Journal of the Pakistan Medical Association最新文献_第6页

Making semaglutide accessible in Pakistan: A crucial step for heart failure treatment.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.21483

Saqib Sattar, Khansa Sattar, Rahman Tanveer

引用次数: 0

Time to broaden pharmacological treatment of cardiovascular disorders with physiological dimensions of Adropin.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.20691

Sana Akhlaq

{"title":"Time to broaden pharmacological treatment of cardiovascular disorders with physiological dimensions of Adropin.","authors":"Sana Akhlaq","doi":"10.47391/JPMA.20691","DOIUrl":"https://doi.org/10.47391/JPMA.20691","url":null,"abstract":"Adropin, an emerging substance hailed for its heartprotective potential, presents a promising avenue for combating cardiovascular ailments. The current narrative review was planned to underscore its link with metabolic syndrome and its role in preventing ischaemic heart disease, accentuating its multifaceted impact on metabolism and cardiac wellbeing. Mechanistically, it operates through diverse pathways, including modulation of endothelial nitric oxide synthase, antiapoptotic properties, and regulation of pyruvate dehydrogenase phosphorylation to boost cellular energy production and mitochondrial function. Furthermore, its interactions with cellular receptors, signalling cascades and metabolic regulators unveil its prowess in mitigating cardiovascular risks and enhancing glycaemic control. To transition adropin from bench to bedside, rigorous human trials are imperative, encompassing dose optimisation, long-term safety assessments, and exploration of genetic influences. Inclusive research targetting diverse populations, especially high-risk cohorts, is advocated to unravel its full therapeutic potential. Interdisciplinary collaboration is pivotal for unravelling its mechanisms as a targetted therapy for cardiovascular disorders.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 2","pages":"275-284"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waiting areas in tertiary-care hospitals in Pakistan, a major risk for airborne infections.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.21321

Muhammad Shahwaiz Lund, Muhammad Uzair Ishaq, Moeen Nawaz

引用次数: 0

Is Depression Dialyzable?

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.25-13

Sourabh Sharma, Sanjay Sanjay

引用次数: 0

Bibliometric analysis of the impacts of COVID-19 on the mental health of college students.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.11284

Jianxiang Tian, Huilin Khan, Linshu Luo, Libo Dai, Junyu Pan

引用次数: 0

Professional consensus on orthodontic risks: what orthodontists should tell their patients. A cross-sectional study at Saidu college of dentistry, Swat.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.11372

Erum Behroz Khan, Huda Ghaffar, Neelam Shah Jehan, Muhammad Zaheen, Tufail Muhammad, Ali Raza Jafri

{"title":"Professional consensus on orthodontic risks: what orthodontists should tell their patients. A cross-sectional study at Saidu college of dentistry, Swat.","authors":"Erum Behroz Khan, Huda Ghaffar, Neelam Shah Jehan, Muhammad Zaheen, Tufail Muhammad, Ali Raza Jafri","doi":"10.47391/JPMA.11372","DOIUrl":"https://doi.org/10.47391/JPMA.11372","url":null,"abstract":"The importance of transparent communication regarding orthodontic risks during the informed consent process in paramount in terms of ensuring a strong orthodontistpatient relationship. Conducted on a national scale in Pakistan, the current study was planned to establish a consensus among orthodontic professionals regarding critical risks involved in such a discussion. The crosssectional survey involving 132 orthodontists across Pakistan led to the emergence of 10 key risks, including relapse, treatment duration and gingivitis. However, the study's sole focus on orthodontists' perspectives limited its insights, overlooking invaluable input from patients' experiences. Nevertheless, the consensus underscored the significance of addressing these risks to ensure informed consent and patient autonomy. Going forward, it is imperative to customise this evidence-based information according to individual patient needs, and maintain an ongoing dialogue regarding potential risks, fostering a collaborative approach to orthodontic care and decision-making.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 2","pages":"293-296"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Importance of early transfer to higher levels of in-patient care - an experience from a lower-middle-income country.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.10971

