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Emerging interactions between mitochondria and NAD+ metabolism in cardiometabolic diseases. 线粒体与 NAD+ 代谢之间在心脏代谢疾病中新出现的相互作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-27 DOI: 10.1016/j.tem.2024.07.010
Azadeh Nasuhidehnavi, Weronika Zarzycka, Ignacy Górecki, Ying Ann Chiao, Chi Fung Lee
{"title":"Emerging interactions between mitochondria and NAD<sup>+</sup> metabolism in cardiometabolic diseases.","authors":"Azadeh Nasuhidehnavi, Weronika Zarzycka, Ignacy Górecki, Ying Ann Chiao, Chi Fung Lee","doi":"10.1016/j.tem.2024.07.010","DOIUrl":"10.1016/j.tem.2024.07.010","url":null,"abstract":"<p><p>Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is an essential coenzyme for redox reactions and regulates cellular catabolic pathways. An intertwined relationship exists between NAD<sup>+</sup> and mitochondria, with consequences for mitochondrial function. Dysregulation in NAD<sup>+</sup> homeostasis can lead to impaired energetics and increased oxidative stress, contributing to the pathogenesis of cardiometabolic diseases. In this review, we explore how disruptions in NAD<sup>+</sup> homeostasis impact mitochondrial function in various cardiometabolic diseases. We discuss emerging studies demonstrating that enhancing NAD<sup>+</sup> synthesis or inhibiting its consumption can ameliorate complications of this family of pathological conditions. Additionally, we highlight the potential role and therapeutic promise of mitochondrial NAD<sup>+</sup> transporters in regulating cellular and mitochondrial NAD<sup>+</sup> homeostasis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"176-190"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the heterogeneous targets of metabolic aging at single-cell resolution. 以单细胞分辨率探索新陈代谢老化的异质靶标。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tem.2024.07.009
Shuhui Sun, Mengmeng Jiang, Shuai Ma, Jie Ren, Guang-Hui Liu
{"title":"Exploring the heterogeneous targets of metabolic aging at single-cell resolution.","authors":"Shuhui Sun, Mengmeng Jiang, Shuai Ma, Jie Ren, Guang-Hui Liu","doi":"10.1016/j.tem.2024.07.009","DOIUrl":"10.1016/j.tem.2024.07.009","url":null,"abstract":"<p><p>Our limited understanding of metabolic aging poses major challenges to comprehending the diverse cellular alterations that contribute to age-related decline, and to devising targeted interventions. This review provides insights into the heterogeneous nature of cellular metabolism during aging and its response to interventions, with a specific focus on cellular heterogeneity and its implications. By synthesizing recent findings using single-cell approaches, we explored the vulnerabilities of distinct cell types and key metabolic pathways. Delving into the cell type-specific alterations underlying the efficacy of systemic interventions, we also discuss the complexity of integrating single-cell data and advocate for leveraging computational tools and artificial intelligence to harness the full potential of these data, develop effective strategies against metabolic aging, and promote healthy aging.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"133-146"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How obesity affects adipocyte turnover. 肥胖是如何影响脂肪细胞周转的？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-01 DOI: 10.1016/j.tem.2024.07.004
Sang Mun Han, Hahn Nahmgoong, Kyung Min Yim, Jae Bum Kim
{"title":"How obesity affects adipocyte turnover.","authors":"Sang Mun Han, Hahn Nahmgoong, Kyung Min Yim, Jae Bum Kim","doi":"10.1016/j.tem.2024.07.004","DOIUrl":"10.1016/j.tem.2024.07.004","url":null,"abstract":"<p><p>Cellular turnover is fundamental for tissue homeostasis and integrity. Adipocyte turnover, accounting for 4% of the total cellular mass turnover in humans, is essential for adipose tissue homeostasis during metabolic stress. In obesity, an altered adipose tissue microenvironment promotes adipocyte death. To clear dead adipocytes, macrophages are recruited and form a distinctive structure known as crown-like structure; subsequently, new adipocytes are generated from adipose stem and progenitor cells in the adipogenic niche to replace dead adipocytes. Accumulating evidence indicates that adipocyte death, clearance, and adipogenesis are sophisticatedly orchestrated during adipocyte turnover. In this Review, we summarize our current understandings of each step in adipocyte turnover, discussing its key players and regulatory mechanisms.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"147-160"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards the recognition of oligogenic forms of type 2 diabetes. 认识 2 型糖尿病的低致病形式。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-07-01 DOI: 10.1016/j.tem.2024.06.006
Lauriane Le Collen, Philippe Froguel, Amélie Bonnefond
