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Patient-derived organoid models to decode liver pathophysiology. 解码肝脏病理生理学的患者衍生类器官模型
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-26 DOI: 10.1016/j.tem.2024.07.019
Benjamin J Dwyer, Janina E E Tirnitz-Parker
{"title":"Patient-derived organoid models to decode liver pathophysiology.","authors":"Benjamin J Dwyer, Janina E E Tirnitz-Parker","doi":"10.1016/j.tem.2024.07.019","DOIUrl":"10.1016/j.tem.2024.07.019","url":null,"abstract":"<p><p>Liver diseases represent a growing global health challenge, and the increasing prevalence of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving regulatory demands, patient-specific in vitro liver models are essential for understanding disease mechanisms and developing new therapeutic approaches. Organoid models, which faithfully recapitulate liver biology, can be established from both non-malignant and malignant liver tissues, offering insight into various liver conditions, from acute injuries to chronic diseases and cancer. Improved understanding of liver microenvironments, innovative biomaterials, and advanced imaging techniques now facilitate comprehensive and unbiased data analysis, paving the way for personalised medicine. In this review, we discuss state-of-the-art patient-derived liver organoid models, recent technological advancements, and strategies to enhance their clinical impact.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"235-248"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid-derived suppressor cells in metabolic and cardiovascular disorders.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 DOI: 10.1016/j.tem.2025.02.001
Jingwei Yan, Shuai Guo, Jun He, Hanpeng Huang, Yiming Xu
{"title":"Myeloid-derived suppressor cells in metabolic and cardiovascular disorders.","authors":"Jingwei Yan, Shuai Guo, Jun He, Hanpeng Huang, Yiming Xu","doi":"10.1016/j.tem.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.001","url":null,"abstract":"<p><p>Dysregulation of immune homeostasis can precipitate chronic inflammation, thus significantly contributing to the onset and progression of metabolic and cardiovascular diseases. Myeloid-derived suppressor cells (MDSCs) constitute a heterogeneous population of immature myeloid cells that are mobilized in response to biological stressors such as tissue damage and inflammation. Although MDSCs have been extensively characterized in the contexts of cancer and infectious diseases, emerging evidence highlights their pivotal roles in the pathophysiology of metabolic and cardiovascular disorders. We discuss growing evidence for the involvement of MDSCs in the progression of metabolic and cardiovascular diseases, with the aim of deepening our understanding of MDSCs in cardiometabolic physiology and identifying the necessary steps for the development of innovative MDSC-targeted therapeutic strategies.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adapt and shape: metabolic features within the metastatic niche. 适应和塑造：转移龛位中的新陈代谢特征。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-08 DOI: 10.1016/j.tem.2024.07.016
Erica Pranzini, Luigi Ippolito, Elisa Pardella, Elisa Giannoni, Paola Chiarugi
{"title":"Adapt and shape: metabolic features within the metastatic niche.","authors":"Erica Pranzini, Luigi Ippolito, Elisa Pardella, Elisa Giannoni, Paola Chiarugi","doi":"10.1016/j.tem.2024.07.016","DOIUrl":"10.1016/j.tem.2024.07.016","url":null,"abstract":"<p><p>The success of disseminating cancer cells (DTCs) at specific metastatic sites is influenced by several metabolic factors. Even before DTCs arrival, metabolic conditioning from the primary tumor participates in creating a favorable premetastatic niche at distant organs. In addition, DTCs adjust their metabolism to better survive along the metastatic journey and successfully colonize their ultimate destination. However, the idea that the environment of the target organs may metabolically impact the metastatic fate is often underestimated. Here, we review the coexistence of two distinct strategies by which cancer cells shape and/or adapt to the metabolic profile of colonized tissues, ultimately creating a proper soil for their seeding and proliferation.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"205-218"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moving from helicopter research to proximity research and capacity building. 从直升机研究转向近距离研究和能力建设。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-10-01 DOI: 10.1016/j.tem.2024.08.011
Fannie Lajeunesse-Trempe, Marie-Ève Piché, Lydia Kaduka, Juan Ricardo Lopez Y Taylor, René Crocker Sagastume
