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Circadian disruption and its impact on the cardiovascular system. 昼夜节律紊乱及其对心血管系统的影响。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-19 DOI: 10.1016/j.tem.2024.11.010
Morag J Young, Seamus Heanue, Monica Kanki, Kegan J Moneghetti
{"title":"Circadian disruption and its impact on the cardiovascular system.","authors":"Morag J Young, Seamus Heanue, Monica Kanki, Kegan J Moneghetti","doi":"10.1016/j.tem.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.010","url":null,"abstract":"<p><p>Circadian rhythms are highly conserved biorhythms of ~24 h that govern many fundamental biological processes, including cardiovascular (CV) homeostasis. Disrupting the timing of cellular oscillators promotes cellular stress, and induction of pathogenic pathways underpins the pathogenesis of many CV diseases (CVDs). Thus, shift work, late eating, sleep disturbances, and other disruptors can result in an elevated risk of heart disease and increased incidence of adverse CV events. Here, we discuss the importance of circadian rhythms for CV homeostasis, recent developments in understanding the impact of disrupted circadian rhythms on CV health and disease progression, and how understanding the interactions between circadian and CV physiology is crucial for improving interventions to mitigate CVD, especially in populations impacted by disrupted circadian rhythms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring tryptophan metabolism in cardiometabolic diseases. 探索色氨酸在心脏代谢疾病中的代谢。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-17 DOI: 10.1016/j.tem.2024.11.009
Nirmala Mouttoulingam, Soraya Taleb
{"title":"Exploring tryptophan metabolism in cardiometabolic diseases.","authors":"Nirmala Mouttoulingam, Soraya Taleb","doi":"10.1016/j.tem.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.009","url":null,"abstract":"<p><p>Tryptophan (Trp) metabolism is linked to health and disease, with indoleamine 2,3-dioxygenase 1 (IDO) being a key enzyme in its breakdown outside the liver. This process produces metabolites that influence metabolic and inflammatory responses. A distinctive feature of the gut is its involvement in three major Trp catabolic pathways: the IDO-driven kynurenine pathway, bacteria-produced indoles, and serotonin. Dysregulation of these pathways is associated with gastrointestinal and chronic inflammatory diseases. Understanding these mechanisms could reveal how gut function affects overall systemic health and disease susceptibility. Here, we review current insights into Trp metabolism, its impact on host physiology and cardiometabolic diseases, and its role in the gut-periphery connection, highlighting its relevance for therapeutic innovation.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter-organ communication is a critical machinery to regulate metabolism and aging. 器官间通讯是调节新陈代谢和衰老的重要机制。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-17 DOI: 10.1016/j.tem.2024.11.013
Kyohei Tokizane, Shin-Ichiro Imai
{"title":"Inter-organ communication is a critical machinery to regulate metabolism and aging.","authors":"Kyohei Tokizane, Shin-Ichiro Imai","doi":"10.1016/j.tem.2024.11.013","DOIUrl":"10.1016/j.tem.2024.11.013","url":null,"abstract":"<p><p>Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks and examine their roles in regulating metabolism and aging. Given the role of the hypothalamus as a high-order control center for aging and longevity, we particularly emphasize the importance of its communication with peripheral organs and pave the way for a better understanding of this critical machinery in metabolism and aging.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skeletal muscle adaptations and post-exertional malaise in long COVID. 长期COVID的骨骼肌适应和运动后不适。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-17 DOI: 10.1016/j.tem.2024.11.008
Braeden T Charlton, Richie P Goulding, Richard T Jaspers, Brent Appelman, Michèle van Vugt, Rob C I Wüst
