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MCU genetically altered mice suggest how mitochondrial Ca2+ regulates metabolism. MCU 基因改变小鼠表明线粒体 Ca2+ 如何调节新陈代谢。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-04-29 DOI: 10.1016/j.tem.2024.04.005
Jiuzhou Huo, Jeffery D Molkentin
{"title":"MCU genetically altered mice suggest how mitochondrial Ca<sup>2+</sup> regulates metabolism.","authors":"Jiuzhou Huo, Jeffery D Molkentin","doi":"10.1016/j.tem.2024.04.005","DOIUrl":"10.1016/j.tem.2024.04.005","url":null,"abstract":"<p><p>Skeletal muscle has a major impact on total body metabolism and obesity, and is characterized by dynamic regulation of substrate utilization. While it is accepted that acute increases in mitochondrial matrix Ca<sup>2+</sup> increase carbohydrate usage to augment ATP production, recent studies in mice with deleted genes for components of the mitochondrial Ca<sup>2+</sup> uniporter (MCU) complex have suggested a more complicated regulatory scenario. Indeed, mice with a deleted Mcu gene in muscle, which lack acute mitochondrial Ca<sup>2+</sup> uptake, have greater fatty acid oxidation (FAO) and less adiposity. By contrast, mice deleted for the inhibitory Mcub gene in skeletal muscle, which have greater acute mitochondrial Ca<sup>2+</sup> uptake, antithetically display reduced FAO and progressive obesity. In this review we discuss the emerging concept that dynamic fluxing of mitochondrial matrix Ca<sup>2+</sup> regulates metabolism.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"918-928"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is mitochondrial morphology important for cellular physiology? 线粒体形态对细胞生理学重要吗？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-06-11 DOI: 10.1016/j.tem.2024.05.005
Timothy Wai
{"title":"Is mitochondrial morphology important for cellular physiology?","authors":"Timothy Wai","doi":"10.1016/j.tem.2024.05.005","DOIUrl":"10.1016/j.tem.2024.05.005","url":null,"abstract":"<p><p>Mitochondria are double membrane-bound organelles the network morphology of which in cells is shaped by opposing events of fusion and fission executed by dynamin-like GTPases. Mutations in these genes can perturb the form and functions of mitochondria in cell and animal models of mitochondrial diseases. An expanding array of chemical, mechanical, and genetic stressors can converge on mitochondrial-shaping proteins and disrupt mitochondrial morphology. In recent years, studies aimed at disentangling the multiple roles of mitochondrial-shaping proteins beyond fission or fusion have provided insights into the homeostatic relevance of mitochondrial morphology. Here, I review the pleiotropy of mitochondrial fusion and fission proteins with the aim of understanding whether mitochondrial morphology is important for cell and tissue physiology.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"854-871"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interorganelle phospholipid communication, a house not so divided. 细胞器间的磷脂交流，一个不那么分裂的房子。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-10-01 Epub Date: 2024-07-06 DOI: 10.1016/j.tem.2024.06.008
Richard G Lee, Danielle L Rudler, Oliver Rackham, Aleksandra Filipovska
{"title":"Interorganelle phospholipid communication, a house not so divided.","authors":"Richard G Lee, Danielle L Rudler, Oliver Rackham, Aleksandra Filipovska","doi":"10.1016/j.tem.2024.06.008","DOIUrl":"10.1016/j.tem.2024.06.008","url":null,"abstract":"<p><p>The presence of membrane-bound organelles with specific functions is one of the main hallmarks of eukaryotic cells. Organelle membranes are composed of specific lipids that govern their function and interorganelle communication. Discoveries in cell biology using imaging and omic technologies have revealed the mechanisms that drive membrane remodeling, organelle contact sites, and metabolite exchange. The interplay between multiple organelles and their interdependence is emerging as the next frontier for discovery using 3D reconstruction of volume electron microscopy (vEM) datasets. We discuss recent findings on the links between organelles that underlie common functions and cellular pathways. Specifically, we focus on the metabolism of ether glycerophospholipids that mediate organelle dynamics and their communication with each other, and the new imaging techniques that are powering these discoveries.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"872-883"},"PeriodicalIF":11.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connecting precision nutrition with the Food is Medicine approach. 将精准营养与 "食物即医学 "方法联系起来。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-27 DOI: 10.1016/j.tem.2024.08.012
Srishti Sinha, Samantha L Huey, Alpana P Shukla, Rebecca Kuriyan, Julia L Finkelstein, Saurabh Mehta
{"title":"Connecting precision nutrition with the Food is Medicine approach.","authors":"Srishti Sinha, Samantha L Huey, Alpana P Shukla, Rebecca Kuriyan, Julia L Finkelstein, Saurabh Mehta","doi":"10.1016/j.tem.2024.08.012","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.012","url":null,"abstract":"<p><p>Two initiatives are reshaping how we can approach and address the persistent and widely prevalent challenge of malnutrition, the leading global risk factor for morbidity and mortality. First is the focus on precision nutrition to identify inter- and intra-individual variation in our responses to diet, and its determinants. Second is the Food is Medicine (FIM) approach, an umbrella term for programs and services that link nutrition and health through the provision of food (e.g., tailored meals, produce prescriptions) and access to healthcare services. This article outlines how interventions and programs using FIM can synergize with precision nutrition approaches to make individual- or population-level tailored nutrition accessible and affordable, help to reduce the risk of metabolic diseases, and improve quality of life.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moving from helicopter research to proximity research and capacity building. 从直升机研究转向近距离研究和能力建设。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-19 DOI: 10.1016/j.tem.2024.08.011
Fannie Lajeunesse-Trempe, Marie-Ève Piché, Lydia Kaduka, Juan Ricardo Lopez Y Taylor, René Crocker Sagastume
