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Glucagon-like peptide-1 receptor agonism and end-organ protection. 胰高血糖素样肽-1受体激动作用和终末器官保护。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1016/j.tem.2025.01.002
Samuel Daniels, Cecilia Karlsson, Patrick Schrauwen, Victoria E R Parker
{"title":"Glucagon-like peptide-1 receptor agonism and end-organ protection.","authors":"Samuel Daniels, Cecilia Karlsson, Patrick Schrauwen, Victoria E R Parker","doi":"10.1016/j.tem.2025.01.002","DOIUrl":"10.1016/j.tem.2025.01.002","url":null,"abstract":"<p><p>Identification of exendin-4 (a glucagon-like peptide-1 receptor agonist, GLP-1RA) in Gila monster venom may be regarded as one of the most serendipitous discoveries of recent times. GLP-1RAs are now an established therapeutic approach in type 2 diabetes (T2D), body weight management, and cardiovascular (CV) risk protection. Furthermore, there is a growing platform of evidence that GLP-1RA has extended benefit in renal, hepatic, respiratory, and neurological diseases. One can speculate on the biological advantage of exendin-4 to the Gila monster, but for humankind GLP-1RAs are peptides with significant potential to improve disease-related outcomes. We report on the latest evidence and mechanisms for GLP-1RA-mediated end-organ protection that uniquely highlight its future development potential across multiple disease areas.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"301-315"},"PeriodicalIF":11.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unexpected role of GIP in transforming obesity treatment. GIP 在改变肥胖症治疗方面发挥了意想不到的作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-04-01 Epub Date: 2024-08-27 DOI: 10.1016/j.tem.2024.07.022
Inuk Zandvakili, Diego Perez-Tilve
{"title":"The unexpected role of GIP in transforming obesity treatment.","authors":"Inuk Zandvakili, Diego Perez-Tilve","doi":"10.1016/j.tem.2024.07.022","DOIUrl":"10.1016/j.tem.2024.07.022","url":null,"abstract":"<p><p>Despite sharing incretin activity with glucagon-like peptide 1 (GLP-1), the development of gastric inhibitory polypeptide (GIP)-based drugs has been hindered by the minor effects of native GIP on appetite and body weight and genetic studies associating loss-of-function with reduced obesity. Yet, pharmacologically optimized GIP-based molecules have demonstrated profound weight lowering benefits of GIPR agonism when combined with GLP-1-based therapies, which has re-energized deeper exploration of the molecular mechanisms and downstream signaling of GIPR. Interestingly, both GIPR agonism and antagonism offer metabolic benefits, leading to differing viewpoints on how to target GIPR therapeutically. Here we summarize the emerging evidence about the tissue-specific mechanisms that positions GIP-based therapies as important targets for the next generation of anti-obesity and metabolic therapies.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"330-338"},"PeriodicalIF":11.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden players in the metabolic vulnerabilities of amyotrophic lateral sclerosis. 肌萎缩性侧索硬化症代谢脆弱性的隐藏参与者。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-15 DOI: 10.1016/j.tem.2025.02.004
Marco Rosina, Silvia Scaricamazza, Gianmarco Fenili, Valentina Nesci, Cristiana Valle, Alberto Ferri, Maria Paola Paronetto
{"title":"Hidden players in the metabolic vulnerabilities of amyotrophic lateral sclerosis.","authors":"Marco Rosina, Silvia Scaricamazza, Gianmarco Fenili, Valentina Nesci, Cristiana Valle, Alberto Ferri, Maria Paola Paronetto","doi":"10.1016/j.tem.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.004","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a complex and rapidly progressive motor neuron disorder with a fatal outcome. Despite the remarkable progress in understanding ALS pathophysiology, which has significantly contributed to clinical trial design, ALS remains a rapidly disabling and life-shortening condition. The non-motor neuron features of ALS, including nutritional status, energy expenditure, and metabolic imbalance, are increasingly gaining attention. Indeed, the bioenergetic failure and mitochondrial dysfunction of patients with ALS impact not only the high energy-demanding motor neurons but also organs and brain areas long considered irrelevant to the disease. As such, here we discuss how considering energy balance in ALS is reshaping research on this disease, opening the path to novel targetable opportunities for its treatment.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing diabetes across female reproductive stages. 管理女性生育阶段的糖尿病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-14 DOI: 10.1016/j.tem.2025.02.003
Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal
{"title":"Managing diabetes across female reproductive stages.","authors":"Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal","doi":"10.1016/j.tem.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.003","url":null,"abstract":"<p><p>Hormonal fluctuations across the female reproductive lifespan lead to physiological adjustments that impact insulin sensitivity and glucose metabolism, generating unique challenges in diabetes management. Although current guidelines focus primarily on diabetes care during pregnancy, they lack tailored recommendations for addressing glycaemic variability associated with menstrual cycles, contraceptive needs, and menopause. Low rates of prepregnancy counselling, limited contraceptive guidance, and underuse of hormone replacement therapy further complicate care for women with diabetes. Here we examine these care gaps, identify unmet needs across reproductive stages, and suggest research directions to develop comprehensive, stage-specific management strategies that better support women's health and improve diabetes outcomes throughout the reproductive years.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognizing the role of fibromyalgia in post-exertional malaise. 认识到纤维肌痛在运动后不适中的作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-11 DOI: 10.1016/j.tem.2025.02.005
Alessandro Giollo, Mariangela Salvato, Andrea Doria
{"title":"Recognizing the role of fibromyalgia in post-exertional malaise.","authors":"Alessandro Giollo, Mariangela Salvato, Andrea Doria","doi":"10.1016/j.tem.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.005","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing health and fostering community involvement in medical research through the Genes & Health study. 通过基因与健康研究促进健康和促进社区参与医学研究。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI: 10.1016/j.tem.2024.11.002
Marie Spreckley, Mehru Raza, Kamrul Islam, Jessry Russell, Karen Hunt, Ceri Durham, Genes Health Research Team, David van Heel, Ahsan Khan, Sarah Finer, Moneeza K Siddiqui
{"title":"Advancing health and fostering community involvement in medical research through the Genes & Health study.","authors":"Marie Spreckley, Mehru Raza, Kamrul Islam, Jessry Russell, Karen Hunt, Ceri Durham, Genes Health Research Team, David van Heel, Ahsan Khan, Sarah Finer, Moneeza K Siddiqui","doi":"10.1016/j.tem.2024.11.002","DOIUrl":"10.1016/j.tem.2024.11.002","url":null,"abstract":"<p><p>The Genes & Health study, an initiative focused on British-Pakistani and British-Bangladeshi volunteers, is at the forefront of diversifying genetic research and driving scientific innovation. Here, we explore how this study has propelled scientific advancements and positively impacted communities, emphasizing its collaborative ethos, dedication to societal needs, and accomplishments.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"196-198"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts. 全氟和多氟烷基物质是具有代谢和内分泌干扰影响的持久性污染物。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tem.2024.07.021
Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau
{"title":"Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts.","authors":"Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau","doi":"10.1016/j.tem.2024.07.021","DOIUrl":"10.1016/j.tem.2024.07.021","url":null,"abstract":"<p><p>The widespread use of per- and polyfluoroalkyl substances (PFASs), and their resistance to degradation, renders human exposure to them inevitable. PFAS exposure disturbs endocrine function, potentially affecting cognitive development in newborns through thyroid dysfunction during pregnancy. Recent studies reveal varying male and female reproductive toxicity across PFAS classes, with alternative analogs affecting sperm parameters and legacy PFASs correlating with conditions like endometriosis. Metabolically, PFASs exposure is linked to metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), dyslipidemia, and liver toxicity, particularly in early childhood. This review focuses on the endocrine-disrupting impact of PFASs, particularly on fertility, thyroid, and metabolic functions. We highlight the complexity of the PFAS issue, given the large number of molecules and their extremely diverse mixed effects.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"249-261"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcellular mitochondrial heterogeneity enables opposing metabolic demands. 亚细胞线粒体异质性使相反的代谢需求。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1016/j.tem.2025.01.003
