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Walking the VLDL tightrope in cardiometabolic diseases. 在心脏代谢疾病中走 "VLDL钢丝"。
IF 12.6 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-26 DOI: 10.1016/j.tem.2024.07.020
Mindy Kim, Ze Zheng
{"title":"Walking the VLDL tightrope in cardiometabolic diseases.","authors":"Mindy Kim, Ze Zheng","doi":"10.1016/j.tem.2024.07.020","DOIUrl":"10.1016/j.tem.2024.07.020","url":null,"abstract":"<p><p>Very-low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein secreted by hepatocytes, is pivotal for supplying peripheral tissues with fatty acids for energy production. As if walking on a tightrope, perturbations in the balance of VLDL metabolism contribute to cardiometabolic dysfunction, promoting pathologies such as cardiovascular disease (CVD) or metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the advent of lipid-lowering therapies, including statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, risks for cardiovascular events persist. With limitations to currently available CVD therapeutics and no US Food and Drug Administration (FDA)-approved treatment for MASLD, this review summarizes the current understanding of VLDL metabolism that sheds light on novel therapeutic avenues to pursue for cardiometabolic disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"278-291"},"PeriodicalIF":12.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-derived organoid models to decode liver pathophysiology. 解码肝脏病理生理学的患者衍生类器官模型
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-26 DOI: 10.1016/j.tem.2024.07.019
Benjamin J Dwyer, Janina E E Tirnitz-Parker
{"title":"Patient-derived organoid models to decode liver pathophysiology.","authors":"Benjamin J Dwyer, Janina E E Tirnitz-Parker","doi":"10.1016/j.tem.2024.07.019","DOIUrl":"10.1016/j.tem.2024.07.019","url":null,"abstract":"<p><p>Liver diseases represent a growing global health challenge, and the increasing prevalence of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving regulatory demands, patient-specific in vitro liver models are essential for understanding disease mechanisms and developing new therapeutic approaches. Organoid models, which faithfully recapitulate liver biology, can be established from both non-malignant and malignant liver tissues, offering insight into various liver conditions, from acute injuries to chronic diseases and cancer. Improved understanding of liver microenvironments, innovative biomaterials, and advanced imaging techniques now facilitate comprehensive and unbiased data analysis, paving the way for personalised medicine. In this review, we discuss state-of-the-art patient-derived liver organoid models, recent technological advancements, and strategies to enhance their clinical impact.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"235-248"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid-derived suppressor cells in metabolic and cardiovascular disorders. 骨髓源性抑制细胞在代谢和心血管疾病中的作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 DOI: 10.1016/j.tem.2025.02.001
Jingwei Yan, Shuai Guo, Jun He, Hanpeng Huang, Yiming Xu
{"title":"Myeloid-derived suppressor cells in metabolic and cardiovascular disorders.","authors":"Jingwei Yan, Shuai Guo, Jun He, Hanpeng Huang, Yiming Xu","doi":"10.1016/j.tem.2025.02.001","DOIUrl":"https://doi.org/10.1016/j.tem.2025.02.001","url":null,"abstract":"<p><p>Dysregulation of immune homeostasis can precipitate chronic inflammation, thus significantly contributing to the onset and progression of metabolic and cardiovascular diseases. Myeloid-derived suppressor cells (MDSCs) constitute a heterogeneous population of immature myeloid cells that are mobilized in response to biological stressors such as tissue damage and inflammation. Although MDSCs have been extensively characterized in the contexts of cancer and infectious diseases, emerging evidence highlights their pivotal roles in the pathophysiology of metabolic and cardiovascular disorders. We discuss growing evidence for the involvement of MDSCs in the progression of metabolic and cardiovascular diseases, with the aim of deepening our understanding of MDSCs in cardiometabolic physiology and identifying the necessary steps for the development of innovative MDSC-targeted therapeutic strategies.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adapt and shape: metabolic features within the metastatic niche. 适应和塑造：转移龛位中的新陈代谢特征。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-08-08 DOI: 10.1016/j.tem.2024.07.016
Erica Pranzini, Luigi Ippolito, Elisa Pardella, Elisa Giannoni, Paola Chiarugi
