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Pediatric thyroid side effects of immune checkpoint inhibitors. 免疫检查点抑制剂对小儿甲状腺的副作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-04-17 DOI: 10.1016/j.tem.2024.04.002
Cesare Morgante, Alessandra Fierabracci, Armando Grossi
{"title":"Pediatric thyroid side effects of immune checkpoint inhibitors.","authors":"Cesare Morgante, Alessandra Fierabracci, Armando Grossi","doi":"10.1016/j.tem.2024.04.002","DOIUrl":"10.1016/j.tem.2024.04.002","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) are associated with multiple endocrine side effects, including thyroid disfunctions. In addition, the efficacy and safety profiles of ICIs in the pediatric population need clarification. Here, we discuss the main evidence regarding the efficacy and thyroid toxicities of ICIs in children.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"765-768"},"PeriodicalIF":11.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the endotoxin-complement cascade the major driver in lipedema? 内毒素-补体级联是脂肪性水肿的主要驱动因素吗？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-04-29 DOI: 10.1016/j.tem.2024.04.004
Ilja L Kruglikov, Philipp E Scherer
{"title":"Is the endotoxin-complement cascade the major driver in lipedema?","authors":"Ilja L Kruglikov, Philipp E Scherer","doi":"10.1016/j.tem.2024.04.004","DOIUrl":"10.1016/j.tem.2024.04.004","url":null,"abstract":"<p><p>Lipedema is a poorly understood disorder of adipose tissue characterized by abnormal but symmetrical deposition of subcutaneous white adipose tissue (WAT) in proximal extremities. Here, we propose that the underlying cause for lipedema could be triggered by a selective accumulation of bacterial lipopolysaccharides (LPS; also known as endotoxin) in gluteofemoral WAT. Together with a malfunctioning complement system, this induces low-grade inflammation in the depot and raises its uncontrollable expansion. Correspondingly, more attention should be paid in future research to the endotoxemia prevalent in patients with lipedema. We would like to propose that proper management of endotoxemia can reduce the progression and even improve the state of disease in patients with lipedema.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"769-780"},"PeriodicalIF":11.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SIRTifying intestinal nucleotide metabolism. 肠道核苷酸代谢的 SIRT 化。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1016/j.tem.2024.07.003
Shweta Tiwary, Cristina D Guerena, Jenna L Jewell
{"title":"SIRTifying intestinal nucleotide metabolism.","authors":"Shweta Tiwary, Cristina D Guerena, Jenna L Jewell","doi":"10.1016/j.tem.2024.07.003","DOIUrl":"10.1016/j.tem.2024.07.003","url":null,"abstract":"<p><p>The intestine is a proliferative tissue subjected to a variety of stresses that disturb its homeostasis. A recent study by Tucker et al. demonstrated that loss of the tumor suppressor SIRT4 leads to increased cell proliferation via the de novo nucleotide biosynthesis pathway over the salvage pathway after ionizing irradiation (IR).</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"763-764"},"PeriodicalIF":11.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An orphan to the rescue of obesity and steatotic liver? 拯救肥胖症和脂肪肝的 "孤儿"？
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-06-29 DOI: 10.1016/j.tem.2024.06.012
Shanu Jain, Arun K Shukla
{"title":"An orphan to the rescue of obesity and steatotic liver?","authors":"Shanu Jain, Arun K Shukla","doi":"10.1016/j.tem.2024.06.012","DOIUrl":"10.1016/j.tem.2024.06.012","url":null,"abstract":"<p><p>In a recent article, Leeson-Payne et al. demonstrate that GPR75 knock-out in mice results in lower body fat and reduced hepatic lipid accumulation, with an increase in physical activity and energy expenditure. Loss-of-function (LoF) GPR75 variants in the UK Biobank (UKBB) are associated with reduced liver steatosis, suggesting potential therapeutic implications in metabolic dysfunction-associated steatotic liver disease (MASLD).</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"761-762"},"PeriodicalIF":11.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributions of white adipose tissue to energy requirements for female reproduction. 白色脂肪组织对雌性繁殖所需能量的贡献。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-05-14 DOI: 10.1016/j.tem.2024.04.012