Brandon Chen, Yatrik M Shah, Costas A Lyssiotis
{"title":"Subcellular mitochondrial heterogeneity enables opposing metabolic demands.","authors":"Brandon Chen, Yatrik M Shah, Costas A Lyssiotis","doi":"10.1016/j.tem.2025.01.003","DOIUrl":"10.1016/j.tem.2025.01.003","url":null,"abstract":"<p><p>Mitochondria perform essential metabolic processes that sustain cellular bioenergetics and biosynthesis. In a recent article, Ryu et al. explored how mitochondria coordinate biochemical reactions with opposing redox demands within the same cell. They demonstrate that subcellular mitochondrial heterogeneity enables metabolic compartmentalization to permit concurrent oxidative ATP production and reductive proline biosynthesis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"202-204"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte involvement in metabolic regulation and disease. 星形胶质细胞参与新陈代谢调节和疾病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-29 DOI: 10.1016/j.tem.2024.08.001
Muhammad Naveed, Kathryn Smedlund, Qi-Gang Zhou, Weikang Cai, Jennifer W Hill
{"title":"Astrocyte involvement in metabolic regulation and disease.","authors":"Muhammad Naveed, Kathryn Smedlund, Qi-Gang Zhou, Weikang Cai, Jennifer W Hill","doi":"10.1016/j.tem.2024.08.001","DOIUrl":"10.1016/j.tem.2024.08.001","url":null,"abstract":"<p><p>Astrocytes, the predominant glial cell type in the mammalian brain, influence a wide variety of brain parameters including neuronal energy metabolism. Exciting recent studies have shown that obesity and diabetes can impact on astrocyte function. We review evidence that dysregulation of astrocytic lipid metabolism and glucose sensing contributes to dysregulation of whole-body energy balance, thermoregulation, and insulin sensitivity. In addition, we consider the overlooked topic of the sex-specific roles of astrocytes and their response to hormonal fluctuations that provide insights into sex differences in metabolic regulation. Finally, we provide an update on potential ways to manipulate astrocyte function, including genetic targeting, optogenetic and chemogenetic techniques, transplantation, and tailored exosome-based therapies, which may lead to improved treatments for metabolic disease.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"219-234"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The biogenesis and transport of triglyceride-rich lipoproteins. 富含甘油三酯的脂蛋白的生物生成和运输。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-19 DOI: 10.1016/j.tem.2024.07.015
Linqi Zhang, Xiao Wang, Xiao-Wei Chen
{"title":"The biogenesis and transport of triglyceride-rich lipoproteins.","authors":"Linqi Zhang, Xiao Wang, Xiao-Wei Chen","doi":"10.1016/j.tem.2024.07.015","DOIUrl":"10.1016/j.tem.2024.07.015","url":null,"abstract":"<p><p>Triglyceride-rich lipoproteins (TRLs) play essential roles in human health and disease by transporting bulk lipids into the circulation. This review summarizes the fundamental mechanisms and diverse factors governing lipoprotein production, secretion, and regulation. Emphasizing the broader implications for human health, we outline the intricate landscape of lipoprotein research and highlight the potential coordination between the biogenesis and transport of TRLs in physiology, particularly the unexpected coupling of metabolic enzymes and transport machineries. Challenges and opportunities in lipoprotein biology with respect to inherited diseases and viral infections are also discussed. Further characterization of the biogenesis and transport of TRLs will advance both basic research in lipid biology and translational medicine for metabolic diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"262-277"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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