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Context-specific fatty acid uptake is a finely-tuned multi-level effort. 针对具体情况的脂肪酸摄取是一项多层次的精细工作。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2024-10-25 DOI: 10.1016/j.tem.2024.10.001
Juan Wang, Huiling Guo, Lang-Fan Zheng, Peng Li, Tong-Jin Zhao
{"title":"Context-specific fatty acid uptake is a finely-tuned multi-level effort.","authors":"Juan Wang, Huiling Guo, Lang-Fan Zheng, Peng Li, Tong-Jin Zhao","doi":"10.1016/j.tem.2024.10.001","DOIUrl":"10.1016/j.tem.2024.10.001","url":null,"abstract":"<p><p>Fatty acids (FAs) are essential nutrients that play multiple roles in cellular activities. To meet cell-specific needs, cells exhibit differential uptake of FAs in diverse physiological or pathological contexts, coordinating to maintain metabolic homeostasis. Cells tightly regulate the localization and transcription of CD36 and other key proteins that transport FAs across the plasma membrane in response to different stimuli. Dysregulation of FA uptake results in diseases such as obesity, steatotic liver, heart failure, and cancer progression. Targeting FA uptake might provide potential therapeutic strategies for metabolic diseases and cancer. Here, we review recent advances in context-specific regulation of FA uptake, focusing on the regulation of CD36 in metabolic organs and other cells.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"577-590"},"PeriodicalIF":11.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GDF15 is still a mystery hormone. GDF15 仍是一种神秘的激素。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2024-10-29 DOI: 10.1016/j.tem.2024.09.002
Casper M Sigvardsen, Michael M Richter, Sarah Engelbeen, Maximilian Kleinert, Erik A Richter
{"title":"GDF15 is still a mystery hormone.","authors":"Casper M Sigvardsen, Michael M Richter, Sarah Engelbeen, Maximilian Kleinert, Erik A Richter","doi":"10.1016/j.tem.2024.09.002","DOIUrl":"10.1016/j.tem.2024.09.002","url":null,"abstract":"<p><p>Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) superfamily. Despite its identification over 20 years ago, the functions of GDF15 remain complex and not fully elucidated. Its concentration in plasma varies widely depending on the physiological and pathophysiological state of the organism. GDF15 has been described to regulate food intake and insulin sensitivity in rodents via the GDNF family receptor α-like (GFRAL) receptor, and to be elevated in pregnancy and many disease states and decreased in physically fit individuals. We discuss the latest developments in the regulation of GDF15 secretion and its diverse physiological effects, and touch upon possible GFRAL-independent effects of GDF15. In addition, we discuss the effects of proteins and peptides derived from the same precursor protein as GDF15.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"591-601"},"PeriodicalIF":11.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary and pharmacological energy restriction and exercise for healthspan extension. 饮食和药理学能量限制和运动延长健康寿命。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2025-05-02 DOI: 10.1016/j.tem.2025.04.001
Maria Lastra Cagigas, Isabella De Ciutiis, Andrius Masedunskas, Luigi Fontana
{"title":"Dietary and pharmacological energy restriction and exercise for healthspan extension.","authors":"Maria Lastra Cagigas, Isabella De Ciutiis, Andrius Masedunskas, Luigi Fontana","doi":"10.1016/j.tem.2025.04.001","DOIUrl":"10.1016/j.tem.2025.04.001","url":null,"abstract":"<p><p>Extending healthspan - the years lived in optimal health - holds transformative potential to reduce chronic diseases and healthcare costs. Dietary restriction (DR), particularly when combined with nutrient-rich diets and exercise, is among the most effective, evidence-based strategies for enhancing metabolic health and longevity. By targeting fundamental pathways, it mitigates the onset and progression of obesity, type 2 diabetes (T2D), cardiovascular disease (CVD), neurodegeneration, and cancer. This review synthesizes human data on the impact of DR and exercise on metabolic and age-related diseases, while emphasizing key biological mechanisms such as nutrient sensing, insulin sensitivity, inflammation, mitochondrial function, and gut microbiota. We also examine the emerging role of pharmacologically induced DR, focusing on glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) that partially mimic DR and present opportunities for chronic disease prevention.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"521-545"},"PeriodicalIF":11.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connecting precision nutrition with the Food is Medicine approach. 将精准营养与 "食物即医学 "方法联系起来。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2024-09-27 DOI: 10.1016/j.tem.2024.08.012
