癌症治疗中的肠道微生物代谢物

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-07-14 DOI:10.1016/j.tem.2024.06.016

Panwei Song, Zhi Peng, Xiaohuan Guo

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引用次数: 0

摘要

肠道微生物群在维持体内平衡和促进健康方面发挥着至关重要的作用。越来越多的研究表明，肠道微生物群可通过其代谢产物影响癌症的发生、预后和治疗。通过重塑肿瘤微环境和调节肿瘤免疫，肠道微生物代谢物可显著影响化疗、放疗和免疫疗法等抗癌疗法的疗效。针对肠道微生物代谢物的几种新型疗法已在癌症模型中显示出巨大前景。在这篇综述中，我们总结了癌症中肠道微生物代谢物的研究现状，旨在为未来的肿瘤治疗提供新的方向。

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Gut microbial metabolites in cancer therapy.

The gut microbiota plays a crucial role in maintaining homeostasis and promoting health. A growing number of studies have indicated that gut microbiota can affect cancer development, prognosis, and treatment through their metabolites. By remodeling the tumor microenvironment and regulating tumor immunity, gut microbial metabolites significantly influence the efficacy of anticancer therapies, including chemo-, radio-, and immunotherapy. Several novel therapies that target gut microbial metabolites have shown great promise in cancer models. In this review, we summarize the current research status of gut microbial metabolites in cancer, aiming to provide new directions for future tumor therapy.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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