Huzefa Jibril, Syed Ahsan Ali, Safia Awan, Muhammad Tariq

{"title":"Importance of early transfer to higher levels of in-patient care - an experience from a lower-middle-income country.","authors":"Huzefa Jibril, Syed Ahsan Ali, Safia Awan, Muhammad Tariq","doi":"10.47391/JPMA.10971","DOIUrl":"https://doi.org/10.47391/JPMA.10971","url":null,"abstract":"Objective: To ascertain the frequency of hospitalised internal medicine patients requiring escalation to a higher level of care, and in-hospital mortality in such cases.Methods: The prospective, observational study was conducted from September 1 to October 15, 2021 at a tertiary care hospital in Karachi, and comprised adult patients of either gender admitted to the internal medicine general wards and high dependency units. Data was collected prospectively using a proforma. Data was analysed using SPSS 23.Results: Of the 837 patients admitted, 617(73.7%) were included. There were 310(50.2%) females and 307(49.8%) males with mean age 52.2±18.8 years. The most common comorbidity was hypertension 288(46.7%). Of the 617 patients, 51(8.3%) required escalation to a higher level of care. Escalation to the intensive care unit and high dependency unit occurred in 19(37.3%) and 32(62.7%) patients, respectively. In-hospital mortality among patients who required escalation to the intensive care unit was 52.6%. In instances where the escalation was required within 48 hours of admission, in-hospital mortality was 8.3% (2/24), whereas, it was 40.7% (11/27) in cases when it was initiated beyond 48 hours of admission (p=0.010). The median length of hospital stay was also significantly lower when the escalation was initiated within 48 hours of admission 5 days (interquartile range: 4-7 days) compared to when it was delayed 13 days (interquartile range: 6-19 days) (p<0.001). The principal discharge diagnosis of sepsis was significantly associated with escalation to a higher level of care (p<0.001) and in-hospital mortality (p<0.001).Conclusions: Initiation of escalation to higher levels of care within 48 hours of admission was found to be associated with reduced in-hospital mortality and length of hospital stay.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 2","pages":"192-196"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thromboembolic event in a patient of immune thrombocytopenic purpura: a case report.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.10689

Maimoona Nazar, Nasir Ashraf, Laiba Sultan, Laiba Sultan

引用次数: 0

Misuse of sedative hypnotics: A call to awareness.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.21110

Ghazi Abdullah, Areesha Zafar

引用次数: 0

Effects of instrument assisted soft tissue mobilisation in patients with chronic mechanical low back pain----A randomized control trial.

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.11511

Sameera Gul, Sana Bashir, Nida Mushtaq Kayani, Zoha Sabir, Hafiza Qurat-Ul-Ain

{"title":"Effects of instrument assisted soft tissue mobilisation in patients with chronic mechanical low back pain----A randomized control trial.","authors":"Sameera Gul, Sana Bashir, Nida Mushtaq Kayani, Zoha Sabir, Hafiza Qurat-Ul-Ain","doi":"10.47391/JPMA.11511","DOIUrl":"https://doi.org/10.47391/JPMA.11511","url":null,"abstract":"Objective: To determine the effects of instrument-assisted soft tissue mobilisation compared to manual myofascial release in terms of managing pain, improving range of motion, and reducing disability in patients with chronic mechanical low back pain.Methods: The randomised controlled trial was conducted from July 2022 to July 2023 at the Foundation University College of Physical Therapy and Gul's Rehab Clinic, Rawalpindi, Pakistan, and comprised patients of either gender diagnosed with chronic mechanical low back pain. The patients were randomised into group A receiving manual myofascial release, and group B receiving instrument-assisted soft tissue mobilisation using long bar tool. The intervention lasted 9 sessions over 3 weeks. Data was analysed using SPSS 21.Results: Of the 50 participants 37(74%) were females and 13(26%) were males. The overall mean age was 25.1±6.9 years. There were 25(50%) patients in each group. Pain, lumbar range of motion, and lumbar disability improved significantly in both groups (p< 0.05). Intergroup difference was not significant (p>0.05).Conclusions: Manual myofascial release and instrument-assisted soft tissue mobilisation were equally effective in the treatment of chronic mechanical low back pain.Rct number: NCT05709925. https://classic.clinicaltrials.gov/.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 2","pages":"181-185"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0