Srishti Sinha, Samantha L Huey, Alpana P Shukla, Rebecca Kuriyan, Julia L Finkelstein, Saurabh Mehta
{"title":"Connecting precision nutrition with the Food is Medicine approach.","authors":"Srishti Sinha, Samantha L Huey, Alpana P Shukla, Rebecca Kuriyan, Julia L Finkelstein, Saurabh Mehta","doi":"10.1016/j.tem.2024.08.012","DOIUrl":"10.1016/j.tem.2024.08.012","url":null,"abstract":"<p><p>Two initiatives are reshaping how we can approach and address the persistent and widely prevalent challenge of malnutrition, the leading global risk factor for morbidity and mortality. First is the focus on precision nutrition to identify inter- and intra-individual variation in our responses to diet, and its determinants. Second is the Food is Medicine (FIM) approach, an umbrella term for programs and services that link nutrition and health through the provision of food (e.g., tailored meals, produce prescriptions) and access to healthcare services. This article outlines how interventions and programs using FIM can synergize with precision nutrition approaches to make individual- or population-level tailored nutrition accessible and affordable, help to reduce the risk of metabolic diseases, and improve quality of life.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"511-520"},"PeriodicalIF":11.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More than carriers, orosomucoids are key metabolic modulators. 与载体相比，orosomucoids是关键的代谢调节剂。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2024-12-18 DOI: 10.1016/j.tem.2024.11.015
Mi Jeong Heo, Inyoung Cheon, Kang Ho Kim
{"title":"More than carriers, orosomucoids are key metabolic modulators.","authors":"Mi Jeong Heo, Inyoung Cheon, Kang Ho Kim","doi":"10.1016/j.tem.2024.11.015","DOIUrl":"10.1016/j.tem.2024.11.015","url":null,"abstract":"<p><p>Orosomucoids (ORMs) have historically been considered as carriers involved in drug and lipid delivery. However, recent studies indicate ORM2 as a hepatokine involved in metabolic regulation. Here, we highlight the functions of ORM2 in controlling metabolic health and disease, focusing on its newly discovered regulatory mechanisms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"507-510"},"PeriodicalIF":11.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of non-sugar sweeteners on metabolism beyond sweet taste perception. 非糖甜味剂对新陈代谢的影响超出了对甜味的感知。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2024-11-16 DOI: 10.1016/j.tem.2024.10.008
Herbert Herzog, Lei Zhang, Luigi Fontana, G Gregory Neely
{"title":"Impact of non-sugar sweeteners on metabolism beyond sweet taste perception.","authors":"Herbert Herzog, Lei Zhang, Luigi Fontana, G Gregory Neely","doi":"10.1016/j.tem.2024.10.008","DOIUrl":"10.1016/j.tem.2024.10.008","url":null,"abstract":"<p><p>Non-sugar sweeteners (NSS), low- or no-calorie alternatives to sugar, are marketed for weight loss and improved blood glucose control in people with diabetes. However, their health effects remain controversial. This review provides a brief overview of sweet taste perception and summarizes experimental findings of the impact of NSS on cardiometabolic health in animal models and humans. We also review evidence suggesting that many NSS are not metabolically inert, highlighting the challenges in related human studies. Given the conflicting and unclear data on health outcomes, additional mechanistic studies, particularly in animal models, are necessary to clarify how NSS influence feeding behaviors and energy homoeostasis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"563-576"},"PeriodicalIF":11.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholic acid. 胆酸
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2024-12-11 DOI: 10.1016/j.tem.2024.11.007
Xi Luo, Kai Wang, Changtao Jiang
