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Adapt and shape: metabolic features within the metastatic niche. 适应和塑造：转移龛位中的新陈代谢特征。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-08 DOI: 10.1016/j.tem.2024.07.016
Erica Pranzini, Luigi Ippolito, Elisa Pardella, Elisa Giannoni, Paola Chiarugi
{"title":"Adapt and shape: metabolic features within the metastatic niche.","authors":"Erica Pranzini, Luigi Ippolito, Elisa Pardella, Elisa Giannoni, Paola Chiarugi","doi":"10.1016/j.tem.2024.07.016","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.016","url":null,"abstract":"<p><p>The success of disseminating cancer cells (DTCs) at specific metastatic sites is influenced by several metabolic factors. Even before DTCs arrival, metabolic conditioning from the primary tumor participates in creating a favorable premetastatic niche at distant organs. In addition, DTCs adjust their metabolism to better survive along the metastatic journey and successfully colonize their ultimate destination. However, the idea that the environment of the target organs may metabolically impact the metastatic fate is often underestimated. Here, we review the coexistence of two distinct strategies by which cancer cells shape and/or adapt to the metabolic profile of colonized tissues, ultimately creating a proper soil for their seeding and proliferation.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses. 妊娠诱导的新陈代谢重编程和对促衰老压力的再生反应。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-08 DOI: 10.1016/j.tem.2024.07.011
Dainan Yu, Lanfang Luo, Hongmei Wang, Ng Shyh-Chang
{"title":"Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses.","authors":"Dainan Yu, Lanfang Luo, Hongmei Wang, Ng Shyh-Chang","doi":"10.1016/j.tem.2024.07.011","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.011","url":null,"abstract":"<p><p>Pregnancy is associated with physiological adaptations that affect virtually all organs, enabling the mother to support the growing fetus and placenta while withstanding the demands of pregnancy. As a result, mammalian pregnancy is a unique state that exerts paradoxical effects on maternal health. On one hand, the metabolic stress induced by pregnancy can accelerate aging and functional decline in organs. On the other hand, pregnancy activates metabolic programming and tissue regenerative responses that can reverse age-related impairments. In this sense, the oocyte-to-blastocyst transition is not the only physiological reprogramming event in the mammalian body, as pregnancy-induced regeneration could constitute a second physiological reprogramming event. Here, we review findings on how pregnancy dualistically leads to aging and rejuvenation in the maternal body.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The sphinx helps to answer the riddle of cardiac regeneration. 狮身人面像有助于解答心脏再生之谜。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-05-16 DOI: 10.1016/j.tem.2024.05.003
Jae Woo Jung, Timothy Hla, Zoltan Arany
{"title":"The sphinx helps to answer the riddle of cardiac regeneration.","authors":"Jae Woo Jung, Timothy Hla, Zoltan Arany","doi":"10.1016/j.tem.2024.05.003","DOIUrl":"10.1016/j.tem.2024.05.003","url":null,"abstract":"<p><p>Cardiomyocyte (CM) death drives heart failure worldwide, and efficient CM regeneration remains a fervently pursued but unachieved goal. Ji and colleagues recently described a novel approach to regeneration by orchestrating divergent sphingolipid signaling pathways in CMs and cardiac fibroblasts (CFs). The findings uncover new biology and offer interesting translational opportunities.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"677-679"},"PeriodicalIF":11.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic remodeling in cancer and senescence and its therapeutic implications. 癌症和衰老中的代谢重塑及其治疗意义。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-03-06 DOI: 10.1016/j.tem.2024.02.008
Yeonju Kim, Yeji Jang, Mi-Sung Kim, Chanhee Kang
{"title":"Metabolic remodeling in cancer and senescence and its therapeutic implications.","authors":"Yeonju Kim, Yeji Jang, Mi-Sung Kim, Chanhee Kang","doi":"10.1016/j.tem.2024.02.008","DOIUrl":"10.1016/j.tem.2024.02.008","url":null,"abstract":"<p><p>Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells - a critical component of the aging process - undergo metabolic changes similar to cancer metabolism. A deeper understanding of the similarities and differences between these disparate pathological conditions will help identify which metabolic reprogramming is most relevant to the therapeutic liabilities of senescence. Here, we compare and contrast cancer and senescence metabolism and discuss how metabolic therapies can be established as a new modality of senotherapy for healthy aging.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"732-744"},"PeriodicalIF":11.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How obesity affects adipocyte turnover. 肥胖是如何影响脂肪细胞周转的？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 DOI: 10.1016/j.tem.2024.07.004
Sang Mun Han, Hahn Nahmgoong, Kyung Min Yim, Jae Bum Kim
{"title":"How obesity affects adipocyte turnover.","authors":"Sang Mun Han, Hahn Nahmgoong, Kyung Min Yim, Jae Bum Kim","doi":"10.1016/j.tem.2024.07.004","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.004","url":null,"abstract":"<p><p>Cellular turnover is fundamental for tissue homeostasis and integrity. Adipocyte turnover, accounting for 4% of the total cellular mass turnover in humans, is essential for adipose tissue homeostasis during metabolic stress. In obesity, an altered adipose tissue microenvironment promotes adipocyte death. To clear dead adipocytes, macrophages are recruited and form a distinctive structure known as crown-like structure; subsequently, new adipocytes are generated from adipose stem and progenitor cells in the adipogenic niche to replace dead adipocytes. Accumulating evidence indicates that adipocyte death, clearance, and adipogenesis are sophisticatedly orchestrated during adipocyte turnover. In this Review, we summarize our current understandings of each step in adipocyte turnover, discussing its key players and regulatory mechanisms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of APOE4 on omega-3 brain metabolism across the lifespan. APOE4对整个生命周期中omega-3脑代谢的影响。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-04-12 DOI: 10.1016/j.tem.2024.03.003
