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Recognizing the role of fibromyalgia in post-exertional malaise. 认识到纤维肌痛在运动后不适中的作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-11 DOI: 10.1016/j.tem.2025.02.005
Alessandro Giollo, Mariangela Salvato, Andrea Doria
{"title":"Recognizing the role of fibromyalgia in post-exertional malaise.","authors":"Alessandro Giollo, Mariangela Salvato, Andrea Doria","doi":"10.1016/j.tem.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.005","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing health and fostering community involvement in medical research through the Genes & Health study. 通过基因与健康研究促进健康和促进社区参与医学研究。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI: 10.1016/j.tem.2024.11.002
Marie Spreckley, Mehru Raza, Kamrul Islam, Jessry Russell, Karen Hunt, Ceri Durham, Genes Health Research Team, David van Heel, Ahsan Khan, Sarah Finer, Moneeza K Siddiqui
{"title":"Advancing health and fostering community involvement in medical research through the Genes & Health study.","authors":"Marie Spreckley, Mehru Raza, Kamrul Islam, Jessry Russell, Karen Hunt, Ceri Durham, Genes Health Research Team, David van Heel, Ahsan Khan, Sarah Finer, Moneeza K Siddiqui","doi":"10.1016/j.tem.2024.11.002","DOIUrl":"10.1016/j.tem.2024.11.002","url":null,"abstract":"<p><p>The Genes & Health study, an initiative focused on British-Pakistani and British-Bangladeshi volunteers, is at the forefront of diversifying genetic research and driving scientific innovation. Here, we explore how this study has propelled scientific advancements and positively impacted communities, emphasizing its collaborative ethos, dedication to societal needs, and accomplishments.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"196-198"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts. 全氟和多氟烷基物质是具有代谢和内分泌干扰影响的持久性污染物。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tem.2024.07.021
Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau
{"title":"Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts.","authors":"Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau","doi":"10.1016/j.tem.2024.07.021","DOIUrl":"10.1016/j.tem.2024.07.021","url":null,"abstract":"<p><p>The widespread use of per- and polyfluoroalkyl substances (PFASs), and their resistance to degradation, renders human exposure to them inevitable. PFAS exposure disturbs endocrine function, potentially affecting cognitive development in newborns through thyroid dysfunction during pregnancy. Recent studies reveal varying male and female reproductive toxicity across PFAS classes, with alternative analogs affecting sperm parameters and legacy PFASs correlating with conditions like endometriosis. Metabolically, PFASs exposure is linked to metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and liver toxicity, particularly in early childhood. This review focuses on the endocrine-disrupting impact of PFASs, particularly on fertility, thyroid, and metabolic functions. We highlight the complexity of the PFAS issue, given the large number of molecules and their extremely diverse mixed effects.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"249-261"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte involvement in metabolic regulation and disease. 星形胶质细胞参与新陈代谢调节和疾病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-29 DOI: 10.1016/j.tem.2024.08.001
Muhammad Naveed, Kathryn Smedlund, Qi-Gang Zhou, Weikang Cai, Jennifer W Hill
{"title":"Astrocyte involvement in metabolic regulation and disease.","authors":"Muhammad Naveed, Kathryn Smedlund, Qi-Gang Zhou, Weikang Cai, Jennifer W Hill","doi":"10.1016/j.tem.2024.08.001","DOIUrl":"10.1016/j.tem.2024.08.001","url":null,"abstract":"<p><p>Astrocytes, the predominant glial cell type in the mammalian brain, influence a wide variety of brain parameters including neuronal energy metabolism. Exciting recent studies have shown that obesity and diabetes can impact on astrocyte function. We review evidence that dysregulation of astrocytic lipid metabolism and glucose sensing contributes to dysregulation of whole-body energy balance, thermoregulation, and insulin sensitivity. In addition, we consider the overlooked topic of the sex-specific roles of astrocytes and their response to hormonal fluctuations that provide insights into sex differences in metabolic regulation. Finally, we provide an update on potential ways to manipulate astrocyte function, including genetic targeting, optogenetic and chemogenetic techniques, transplantation, and tailored exosome-based therapies, which may lead to improved treatments for metabolic disease.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"219-234"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcellular mitochondrial heterogeneity enables opposing metabolic demands. 亚细胞线粒体异质性使相反的代谢需求。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1016/j.tem.2025.01.003
Brandon Chen, Yatrik M Shah, Costas A Lyssiotis
{"title":"Subcellular mitochondrial heterogeneity enables opposing metabolic demands.","authors":"Brandon Chen, Yatrik M Shah, Costas A Lyssiotis","doi":"10.1016/j.tem.2025.01.003","DOIUrl":"10.1016/j.tem.2025.01.003","url":null,"abstract":"<p><p>Mitochondria perform essential metabolic processes that sustain cellular bioenergetics and biosynthesis. In a recent article, Ryu et al. explored how mitochondria coordinate biochemical reactions with opposing redox demands within the same cell. They demonstrate that subcellular mitochondrial heterogeneity enables metabolic compartmentalization to permit concurrent oxidative ATP production and reductive proline biosynthesis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"202-204"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The biogenesis and transport of triglyceride-rich lipoproteins. 富含甘油三酯的脂蛋白的生物生成和运输。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-19 DOI: 10.1016/j.tem.2024.07.015
Linqi Zhang, Xiao Wang, Xiao-Wei Chen
