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Formate. 培训。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-10-04 DOI: 10.1016/j.tem.2025.09.005
Mohaned Benzarti, Elisabeth Letellier, Johannes Meiser
{"title":"Formate.","authors":"Mohaned Benzarti, Elisabeth Letellier, Johannes Meiser","doi":"10.1016/j.tem.2025.09.005","DOIUrl":"https://doi.org/10.1016/j.tem.2025.09.005","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin. 胰岛素
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-10-01 Epub Date: 2024-10-16 DOI: 10.1016/j.tem.2024.09.001
Wenqiang Chen, C Ronald Kahn
{"title":"Insulin.","authors":"Wenqiang Chen, C Ronald Kahn","doi":"10.1016/j.tem.2024.09.001","DOIUrl":"10.1016/j.tem.2024.09.001","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"968-969"},"PeriodicalIF":12.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shaping the future of youth-onset type 2 diabetes: a call to action. 塑造青年2型糖尿病的未来：行动呼吁。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-10-01 Epub Date: 2025-04-04 DOI: 10.1016/j.tem.2025.03.003
Amy S Shah, Megan M Kelsey, Risa M Wolf, Kristen J Nadeau
{"title":"Shaping the future of youth-onset type 2 diabetes: a call to action.","authors":"Amy S Shah, Megan M Kelsey, Risa M Wolf, Kristen J Nadeau","doi":"10.1016/j.tem.2025.03.003","DOIUrl":"10.1016/j.tem.2025.03.003","url":null,"abstract":"<p><p>Youth-onset type 2 diabetes (YO-T2D) is an urgent public health challenge that demands immediate and innovative action. The devastating trajectory of this disease - from rapid β-cell decline to early complications and poor responses to medications - compels us to rethink our approach. Here, we argue that by investing in targeted research to unravel the unique mechanisms of this condition, ensuring equitable access to cutting-edge clinical trials, and building clinical care models tailored specifically for youth, we can rewrite the narrative for these at-risk youth.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"882-888"},"PeriodicalIF":12.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The growing range of complications of diabetes mellitus. 糖尿病的并发症越来越多。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-10-01 Epub Date: 2025-01-03 DOI: 10.1016/j.tem.2024.12.006
Peter S Hamblin, Anthony W Russell, Stella Talic, Sophia Zoungas
{"title":"The growing range of complications of diabetes mellitus.","authors":"Peter S Hamblin, Anthony W Russell, Stella Talic, Sophia Zoungas","doi":"10.1016/j.tem.2024.12.006","DOIUrl":"10.1016/j.tem.2024.12.006","url":null,"abstract":"<p><p>With the rising prevalence of type 2 diabetes mellitus (T2DM) and obesity, several previously under-recognised complications associated with T2DM are becoming more evident. The most common of these emerging complications are metabolic dysfunction-associated steatotic liver disease (MASLD), cancer, dementia, sarcopenia, and frailty, as well as other conditions involving the lung, heart, and intestinal tract. Likely causative factors are chronic inflammation and insulin resistance, whereas blood glucose levels appear to play a lesser role. We discuss these complications and the new approaches being developed to prevent and manage them, especially incretin-based therapies. We argue that these new interventions may work in a complementary way to other proven cardiorenal protective therapies to reduce the burden of T2DM complications.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"943-954"},"PeriodicalIF":12.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediabetes remission to reduce the global burden of type 2 diabetes. 糖尿病前期缓解减轻全球2型糖尿病负担
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-10-01 Epub Date: 2025-02-14 DOI: 10.1016/j.tem.2025.01.004
Leontine Sandforth, Stephanie Kullmann, Arvid Sandforth, Andreas Fritsche, Reiner Jumpertz-von Schwartzenberg, Norbert Stefan, Andreas L Birkenfeld
{"title":"Prediabetes remission to reduce the global burden of type 2 diabetes.","authors":"Leontine Sandforth, Stephanie Kullmann, Arvid Sandforth, Andreas Fritsche, Reiner Jumpertz-von Schwartzenberg, Norbert Stefan, Andreas L Birkenfeld","doi":"10.1016/j.tem.2025.01.004","DOIUrl":"10.1016/j.tem.2025.01.004","url":null,"abstract":"<p><p>Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) and associated comorbidities. The phenotypic characteristics of individuals at risk for diabetes are associated with both specific risk profiles for progression and a differential potential to facilitate prediabetes remission and reduce the risk of future T2D. This review examines the current definition and global prevalence of prediabetes and evaluates the potential of prediabetes remission to reduce the alarming increase in the global burden of T2D.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"899-916"},"PeriodicalIF":12.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut feelings on short-chain fatty acids to regulate respiratory health. 肠道对短链脂肪酸的感觉调节呼吸系统健康。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-10-01 Epub Date: 2025-01-04 DOI: 10.1016/j.tem.2024.12.007
Samantha N Rowland, Christopher G Green, John R Halliwill, Aran Singanayagam, Liam M Heaney