{"title":"Cholic acid.","authors":"Xi Luo, Kai Wang, Changtao Jiang","doi":"10.1016/j.tem.2024.11.007","DOIUrl":"10.1016/j.tem.2024.11.007","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"602-603"},"PeriodicalIF":11.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights from omics research on plant-based diets and cardiometabolic health. 来自植物性饮食和心脏代谢健康的组学研究的见解。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-06-01 Epub Date: 2025-02-20 DOI: 10.1016/j.tem.2025.01.007
Hyunju Kim, Casey M Rebholz
{"title":"Insights from omics research on plant-based diets and cardiometabolic health.","authors":"Hyunju Kim, Casey M Rebholz","doi":"10.1016/j.tem.2025.01.007","DOIUrl":"10.1016/j.tem.2025.01.007","url":null,"abstract":"<p><p>Plant-based diets emphasize higher intake of plant foods and are low in animal products. Individuals following plant-based diets have a lower risk of chronic conditions; however, the mechanisms underlying these associations are not completely understood. Omics data have opened opportunities to investigate the mechanistic effect of dietary intake on health outcomes. Here, we review omics analyses of plant-based diets in feeding and observational studies, showing that although metabolomics and proteomics identified candidate biomarkers and distinct pathways modifiable by plant-based diets, current evidence from transcriptomics and methylomics is limited. We also argue that future studies should examine how unhealthful plant-based diets are associated with a higher risk of health outcomes and integrate multiple omics data from feeding studies to provide further mechanistic insights.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"546-562"},"PeriodicalIF":11.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding metabolic resilience by unraveling temporal dynamics of cellular responses. 通过揭示细胞反应的时间动态来理解代谢弹性。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-26 DOI: 10.1016/j.tem.2025.04.006
Paniz Jasbi, Alex E Mohr, Meghana Hosahalli Shivananda Murthy, Judith Klein-Seetharaman
{"title":"Understanding metabolic resilience by unraveling temporal dynamics of cellular responses.","authors":"Paniz Jasbi, Alex E Mohr, Meghana Hosahalli Shivananda Murthy, Judith Klein-Seetharaman","doi":"10.1016/j.tem.2025.04.006","DOIUrl":"10.1016/j.tem.2025.04.006","url":null,"abstract":"<p><p>Metabolic resilience is essential for organismal homeostasis under diverse external pressures, because responding and adapting to stressors requires energy and drives changes at every omic level. The goal of this paper is to synthesize recent advances in understanding the intricate interplay, especially between metabolic and transcriptomic responses, involved in addressing external perturbations. We highlight the importance of timing and sequence in immediate and long-term adjustments; furthermore, we underscore the evolutionary significance of metabolic resilience and its potential for developing innovative therapeutic interventions, making it a timely contribution to contemporary biological, biomedical, and environmental research fields.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TREM2-expressing macrophages in liver diseases. 肝脏疾病中表达trem2的巨噬细胞。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-13 DOI: 10.1016/j.tem.2025.04.009
Xiaochen Wang, Zhiyu Qiu, Zhenyu Zhong, Shuang Liang
{"title":"TREM2-expressing macrophages in liver diseases.","authors":"Xiaochen Wang, Zhiyu Qiu, Zhenyu Zhong, Shuang Liang","doi":"10.1016/j.tem.2025.04.009","DOIUrl":"10.1016/j.tem.2025.04.009","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of the global population and spans a spectrum of liver abnormalities, including simple steatosis, inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Recent studies have identified triggering receptors expressed on myeloid cells 2 (TREM2)-expressing macrophages as key regulators of MASLD progression. TREM2 plays a pivotal role in regulating macrophage-mediated processes such as efferocytosis, inflammatory control, and fibrosis resolution. Additionally, soluble TREM2 (sTREM2) was proposed as a noninvasive biomarker for diagnosing and monitoring MASLD progression. However, the molecular mechanisms through which TREM2 influences MASLD pathogenesis remain incompletely understood. This review summarizes the current understanding of TREM2-expressing macrophages in MASLD, with the goal of illuminating future research and guiding the development of innovative therapeutic strategies targeting TREM2 signaling pathways.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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