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Understanding gut dysbiosis for hepatocellular carcinoma diagnosis and treatment. 了解肠道菌群失调对肝细胞癌诊断和治疗的影响。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-07-05 DOI: 10.1016/j.tem.2024.06.003
Jingjing Yu, Xiaoping Chen, Xiangliang Yang, Bixiang Zhang
{"title":"Understanding gut dysbiosis for hepatocellular carcinoma diagnosis and treatment.","authors":"Jingjing Yu, Xiaoping Chen, Xiangliang Yang, Bixiang Zhang","doi":"10.1016/j.tem.2024.06.003","DOIUrl":"10.1016/j.tem.2024.06.003","url":null,"abstract":"<p><p>The gut microbiome can play a crucial role in hepatocellular carcinoma (HCC) progression through the enterohepatic circulation, primarily acting via metabolic reprogramming and alterations in the hepatic immune microenvironment triggered by microbe-associated molecular patterns (MAMPs), metabolites, and fungi. In addition, the gut microbiome shows potential as a biomarker for early HCC diagnosis and for assessing the efficacy of immunotherapy in unresectable HCC. This review examines how gut microbiota dysbiosis, with varied functional profiles, contributes to HCCs of different etiologies. We discuss therapeutic strategies to modulate the gut microbiome including diets, antibiotics, probiotics, fecal microbiota transplantation, and nano-delivery systems, and underscore their potential as an adjunctive treatment modality for HCC.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1006-1020"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing beta cell regeneration biology for diabetes therapy. 利用β细胞再生生物学治疗糖尿病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-04-21 DOI: 10.1016/j.tem.2024.03.006
Stephanie Bourgeois, Sophie Coenen, Laure Degroote, Lien Willems, Annelore Van Mulders, Julie Pierreux, Yves Heremans, Nico De Leu, Willem Staels
{"title":"Harnessing beta cell regeneration biology for diabetes therapy.","authors":"Stephanie Bourgeois, Sophie Coenen, Laure Degroote, Lien Willems, Annelore Van Mulders, Julie Pierreux, Yves Heremans, Nico De Leu, Willem Staels","doi":"10.1016/j.tem.2024.03.006","DOIUrl":"10.1016/j.tem.2024.03.006","url":null,"abstract":"<p><p>The pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic β-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate β-cells directly within the pancreas; however, while several approaches for β-cell regeneration have been proposed in the past, clinical translation has proven challenging. This review scrutinizes recent findings in β-cell regeneration and discusses their potential clinical implementation. Hereby, we aim to delineate a path for innovative, targeted therapies to help shift from 'caring for' to 'curing' diabetes.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"951-966"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid-associated macrophages between aggravation and alleviation of metabolic diseases. 代谢性疾病恶化与缓解之间的脂质相关巨噬细胞。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-05-04 DOI: 10.1016/j.tem.2024.04.009
Ruonan Xu, Nemanja Vujić, Valentina Bianco, Isabel Reinisch, Dagmar Kratky, Jelena Krstic, Andreas Prokesch
{"title":"Lipid-associated macrophages between aggravation and alleviation of metabolic diseases.","authors":"Ruonan Xu, Nemanja Vujić, Valentina Bianco, Isabel Reinisch, Dagmar Kratky, Jelena Krstic, Andreas Prokesch","doi":"10.1016/j.tem.2024.04.009","DOIUrl":"10.1016/j.tem.2024.04.009","url":null,"abstract":"<p><p>Lipid-associated macrophages (LAMs) are phagocytic cells with lipid-handling capacity identified in various metabolic derangements. During disease development, they locate to atherosclerotic plaques, adipose tissue (AT) of individuals with obesity, liver lesions in steatosis and steatohepatitis, and the intestinal lamina propria. LAMs can also emerge in the metabolically demanding microenvironment of certain tumors. In this review, we discuss major questions regarding LAM recruitment, differentiation, and self-renewal, and, ultimately, their acute and chronic functional impact on the development of metabolic diseases. Further studies need to clarify whether and under which circumstances LAMs drive disease progression or resolution and how their phenotype can be modulated to ameliorate metabolic disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"981-995"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gonadotropin-releasing hormone. 促性腺激素释放激素。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-31 DOI: 10.1016/j.tem.2024.10.003
Miguel Ruiz-Cruz, Juan Roa, Manuel Tena-Sempere
{"title":"Gonadotropin-releasing hormone.","authors":"Miguel Ruiz-Cruz, Juan Roa, Manuel Tena-Sempere","doi":"10.1016/j.tem.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.003","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GDF15 is still a mystery hormone. GDF15 仍是一种神秘的激素。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-29 DOI: 10.1016/j.tem.2024.09.002
Casper M Sigvardsen, Michael M Richter, Sarah Engelbeen, Maximilian Kleinert, Erik A Richter
{"title":"GDF15 is still a mystery hormone.","authors":"Casper M Sigvardsen, Michael M Richter, Sarah Engelbeen, Maximilian Kleinert, Erik A Richter","doi":"10.1016/j.tem.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.tem.2024.09.002","url":null,"abstract":"<p><p>Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) superfamily. Despite its identification over 20 years ago, the functions of GDF15 remain complex and not fully elucidated. Its concentration in plasma varies widely depending on the physiological and pathophysiological state of the organism. GDF15 has been described to regulate food intake and insulin sensitivity in rodents via the GDNF family receptor α-like (GFRAL) receptor, and to be elevated in pregnancy and many disease states and decreased in physically fit individuals. We discuss the latest developments in the regulation of GDF15 secretion and its diverse physiological effects, and touch upon possible GFRAL-independent effects of GDF15. In addition, we discuss the effects of proteins and peptides derived from the same precursor protein as GDF15.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Context-specific fatty acid uptake is a finely-tuned multi-level effort. 针对具体情况的脂肪酸摄取是一项多层次的精细工作。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-25 DOI: 10.1016/j.tem.2024.10.001