{"title":"Moving from helicopter research to proximity research and capacity building.","authors":"Fannie Lajeunesse-Trempe, Marie-Ève Piché, Lydia Kaduka, Juan Ricardo Lopez Y Taylor, René Crocker Sagastume","doi":"10.1016/j.tem.2024.08.011","DOIUrl":"10.1016/j.tem.2024.08.011","url":null,"abstract":"<p><p>Health funding agencies are increasingly prioritizing equity, diversity, and inclusion (EDI) strategies. This shift, while essential, can inadvertently lead to 'helicopter research', especially among junior researchers, due to insufficient institutional support. We warn against such unethical practices and propose strategies for academia and funding bodies to address them.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"193-195"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hallmarks of ovarian aging. 卵巢衰老的标志
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-24 DOI: 10.1016/j.tem.2025.01.005
Chuqing Wu, Dan Chen, Michael B Stout, Meng Wu, Shixuan Wang
{"title":"Hallmarks of ovarian aging.","authors":"Chuqing Wu, Dan Chen, Michael B Stout, Meng Wu, Shixuan Wang","doi":"10.1016/j.tem.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.tem.2025.01.005","url":null,"abstract":"<p><p>Ovarian aging is considered to be the pacemaker of female aging, and is linked to various comorbidities such as osteoporosis, cardiovascular diseases, and cognitive decline. Many efforts have been made to determine the mechanisms underlying ovarian aging, but their potential to act as hallmarks to predict and intervene in this process currently remains unclear. In this review we propose nine hallmarks as common features of ovarian aging: genomic instability, telomere attrition, epigenetic alterations, impaired autophagy, cellular senescence, deregulated nutrient-sensing, mitochondrial dysfunction, oxidative stress, and chronic inflammation. Understanding the interaction between these hallmarks poses a significant challenge but may also pave the way to the identification of pharmaceutical targets that can attenuate ovarian aging.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143505964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights from omics research on plant-based diets and cardiometabolic health.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-20 DOI: 10.1016/j.tem.2025.01.007
Hyunju Kim, Casey M Rebholz
{"title":"Insights from omics research on plant-based diets and cardiometabolic health.","authors":"Hyunju Kim, Casey M Rebholz","doi":"10.1016/j.tem.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.tem.2025.01.007","url":null,"abstract":"<p><p>Plant-based diets emphasize higher intake of plant foods and are low in animal products. Individuals following plant-based diets have a lower risk of chronic conditions; however, the mechanisms underlying these associations are not completely understood. Omics data have opened opportunities to investigate the mechanistic effect of dietary intake on health outcomes. Here, we review omics analyses of plant-based diets in feeding and observational studies, showing that although metabolomics and proteomics identified candidate biomarkers and distinct pathways modifiable by plant-based diets, current evidence from transcriptomics and methylomics is limited. We also argue that future studies should examine how unhealthful plant-based diets are associated with a higher risk of health outcomes and integrate multiple omics data from feeding studies to provide further mechanistic insights.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediabetes remission to reduce the global burden of type 2 diabetes.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-14 DOI: 10.1016/j.tem.2025.01.004
Leontine Sandforth, Stephanie Kullmann, Arvid Sandforth, Andreas Fritsche, Reiner Jumpertz-von Schwartzenberg, Norbert Stefan, Andreas L Birkenfeld
{"title":"Prediabetes remission to reduce the global burden of type 2 diabetes.","authors":"Leontine Sandforth, Stephanie Kullmann, Arvid Sandforth, Andreas Fritsche, Reiner Jumpertz-von Schwartzenberg, Norbert Stefan, Andreas L Birkenfeld","doi":"10.1016/j.tem.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.tem.2025.01.004","url":null,"abstract":"<p><p>Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) and associated comorbidities. The phenotypic characteristics of individuals at risk for diabetes are associated with both specific risk profiles for progression and a differential potential to facilitate prediabetes remission and reduce the risk of future T2D. This review examines the current definition and global prevalence of prediabetes and evaluates the potential of prediabetes remission to reduce the alarming increase in the global burden of T2D.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do weight loss interventions challenge the obesity paradox in heart failure?
