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Gonadotropin-releasing hormone. 促性腺激素释放激素。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-11-01 DOI: 10.1016/j.tem.2024.10.003
Miguel Ruiz-Cruz, Juan Roa, Manuel Tena-Sempere
{"title":"Gonadotropin-releasing hormone.","authors":"Miguel Ruiz-Cruz, Juan Roa, Manuel Tena-Sempere","doi":"10.1016/j.tem.2024.10.003","DOIUrl":"10.1016/j.tem.2024.10.003","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"495-496"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing diabetes across female reproductive stages. 管理女性生育阶段的糖尿病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1016/j.tem.2025.02.003
Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal
{"title":"Managing diabetes across female reproductive stages.","authors":"Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal","doi":"10.1016/j.tem.2025.02.003","DOIUrl":"10.1016/j.tem.2025.02.003","url":null,"abstract":"<p><p>Hormonal fluctuations across the female reproductive lifespan lead to physiological adjustments that impact insulin sensitivity and glucose metabolism, generating unique challenges in diabetes management. Although current guidelines focus primarily on diabetes care during pregnancy, they lack tailored recommendations for addressing glycaemic variability associated with menstrual cycles, contraceptive needs, and menopause. Low rates of prepregnancy counselling, limited contraceptive guidance, and underuse of hormone replacement therapy further complicate care for women with diabetes. Here we examine these care gaps, identify unmet needs across reproductive stages, and suggest research directions to develop comprehensive, stage-specific management strategies that better support women's health and improve diabetes outcomes throughout the reproductive years.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"403-417"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic inheritance of PCOS by developmental programming and germline transmission. 多囊卵巢综合征的发育规划和种系遗传。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-12-27 DOI: 10.1016/j.tem.2024.12.002
Elisabet Stener-Victorin, Qiaolin Deng
{"title":"Epigenetic inheritance of PCOS by developmental programming and germline transmission.","authors":"Elisabet Stener-Victorin, Qiaolin Deng","doi":"10.1016/j.tem.2024.12.002","DOIUrl":"10.1016/j.tem.2024.12.002","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder, affecting approximately 11-13% of women of reproductive age. Women with PCOS experience a higher prevalence of infertility, pregnancy complications, and cardiometabolic disorders such as obesity, insulin resistance, and type 2 diabetes mellitus. Furthermore, psychiatric comorbidities, including depression and anxiety, significantly impact the quality of life in this population. Although obesity exacerbates these health risks, the exact etiology and pathophysiology of PCOS remain complex and only partially understood. Emerging research suggests potential transgenerational inheritance through genetic and epigenetic mechanisms, highlighting the possibility of PCOS-related risks affecting subsequent generations, including sons. This review synthesizes recent findings on PCOS inheritance patterns and underscores areas for future clinical and research exploration.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"472-481"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses. 妊娠诱导的新陈代谢重编程和对促衰老压力的再生反应。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-08-08 DOI: 10.1016/j.tem.2024.07.011
Dainan Yu, Lanfang Luo, Hongmei Wang, Ng Shyh-Chang
{"title":"Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses.","authors":"Dainan Yu, Lanfang Luo, Hongmei Wang, Ng Shyh-Chang","doi":"10.1016/j.tem.2024.07.011","DOIUrl":"10.1016/j.tem.2024.07.011","url":null,"abstract":"<p><p>Pregnancy is associated with physiological adaptations that affect virtually all organs, enabling the mother to support the growing fetus and placenta while withstanding the demands of pregnancy. As a result, mammalian pregnancy is a unique state that exerts paradoxical effects on maternal health. On one hand, the metabolic stress induced by pregnancy can accelerate aging and functional decline in organs. On the other hand, pregnancy activates metabolic programming and tissue regenerative responses that can reverse age-related impairments. In this sense, the oocyte-to-blastocyst transition is not the only physiological reprogramming event in the mammalian body, as pregnancy-induced regeneration could constitute a second physiological reprogramming event. Here, we review findings on how pregnancy dualistically leads to aging and rejuvenation in the maternal body.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"482-494"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is cardiovascular disease in PCOS driven by MASLD? 多囊卵巢综合征的心血管疾病是由 MASLD 引起的吗？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-05-01 Epub Date: 2024-11-07 DOI: 10.1016/j.tem.2024.10.005
Huadong Chen, Pomme I H G Simons, Martijn C G J Brouwers