Juan Wang, Huiling Guo, Lang-Fan Zheng, Peng Li, Tong-Jin Zhao
{"title":"Context-specific fatty acid uptake is a finely-tuned multi-level effort.","authors":"Juan Wang, Huiling Guo, Lang-Fan Zheng, Peng Li, Tong-Jin Zhao","doi":"10.1016/j.tem.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.001","url":null,"abstract":"<p><p>Fatty acids (FAs) are essential nutrients that play multiple roles in cellular activities. To meet cell-specific needs, cells exhibit differential uptake of FAs in diverse physiological or pathological contexts, coordinating to maintain metabolic homeostasis. Cells tightly regulate the localization and transcription of CD36 and other key proteins that transport FAs across the plasma membrane in response to different stimuli. Dysregulation of FA uptake results in diseases such as obesity, steatotic liver, heart failure, and cancer progression. Targeting FA uptake might provide potential therapeutic strategies for metabolic diseases and cancer. Here, we review recent advances in context-specific regulation of FA uptake, focusing on the regulation of CD36 in metabolic organs and other cells.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin. 胰岛素
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-16 DOI: 10.1016/j.tem.2024.09.001
Wenqiang Chen, C Ronald Kahn
{"title":"Insulin.","authors":"Wenqiang Chen, C Ronald Kahn","doi":"10.1016/j.tem.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.tem.2024.09.001","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ISR pathway contribution to tissue specificity of mitochondrial diseases. ISR 途径对线粒体疾病组织特异性的贡献。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-05-27 DOI: 10.1016/j.tem.2024.05.001
Ana Vela-Sebastián, Pilar Bayona-Bafaluy, David Pacheu-Grau
{"title":"ISR pathway contribution to tissue specificity of mitochondrial diseases.","authors":"Ana Vela-Sebastián, Pilar Bayona-Bafaluy, David Pacheu-Grau","doi":"10.1016/j.tem.2024.05.001","DOIUrl":"10.1016/j.tem.2024.05.001","url":null,"abstract":"<p><p>Mitochondrial genetic defects caused by whole-body mutations typically affect different tissues in different ways. Elucidating the molecular determinants that cause certain cell types to be primarily affected has become a critical research target within the field. We propose a differential activation of the integrated stress response as a potential contributor to this tissue specificity.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"851-853"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial morphology, distribution and activity during oocyte development. 卵母细胞发育过程中线粒体的形态、分布和活性。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-04-09 DOI: 10.1016/j.tem.2024.03.002
Devesh Bahety, Elvan Böke, Aida Rodríguez-Nuevo
{"title":"Mitochondrial morphology, distribution and activity during oocyte development.","authors":"Devesh Bahety, Elvan Böke, Aida Rodríguez-Nuevo","doi":"10.1016/j.tem.2024.03.002","DOIUrl":"10.1016/j.tem.2024.03.002","url":null,"abstract":"<p><p>Mitochondria have a crucial role in cellular function and exhibit remarkable plasticity, adjusting both their structure and activity to meet the changing energy demands of a cell. Oocytes, female germ cells that become eggs, undergo unique transformations: the extended dormancy period, followed by substantial increase in cell size and subsequent maturation involving the segregation of genetic material for the next generation, present distinct metabolic challenges necessitating varied mitochondrial adaptations. Recent findings in dormant oocytes challenged the established respiratory complex hierarchies and underscored the extent of mitochondrial plasticity in long-lived oocytes. In this review, we discuss mitochondrial adaptations observed during oocyte development across three vertebrate species (Xenopus, mouse, and human), emphasising current knowledge, acknowledging limitations, and outlining future research directions.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"902-917"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MCU genetically altered mice suggest how mitochondrial Ca2+ regulates metabolism. MCU 基因改变小鼠表明线粒体 Ca2+ 如何调节新陈代谢。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-04-29 DOI: 10.1016/j.tem.2024.04.005
Jiuzhou Huo, Jeffery D Molkentin
{"title":"MCU genetically altered mice suggest how mitochondrial Ca<sup>2+</sup> regulates metabolism.","authors":"Jiuzhou Huo, Jeffery D Molkentin","doi":"10.1016/j.tem.2024.04.005","DOIUrl":"10.1016/j.tem.2024.04.005","url":null,"abstract":"<p><p>Skeletal muscle has a major impact on total body metabolism and obesity, and is characterized by dynamic regulation of substrate utilization. While it is accepted that acute increases in mitochondrial matrix Ca<sup>2+</sup> increase carbohydrate usage to augment ATP production, recent studies in mice with deleted genes for components of the mitochondrial Ca<sup>2+</sup> uniporter (MCU) complex have suggested a more complicated regulatory scenario. Indeed, mice with a deleted Mcu gene in muscle, which lack acute mitochondrial Ca<sup>2+</sup> uptake, have greater fatty acid oxidation (FAO) and less adiposity. By contrast, mice deleted for the inhibitory Mcub gene in skeletal muscle, which have greater acute mitochondrial Ca<sup>2+</sup> uptake, antithetically display reduced FAO and progressive obesity. In this review we discuss the emerging concept that dynamic fluxing of mitochondrial matrix Ca<sup>2+</sup> regulates metabolism.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"918-928"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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