosis, and treatment through their metabolites. By remodeling the tumor microenvironment and regulating tumor immunity, gut microbial metabolites significantly influence the efficacy of anticancer therapies, including chemo-, radio-, and immunotherapy. Several novel therapies that target gut microbial metabolites have shown great promise in cancer models. In this review, we summarize the current research status of gut microbial metabolites in cancer, aiming to provide new directions for future tumor therapy.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"55-69"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissociating the metabolic and tumor-suppressive activity of p53. 分解 p53 的代谢活性和肿瘤抑制活性。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-02 DOI: 10.1016/j.tem.2024.07.018
Yoshitaka Sakurai, Naoto Kubota, Takashi Kadowaki
{"title":"Dissociating the metabolic and tumor-suppressive activity of p53.","authors":"Yoshitaka Sakurai, Naoto Kubota, Takashi Kadowaki","doi":"10.1016/j.tem.2024.07.018","DOIUrl":"10.1016/j.tem.2024.07.018","url":null,"abstract":"<p><p>The tumor suppressor p53 regulates metabolic homeostasis. Recently, Tsaousidou et al. reported that selective activation of p53 via downregulation of Tudor interacting repair regulator (TIRR) confers protection against cancer despite obesity and insulin resistance, providing new insights into the role of p53 at the intersection of oncogenesis and systemic metabolism.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"4-6"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host-microbe serotonin metabolism. 宿主-微生物血清素代谢
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-13 DOI: 10.1016/j.tem.2024.07.014
Emilia Nunzi, Marilena Pariano, Claudio Costantini, Enrico Garaci, Paolo Puccetti, Luigina Romani
{"title":"Host-microbe serotonin metabolism.","authors":"Emilia Nunzi, Marilena Pariano, Claudio Costantini, Enrico Garaci, Paolo Puccetti, Luigina Romani","doi":"10.1016/j.tem.2024.07.014","DOIUrl":"10.1016/j.tem.2024.07.014","url":null,"abstract":"<p><p>As a result of a long evolutionary history, serotonin plays a variety of physiological roles, including neurological, cardiovascular, gastrointestinal, and endocrine functions. While many of these activities can be accommodated within the serotoninergic activity, recent findings have revealed an unsuspected role of serotonin in orchestrating host and microbial dialogue at the tryptophan dining table, to the benefit of local and systemic homeostasis. Herein we review the dual role of serotonin at the host-microbe interface and discuss how unraveling the interconnections among the host and microbial pathways of tryptophan degradation may help to accommodate the versatility of serotonin in physiology and pathology.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"83-95"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrine gut-brain signaling in obesity. 肥胖症中的肠脑神经内分泌信号传导。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-05-30 DOI: 10.1016/j.tem.2024.05.002
Tim Gruber, Franziska Lechner, Jean-Philippe Krieger, Cristina García-Cáceres
{"title":"Neuroendocrine gut-brain signaling in obesity.","authors":"Tim Gruber, Franziska Lechner, Jean-Philippe Krieger, Cristina García-Cáceres","doi":"10.1016/j.tem.2024.05.002","DOIUrl":"10.1016/j.tem.2024.05.002","url":null,"abstract":"<p><p>The past decades have witnessed the rise and fall of several, largely unsuccessful, therapeutic attempts to bring the escalating obesity pandemic to a halt. Looking back to look ahead, the field has now put its highest hopes in translating insights from how the gastrointestinal (GI) tract communicates with the brain to calibrate behavior, physiology, and metabolism. A major focus of this review is to summarize the latest advances in comprehending the neuroendocrine aspects of this so-called 'gut-brain axis' and to explore novel concepts, cutting-edge technologies, and recent paradigm-shifting experiments. These exciting insights continue to refine our understanding of gut-brain crosstalk and are poised to promote the development of additional therapeutic avenues at the dawn of a new era of antiobesity therapeutics.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"42-54"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ceramides in the central control of metabolism. 代谢中枢控制中的神经酰胺。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-07-06 DOI: 10.1016/j.tem.2024.06.007
Miguel López, Carlos Diéguez, Manuel Tena-Sempere, Ismael González-García
{"title":"Ceramides in the central control of metabolism.","authors":"Miguel López, Carlos Diéguez, Manuel Tena-Sempere, Ismael González-García","doi":"10.1016/j.tem.2024.06.007","DOIUrl":"10.1016/j.tem.2024.06.007","url":null,"abstract":"<p><p>Central ceramides regulate energy metabolism by impacting hypothalamic neurons. This allows ceramides to integrate endocrine signals - such as leptin, ghrelin, thyroid hormones, or estradiol - and to modulate the central control of puberty. In this forum article we discuss recent evidence suggesting that specific ceramide species and neuronal populations are involved in these effects.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"11-14"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-SCFA microbial metabolites associated with fiber fermentation and host health. 与纤维发酵和宿主健康相关的非SCFA 微生物代谢物
