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Autophagy and lysosomal dysfunction in diabetes and its complications. 糖尿病及其并发症中的自噬和溶酶体功能障碍。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-01 Epub Date: 2024-07-24 DOI: 10.1016/j.tem.2024.06.010
Catherine Arden, Seo H Park, Xaviera Riani Yasasilka, Eun Y Lee, Myung-Shik Lee
{"title":"Autophagy and lysosomal dysfunction in diabetes and its complications.","authors":"Catherine Arden, Seo H Park, Xaviera Riani Yasasilka, Eun Y Lee, Myung-Shik Lee","doi":"10.1016/j.tem.2024.06.010","DOIUrl":"10.1016/j.tem.2024.06.010","url":null,"abstract":"<p><p>Autophagy is critical for energy homeostasis and the function of organelles such as endoplasmic reticulum (ER) and mitochondria. Dysregulated autophagy due to aging, environmental factors, or genetic predisposition can be an underlying cause of not only diabetes through β-cell dysfunction and metabolic inflammation, but also diabetic complications such as diabetic kidney diseases (DKDs). Dysfunction of lysosomes, effector organelles of autophagic degradation, due to metabolic stress or nutrients/metabolites accumulating in metabolic diseases is also emerging as a cause or aggravating element in diabetes and its complications. Here, we discuss the etiological role of dysregulated autophagy and lysosomal dysfunction in diabetes and a potential role of autophagy or lysosomal modulation as a new avenue for treatment of diabetes and its complications.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1078-1090"},"PeriodicalIF":11.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased hepatic gluconeogenesis and type 2 diabetes mellitus. 肝糖生成增加和 2 型糖尿病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-01 Epub Date: 2024-05-29 DOI: 10.1016/j.tem.2024.05.006
Emma Barroso, Javier Jurado-Aguilar, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
{"title":"Increased hepatic gluconeogenesis and type 2 diabetes mellitus.","authors":"Emma Barroso, Javier Jurado-Aguilar, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera","doi":"10.1016/j.tem.2024.05.006","DOIUrl":"10.1016/j.tem.2024.05.006","url":null,"abstract":"<p><p>Abnormally increased hepatic gluconeogenesis is a significant contributor to hyperglycemia in the fasting state in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance. Metformin, the most prescribed drug for the treatment of T2DM, is believed to exert its effect mainly by reducing hepatic gluconeogenesis. Here, we discuss how increased hepatic gluconeogenesis contributes to T2DM and we review newly revealed mechanisms underlying the attenuation of gluconeogenesis by metformin. In addition, we analyze the recent findings on new determinants involved in the regulation of gluconeogenesis, which might ultimately lead to the identification of novel and targeted treatment strategies for T2DM.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1062-1077"},"PeriodicalIF":11.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid droplets as cell fate determinants in skeletal muscle. 脂滴作为骨骼肌细胞命运的决定因素。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-28 DOI: 10.1016/j.tem.2024.10.006
Jingjuan Chen, James F Markworth, Christina Ferreira, Chi Zhang, Shihuan Kuang
{"title":"Lipid droplets as cell fate determinants in skeletal muscle.","authors":"Jingjuan Chen, James F Markworth, Christina Ferreira, Chi Zhang, Shihuan Kuang","doi":"10.1016/j.tem.2024.10.006","DOIUrl":"10.1016/j.tem.2024.10.006","url":null,"abstract":"<p><p>Lipid droplets (LDs) are dynamic organelles that communicate with other cellular components to orchestrate energetic homeostasis and signal transduction. In skeletal muscle, the presence and importance of LDs have been widely studied in myofibers of both rodents and humans under physiological conditions and in metabolic disorders. However, the role of LDs in myogenic stem cells has only recently begun to be unveiled. In this review we briefly summarize the process of LD biogenesis and degradation in the most prevalent model. We then review recent knowledge on LDs in skeletal muscle and muscle stem cells. We further introduce advanced methodologies for LD imaging and mass spectrometry that have propelled our understanding of the dynamics and heterogeneity of LDs.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host metabolic inflammation fueled by bacterial DNA. 宿主代谢炎症由细菌DNA引起。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-27 DOI: 10.1016/j.tem.2024.11.003