Elizabeth S Anaya, Evelyn L de Groot, John P Lydon, Stephanie A Pangas, Sean M Hartig
{"title":"Contributions of white adipose tissue to energy requirements for female reproduction.","authors":"Elizabeth S Anaya, Evelyn L de Groot, John P Lydon, Stephanie A Pangas, Sean M Hartig","doi":"10.1016/j.tem.2024.04.012","DOIUrl":"10.1016/j.tem.2024.04.012","url":null,"abstract":"<p><p>Body composition impacts female fertility and there are established relationships between adipose tissue and the reproductive system. Maintaining functional adipose tissue is vital for meeting the energetic demands during the reproductive process, from ovulation to delivery and lactation. White adipose tissue (WAT) shows plastic responses to daily physiology and secretes diverse adipokines that affect the hypothalamic-pituitary-ovarian axis, but many other interorgan interactions remain to be determined. This review summarizes the current state of research on the dialogue between WAT and the female reproductive system, focusing on the impact of this crosstalk on ovarian and endometrial factors essential for fecundity.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"809-820"},"PeriodicalIF":11.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selenium, diabetes, and their intricate sex-specific relationship. 硒、糖尿病及其错综复杂的性别特异性关系。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-04-10 DOI: 10.1016/j.tem.2024.03.004
Kamil Demircan, Thilo Samson Chillon, Jeyoung Bang, Vadim N Gladyshev, Lutz Schomburg
{"title":"Selenium, diabetes, and their intricate sex-specific relationship.","authors":"Kamil Demircan, Thilo Samson Chillon, Jeyoung Bang, Vadim N Gladyshev, Lutz Schomburg","doi":"10.1016/j.tem.2024.03.004","DOIUrl":"10.1016/j.tem.2024.03.004","url":null,"abstract":"<p><p>Selenium (Se) is an essential trace element, which is inserted as selenocysteine (Sec) into selenoproteins during biosynthesis, orchestrating their expression and activity. Se is associated with both beneficial and detrimental health effects; deficient supply or uncontrolled supplementation raises concerns. In particular, Se was associated with an increased incidence of type 2 diabetes (T2D) in a secondary analysis of a randomized controlled trial (RCT). In this review, we discuss the intricate relationship between Se and diabetes and the limitations of the available clinical and experimental studies. Recent evidence points to sexual dimorphism and an association of Se deficiency with gestational diabetes mellitus (GDM). We highlight the emerging evidence linking high Se status with improved prognosis in patients with T2D and lower risk of macrovascular complications.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"781-792"},"PeriodicalIF":11.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intermittent fasting influences immunity and metabolism. 间歇性禁食会影响免疫力和新陈代谢。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-05-08 DOI: 10.1016/j.tem.2024.04.014
Daniel M Marko, Meghan O Conn, Jonathan D Schertzer
{"title":"Intermittent fasting influences immunity and metabolism.","authors":"Daniel M Marko, Meghan O Conn, Jonathan D Schertzer","doi":"10.1016/j.tem.2024.04.014","DOIUrl":"10.1016/j.tem.2024.04.014","url":null,"abstract":"<p><p>Intermittent fasting (IF) modifies cell- and tissue-specific immunometabolic responses that dictate metabolic flexibility and inflammation during obesity and type 2 diabetes (T2D). Fasting forces periods of metabolic flexibility and necessitates increased use of different substrates. IF can lower metabolic inflammation and improve glucose metabolism without lowering obesity and can influence time-dependent, compartmentalized changes in immunity. Liver, adipose tissue, skeletal muscle, and immune cells communicate to relay metabolic and immune signals during fasting. Here we review the connections between metabolic and immune cells to explain the divergent effects of IF compared with classic caloric restriction (CR) strategies. We also explore how the immunometabolism of metabolic diseases dictates certain IF outcomes, where the gut microbiota triggers changes in immunity and metabolism during fasting.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"821-833"},"PeriodicalIF":11.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte involvement in metabolic regulation and disease. 星形胶质细胞参与新陈代谢调节和疾病。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-29 DOI: 10.1016/j.tem.2024.08.001
