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Melatonin. 褪黑素
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-07-30 DOI: 10.1016/j.tem.2024.07.007
Gregory E Demas, Yuqi Han, Hannah F Fink
{"title":"Melatonin.","authors":"Gregory E Demas, Yuqi Han, Hannah F Fink","doi":"10.1016/j.tem.2024.07.007","DOIUrl":"10.1016/j.tem.2024.07.007","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"191-192"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unleashing metabolic power for axonal regeneration. 为轴突再生释放新陈代谢能量
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-07-27 DOI: 10.1016/j.tem.2024.07.001
Xiaoyan Yang, Bing Zhou
{"title":"Unleashing metabolic power for axonal regeneration.","authors":"Xiaoyan Yang, Bing Zhou","doi":"10.1016/j.tem.2024.07.001","DOIUrl":"10.1016/j.tem.2024.07.001","url":null,"abstract":"<p><p>Axon regeneration requires the mobilization of intracellular resources, including proteins, lipids, and nucleotides. After injury, neurons need to adapt their metabolism to meet the biosynthetic demands needed to achieve axonal regeneration. However, the exact contribution of cellular metabolism to this process remains elusive. Insights into the metabolic characteristics of proliferative cells may illuminate similar mechanisms operating in axon regeneration; therefore, unraveling previously unappreciated roles of metabolic adaptation is critical to achieving neuron regrowth, which is connected to the therapeutic strategies for neurological conditions necessitating nerve repairs, such as spinal cord injury and stroke. Here, we outline the metabolic role in axon regeneration and discuss factors enhancing nerve regrowth, highlighting potential novel metabolic treatments for restoring nerve function.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"161-175"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Standardizing methodologies to study microplastics and nanoplastics in cardiovascular diseases. 研究心血管疾病中的微塑料和纳米塑料的标准化方法。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-08 DOI: 10.1016/j.tem.2024.07.013
Yilin Pan, Suowen Xu, Xiubin Yang
{"title":"Standardizing methodologies to study microplastics and nanoplastics in cardiovascular diseases.","authors":"Yilin Pan, Suowen Xu, Xiubin Yang","doi":"10.1016/j.tem.2024.07.013","DOIUrl":"10.1016/j.tem.2024.07.013","url":null,"abstract":"<p><p>Microplastics and nanoplastics (MNPs) are being recognized as new cardiovascular risk factors, impacting vascular cell functions and exacerbating atherosclerosis through diverse mechanisms. However, the varied concentrations of MNPs detected in major cardiovascular tissues highlight the urgent need for standardized research methodologies to better understand their impact and inform future health guidelines.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"105-108"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New anti-inflammatory mechanism of glucocorticoids uncovered. 糖皮质激素抗炎新机制揭秘
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tem.2024.08.003
Carolyn L Cummins, Ido Goldstein
{"title":"New anti-inflammatory mechanism of glucocorticoids uncovered.","authors":"Carolyn L Cummins, Ido Goldstein","doi":"10.1016/j.tem.2024.08.003","DOIUrl":"10.1016/j.tem.2024.08.003","url":null,"abstract":"<p><p>Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"99-101"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced microbiome therapeutics as a novel modality for oral delivery of peptides to manage metabolic diseases. 先进的微生物组疗法是口服多肽治疗代谢性疾病的一种新方法。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-05-22 DOI: 10.1016/j.tem.2024.04.021
Ruben Vazquez-Uribe, Karl Alex Hedin, Tine Rask Licht, Max Nieuwdorp, Morten O A Sommer
{"title":"Advanced microbiome therapeutics as a novel modality for oral delivery of peptides to manage metabolic diseases.","authors":"Ruben Vazquez-Uribe, Karl Alex Hedin, Tine Rask Licht, Max Nieuwdorp, Morten O A Sommer","doi":"10.1016/j.tem.2024.04.021","DOIUrl":"10.1016/j.tem.2024.04.021","url":null,"abstract":"<p><p>The rising prevalence of metabolic diseases calls for innovative treatments. Peptide-based drugs have transformed the management of conditions such as obesity and type 2 diabetes. Yet, challenges persist in oral delivery of these peptides. This review explores the potential of 'advanced microbiome therapeutics' (AMTs), which involve engineered microbes for delivery of peptides in situ, thereby enhancing their bioavailability. Preclinical work on AMTs has shown promise in treating animal models of metabolic diseases, including obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease. Outstanding challenges toward realizing the potential of AMTs involve improving peptide expression, ensuring predictable colonization control, enhancing stability, and managing safety and biocontainment concerns. Still, AMTs have potential for revolutionizing the treatment of metabolic diseases, potentially offering dynamic and personalized novel therapeutic approaches.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"29-41"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbes put drugs in(action). 微生物让药物发挥作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-09-03 DOI: 10.1016/j.tem.2024.08.005
Jennifer van der Laan, Filipe Cabreiro