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-11 DOI: 10.1016/j.tem.2025.01.006
Salva R Yurista, Robert A Eder, W Scott Butsch, Ivan Luptak
{"title":"Do weight loss interventions challenge the obesity paradox in heart failure?","authors":"Salva R Yurista, Robert A Eder, W Scott Butsch, Ivan Luptak","doi":"10.1016/j.tem.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.tem.2025.01.006","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) remains a significant global health concern, with obesity recognized as a prominent risk factor. The 'obesity paradox' (OP) suggests that obesity does not always lead to adverse outcomes, particularly in heart failure (HF). In this forum, we discuss the relevance of the OP in the current therapeutic landscape for cardiometabolic diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucagon-like peptide-1 receptor agonism and end-organ protection.
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-10 DOI: 10.1016/j.tem.2025.01.002
Samuel Daniels, Cecilia Karlsson, Patrick Schrauwen, Victoria E R Parker
{"title":"Glucagon-like peptide-1 receptor agonism and end-organ protection.","authors":"Samuel Daniels, Cecilia Karlsson, Patrick Schrauwen, Victoria E R Parker","doi":"10.1016/j.tem.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.tem.2025.01.002","url":null,"abstract":"<p><p>Identification of exendin-4 (a glucagon-like peptide 1 receptor agonist, GLP-1RA) in Gila monster venom may be regarded as one of the most serendipitous discoveries of recent times. GLP-1RAs are now an established therapeutic approach in type 2 diabetes (T2D), body weight management, and cardiovascular (CV) risk protection. Furthermore, there is a growing platform of evidence that GLP-1RA has extended benefit in renal, hepatic, respiratory, and neurological diseases. One can speculate on the biological advantage of exendin-4 to the Gila monster, but for humankind GLP-1RAs are peptides with significant potential to improve disease-related outcomes. We report on the latest evidence and mechanisms for GLP-1RA-mediated end-organ protection that uniquely highlight its future development potential across multiple disease areas.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery. 通过代谢减肥手术对 MASLD 相关性肝硬化进行补偿。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-06-21 DOI: 10.1016/j.tem.2024.05.009
Gong Feng, Yu Han, Wah Yang, Scott Shikora, Kamal Mahawar, Tan To Cheung, Giovanni Targher, Christopher D Byrne, Virginia Hernandez-Gea, Herbert Tilg, Ming-Hua Zheng
{"title":"Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery.","authors":"Gong Feng, Yu Han, Wah Yang, Scott Shikora, Kamal Mahawar, Tan To Cheung, Giovanni Targher, Christopher D Byrne, Virginia Hernandez-Gea, Herbert Tilg, Ming-Hua Zheng","doi":"10.1016/j.tem.2024.05.009","DOIUrl":"10.1016/j.tem.2024.05.009","url":null,"abstract":"<p><p>The prognosis of patients with decompensated cirrhosis is poor, with significantly increased liver-related mortality rates. With the rising tide of decompensated cirrhosis associated with metabolic dysfunction-associated steatotic liver disease (MASLD), the role of metabolic bariatric surgery (MBS) in achieving hepatic recompensation is garnering increasing attention. However, the complexity of preoperative assessment, the risk of postoperative disease recurrence, and the potential for patients to experience surgical complications of the MBS present challenges. In this opinion article we analyze the potential of MBS to induce recompensation in MASLD-related cirrhosis, discuss the mechanisms by which MBS may affect recompensation, and compare the characteristics of different MBS procedures; we highlight the therapeutic potential of MBS in MASLD-related cirrhosis recompensation and advocate for research in this complex area.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"118-132"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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