New anti-inflammatory mechanism of glucocorticoids uncovered.

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-08-23 DOI:10.1016/j.tem.2024.08.003

Carolyn L Cummins, Ido Goldstein

引用次数: 0

Abstract

Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.

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糖皮质激素抗炎新机制揭秘

糖皮质激素（GCs）是一种强效抗炎药物。Auger 等人的一项新研究发现，GCs 可通过促进细胞膜丙酮酸脱氢酶（PDH）向线粒体移动来增加伊塔康酸（一种抗炎的三羧酸（TCA）循环中间体）。伊塔康酸足以介导 GCs 在小鼠体内的抗炎作用，从而推翻了核糖皮质激素受体（GR）是抑制炎症的必要条件这一观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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