{"title":"Microbes put drugs in(action).","authors":"Jennifer van der Laan, Filipe Cabreiro","doi":"10.1016/j.tem.2024.08.005","DOIUrl":"10.1016/j.tem.2024.08.005","url":null,"abstract":"<p><p>Interactions between the gut microbiome, nutrients, drugs, and host physiology are inherently complex. Gut microbes contribute significantly towards host homeostasis and can modulate host-targeted drugs, affecting therapeutic outcomes. Finding ways to harness the gut microbiome to improve drug efficacy can be a promising strategy to advance precision medicine.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"7-10"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbial metabolites in cancer therapy. 癌症治疗中的肠道微生物代谢物
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-07-14 DOI: 10.1016/j.tem.2024.06.016
Panwei Song, Zhi Peng, Xiaohuan Guo
{"title":"Gut microbial metabolites in cancer therapy.","authors":"Panwei Song, Zhi Peng, Xiaohuan Guo","doi":"10.1016/j.tem.2024.06.016","DOIUrl":"10.1016/j.tem.2024.06.016","url":null,"abstract":"<p><p>The gut microbiota plays a crucial role in maintaining homeostasis and promoting health. A growing number of studies have indicated that gut microbiota can affect cancer development, prognosis, and treatment through their metabolites. By remodeling the tumor microenvironment and regulating tumor immunity, gut microbial metabolites significantly influence the efficacy of anticancer therapies, including chemo-, radio-, and immunotherapy. Several novel therapies that target gut microbial metabolites have shown great promise in cancer models. In this review, we summarize the current research status of gut microbial metabolites in cancer, aiming to provide new directions for future tumor therapy.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"55-69"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissociating the metabolic and tumor-suppressive activity of p53. 分解 p53 的代谢活性和肿瘤抑制活性。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-02 DOI: 10.1016/j.tem.2024.07.018
Yoshitaka Sakurai, Naoto Kubota, Takashi Kadowaki
{"title":"Dissociating the metabolic and tumor-suppressive activity of p53.","authors":"Yoshitaka Sakurai, Naoto Kubota, Takashi Kadowaki","doi":"10.1016/j.tem.2024.07.018","DOIUrl":"10.1016/j.tem.2024.07.018","url":null,"abstract":"<p><p>The tumor suppressor p53 regulates metabolic homeostasis. Recently, Tsaousidou et al. reported that selective activation of p53 via downregulation of Tudor interacting repair regulator (TIRR) confers protection against cancer despite obesity and insulin resistance, providing new insights into the role of p53 at the intersection of oncogenesis and systemic metabolism.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"4-6"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host-microbe serotonin metabolism. 宿主-微生物血清素代谢
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-08-13 DOI: 10.1016/j.tem.2024.07.014
Emilia Nunzi, Marilena Pariano, Claudio Costantini, Enrico Garaci, Paolo Puccetti, Luigina Romani
{"title":"Host-microbe serotonin metabolism.","authors":"Emilia Nunzi, Marilena Pariano, Claudio Costantini, Enrico Garaci, Paolo Puccetti, Luigina Romani","doi":"10.1016/j.tem.2024.07.014","DOIUrl":"10.1016/j.tem.2024.07.014","url":null,"abstract":"<p><p>As a result of a long evolutionary history, serotonin plays a variety of physiological roles, including neurological, cardiovascular, gastrointestinal, and endocrine functions. While many of these activities can be accommodated within the serotoninergic activity, recent findings have revealed an unsuspected role of serotonin in orchestrating host and microbial dialogue at the tryptophan dining table, to the benefit of local and systemic homeostasis. Herein we review the dual role of serotonin at the host-microbe interface and discuss how unraveling the interconnections among the host and microbial pathways of tryptophan degradation may help to accommodate the versatility of serotonin in physiology and pathology.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"83-95"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrine gut-brain signaling in obesity. 肥胖症中的肠脑神经内分泌信号传导。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-05-30 DOI: 10.1016/j.tem.2024.05.002
Tim Gruber, Franziska Lechner, Jean-Philippe Krieger, Cristina García-Cáceres
{"title":"Neuroendocrine gut-brain signaling in obesity.","authors":"Tim Gruber, Franziska Lechner, Jean-Philippe Krieger, Cristina García-Cáceres","doi":"10.1016/j.tem.2024.05.002","DOIUrl":"10.1016/j.tem.2024.05.002","url":null,"abstract":"<p><p>The past decades have witnessed the rise and fall of several, largely unsuccessful, therapeutic attempts to bring the escalating obesity pandemic to a halt. Looking back to look ahead, the field has now put its highest hopes in translating insights from how the gastrointestinal (GI) tract communicates with the brain to calibrate behavior, physiology, and metabolism. A major focus of this review is to summarize the latest advances in comprehending the neuroendocrine aspects of this so-called 'gut-brain axis' and to explore novel concepts, cutting-edge technologies, and recent paradigm-shifting experiments. These exciting insights continue to refine our understanding of gut-brain crosstalk and are poised to promote the development of additional therapeutic avenues at the dawn of a new era of antiobesity therapeutics.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"42-54"},"PeriodicalIF":11.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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