Ke Wang, Karina Cunha E Rocha, Houji Qin, Zixuan Zeng, Wei Ying
{"title":"Host metabolic inflammation fueled by bacterial DNA.","authors":"Ke Wang, Karina Cunha E Rocha, Houji Qin, Zixuan Zeng, Wei Ying","doi":"10.1016/j.tem.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.003","url":null,"abstract":"<p><p>Metabolic diseases, characterized by chronic low-grade inflammation, exhibit a compromised gut barrier allowing the translocation of bacteria-derived products to bloodstream and distant metabolic organs. Bacterial DNA can be detected in metabolic tissues during the onset of these diseases, highlighting its role in the development of metabolic diseases. Extracellular vesicles (EVs) are involved in the delivery of bacterial DNA to the local tissues, and its sensing by the host triggers local and system inflammation. Understanding bacterial DNA translocation and its induced inflammation is crucial in deciphering metabolic disease pathways. Here, we delve into the mechanisms dictating the interaction between host physiology and bacterial DNA, focusing on its origin and delivery, host immune responses against it, and its roles in metabolic disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria as sensors of intracellular pathogens. 线粒体是细胞内病原体的传感器。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-22 DOI: 10.1016/j.tem.2024.10.009
Jose M Delgado, Lena Pernas
{"title":"Mitochondria as sensors of intracellular pathogens.","authors":"Jose M Delgado, Lena Pernas","doi":"10.1016/j.tem.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.009","url":null,"abstract":"<p><p>Mitochondria must sense their environment to enable cells and organisms to adapt to diverse environments and survive during stress. However, during microbial infection, an evolutionary pressure since the inception of the eukaryotic cell, these organelles are traditionally viewed as targets for microbes. In this opinion we consider the perspective that mitochondria are domesticated microbes that sense and guard their 'host' cell against pathogens. We explore potential mechanisms by which mitochondria detect intracellular pathogens and induce mitochondria-autonomous responses that activate cellular defenses.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A three-layer perspective on miRNA regulation in β cell inflammation. 从三层视角看β细胞炎症中的 miRNA 调控。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-11 DOI: 10.1016/j.tem.2024.10.002
Stefano Auddino, Elena Aiello, Giuseppina Emanuela Grieco, Francesco Dotta, Guido Sebastiani
{"title":"A three-layer perspective on miRNA regulation in β cell inflammation.","authors":"Stefano Auddino, Elena Aiello, Giuseppina Emanuela Grieco, Francesco Dotta, Guido Sebastiani","doi":"10.1016/j.tem.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.002","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression post-transcriptionally and influence numerous biological processes. Aberrant miRNA expression is linked to diseases such as diabetes mellitus; indeed, miRNAs regulate pancreatic islet inflammation in both type 1 (T1D) and type 2 diabetes (T2D). Traditionally, miRNA research has focused on canonical sequences and offers a two-layer view - from expression to function. However, advances in RNA sequencing have revealed miRNA variants, called isomiRs, that arise from alternative processing or modifications of canonical sequences. This introduces a three-layer view - from expression, through sequence modifications, to function. We discuss the potential link between cellular stresses and isomiR biogenesis, and how this association could improve our knowledge of islet inflammation and dysfunction.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose tissue-gut microbiome crosstalk in inflammation and thermogenesis. 脂肪组织-肠道微生物组在炎症和产热过程中的相互影响
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-07 DOI: 10.1016/j.tem.2024.10.004
