Journal of the Pakistan Medical Association最新文献_第7页

68Ga-FAPI PET in detection of 18F-FDG PET Negative Cholangiocarcinoma: A Case Report on Alternative Molecular Imaging in Biliary Tract Malignancy. 68Ga-FAPI PET检测18F-FDG PET阴性胆管癌：胆道恶性肿瘤替代分子显像1例报告

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.25-58

Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Asiya Al Busaidi, Asim Jamal Shaikh

{"title":"68Ga-FAPI PET in detection of 18F-FDG PET Negative Cholangiocarcinoma: A Case Report on Alternative Molecular Imaging in Biliary Tract Malignancy.","authors":"Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Asiya Al Busaidi, Asim Jamal Shaikh","doi":"10.47391/JPMA.25-58","DOIUrl":"https://doi.org/10.47391/JPMA.25-58","url":null,"abstract":"Fibroblast activation protein inhibitors (FAPI) PET is a new imaging approach that targets the cell population in the tumour surrounding stroma, particularly cancer-associated fibroblasts, rather than tumour cells. 68Ga-FAPI PET/CT FAPI PET/CT provides better lesion characterisation due to a higher tumour-to-background ratio and exhibits high diagnostic accuracy, especially for cancers that exhibit low-to-moderate uptake of 18F-FDG. We report the case of a 77-year-old woman with known renal cell carcinoma treated ten years ago, and recently presented with cholangitis and a liver lesion. 18FDG PET-CT showed a mild hypermetabolic lesion at segment V. 68Ga-FAPI PET/CT was performed for further assessment. 68Ga-FAPI PET/CT demonstrates an intensely tracer avid lesion at hepatic segment V. These findings are likely due to primary cholangiocarcinoma. Biopsy confirms intrahepatic cholangiocarcinoma. 68Ga-FAPI PET/CT FAPI PET/CT provides better lesion characterization due to a higher tumor-to-background ratio and exhibits high diagnostic accuracy in cholangiocarcinomas.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 7","pages":"1151-1152"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal Barocrinology: The Interface between Obesity and Kidney Health. 肾脏气压学：肥胖和肾脏健康之间的接口。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.25-56

Sourabh Sharma, Sabine Karam, Nitin Kapoor, Sanjay Kalra

引用次数: 0

Tech strain: the musculoskeletal impact of electronic devices on young adults: A cross-sectional study. 技术应变：电子设备对年轻人肌肉骨骼的影响：一项横断面研究。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.22334

Mehwish Mehmood, Mehmood Rashid Khan, Aiesha Ishaque, Rabbia Tariq, Gulshan Himani

{"title":"Tech strain: the musculoskeletal impact of electronic devices on young adults: A cross-sectional study.","authors":"Mehwish Mehmood, Mehmood Rashid Khan, Aiesha Ishaque, Rabbia Tariq, Gulshan Himani","doi":"10.47391/JPMA.22334","DOIUrl":"https://doi.org/10.47391/JPMA.22334","url":null,"abstract":"Objectives: To determine the prevalence of upper extremity musculoskeletal disorders among young adults using handheld devices.Methods: The cross-sectional study was conducted from September 2022 to March 2023 at the Indus Hospital and Health Network, Karachi, and comprised young adults of either gender aged 18-25 years studying in the affiliated colleges of nursing, biomedicine and physiotherapy. Data was collected using the online RedCap questionnaire. Data was analysed using SPSS 26.Results: Of the 412 participants, 242(58.7%) were females. The overall median age was 21 years (interquartile range: 20-23 years). A total of 280(68%) subjects had experienced upper musculoskeletal pain, and it was significantly associated with the frequency of using handheld devices (p=0.026), gender (p=0.001), frequently used hand (p=0.039) and purpose of mobile use (p=0.033).Conclusions: Duration of cell phone or hand-held device usage caused symptoms of musculoskeletal disorders.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 7","pages":"1086-1090"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive Metabolic Medicine in Primary Care. 初级保健中的预防代谢医学。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.25-54

Tint Swe Latt, Madhur Verma, Nitin Kapoor, Sanjay Kalra

引用次数: 0

The Peptide Paradox in Pharmacology of Obesity. 肥胖药理学中的肽悖论。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.25-53

Sanjay Kalra, Amandeep Singh, Nitin Kapoor

引用次数: 0

Digital brVitamin K2: A promising new treatment for nocturnal leg cramps. 数字维生素K2：一种治疗夜间腿抽筋的新方法。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.23059

Aroosha Waheed, Arham Khalid

引用次数: 0

Exploring Sinomenine: New frontier in early brain injury treatment. 探索青藤碱：早期脑损伤治疗的新前沿。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.21490