{"title":"Skeletal muscle adaptations and post-exertional malaise in long COVID.","authors":"Braeden T Charlton, Richie P Goulding, Richard T Jaspers, Brent Appelman, Michèle van Vugt, Rob C I Wüst","doi":"10.1016/j.tem.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.008","url":null,"abstract":"<p><p>When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional malaise (PEM), which is the worsening of symptoms following mental or physical exertion. There is little consensus on the pathophysiology of exercise-induced PEM and skeletal-muscle-related symptoms. In this opinion article we highlight intrinsic mitochondrial dysfunction, endothelial abnormalities, and a muscle fiber type shift towards a more glycolytic phenotype as main contributors to the reduced exercise capacity in long COVID. The mechanistic trigger for physical exercise to induce PEM is unknown, but rapid skeletal muscle tissue damage and intramuscular infiltration of immune cells contribute to PEM-related symptoms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracellular endothelial cell metabolism in vascular function and dysfunction. 细胞内内皮细胞代谢与血管功能障碍。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-12 DOI: 10.1016/j.tem.2024.11.004
Kathryn M Citrin, Balkrishna Chaube, Carlos Fernández-Hernando, Yajaira Suárez
{"title":"Intracellular endothelial cell metabolism in vascular function and dysfunction.","authors":"Kathryn M Citrin, Balkrishna Chaube, Carlos Fernández-Hernando, Yajaira Suárez","doi":"10.1016/j.tem.2024.11.004","DOIUrl":"10.1016/j.tem.2024.11.004","url":null,"abstract":"<p><p>Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular function and homeostasis. They regulate vascular tone, oxidative stress, and permeability. Dysfunction leads to increased permeability, leukocyte adhesion, and thrombosis. ECs undergo metabolic changes in conditions such as wound healing, cancer, atherosclerosis, and diabetes, and can influence disease progression. We discuss recent research that has revealed diverse intracellular metabolic pathways in ECs that are tailored to their functional needs, including lipid handling, glycolysis, and fatty acid oxidation (FAO). Understanding EC metabolic signatures in health and disease will be crucial not only for basic biology but can also be exploited when designing new therapies to target EC-related functions in different vascular diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can brain neurons change identity? Lessons from obesity. 大脑神经元能改变身份吗？肥胖的教训。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-05 DOI: 10.1016/j.tem.2024.11.006
Jean Charles Nicolas, Thomas H Lee, Carmelo Quarta
{"title":"Can brain neurons change identity? Lessons from obesity.","authors":"Jean Charles Nicolas, Thomas H Lee, Carmelo Quarta","doi":"10.1016/j.tem.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.tem.2024.11.006","url":null,"abstract":"<p><p>It has long been thought that the functional identity of mammalian brain neurons is programmed during development and remains stable throughout adult life; however, certain populations of neurons continue to express active regulators of neuronal identity into adulthood. Prolonged exposure to diet-induced metabolic stress induces features of neuronal identity modification in adult mice, and maladaptive changes in neuronal identity maintenance have been linked to cognitive impairment in humans suffering from neurodegenerative diseases often associated with obesity. Here we discuss how, by unraveling the neurological roots of obesity, we may solve the puzzle of whether mammalian brain neurons retain identity plasticity into adulthood, while advancing knowledge of the pathogenic mechanisms at the interface of metabolic and neurodegenerative disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rewiring of the glymphatic landscape in metabolic disorders. 代谢紊乱中淋巴系统景观的重新布线。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-04 DOI: 10.1016/j.tem.2024.11.005
Bandy Chen, David Meseguer, Stephanie Lenck, Jean-Leon Thomas, Marc Schneeberger