Brandon Ebright, Marlon V Duro, Kai Chen, Stan Louie, Hussein N Yassine
{"title":"Effects of APOE4 on omega-3 brain metabolism across the lifespan.","authors":"Brandon Ebright, Marlon V Duro, Kai Chen, Stan Louie, Hussein N Yassine","doi":"10.1016/j.tem.2024.03.003","DOIUrl":"10.1016/j.tem.2024.03.003","url":null,"abstract":"<p><p>Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), have important roles in human nutrition and brain health by promoting neuronal functions, maintaining inflammatory homeostasis, and providing structural integrity. As Alzheimer's disease (AD) pathology progresses, DHA metabolism in the brain becomes dysregulated, the timing and extent of which may be influenced by the apolipoprotein E ε4 (APOE4) allele. Here, we discuss how maintaining adequate DHA intake early in life may slow the progression to AD dementia in cognitively normal individuals with APOE4, how recent advances in DHA brain imaging could offer insights leading to more personalized preventive strategies, and how alternative strategies targeting PUFA metabolism pathways may be more effective in mitigating disease progression in patients with existing AD dementia.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"745-757"},"PeriodicalIF":11.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opportunities and challenges in phage therapy for cardiometabolic diseases. 噬菌体疗法治疗心脏代谢疾病的机遇与挑战。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-04-17 DOI: 10.1016/j.tem.2024.03.007
Koen Wortelboer, Hilde Herrema
{"title":"Opportunities and challenges in phage therapy for cardiometabolic diseases.","authors":"Koen Wortelboer, Hilde Herrema","doi":"10.1016/j.tem.2024.03.007","DOIUrl":"10.1016/j.tem.2024.03.007","url":null,"abstract":"<p><p>The worldwide prevalence of cardiometabolic diseases (CMD) is increasing, and emerging evidence implicates the gut microbiota in this multifactorial disease development. Bacteriophages (phages) are viruses that selectively target a bacterial host; thus, phage therapy offers a precise means of modulating the gut microbiota, limiting collateral damage on the ecosystem. Several studies demonstrate the potential of phages in human disease, including alcoholic and steatotic liver disease. In this opinion article we discuss the potential of phage therapy as a predefined medicinal product for CMD and discuss its current challenges, including the generation of effective phage combinations, product formulation, and strict manufacturing requirements.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"687-696"},"PeriodicalIF":11.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melatonin. 褪黑素
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-07-30 DOI: 10.1016/j.tem.2024.07.007
Gregory E Demas, Yuqi Han, Hannah F Fink
{"title":"Melatonin.","authors":"Gregory E Demas, Yuqi Han, Hannah F Fink","doi":"10.1016/j.tem.2024.07.007","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.007","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unleashing metabolic power for axonal regeneration. 为轴突再生释放新陈代谢能量
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-07-27 DOI: 10.1016/j.tem.2024.07.001
Xiaoyan Yang, Bing Zhou
{"title":"Unleashing metabolic power for axonal regeneration.","authors":"Xiaoyan Yang, Bing Zhou","doi":"10.1016/j.tem.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.001","url":null,"abstract":"<p><p>Axon regeneration requires the mobilization of intracellular resources, including proteins, lipids, and nucleotides. After injury, neurons need to adapt their metabolism to meet the biosynthetic demands needed to achieve axonal regeneration. However, the exact contribution of cellular metabolism to this process remains elusive. Insights into the metabolic characteristics of proliferative cells may illuminate similar mechanisms operating in axon regeneration; therefore, unraveling previously unappreciated roles of metabolic adaptation is critical to achieving neuron regrowth, which is connected to the therapeutic strategies for neurological conditions necessitating nerve repairs, such as spinal cord injury and stroke. Here, we outline the metabolic role in axon regeneration and discuss factors enhancing nerve regrowth, highlighting potential novel metabolic treatments for restoring nerve function.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial Venus is more likely to have a lower birthweight. 线粒体维纳斯更有可能出生体重较轻。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-07-01 Epub Date: 2024-04-24 DOI: 10.1016/j.tem.2024.04.011
Elina Aleksejeva, Masoud Zamani Esteki, Andres Salumets
{"title":"Mitochondrial Venus is more likely to have a lower birthweight.","authors":"Elina Aleksejeva, Masoud Zamani Esteki, Andres Salumets","doi":"10.1016/j.tem.2024.04.011","DOIUrl":"10.1016/j.tem.2024.04.011","url":null,"abstract":"<p><p>Assisted reproductive technologies (ART) are associated with a moderately higher risk of preterm birth and low birthweight, but the causes are unknown. A recent study by Mertens et al. reveals a link between being born through ART, ovarian stimulation, and an increased incidence of mitochondrial heteroplasmic variants that correlate with lower birthweight.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"569-571"},"PeriodicalIF":11.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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