Syeda Sana Tanveer, Ahsan Shabbir

引用次数: 0

Evaluating postoperative complications in radical cystectomy and ileal conduit for bladder cancer using the clavien-dindo grading system. 应用clavien-dindo分级系统评价膀胱癌根治性膀胱切除术和回肠导管术后并发症。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.11614

Shuah Ullah, Laraib Gul, Shariq Bin Yousuf, Bazgha Hassan, Tanzeel-Ur-Rahman Gazder, Asad Shahzad Hassan

{"title":"Evaluating postoperative complications in radical cystectomy and ileal conduit for bladder cancer using the clavien-dindo grading system.","authors":"Shuah Ullah, Laraib Gul, Shariq Bin Yousuf, Bazgha Hassan, Tanzeel-Ur-Rahman Gazder, Asad Shahzad Hassan","doi":"10.47391/JPMA.11614","DOIUrl":"10.47391/JPMA.11614","url":null,"abstract":"Objective: To determine the frequency of postoperative complications after radical cystectomy with ileal conduit surgery in patients diagnosed with urinary bladder cancer.Methods: This prospective observational study was conducted at the Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, from 30TH December 2019 to 30TH June 2020, following approval from the SIUT Ethics Review Board. The study comprised patients aged 25-70 years diagnosed with urinary bladder cancer who underwent elective radical cystectomy with ileal conduit. Complications were compared with respect to preoperative characteristics, such as disease stage, chemotherapy, radiotherapy, and intraoperative variables, like operation time, predicted blood loss, and the requirement for blood transfusion, as well as postoperative therapies. All postoperative complications occurring within a 60-day period were classified using the Clavien-Dindo grading system. Data was analysed using SPSS 22.Results: Of the 34 patients, 22(64.7%) were males and 12(35.3%) were females. The overall mean age was 51.00±12.84 years. Grade 0 complications were observed in 14(41.18%) patients, grade 1 13(28.24%), grade 2 3(8.82%), grade 3a 2(5.88%), and grade 4a 2(5.88%). The severity was significantly associated with female gender, preoperative irradiation, larger volume of blood loss, and the requirement of numerous transfusions (p<0.05).Conclusions: The early complications of radical cystectomy and urinary diversion had a substantial impact on the overall success of the procedure.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 7","pages":"1053-1057"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurofibromatosis type 2: A challenging case report and multidisciplinary management approach. 2型神经纤维瘤病：一个具有挑战性的病例报告和多学科管理方法。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.21415

Muhammad Usman, Syed Muhammad Salman Hassan, Maria Batool, Ramisha Chaudhary, Salman Ahmed Malik

引用次数: 0

Rare case of refractory hypokalaemia in a patient with acute myelomonocytic leukaemia (AML M4): A case report. 罕见的难治性低钾血症患者急性髓细胞白血病（AML M4）： 1例报告。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI: 10.47391/JPMA.21371

Sadia Shakeel, Muhammad Muneeb Khan, Adil Hussain Shah, Awais Waqar, Muhammad Bilal

{"title":"Rare case of refractory hypokalaemia in a patient with acute myelomonocytic leukaemia (AML M4): A case report.","authors":"Sadia Shakeel, Muhammad Muneeb Khan, Adil Hussain Shah, Awais Waqar, Muhammad Bilal","doi":"10.47391/JPMA.21371","DOIUrl":"https://doi.org/10.47391/JPMA.21371","url":null,"abstract":"A 39-year-old man, who was recently diagnosed with Acute Myelomonocytic Leukaemia (AML M4 subtype), presented at the Emergency Department of Ayub Teaching Hospital, Abbottabad, with all the common symptoms of AML, including anaemia, bleeding, and generalised weakness. What makes this case report interesting is the presence of severe refractory hypokalaemia. He was admitted to the Medical D unit of Ayub Teaching Hospital, Abbottabad, on January 14, 2024. His serum potassium remained low at 2.4mmol/L, (n=3.5-5.1 mmol/L) despite aggressive potassium replacement. Urinary electrolyte analysis showed renal potassium wasting, likely due to activation of the renin-angiotensin-aldosterone system (RAAS). Elevated serum renin levels supported this mechanism. In addition, the patient also had acute kidney injury and electrolyte abnormalities potentially caused by excessive lysozyme secretion by monocytes, as described in a prior case report. Refractory hypokalaemia in AML M4 is rare and has a poor prognosis. Early recognition and management of hypokalaemia is crucial to prevent complications and improve patient outcomes. This case highlights the importance of monitoring electrolytes and the need for further research on ideal management protocols for refractory hypokalaemia in AML M4.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 7","pages":"1125-1127"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0