{"title":"Adapt and shape: metabolic features within the metastatic niche.","authors":"Erica Pranzini, Luigi Ippolito, Elisa Pardella, Elisa Giannoni, Paola Chiarugi","doi":"10.1016/j.tem.2024.07.016","DOIUrl":"10.1016/j.tem.2024.07.016","url":null,"abstract":"<p><p>The success of disseminating cancer cells (DTCs) at specific metastatic sites is influenced by several metabolic factors. Even before DTCs arrival, metabolic conditioning from the primary tumor participates in creating a favorable premetastatic niche at distant organs. In addition, DTCs adjust their metabolism to better survive along the metastatic journey and successfully colonize their ultimate destination. However, the idea that the environment of the target organs may metabolically impact the metastatic fate is often underestimated. Here, we review the coexistence of two distinct strategies by which cancer cells shape and/or adapt to the metabolic profile of colonized tissues, ultimately creating a proper soil for their seeding and proliferation.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"205-218"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moving from helicopter research to proximity research and capacity building. 从直升机研究转向近距离研究和能力建设。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-03-01 Epub Date: 2024-10-01 DOI: 10.1016/j.tem.2024.08.011
Fannie Lajeunesse-Trempe, Marie-Ève Piché, Lydia Kaduka, Juan Ricardo Lopez Y Taylor, René Crocker Sagastume
{"title":"Moving from helicopter research to proximity research and capacity building.","authors":"Fannie Lajeunesse-Trempe, Marie-Ève Piché, Lydia Kaduka, Juan Ricardo Lopez Y Taylor, René Crocker Sagastume","doi":"10.1016/j.tem.2024.08.011","DOIUrl":"10.1016/j.tem.2024.08.011","url":null,"abstract":"<p><p>Health funding agencies are increasingly prioritizing equity, diversity, and inclusion (EDI) strategies. This shift, while essential, can inadvertently lead to 'helicopter research', especially among junior researchers, due to insufficient institutional support. We warn against such unethical practices and propose strategies for academia and funding bodies to address them.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"193-195"},"PeriodicalIF":11.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging interactions between mitochondria and NAD+ metabolism in cardiometabolic diseases. 线粒体与 NAD+ 代谢之间在心脏代谢疾病中新出现的相互作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-27 DOI: 10.1016/j.tem.2024.07.010
Azadeh Nasuhidehnavi, Weronika Zarzycka, Ignacy Górecki, Ying Ann Chiao, Chi Fung Lee
{"title":"Emerging interactions between mitochondria and NAD<sup>+</sup> metabolism in cardiometabolic diseases.","authors":"Azadeh Nasuhidehnavi, Weronika Zarzycka, Ignacy Górecki, Ying Ann Chiao, Chi Fung Lee","doi":"10.1016/j.tem.2024.07.010","DOIUrl":"10.1016/j.tem.2024.07.010","url":null,"abstract":"<p><p>Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is an essential coenzyme for redox reactions and regulates cellular catabolic pathways. An intertwined relationship exists between NAD<sup>+</sup> and mitochondria, with consequences for mitochondrial function. Dysregulation in NAD<sup>+</sup> homeostasis can lead to impaired energetics and increased oxidative stress, contributing to the pathogenesis of cardiometabolic diseases. In this review, we explore how disruptions in NAD<sup>+</sup> homeostasis impact mitochondrial function in various cardiometabolic diseases. We discuss emerging studies demonstrating that enhancing NAD<sup>+</sup> synthesis or inhibiting its consumption can ameliorate complications of this family of pathological conditions. Additionally, we highlight the potential role and therapeutic promise of mitochondrial NAD<sup>+</sup> transporters in regulating cellular and mitochondrial NAD<sup>+</sup> homeostasis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"176-190"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery. 通过代谢减肥手术对 MASLD 相关性肝硬化进行补偿。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-06-21 DOI: 10.1016/j.tem.2024.05.009
Gong Feng, Yu Han, Wah Yang, Scott Shikora, Kamal Mahawar, Tan To Cheung, Giovanni Targher, Christopher D Byrne, Virginia Hernandez-Gea, Herbert Tilg, Ming-Hua Zheng
{"title":"Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery.","authors":"Gong Feng, Yu Han, Wah Yang, Scott Shikora, Kamal Mahawar, Tan To Cheung, Giovanni Targher, Christopher D Byrne, Virginia Hernandez-Gea, Herbert Tilg, Ming-Hua Zheng","doi":"10.1016/j.tem.2024.05.009","DOIUrl":"10.1016/j.tem.2024.05.009","url":null,"abstract":"<p><p>The prognosis of patients with decompensated cirrhosis is poor, with significantly increased liver-related mortality rates. With the rising tide of decompensated cirrhosis associated with metabolic dysfunction-associated steatotic liver disease (MASLD), the role of metabolic bariatric surgery (MBS) in achieving hepatic recompensation is garnering increasing attention. However, the complexity of preoperative assessment, the risk of postoperative disease recurrence, and the potential for patients to experience surgical complications of the MBS present challenges. In this opinion article we analyze the potential of MBS to induce recompensation in MASLD-related cirrhosis, discuss the mechanisms by which MBS may affect recompensation, and compare the characteristics of different MBS procedures; we highlight the therapeutic potential of MBS in MASLD-related cirrhosis recompensation and advocate for research in this complex area.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"118-132"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards the recognition of oligogenic forms of type 2 diabetes. 认识 2 型糖尿病的低致病形式。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-07-01 DOI: 10.1016/j.tem.2024.06.006
