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The unexpected role of GIP in transforming obesity treatment. GIP 在改变肥胖症治疗方面发挥了意想不到的作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-27 DOI: 10.1016/j.tem.2024.07.022
Inuk Zandvakili, Diego Perez-Tilve
{"title":"The unexpected role of GIP in transforming obesity treatment.","authors":"Inuk Zandvakili, Diego Perez-Tilve","doi":"10.1016/j.tem.2024.07.022","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.022","url":null,"abstract":"<p><p>Despite sharing incretin activity with glucagon-like peptide 1 (GLP-1), the development of gastric inhibitory polypeptide (GIP)-based drugs has been hindered by the minor effects of native GIP on appetite and body weight and genetic studies associating loss-of-function with reduced obesity. Yet, pharmacologically optimized GIP-based molecules have demonstrated profound weight lowering benefits of GIPR agonism when combined with GLP-1-based therapies, which has re-energized deeper exploration of the molecular mechanisms and downstream signaling of GIPR. Interestingly, both GIPR agonism and antagonism offer metabolic benefits, leading to differing viewpoints on how to target GIPR therapeutically. Here we summarize the emerging evidence about the tissue-specific mechanisms that positions GIP-based therapies as important targets for the next generation of anti-obesity and metabolic therapies.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Walking the VLDL tightrope in cardiometabolic diseases. 在心脏代谢疾病中走 "VLDL钢丝"。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-26 DOI: 10.1016/j.tem.2024.07.020
Mindy Kim, Ze Zheng
{"title":"Walking the VLDL tightrope in cardiometabolic diseases.","authors":"Mindy Kim, Ze Zheng","doi":"10.1016/j.tem.2024.07.020","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.020","url":null,"abstract":"<p><p>Very-low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein secreted by hepatocytes, is pivotal for supplying peripheral tissues with fatty acids for energy production. As if walking on a tightrope, perturbations in the balance of VLDL metabolism contribute to cardiometabolic dysfunction, promoting pathologies such as cardiovascular disease (CVD) or metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the advent of lipid-lowering therapies, including statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, risks for cardiovascular events persist. With limitations to currently available CVD therapeutics and no US Food and Drug Administration (FDA)-approved treatment for MASLD, this review summarizes the current understanding of VLDL metabolism that sheds light on novel therapeutic avenues to pursue for cardiometabolic disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-derived organoid models to decode liver pathophysiology. 解码肝脏病理生理学的患者衍生类器官模型
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-26 DOI: 10.1016/j.tem.2024.07.019
Benjamin J Dwyer, Janina E E Tirnitz-Parker
{"title":"Patient-derived organoid models to decode liver pathophysiology.","authors":"Benjamin J Dwyer, Janina E E Tirnitz-Parker","doi":"10.1016/j.tem.2024.07.019","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.019","url":null,"abstract":"<p><p>Liver diseases represent a growing global health challenge, and the increasing prevalence of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving regulatory demands, patient-specific in vitro liver models are essential for understanding disease mechanisms and developing new therapeutic approaches. Organoid models, which faithfully recapitulate liver biology, can be established from both non-malignant and malignant liver tissues, offering insight into various liver conditions, from acute injuries to chronic diseases and cancer. Improved understanding of liver microenvironments, innovative biomaterials, and advanced imaging techniques now facilitate comprehensive and unbiased data analysis, paving the way for personalised medicine. In this review, we discuss state-of-the-art patient-derived liver organoid models, recent technological advancements, and strategies to enhance their clinical impact.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the heterogeneous targets of metabolic aging at single-cell resolution. 以单细胞分辨率探索新陈代谢老化的异质靶标。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-23 DOI: 10.1016/j.tem.2024.07.009
Shuhui Sun, Mengmeng Jiang, Shuai Ma, Jie Ren, Guang-Hui Liu
{"title":"Exploring the heterogeneous targets of metabolic aging at single-cell resolution.","authors":"Shuhui Sun, Mengmeng Jiang, Shuai Ma, Jie Ren, Guang-Hui Liu","doi":"10.1016/j.tem.2024.07.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.009","url":null,"abstract":"<p><p>Our limited understanding of metabolic aging poses major challenges to comprehending the diverse cellular alterations that contribute to age-related decline, and to devising targeted interventions. This review provides insights into the heterogeneous nature of cellular metabolism during aging and its response to interventions, with a specific focus on cellular heterogeneity and its implications. By synthesizing recent findings using single-cell approaches, we explored the vulnerabilities of distinct cell types and key metabolic pathways. Delving into the cell type-specific alterations underlying the efficacy of systemic interventions, we also discuss the complexity of integrating single-cell data and advocate for leveraging computational tools and artificial intelligence to harness the full potential of these data, develop effective strategies against metabolic aging, and promote healthy aging.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts. 全氟和多氟烷基物质是具有代谢和内分泌干扰影响的持久性污染物。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-23 DOI: 10.1016/j.tem.2024.07.021
Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau
{"title":"Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts.","authors":"Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau","doi":"10.1016/j.tem.2024.07.021","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.021","url":null,"abstract":"<p><p>The widespread use of per- and polyfluoroalkyl substances (PFASs), and their resistance to degradation, renders human exposure to them inevitable. PFAS exposure disturbs endocrine function, potentially affecting cognitive development in newborns through thyroid dysfunction during pregnancy. Recent studies reveal varying male and female reproductive toxicity across PFAS classes, with alternative analogs affecting sperm parameters and legacy PFASs correlating with conditions like endometriosis. Metabolically, PFASs exposure is linked to metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and liver toxicity, particularly in early childhood. This review focuses on the endocrine-disrupting impact of PFASs, particularly on fertility, thyroid, and metabolic functions. We highlight the complexity of the PFAS issue, given the large number of molecules and their extremely diverse mixed effects.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New anti-inflammatory mechanism of glucocorticoids uncovered. 糖皮质激素抗炎新机制揭秘
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-23 DOI: 10.1016/j.tem.2024.08.003
Carolyn L Cummins, Ido Goldstein
{"title":"New anti-inflammatory mechanism of glucocorticoids uncovered.","authors":"Carolyn L Cummins, Ido Goldstein","doi":"10.1016/j.tem.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.003","url":null,"abstract":"<p><p>Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The biogenesis and transport of triglyceride-rich lipoproteins. 富含甘油三酯的脂蛋白的生物生成和运输。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-19 DOI: 10.1016/j.tem.2024.07.015
Linqi Zhang, Xiao Wang, Xiao-Wei Chen
{"title":"The biogenesis and transport of triglyceride-rich lipoproteins.","authors":"Linqi Zhang, Xiao Wang, Xiao-Wei Chen","doi":"10.1016/j.tem.2024.07.015","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.015","url":null,"abstract":"<p><p>Triglyceride-rich lipoproteins (TRLs) play essential roles in human health and disease by transporting bulk lipids into the circulation. This review summarizes the fundamental mechanisms and diverse factors governing lipoprotein production, secretion, and regulation. Emphasizing the broader implications for human health, we outline the intricate landscape of lipoprotein research and highlight the potential coordination between the biogenesis and transport of TRLs in physiology, particularly the unexpected coupling of metabolic enzymes and transport machineries. Challenges and opportunities in lipoprotein biology with respect to inherited diseases and viral infections are also discussed. Further characterization of the biogenesis and transport of TRLs will advance both basic research in lipid biology and translational medicine for metabolic diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host-microbe serotonin metabolism. 宿主-微生物血清素代谢
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-13 DOI: 10.1016/j.tem.2024.07.014
Emilia Nunzi, Marilena Pariano, Claudio Costantini, Enrico Garaci, Paolo Puccetti, Luigina Romani
{"title":"Host-microbe serotonin metabolism.","authors":"Emilia Nunzi, Marilena Pariano, Claudio Costantini, Enrico Garaci, Paolo Puccetti, Luigina Romani","doi":"10.1016/j.tem.2024.07.014","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.014","url":null,"abstract":"<p><p>As a result of a long evolutionary history, serotonin plays a variety of physiological roles, including neurological, cardiovascular, gastrointestinal, and endocrine functions. While many of these activities can be accommodated within the serotoninergic activity, recent findings have revealed an unsuspected role of serotonin in orchestrating host and microbial dialogue at the tryptophan dining table, to the benefit of local and systemic homeostasis. Herein we review the dual role of serotonin at the host-microbe interface and discuss how unraveling the interconnections among the host and microbial pathways of tryptophan degradation may help to accommodate the versatility of serotonin in physiology and pathology.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopamine. 多巴胺
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-12 DOI: 10.1016/j.tem.2024.07.005
Siyao Zhou, Wenqiang Chen, Hongbin Yang
{"title":"Dopamine.","authors":"Siyao Zhou, Wenqiang Chen, Hongbin Yang","doi":"10.1016/j.tem.2024.07.005","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.005","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardioprotective benefits of metabolic surgery and GLP-1 receptor agonist-based therapies. 代谢手术和基于 GLP-1 受体激动剂的疗法对保护心脏的益处。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-10 DOI: 10.1016/j.tem.2024.07.012
Arianne Morissette, Erin E Mulvihill
{"title":"Cardioprotective benefits of metabolic surgery and GLP-1 receptor agonist-based therapies.","authors":"Arianne Morissette, Erin E Mulvihill","doi":"10.1016/j.tem.2024.07.012","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.012","url":null,"abstract":"<p><p>Individuals with excessive adipose tissue and type 2 diabetes mellitus (T2DM) face a heightened risk of cardiovascular morbidity and mortality. Metabolic surgery is an effective therapy for people with severe obesity to achieve significant weight loss. Additionally, metabolic surgery improves blood glucose levels and can lead to T2DM remission, reducing major adverse cardiovascular outcomes (MACE). Glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RAs) are a class of medication that effectively reduce body weight and MACE in patients with T2DM. This review explores the potential mechanisms underlying the cardioprotective benefits of metabolic surgery and GLP-1RA-based therapies and discusses recent evidence and emerging therapies in this dynamic area of research.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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