{"title":"Gut feelings on short-chain fatty acids to regulate respiratory health.","authors":"Samantha N Rowland, Christopher G Green, John R Halliwill, Aran Singanayagam, Liam M Heaney","doi":"10.1016/j.tem.2024.12.007","DOIUrl":"10.1016/j.tem.2024.12.007","url":null,"abstract":"<p><p>Respiratory infections and diseases pose significant challenges to society and healthcare systems, underscoring the need for preventative and therapeutic strategies. Recent research in rodent models indicates that short-chain fatty acids (SCFAs), metabolites produced by gut bacteria, may offer medicinal benefits for respiratory conditions. In this opinion, we summarize the current literature that highlights the potential of SCFAs to enhance immune balance in humans. SCFAs have demonstrated the potential to decrease the risk of primary and secondary respiratory infections, modulate allergic airway exacerbations, and improve overall epithelial pathogen defenses. Therefore, we suggest that systemic SCFA levels could be targeted to support gut and respiratory health in specific groups, such as patients in hospital, women and their offspring, children, older adults, and athletes/military personnel.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"889-898"},"PeriodicalIF":12.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The dual role of taurine in cancer and immune metabolism. 牛磺酸在癌症和免疫代谢中的双重作用。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-10-01 Epub Date: 2025-08-29 DOI: 10.1016/j.tem.2025.08.001
Miaochun Xu, Yang Yu, Canhui Cao
{"title":"The dual role of taurine in cancer and immune metabolism.","authors":"Miaochun Xu, Yang Yu, Canhui Cao","doi":"10.1016/j.tem.2025.08.001","DOIUrl":"10.1016/j.tem.2025.08.001","url":null,"abstract":"<p><p>Taurine is a conditionally essential amino acid with paradoxical roles in cancer, as both tumor and immune cells rely on it for vital functions. Here, we discuss the emerging context-dependent functions of taurine and propose therapeutic strategies that leverage or inhibit its metabolism to modulate cancer progression and immunity.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"878-881"},"PeriodicalIF":12.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex- and endurance training-mediated cardiovascular protection through lipids during exercise. 性和耐力训练通过运动中的脂质介导心血管保护。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-09-01 Epub Date: 2024-12-31 DOI: 10.1016/j.tem.2024.12.004
Julia An, Ariel S Thorson, David H Wasserman, John M Stafford, Lin Zhu
{"title":"Sex- and endurance training-mediated cardiovascular protection through lipids during exercise.","authors":"Julia An, Ariel S Thorson, David H Wasserman, John M Stafford, Lin Zhu","doi":"10.1016/j.tem.2024.12.004","DOIUrl":"10.1016/j.tem.2024.12.004","url":null,"abstract":"<p><p>Premenopausal women and endurance-trained individuals of either sex have reduced cardiovascular disease (CVD) risk. Endurance training shifts fuel selection towards fats to spare carbohydrates; interestingly, women prioritize fats as an energy resource more than men do during exercise. Relying on fats during exercise drives whole-body lipolysis and promotes lipid uptake and oxidation capacity in skeletal muscles. These metabolic adaptations during exercise result in protection against diet-induced obesity, a healthy body fat distribution, and reduced plasma triacylglycerol (TG) concentrations. Here, we analyze how sex differences and endurance training mediate changes in skeletal muscles, including exercise-induced lipolysis, lipid uptake and β-oxidation, intramuscular TG storage, and postexercise lipid metabolism, and discuss how regulating this processes affects CVD risk.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"827-841"},"PeriodicalIF":12.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palmitate. 棕榈酸酯。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-01-20 DOI: 10.1016/j.tem.2025.01.001
Atrayee Gope, Claudio Mauro
{"title":"Palmitate.","authors":"Atrayee Gope, Claudio Mauro","doi":"10.1016/j.tem.2025.01.001","DOIUrl":"10.1016/j.tem.2025.01.001","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"867-868"},"PeriodicalIF":12.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting cholesterol-dependent adrenal steroidogenesis for management of primary aldosteronism. 靶向胆固醇依赖型肾上腺甾体生成治疗原发性醛固酮增多症。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-09-01 Epub Date: 2025-01-06 DOI: 10.1016/j.tem.2024.12.001
Hao Wu, Hongbo He, Tong Han, Xiaoyu Tian, Zhiming Zhu
{"title":"Targeting cholesterol-dependent adrenal steroidogenesis for management of primary aldosteronism.","authors":"Hao Wu, Hongbo He, Tong Han, Xiaoyu Tian, Zhiming Zhu","doi":"10.1016/j.tem.2024.12.001","DOIUrl":"10.1016/j.tem.2024.12.001","url":null,"abstract":"<p><p>Primary aldosteronism (PA) is a common, salt-sensitive form of endocrine hypertension. Compared with essential hypertension (EH), PA is more susceptible to cardiorenal complications and metabolic risks. However, PA has a low screening rate and a poor response to mineralocorticoid receptor antagonists (MRAs). In addition to somatic ion channel mutations and epigenetic alterations, which contribute to excessive production of aldosterone, cholesterol, as a crucial precursor for aldosterone biosynthesis, may be involved in PA pathogenesis. Abnormal adrenal cholesterol uptake and steroidogenesis have been found in patients with PA. Therefore, we propose that a statin-based therapeutic strategy may be pivotal for antagonizing PA-related comorbidities by targeting cholesterol-dependent adrenal steroidogenesis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":"36 9","pages":"789-801"},"PeriodicalIF":12.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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