{"title":"Is cardiovascular disease in PCOS driven by MASLD?","authors":"Huadong Chen, Pomme I H G Simons, Martijn C G J Brouwers","doi":"10.1016/j.tem.2024.10.005","DOIUrl":"10.1016/j.tem.2024.10.005","url":null,"abstract":"<p><p>Recent genetic studies have implicated an active role for intrahepatic lipid accumulation in the pathogenesis of both polycystic ovary syndrome (PCOS) and cardiovascular disease. These new insights may provide novel (non)pharmacological opportunities for the prevention and treatment of PCOS and cardiovascular disease at both the societal and clinical level.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"389-391"},"PeriodicalIF":11.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crotonyl-coenzyme A (crotonyl-CoA). crotonyl-辅酶A (crotonyl-CoA)。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-04-10 DOI: 10.1016/j.tem.2025.03.004
Yu Wang, Hou-Zao Chen, Xiaoqiang Tang
{"title":"Crotonyl-coenzyme A (crotonyl-CoA).","authors":"Yu Wang, Hou-Zao Chen, Xiaoqiang Tang","doi":"10.1016/j.tem.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.tem.2025.03.004","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver-expressed antimicrobial peptide 2 (LEAP2). 肝脏表达的抗菌肽2 （LEAP2）。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-04-09 DOI: 10.1016/j.tem.2025.03.005
María F Andreoli, Pablo N De Francesco, Mario Perelló
{"title":"Liver-expressed antimicrobial peptide 2 (LEAP2).","authors":"María F Andreoli, Pablo N De Francesco, Mario Perelló","doi":"10.1016/j.tem.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.tem.2025.03.005","url":null,"abstract":"","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating cancer medicine into metabolic rhythms. 将癌症药物与代谢节律结合起来。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-04-07 DOI: 10.1016/j.tem.2025.03.007
Keyu Su, Deshun Zeng, Weiru Zhang, Fei Peng, Bai Cui, Quentin Liu
{"title":"Integrating cancer medicine into metabolic rhythms.","authors":"Keyu Su, Deshun Zeng, Weiru Zhang, Fei Peng, Bai Cui, Quentin Liu","doi":"10.1016/j.tem.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.tem.2025.03.007","url":null,"abstract":"<p><p>Circadian rhythms are cell-intrinsic time-keeping mechanisms that allow organisms to adapt to 24-h environmental changes, ensuring coordinated physiological functions by aligning internal metabolic oscillations with external timing cues. Disruption of daily metabolic rhythms is associated with pathological events such as cancer development, yet the mechanisms by which perturbed metabolic rhythms contribute to tumorigenesis remain unclear. Herein we review how circadian clocks drive balanced rhythmic metabolism which in turn governs physiological functions of locomotor, immune, and neuroendocrine systems. Misaligned metabolic rhythms cause pathological states which further drive cancer initiation, progression, and metastasis. Restoring the balance of metabolic rhythms with chemical, hormonal, and behavioral interventions serves as a promising strategy for cancer therapy.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can kisspeptin be a new treatment for sexual dysfunction? kisspeptin能成为治疗性功能障碍的新方法吗？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-04-05 DOI: 10.1016/j.tem.2025.03.002
Julie Bakker
{"title":"Can kisspeptin be a new treatment for sexual dysfunction?","authors":"Julie Bakker","doi":"10.1016/j.tem.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.tem.2025.03.002","url":null,"abstract":"<p><p>The neuropeptide kisspeptin activates the hypothalamic-pituitary-gonadal (HPG) axis and influences neural circuits controlling sexual behavior. Animal studies have determined its sex-specific roles in reproductive behaviors, whereas human research has linked kisspeptin to increased brain activity in regions associated with sexual and emotional processing, making it a potential treatment for disorders of sexual desire. Here I discuss the current evidence on the promise of kisspeptin as a therapy for sexual dysfunction, highlight the challenges currently hindering its application, and advocate future studies focusing on sex-specific effects and interactions within the neuroendocrine system. Understanding its broader physiological roles and improving delivery methods will be key to unlocking kisspeptin's therapeutic potential.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shaping the future of youth-onset type 2 diabetes: a call to action. 塑造青年2型糖尿病的未来：行动呼吁。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2025-04-04 DOI: 10.1016/j.tem.2025.03.003
Amy S Shah, Megan M Kelsey, Risa M Wolf, Kristen J Nadeau
{"title":"Shaping the future of youth-onset type 2 diabetes: a call to action.","authors":"Amy S Shah, Megan M Kelsey, Risa M Wolf, Kristen J Nadeau","doi":"10.1016/j.tem.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.tem.2025.03.003","url":null,"abstract":"<p><p>Youth-onset type 2 diabetes (YO-T2D) is an urgent public health challenge that demands immediate and innovative action. The devastating trajectory of this disease - from rapid β-cell decline to early complications and poor responses to medications - compels us to rethink our approach. Here, we argue that by investing in targeted research to unravel the unique mechanisms of this condition, ensuring equitable access to cutting-edge clinical trials, and building clinical care models tailored specifically for youth, we can rewrite the narrative for these at-risk youth.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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