{"title":"Towards the recognition of oligogenic forms of type 2 diabetes.","authors":"Lauriane Le Collen, Philippe Froguel, Amélie Bonnefond","doi":"10.1016/j.tem.2024.06.006","DOIUrl":"10.1016/j.tem.2024.06.006","url":null,"abstract":"<p><p>The demarcation between monogenic and polygenic type 2 diabetes (T2D) is less distinct than previously believed. Notably, recent research has highlighted a new entity, that we suggest calling oligogenic forms of T2D, serving as a genetic link between these two forms. In this opinion article, we have reviewed scientific advances that suggest categorizing genes involved in oligogenic T2D. Research focused on polygenic T2D has faced challenges in deepening our comprehension of the pathophysiology of T2D due to the inability to directly establish causal links between a signal and the molecular mechanisms underlying the disease. However, the study of oligogenic forms of T2D has illuminated distinct causal connections between genes and disease risk, thereby indicating potential new drug targets.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"109-117"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melatonin. 褪黑素
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-07-30 DOI: 10.1016/j.tem.2024.07.007
Gregory E Demas, Yuqi Han, Hannah F Fink
{"title":"Melatonin.","authors":"Gregory E Demas, Yuqi Han, Hannah F Fink","doi":"10.1016/j.tem.2024.07.007","DOIUrl":"10.1016/j.tem.2024.07.007","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"191-192"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unleashing metabolic power for axonal regeneration. 为轴突再生释放新陈代谢能量
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-07-27 DOI: 10.1016/j.tem.2024.07.001
Xiaoyan Yang, Bing Zhou
{"title":"Unleashing metabolic power for axonal regeneration.","authors":"Xiaoyan Yang, Bing Zhou","doi":"10.1016/j.tem.2024.07.001","DOIUrl":"10.1016/j.tem.2024.07.001","url":null,"abstract":"<p><p>Axon regeneration requires the mobilization of intracellular resources, including proteins, lipids, and nucleotides. After injury, neurons need to adapt their metabolism to meet the biosynthetic demands needed to achieve axonal regeneration. However, the exact contribution of cellular metabolism to this process remains elusive. Insights into the metabolic characteristics of proliferative cells may illuminate similar mechanisms operating in axon regeneration; therefore, unraveling previously unappreciated roles of metabolic adaptation is critical to achieving neuron regrowth, which is connected to the therapeutic strategies for neurological conditions necessitating nerve repairs, such as spinal cord injury and stroke. Here, we outline the metabolic role in axon regeneration and discuss factors enhancing nerve regrowth, highlighting potential novel metabolic treatments for restoring nerve function.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"161-175"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Standardizing methodologies to study microplastics and nanoplastics in cardiovascular diseases. 研究心血管疾病中的微塑料和纳米塑料的标准化方法。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-08 DOI: 10.1016/j.tem.2024.07.013
Yilin Pan, Suowen Xu, Xiubin Yang
{"title":"Standardizing methodologies to study microplastics and nanoplastics in cardiovascular diseases.","authors":"Yilin Pan, Suowen Xu, Xiubin Yang","doi":"10.1016/j.tem.2024.07.013","DOIUrl":"10.1016/j.tem.2024.07.013","url":null,"abstract":"<p><p>Microplastics and nanoplastics (MNPs) are being recognized as new cardiovascular risk factors, impacting vascular cell functions and exacerbating atherosclerosis through diverse mechanisms. However, the varied concentrations of MNPs detected in major cardiovascular tissues highlight the urgent need for standardized research methodologies to better understand their impact and inform future health guidelines.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"105-108"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New anti-inflammatory mechanism of glucocorticoids uncovered. 糖皮质激素抗炎新机制揭秘
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-02-01 Epub Date: 2024-08-23 DOI: 10.1016/j.tem.2024.08.003
Carolyn L Cummins, Ido Goldstein
{"title":"New anti-inflammatory mechanism of glucocorticoids uncovered.","authors":"Carolyn L Cummins, Ido Goldstein","doi":"10.1016/j.tem.2024.08.003","DOIUrl":"10.1016/j.tem.2024.08.003","url":null,"abstract":"<p><p>Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"99-101"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palmitate. 棕榈酸酯。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-20 DOI: 10.1016/j.tem.2025.01.001
Atrayee Gope, Claudio Mauro
{"title":"Palmitate.","authors":"Atrayee Gope, Claudio Mauro","doi":"10.1016/j.tem.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.tem.2025.01.001","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucagon-like peptide-1. Glucagon-like peptide-1。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-01-15 DOI: 10.1016/j.tem.2024.12.011
Darleen A Sandoval
{"title":"Glucagon-like peptide-1.","authors":"Darleen A Sandoval","doi":"10.1016/j.tem.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.tem.2024.12.011","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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