Erin E Mauney, Marsha C Wibowo, Yu-Hua Tseng, Aleksandar D Kostic
{"title":"Adipose tissue-gut microbiome crosstalk in inflammation and thermogenesis.","authors":"Erin E Mauney, Marsha C Wibowo, Yu-Hua Tseng, Aleksandar D Kostic","doi":"10.1016/j.tem.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.tem.2024.10.004","url":null,"abstract":"<p><p>Previously characterized as inert fat depots, adipocytes are now recognized as dynamic mediators of inflammatory tone, metabolic health, and nutrient homeostasis. As endocrine organs, specialized depots of adipose tissue engage in crosstalk between the gut, liver, pancreas, and brain to coordinate appetite, thermogenesis, and ultimately body weight. These functions are tightly linked to the inflammatory status of adipose tissue, which is in turn influenced by the health of the gut microbiome. Here, we review recent findings linking specific gut microbes and their secreted factors, including recently identified elements such as bacterial extracellular vesicles, to the functional status of adipocytes. We conclude that further study may generate novel approaches for treating obesity and metabolic disease.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ghrelin. 胃泌素
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI: 10.1016/j.tem.2024.07.002
Maria E R Garcia-Rendueles, Luis Varela, Tamas L Horvath
{"title":"Ghrelin.","authors":"Maria E R Garcia-Rendueles, Luis Varela, Tamas L Horvath","doi":"10.1016/j.tem.2024.07.002","DOIUrl":"10.1016/j.tem.2024.07.002","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1021-1022"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-carbon metabolism shapes T cell immunity in cancer. 一碳代谢影响癌症中的 T 细胞免疫。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-06-25 DOI: 10.1016/j.tem.2024.05.010
Yajing Qiu, Ermei Xie, Haipeng Xu, Hongcheng Cheng, Guideng Li
{"title":"One-carbon metabolism shapes T cell immunity in cancer.","authors":"Yajing Qiu, Ermei Xie, Haipeng Xu, Hongcheng Cheng, Guideng Li","doi":"10.1016/j.tem.2024.05.010","DOIUrl":"10.1016/j.tem.2024.05.010","url":null,"abstract":"<p><p>One-carbon metabolism (1CM), comprising folate metabolism and methionine metabolism, serves as an important mechanism for cellular energy provision and the production of vital signaling molecules, including single-carbon moieties. Its regulation is instrumental in sustaining the proliferation of cancer cells and facilitating metastasis; in addition, recent research has shed light on its impact on the efficacy of T cell-mediated immunotherapy. In this review, we consolidate current insights into how 1CM affects T cell activation, differentiation, and functionality. Furthermore, we delve into the strategies for modulating 1CM in both T cells and tumor cells to enhance the efficacy of adoptively transferred T cells, overcome metabolic challenges in the tumor microenvironment (TME), and maximize the benefits of T cell-mediated immunotherapy.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"967-980"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose stem cells drive T cell infiltration in obesity. 脂肪干细胞驱动肥胖症中的 T 细胞浸润。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-11-01 Epub Date: 2024-06-29 DOI: 10.1016/j.tem.2024.06.013
Aneta Balcerczyk, Assia Eljaafari, Luciano Pirola
{"title":"Adipose stem cells drive T cell infiltration in obesity.","authors":"Aneta Balcerczyk, Assia Eljaafari, Luciano Pirola","doi":"10.1016/j.tem.2024.06.013","DOIUrl":"10.1016/j.tem.2024.06.013","url":null,"abstract":"<p><p>Obesity is often associated with adipose tissue (AT) inflammation and immune cell infiltration. Writing recently in Cell Reports, Liao et al. investigated the mechanisms of T cell infiltration of AT using single cell (sc)RNA-sequencing (RNA-seq), transplantation studies, in vitro co-cultures, and knock-out mice. They highlighted the crucial role of C-C motif chemokine ligand 5 (CCL5)-secreting adipose stem cells (ASCs), offering insights for potential therapies.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"931-933"},"PeriodicalIF":11.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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