Lauriane Le Collen, Philippe Froguel, Amélie Bonnefond
{"title":"Towards the recognition of oligogenic forms of type 2 diabetes.","authors":"Lauriane Le Collen, Philippe Froguel, Amélie Bonnefond","doi":"10.1016/j.tem.2024.06.006","DOIUrl":"10.1016/j.tem.2024.06.006","url":null,"abstract":"<p><p>The demarcation between monogenic and polygenic type 2 diabetes (T2D) is less distinct than previously believed. Notably, recent research has highlighted a new entity, that we suggest calling oligogenic forms of T2D, serving as a genetic link between these two forms. In this opinion article, we have reviewed scientific advances that suggest categorizing genes involved in oligogenic T2D. Research focused on polygenic T2D has faced challenges in deepening our comprehension of the pathophysiology of T2D due to the inability to directly establish causal links between a signal and the molecular mechanisms underlying the disease. However, the study of oligogenic forms of T2D has illuminated distinct causal connections between genes and disease risk, thereby indicating potential new drug targets.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"109-117"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How obesity affects adipocyte turnover. 肥胖是如何影响脂肪细胞周转的？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-01 DOI: 10.1016/j.tem.2024.07.004
Sang Mun Han, Hahn Nahmgoong, Kyung Min Yim, Jae Bum Kim
{"title":"How obesity affects adipocyte turnover.","authors":"Sang Mun Han, Hahn Nahmgoong, Kyung Min Yim, Jae Bum Kim","doi":"10.1016/j.tem.2024.07.004","DOIUrl":"10.1016/j.tem.2024.07.004","url":null,"abstract":"<p><p>Cellular turnover is fundamental for tissue homeostasis and integrity. Adipocyte turnover, accounting for 4% of the total cellular mass turnover in humans, is essential for adipose tissue homeostasis during metabolic stress. In obesity, an altered adipose tissue microenvironment promotes adipocyte death. To clear dead adipocytes, macrophages are recruited and form a distinctive structure known as crown-like structure; subsequently, new adipocytes are generated from adipose stem and progenitor cells in the adipogenic niche to replace dead adipocytes. Accumulating evidence indicates that adipocyte death, clearance, and adipogenesis are sophisticatedly orchestrated during adipocyte turnover. In this Review, we summarize our current understandings of each step in adipocyte turnover, discussing its key players and regulatory mechanisms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"147-160"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the heterogeneous targets of metabolic aging at single-cell resolution. 以单细胞分辨率探索新陈代谢老化的异质靶标。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tem.2024.07.009
Shuhui Sun, Mengmeng Jiang, Shuai Ma, Jie Ren, Guang-Hui Liu
{"title":"Exploring the heterogeneous targets of metabolic aging at single-cell resolution.","authors":"Shuhui Sun, Mengmeng Jiang, Shuai Ma, Jie Ren, Guang-Hui Liu","doi":"10.1016/j.tem.2024.07.009","DOIUrl":"10.1016/j.tem.2024.07.009","url":null,"abstract":"<p><p>Our limited understanding of metabolic aging poses major challenges to comprehending the diverse cellular alterations that contribute to age-related decline, and to devising targeted interventions. This review provides insights into the heterogeneous nature of cellular metabolism during aging and its response to interventions, with a specific focus on cellular heterogeneity and its implications. By synthesizing recent findings using single-cell approaches, we explored the vulnerabilities of distinct cell types and key metabolic pathways. Delving into the cell type-specific alterations underlying the efficacy of systemic interventions, we also discuss the complexity of integrating single-cell data and advocate for leveraging computational tools and artificial intelligence to harness the full potential of these data, develop effective strategies against metabolic aging, and promote healthy aging.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"133-146"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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