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Trends in Endocrinology and Metabolism最新文献

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Hidden players in the metabolic vulnerabilities of amyotrophic lateral sclerosis.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-15 DOI: 10.1016/j.tem.2025.02.004
Marco Rosina, Silvia Scaricamazza, Gianmarco Fenili, Valentina Nesci, Cristiana Valle, Alberto Ferri, Maria Paola Paronetto
{"title":"Hidden players in the metabolic vulnerabilities of amyotrophic lateral sclerosis.","authors":"Marco Rosina, Silvia Scaricamazza, Gianmarco Fenili, Valentina Nesci, Cristiana Valle, Alberto Ferri, Maria Paola Paronetto","doi":"10.1016/j.tem.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.004","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a complex and rapidly progressive motor neuron disorder with a fatal outcome. Despite the remarkable progress in understanding ALS pathophysiology, which has significantly contributed to clinical trial design, ALS remains a rapidly disabling and life-shortening condition. The non-motor neuron features of ALS, including nutritional status, energy expenditure, and metabolic imbalance, are increasingly gaining attention. Indeed, the bioenergetic failure and mitochondrial dysfunction of patients with ALS impact not only the high energy-demanding motor neurons but also organs and brain areas long considered irrelevant to the disease. As such, here we discuss how considering energy balance in ALS is reshaping research on this disease, opening the path to novel targetable opportunities for its treatment.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing diabetes across female reproductive stages.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-14 DOI: 10.1016/j.tem.2025.02.003
Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal
{"title":"Managing diabetes across female reproductive stages.","authors":"Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal","doi":"10.1016/j.tem.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.003","url":null,"abstract":"<p><p>Hormonal fluctuations across the female reproductive lifespan lead to physiological adjustments that impact insulin sensitivity and glucose metabolism, generating unique challenges in diabetes management. Although current guidelines focus primarily on diabetes care during pregnancy, they lack tailored recommendations for addressing glycaemic variability associated with menstrual cycles, contraceptive needs, and menopause. Low rates of prepregnancy counselling, limited contraceptive guidance, and underuse of hormone replacement therapy further complicate care for women with diabetes. Here we examine these care gaps, identify unmet needs across reproductive stages, and suggest research directions to develop comprehensive, stage-specific management strategies that better support women's health and improve diabetes outcomes throughout the reproductive years.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing the role of fibromyalgia in post-exertional malaise.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-11 DOI: 10.1016/j.tem.2025.02.005
Alessandro Giollo, Mariangela Salvato, Andrea Doria
{"title":"Recognizing the role of fibromyalgia in post-exertional malaise.","authors":"Alessandro Giollo, Mariangela Salvato, Andrea Doria","doi":"10.1016/j.tem.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.005","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancer binding as a KEysTONE of fasting response.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-07 DOI: 10.1016/j.tem.2025.02.002
Nathaniel F Henneman, Ganna Panasyuk
{"title":"Enhancer binding as a KEysTONE of fasting response.","authors":"Nathaniel F Henneman, Ganna Panasyuk","doi":"10.1016/j.tem.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.002","url":null,"abstract":"<p><p>Fasting is a recurrent daily energy stress that benefits healthspan and lifespan. While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood. Recently, Korenfeld et al. revealed peroxisome proliferator-activated receptor alpha (PPARα)-dependent enhancer priming as a keystone for ketone production, increasing our understanding of mechanisms underlying metabolic benefits of alternate-day fasting (ADF).</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing health and fostering community involvement in medical research through the Genes & Health study. 通过基因与健康研究促进健康和促进社区参与医学研究。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI: 10.1016/j.tem.2024.11.002
Marie Spreckley, Mehru Raza, Kamrul Islam, Jessry Russell, Karen Hunt, Ceri Durham, Genes Health Research Team, David van Heel, Ahsan Khan, Sarah Finer, Moneeza K Siddiqui
{"title":"Advancing health and fostering community involvement in medical research through the Genes & Health study.","authors":"Marie Spreckley, Mehru Raza, Kamrul Islam, Jessry Russell, Karen Hunt, Ceri Durham, Genes Health Research Team, David van Heel, Ahsan Khan, Sarah Finer, Moneeza K Siddiqui","doi":"10.1016/j.tem.2024.11.002","DOIUrl":"10.1016/j.tem.2024.11.002","url":null,"abstract":"<p><p>The Genes & Health study, an initiative focused on British-Pakistani and British-Bangladeshi volunteers, is at the forefront of diversifying genetic research and driving scientific innovation. Here, we explore how this study has propelled scientific advancements and positively impacted communities, emphasizing its collaborative ethos, dedication to societal needs, and accomplishments.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"196-198"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts. 全氟和多氟烷基物质是具有代谢和内分泌干扰影响的持久性污染物。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tem.2024.07.021
Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau
{"title":"Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts.","authors":"Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau","doi":"10.1016/j.tem.2024.07.021","DOIUrl":"10.1016/j.tem.2024.07.021","url":null,"abstract":"<p><p>The widespread use of per- and polyfluoroalkyl substances (PFASs), and their resistance to degradation, renders human exposure to them inevitable. PFAS exposure disturbs endocrine function, potentially affecting cognitive development in newborns through thyroid dysfunction during pregnancy. Recent studies reveal varying male and female reproductive toxicity across PFAS classes, with alternative analogs affecting sperm parameters and legacy PFASs correlating with conditions like endometriosis. Metabolically, PFASs exposure is linked to metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and liver toxicity, particularly in early childhood. This review focuses on the endocrine-disrupting impact of PFASs, particularly on fertility, thyroid, and metabolic functions. We highlight the complexity of the PFAS issue, given the large number of molecules and their extremely diverse mixed effects.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"249-261"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte involvement in metabolic regulation and disease. 星形胶质细胞参与新陈代谢调节和疾病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-29 DOI: 10.1016/j.tem.2024.08.001
Muhammad Naveed, Kathryn Smedlund, Qi-Gang Zhou, Weikang Cai, Jennifer W Hill
{"title":"Astrocyte involvement in metabolic regulation and disease.","authors":"Muhammad Naveed, Kathryn Smedlund, Qi-Gang Zhou, Weikang Cai, Jennifer W Hill","doi":"10.1016/j.tem.2024.08.001","DOIUrl":"10.1016/j.tem.2024.08.001","url":null,"abstract":"<p><p>Astrocytes, the predominant glial cell type in the mammalian brain, influence a wide variety of brain parameters including neuronal energy metabolism. Exciting recent studies have shown that obesity and diabetes can impact on astrocyte function. We review evidence that dysregulation of astrocytic lipid metabolism and glucose sensing contributes to dysregulation of whole-body energy balance, thermoregulation, and insulin sensitivity. In addition, we consider the overlooked topic of the sex-specific roles of astrocytes and their response to hormonal fluctuations that provide insights into sex differences in metabolic regulation. Finally, we provide an update on potential ways to manipulate astrocyte function, including genetic targeting, optogenetic and chemogenetic techniques, transplantation, and tailored exosome-based therapies, which may lead to improved treatments for metabolic disease.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"219-234"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The biogenesis and transport of triglyceride-rich lipoproteins. 富含甘油三酯的脂蛋白的生物生成和运输。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-19 DOI: 10.1016/j.tem.2024.07.015
Linqi Zhang, Xiao Wang, Xiao-Wei Chen
{"title":"The biogenesis and transport of triglyceride-rich lipoproteins.","authors":"Linqi Zhang, Xiao Wang, Xiao-Wei Chen","doi":"10.1016/j.tem.2024.07.015","DOIUrl":"10.1016/j.tem.2024.07.015","url":null,"abstract":"<p><p>Triglyceride-rich lipoproteins (TRLs) play essential roles in human health and disease by transporting bulk lipids into the circulation. This review summarizes the fundamental mechanisms and diverse factors governing lipoprotein production, secretion, and regulation. Emphasizing the broader implications for human health, we outline the intricate landscape of lipoprotein research and highlight the potential coordination between the biogenesis and transport of TRLs in physiology, particularly the unexpected coupling of metabolic enzymes and transport machineries. Challenges and opportunities in lipoprotein biology with respect to inherited diseases and viral infections are also discussed. Further characterization of the biogenesis and transport of TRLs will advance both basic research in lipid biology and translational medicine for metabolic diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"262-277"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcellular mitochondrial heterogeneity enables opposing metabolic demands.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1016/j.tem.2025.01.003
Brandon Chen, Yatrik M Shah, Costas A Lyssiotis
{"title":"Subcellular mitochondrial heterogeneity enables opposing metabolic demands.","authors":"Brandon Chen, Yatrik M Shah, Costas A Lyssiotis","doi":"10.1016/j.tem.2025.01.003","DOIUrl":"10.1016/j.tem.2025.01.003","url":null,"abstract":"<p><p>Mitochondria perform essential metabolic processes that sustain cellular bioenergetics and biosynthesis. In a recent article, Ryu et al. explored how mitochondria coordinate biochemical reactions with opposing redox demands within the same cell. They demonstrate that subcellular mitochondrial heterogeneity enables metabolic compartmentalization to permit concurrent oxidative ATP production and reductive proline biosynthesis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"202-204"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Walking the VLDL tightrope in cardiometabolic diseases. 在心脏代谢疾病中走 "VLDL钢丝"。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-26 DOI: 10.1016/j.tem.2024.07.020
Mindy Kim, Ze Zheng
{"title":"Walking the VLDL tightrope in cardiometabolic diseases.","authors":"Mindy Kim, Ze Zheng","doi":"10.1016/j.tem.2024.07.020","DOIUrl":"10.1016/j.tem.2024.07.020","url":null,"abstract":"<p><p>Very-low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein secreted by hepatocytes, is pivotal for supplying peripheral tissues with fatty acids for energy production. As if walking on a tightrope, perturbations in the balance of VLDL metabolism contribute to cardiometabolic dysfunction, promoting pathologies such as cardiovascular disease (CVD) or metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the advent of lipid-lowering therapies, including statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, risks for cardiovascular events persist. With limitations to currently available CVD therapeutics and no US Food and Drug Administration (FDA)-approved treatment for MASLD, this review summarizes the current understanding of VLDL metabolism that sheds light on novel therapeutic avenues to pursue for cardiometabolic disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"278-291"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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