{"title":"The biogenesis and transport of triglyceride-rich lipoproteins.","authors":"Linqi Zhang, Xiao Wang, Xiao-Wei Chen","doi":"10.1016/j.tem.2024.07.015","DOIUrl":"10.1016/j.tem.2024.07.015","url":null,"abstract":"<p><p>Triglyceride-rich lipoproteins (TRLs) play essential roles in human health and disease by transporting bulk lipids into the circulation. This review summarizes the fundamental mechanisms and diverse factors governing lipoprotein production, secretion, and regulation. Emphasizing the broader implications for human health, we outline the intricate landscape of lipoprotein research and highlight the potential coordination between the biogenesis and transport of TRLs in physiology, particularly the unexpected coupling of metabolic enzymes and transport machineries. Challenges and opportunities in lipoprotein biology with respect to inherited diseases and viral infections are also discussed. Further characterization of the biogenesis and transport of TRLs will advance both basic research in lipid biology and translational medicine for metabolic diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"262-277"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Walking the VLDL tightrope in cardiometabolic diseases. 在心脏代谢疾病中走 "VLDL钢丝"。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-26 DOI: 10.1016/j.tem.2024.07.020
Mindy Kim, Ze Zheng
{"title":"Walking the VLDL tightrope in cardiometabolic diseases.","authors":"Mindy Kim, Ze Zheng","doi":"10.1016/j.tem.2024.07.020","DOIUrl":"10.1016/j.tem.2024.07.020","url":null,"abstract":"<p><p>Very-low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein secreted by hepatocytes, is pivotal for supplying peripheral tissues with fatty acids for energy production. As if walking on a tightrope, perturbations in the balance of VLDL metabolism contribute to cardiometabolic dysfunction, promoting pathologies such as cardiovascular disease (CVD) or metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the advent of lipid-lowering therapies, including statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, risks for cardiovascular events persist. With limitations to currently available CVD therapeutics and no US Food and Drug Administration (FDA)-approved treatment for MASLD, this review summarizes the current understanding of VLDL metabolism that sheds light on novel therapeutic avenues to pursue for cardiometabolic disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"278-291"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-derived organoid models to decode liver pathophysiology. 解码肝脏病理生理学的患者衍生类器官模型
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-26 DOI: 10.1016/j.tem.2024.07.019
Benjamin J Dwyer, Janina E E Tirnitz-Parker
{"title":"Patient-derived organoid models to decode liver pathophysiology.","authors":"Benjamin J Dwyer, Janina E E Tirnitz-Parker","doi":"10.1016/j.tem.2024.07.019","DOIUrl":"10.1016/j.tem.2024.07.019","url":null,"abstract":"<p><p>Liver diseases represent a growing global health challenge, and the increasing prevalence of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving regulatory demands, patient-specific in vitro liver models are essential for understanding disease mechanisms and developing new therapeutic approaches. Organoid models, which faithfully recapitulate liver biology, can be established from both non-malignant and malignant liver tissues, offering insight into various liver conditions, from acute injuries to chronic diseases and cancer. Improved understanding of liver microenvironments, innovative biomaterials, and advanced imaging techniques now facilitate comprehensive and unbiased data analysis, paving the way for personalised medicine. In this review, we discuss state-of-the-art patient-derived liver organoid models, recent technological advancements, and strategies to enhance their clinical impact.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"235-248"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid-derived suppressor cells in metabolic and cardiovascular disorders. 骨髓源性抑制细胞在代谢和心血管疾病中的作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 DOI: 10.1016/j.tem.2025.02.001
Jingwei Yan, Shuai Guo, Jun He, Hanpeng Huang, Yiming Xu
{"title":"Myeloid-derived suppressor cells in metabolic and cardiovascular disorders.","authors":"Jingwei Yan, Shuai Guo, Jun He, Hanpeng Huang, Yiming Xu","doi":"10.1016/j.tem.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.001","url":null,"abstract":"<p><p>Dysregulation of immune homeostasis can precipitate chronic inflammation, thus significantly contributing to the onset and progression of metabolic and cardiovascular diseases. Myeloid-derived suppressor cells (MDSCs) constitute a heterogeneous population of immature myeloid cells that are mobilized in response to biological stressors such as tissue damage and inflammation. Although MDSCs have been extensively characterized in the contexts of cancer and infectious diseases, emerging evidence highlights their pivotal roles in the pathophysiology of metabolic and cardiovascular disorders. We discuss growing evidence for the involvement of MDSCs in the progression of metabolic and cardiovascular diseases, with the aim of deepening our understanding of MDSCs in cardiometabolic physiology and identifying the necessary steps for the development of innovative MDSC-targeted therapeutic strategies.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adapt and shape: metabolic features within the metastatic niche. 适应和塑造：转移龛位中的新陈代谢特征。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-08 DOI: 10.1016/j.tem.2024.07.016
Erica Pranzini, Luigi Ippolito, Elisa Pardella, Elisa Giannoni, Paola Chiarugi
{"title":"Adapt and shape: metabolic features within the metastatic niche.","authors":"Erica Pranzini, Luigi Ippolito, Elisa Pardella, Elisa Giannoni, Paola Chiarugi","doi":"10.1016/j.tem.2024.07.016","DOIUrl":"10.1016/j.tem.2024.07.016","url":null,"abstract":"<p><p>The success of disseminating cancer cells (DTCs) at specific metastatic sites is influenced by several metabolic factors. Even before DTCs arrival, metabolic conditioning from the primary tumor participates in creating a favorable premetastatic niche at distant organs. In addition, DTCs adjust their metabolism to better survive along the metastatic journey and successfully colonize their ultimate destination. However, the idea that the environment of the target organs may metabolically impact the metastatic fate is often underestimated. Here, we review the coexistence of two distinct strategies by which cancer cells shape and/or adapt to the metabolic profile of colonized tissues, ultimately creating a proper soil for their seeding and proliferation.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"205-218"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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