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-07-10 DOI: 10.1016/j.tem.2024.06.009
Erica T Grant, Hélène De Franco, Mahesh S Desai
{"title":"Non-SCFA microbial metabolites associated with fiber fermentation and host health.","authors":"Erica T Grant, Hélène De Franco, Mahesh S Desai","doi":"10.1016/j.tem.2024.06.009","DOIUrl":"10.1016/j.tem.2024.06.009","url":null,"abstract":"<p><p>Dietary fiber is degraded by commensal gut microbes to yield host-beneficial short-chain fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for other microbial metabolites in shaping host health. In this review we summarize recent findings from dietary fiber intervention studies describing health impacts attributed to microbial metabolites other than SCFAs, particularly secondary bile acids (2°BAs), aromatic amino acid derivatives, neurotransmitters, and B vitamins. We also discuss shifts in microbial metabolism occurring through altered maternal dietary fiber intake and agricultural practices, which warrant further investigation. To optimize the health benefits of dietary fibers, it is essential to survey a range of metabolites and adapt recommendations on a personalized basis, according to the different functional aspects of the microbiome.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"70-82"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why do some individuals with obesity remain metabolically healthy? 为什么有些肥胖症患者的新陈代谢依然健康？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-07-02 DOI: 10.1016/j.tem.2024.06.015
Christoph Buettner, Kenichi Sakamoto, Mary A Butera
{"title":"Why do some individuals with obesity remain metabolically healthy?","authors":"Christoph Buettner, Kenichi Sakamoto, Mary A Butera","doi":"10.1016/j.tem.2024.06.015","DOIUrl":"10.1016/j.tem.2024.06.015","url":null,"abstract":"<p><p>A recent study by Peterson et al. that characterized individuals with metabolically healthy obesity (MHO) or metabolically unhealthy obesity (MUO) in depth provides insights into the potential pathogenesis of MUO that accounts for much of the cardiometabolic disease and excess mortality caused by the obesity epidemic.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1-3"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota and eating behaviour in circadian syndrome. 昼夜节律综合征中的肠道微生物群和饮食行为。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-01 DOI: 10.1016/j.tem.2024.07.008
Jorge R Soliz-Rueda, Cristina Cuesta-Marti, Siobhain M O'Mahony, Gerard Clarke, Harriët Schellekens, Begoña Muguerza
{"title":"Gut microbiota and eating behaviour in circadian syndrome.","authors":"Jorge R Soliz-Rueda, Cristina Cuesta-Marti, Siobhain M O'Mahony, Gerard Clarke, Harriët Schellekens, Begoña Muguerza","doi":"10.1016/j.tem.2024.07.008","DOIUrl":"10.1016/j.tem.2024.07.008","url":null,"abstract":"<p><p>Eating behaviour and circadian rhythms are closely related. The type, timing, and quantity of food consumed, and host circadian rhythms, directly influence the intestinal microbiota, which in turn impacts host circadian rhythms and regulates food intake beyond homeostatic eating. This Opinion discusses the impact of food intake and circadian disruptions induced by an obesogenic environment on gut-brain axis signalling. We also explore potential mechanisms underlying the effects of altered gut microbiota on food intake behaviour and circadian rhythmicity. Understanding the crosstalk between gut microbiota, circadian rhythms, and unhealthy eating behaviour is crucial to addressing the obesity epidemic, which remains one of the biggest societal challenges of our time.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"15-28"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex- and endurance training-mediated cardiovascular protection through lipids during exercise. 性和耐力训练通过运动中的脂质介导心血管保护。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-31 DOI: 10.1016/j.tem.2024.12.004
Julia An, Ariel S Thorson, David H Wasserman, John M Stafford, Lin Zhu
{"title":"Sex- and endurance training-mediated cardiovascular protection through lipids during exercise.","authors":"Julia An, Ariel S Thorson, David H Wasserman, John M Stafford, Lin Zhu","doi":"10.1016/j.tem.2024.12.004","DOIUrl":"10.1016/j.tem.2024.12.004","url":null,"abstract":"<p><p>Premenopausal women and endurance-trained individuals of either sex have reduced cardiovascular disease (CVD) risk. Endurance training shifts fuel selection towards fats to spare carbohydrates; interestingly, women prioritize fats as an energy resource more than men do during exercise. Relying on fats during exercise drives whole-body lipolysis and promotes lipid uptake and oxidation capacity in skeletal muscles. These metabolic adaptations during exercise result in protection against diet-induced obesity, a healthy body fat distribution, and reduced plasma triacylglycerol (TG) concentrations. Here, we analyze how sex differences and endurance training mediate changes in skeletal muscles, including exercise-induced lipolysis, lipid uptake and β-oxidation, intramuscular TG storage, and postexercise lipid metabolism, and discuss how regulating this processes affects CVD risk.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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