{"title":"Rewiring of the glymphatic landscape in metabolic disorders.","authors":"Bandy Chen, David Meseguer, Stephanie Lenck, Jean-Leon Thomas, Marc Schneeberger","doi":"10.1016/j.tem.2024.11.005","DOIUrl":"10.1016/j.tem.2024.11.005","url":null,"abstract":"<p><p>The incorporation of the glymphatic clearance system in the study of brain physiology aids in the advancement of innovative diagnostic and treatment strategies for neurological disorders. Exploring the glymphatic system across (from) neurological and (to) metabolic diseases may provide a better link between obesity and neurological disorders. Recent studies indicate the role of metabolic dysfunction as a risk factor for cognitive decline and neurological disorders through the disruption of the glymphatic system. Further investigation into how metabolic dysfunction disrupts glymphatic homeostasis and the domino effects on the neurovascular landscape, including neurovascular uncoupling, cerebral blood flow disruptions, blood-brain barrier leakage, and demyelination, can provide mechanistic insights into the link between obesity and neurological disorders.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why cells need iron: a compendium of iron utilisation. 细胞为什么需要铁：铁利用简编》。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-01 Epub Date: 2024-05-17 DOI: 10.1016/j.tem.2024.04.015
Megan R Teh, Andrew E Armitage, Hal Drakesmith
{"title":"Why cells need iron: a compendium of iron utilisation.","authors":"Megan R Teh, Andrew E Armitage, Hal Drakesmith","doi":"10.1016/j.tem.2024.04.015","DOIUrl":"10.1016/j.tem.2024.04.015","url":null,"abstract":"<p><p>Iron deficiency is globally prevalent, causing an array of developmental, haematological, immunological, neurological, and cardiometabolic impairments, and is associated with symptoms ranging from chronic fatigue to hair loss. Within cells, iron is utilised in a variety of ways by hundreds of different proteins. Here, we review links between molecular activities regulated by iron and the pathophysiological effects of iron deficiency. We identify specific enzyme groups, biochemical pathways, cellular functions, and cell lineages that are particularly iron dependent. We provide examples of how iron deprivation influences multiple key systems and tissues, including immunity, hormone synthesis, and cholesterol metabolism. We propose that greater mechanistic understanding of how cellular iron influences physiological processes may lead to new therapeutic opportunities across a range of diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1026-1049"},"PeriodicalIF":11.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reconsidering lactate disallowance in pancreatic β cells. 重新考虑胰腺β细胞中的乳酸抑制作用
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1016/j.tem.2024.06.014
Accalia Fu
{"title":"Reconsidering lactate disallowance in pancreatic β cells.","authors":"Accalia Fu","doi":"10.1016/j.tem.2024.06.014","DOIUrl":"10.1016/j.tem.2024.06.014","url":null,"abstract":"<p><p>Lactate synthesis via lactate dehydrogenase A (LDHA), traditionally considered to be a 'disallowed' function in pancreatic β cells, is redefined by Cuozzo et al. who find that lactate produced by β cells regulates fasting insulin secretion via LDHB. The metabolic sources, fates, and relevance of β cell lactate are further examined.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1023-1025"},"PeriodicalIF":11.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D and major chronic diseases. 维生素 D 与主要慢性疾病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-12-01 Epub Date: 2024-05-31 DOI: 10.1016/j.tem.2024.04.018
Shiyu Zhao, Frank Qian, Zhenzhen Wan, Xue Chen, An Pan, Gang Liu
{"title":"Vitamin D and major chronic diseases.","authors":"Shiyu Zhao, Frank Qian, Zhenzhen Wan, Xue Chen, An Pan, Gang Liu","doi":"10.1016/j.tem.2024.04.018","DOIUrl":"10.1016/j.tem.2024.04.018","url":null,"abstract":"<p><p>Numerous observational studies have demonstrated a significant inverse association between vitamin D status and the risk of major chronic disease, including type 2 diabetes (T2D), cardiovascular disease (CVD), and cancer. However, findings from Mendelian randomization (MR) studies and randomized controlled trials (RCTs) suggest minimal or no benefit of increased vitamin D levels. We provide an overview of recent literature linking vitamin D to major chronic diseases. Because emerging evidence indicates a potential threshold effect of vitamin D, future well-designed studies focused on diverse populations with vitamin D deficiency or insufficiency are warranted for a more comprehensive understanding of the effect of maintaining sufficient vitamin D status on the prevention of major chronic diseases.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"1050-1061"},"PeriodicalIF":11.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141187024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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