{"title":"Moving from helicopter research to proximity research and capacity building.","authors":"Fannie Lajeunesse-Trempe, Marie-Ève Piché, Lydia Kaduka, Juan Ricardo Lopez Y Taylor, René Crocker Sagastume","doi":"10.1016/j.tem.2024.08.011","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.011","url":null,"abstract":"<p><p>Health funding agencies are increasingly prioritizing equity, diversity, and inclusion (EDI) strategies. This shift, while essential, can inadvertently lead to 'helicopter research', especially among junior researchers, due to insufficient institutional support. We warn against such unethical practices and propose strategies for academia and funding bodies to address them.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How purine metabolites impact reproduction. 嘌呤代谢物如何影响生殖。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-12 DOI: 10.1016/j.tem.2024.08.010
Sifan Rong, Yixuan Fu, Yue Zhao, Wencheng Zhu, Liangshan Mu
{"title":"How purine metabolites impact reproduction.","authors":"Sifan Rong, Yixuan Fu, Yue Zhao, Wencheng Zhu, Liangshan Mu","doi":"10.1016/j.tem.2024.08.010","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.010","url":null,"abstract":"<p><p>Purine metabolism is one of the core biochemical processes essential for cell survival and function. During development, purines are involved in germ cell development, ovarian function, and pregnancy outcomes. Here, we discuss the relationships between purine metabolism and reproductive health, offering insights into the future directions of the field.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbes put drugs in(action). 微生物让药物发挥作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-03 DOI: 10.1016/j.tem.2024.08.005
Jennifer van der Laan, Filipe Cabreiro
{"title":"Microbes put drugs in(action).","authors":"Jennifer van der Laan, Filipe Cabreiro","doi":"10.1016/j.tem.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.005","url":null,"abstract":"<p><p>Interactions between the gut microbiome, nutrients, drugs, and host physiology are inherently complex. Gut microbes contribute significantly towards host homeostasis and can modulate host-targeted drugs, affecting therapeutic outcomes. Finding ways to harness the gut microbiome to improve drug efficacy can be a promising strategy to advance precision medicine.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new clinical age of aging research. 老龄化研究的临床新时代。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-02 DOI: 10.1016/j.tem.2024.08.004
Zhen Zhang, Renlei Yang, Zhike Zi, Baohua Liu
{"title":"A new clinical age of aging research.","authors":"Zhen Zhang, Renlei Yang, Zhike Zi, Baohua Liu","doi":"10.1016/j.tem.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.004","url":null,"abstract":"<p><p>Aging is a major risk factor for a variety of diseases, thus, translation of aging research into practical applications is driven by the unmet need for existing clinical therapeutic options. Basic and translational research efforts are converging at a critical stage, yielding insights into how fundamental aging mechanisms are used to identify promising geroprotectors or therapeutics. This review highlights several research areas from a clinical perspective, including senescent cell targeting, alleviation of inflammaging, and optimization of metabolism with endogenous metabolites or precursors. Refining our understanding of these key areas, especially from the clinical angle, may help us to better understand and attenuate aging processes and improve overall health outcomes.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The direct targets of metformin in diabetes and beyond. 二甲双胍在糖尿病及其他疾病中的直接靶点。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-02 DOI: 10.1016/j.tem.2024.07.017
Luxia Yao, Lei Wang, Runshuai Zhang, Alexander A Soukas, Lianfeng Wu
{"title":"The direct targets of metformin in diabetes and beyond.","authors":"Luxia Yao, Lei Wang, Runshuai Zhang, Alexander A Soukas, Lianfeng Wu","doi":"10.1016/j.tem.2024.07.017","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.017","url":null,"abstract":"<p><p>Metformin, an oral antihyperglycemic drug that has been in use for over 60 years, remains a first-line therapy for type 2 diabetes (T2D). Numerous studies have suggested that metformin promotes health benefits beyond T2D management, including weight loss, cancer prevention and treatment, and anti-aging, through several proposed mechanistic targets. Here we discuss the established effects of metformin and the progress made in identifying its direct targets. Additionally, we emphasize the importance of elucidating the structural bases of the drug and its direct targets. Ultimately, this review aims to highlight the current state of knowledge regarding metformin and its related emerging discoveries, while also outlining critical future research directions.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatic islet adaptation in pregnancy and postpartum. 胰岛在孕期和产后的适应性。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-05-01 DOI: 10.1016/j.tem.2024.04.007
Nelmari Ruiz-Otero, Jeffery S Tessem, Ronadip R Banerjee
{"title":"Pancreatic islet adaptation in pregnancy and postpartum.","authors":"Nelmari Ruiz-Otero, Jeffery S Tessem, Ronadip R Banerjee","doi":"10.1016/j.tem.2024.04.007","DOIUrl":"10.1016/j.tem.2024.04.007","url":null,"abstract":"<p><p>Pancreatic islets, particularly insulin-producing β-cells, are central regulators of glucose homeostasis capable of responding to a variety of metabolic stressors. Pregnancy is a unique physiological stressor, necessitating the islets to adapt to the complex interplay of maternal and fetal-placental factors influencing the metabolic milieu. In this review we highlight studies defining gestational adaptation mechanisms within maternal islets and emerging studies revealing islet adaptations during the early postpartum and lactation periods. These include adaptations in both β and in 'non-β' islet cells. We also discuss insights into how gestational and postpartum adaptation may inform pregnancy-specific and general mechanisms of islet responses to metabolic stress and contribute to investigation of gestational diabetes.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"834-847"},"PeriodicalIF":11.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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