Muhammad Naveed, Kathryn Smedlund, Qi-Gang Zhou, Weikang Cai, Jennifer W Hill
{"title":"Astrocyte involvement in metabolic regulation and disease.","authors":"Muhammad Naveed, Kathryn Smedlund, Qi-Gang Zhou, Weikang Cai, Jennifer W Hill","doi":"10.1016/j.tem.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.001","url":null,"abstract":"<p><p>Astrocytes, the predominant glial cell type in the mammalian brain, influence a wide variety of brain parameters including neuronal energy metabolism. Exciting recent studies have shown that obesity and diabetes can impact on astrocyte function. We review evidence that dysregulation of astrocytic lipid metabolism and glucose sensing contributes to dysregulation of whole-body energy balance, thermoregulation, and insulin sensitivity. In addition, we consider the overlooked topic of the sex-specific roles of astrocytes and their response to hormonal fluctuations that provide insights into sex differences in metabolic regulation. Finally, we provide an update on potential ways to manipulate astrocyte function, including genetic targeting, optogenetic and chemogenetic techniques, transplantation, and tailored exosome-based therapies, which may lead to improved treatments for metabolic disease.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging interactions between mitochondria and NAD+ metabolism in cardiometabolic diseases. 线粒体与 NAD+ 代谢之间在心脏代谢疾病中新出现的相互作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-27 DOI: 10.1016/j.tem.2024.07.010
Azadeh Nasuhidehnavi, Weronika Zarzycka, Ignacy Górecki, Ying Ann Chiao, Chi Fung Lee
{"title":"Emerging interactions between mitochondria and NAD<sup>+</sup> metabolism in cardiometabolic diseases.","authors":"Azadeh Nasuhidehnavi, Weronika Zarzycka, Ignacy Górecki, Ying Ann Chiao, Chi Fung Lee","doi":"10.1016/j.tem.2024.07.010","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.010","url":null,"abstract":"<p><p>Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is an essential coenzyme for redox reactions and regulates cellular catabolic pathways. An intertwined relationship exists between NAD<sup>+</sup> and mitochondria, with consequences for mitochondrial function. Dysregulation in NAD<sup>+</sup> homeostasis can lead to impaired energetics and increased oxidative stress, contributing to the pathogenesis of cardiometabolic diseases. In this review, we explore how disruptions in NAD<sup>+</sup> homeostasis impact mitochondrial function in various cardiometabolic diseases. We discuss emerging studies demonstrating that enhancing NAD<sup>+</sup> synthesis or inhibiting its consumption can ameliorate complications of this family of pathological conditions. Additionally, we highlight the potential role and therapeutic promise of mitochondrial NAD<sup>+</sup> transporters in regulating cellular and mitochondrial NAD<sup>+</sup> homeostasis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unexpected role of GIP in transforming obesity treatment. GIP 在改变肥胖症治疗方面发挥了意想不到的作用。
IF 11.4 1区 医学
Trends in Endocrinology and Metabolism Pub Date : 2024-08-27 DOI: 10.1016/j.tem.2024.07.022
Inuk Zandvakili, Diego Perez-Tilve
{"title":"The unexpected role of GIP in transforming obesity treatment.","authors":"Inuk Zandvakili, Diego Perez-Tilve","doi":"10.1016/j.tem.2024.07.022","DOIUrl":"https://doi.org/10.1016/j.tem.2024.07.022","url":null,"abstract":"<p><p>Despite sharing incretin activity with glucagon-like peptide 1 (GLP-1), the development of gastric inhibitory polypeptide (GIP)-based drugs has been hindered by the minor effects of native GIP on appetite and body weight and genetic studies associating loss-of-function with reduced obesity. Yet, pharmacologically optimized GIP-based molecules have demonstrated profound weight lowering benefits of GIPR agonism when combined with GLP-1-based therapies, which has re-energized deeper exploration of the molecular mechanisms and downstream signaling of GIPR. Interestingly, both GIPR agonism and antagonism offer metabolic benefits, leading to differing viewpoints on how to target GIPR therapeutically. Here we summarize the emerging evidence about the tissue-specific mechanisms that positions GIP-based therapies as important targets for the next generation of anti-obesity and metabolic therapies.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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