Journal of the Pakistan Medical Association最新文献_第10页

Toripalimab: A new age in fighting Nasopharyngeal Carcinoma. 多利帕利单抗：对抗鼻咽癌的新时代。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.20757

Taha Ahmad Siddiqui, Aamrah Wakil, Maham Imran

引用次数: 0

Immunotherapy in Type 1 Diabetes: Emerging Therapies and Future Directions. 1型糖尿病的免疫治疗：新兴疗法和未来方向。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.25-10

Simran Thakkar, Saptarshi Bhattacharya, Lakshmi Nagendra, Sanjay Kalra

引用次数: 0

Short-term outcome of metabolic surgery versus intensive medical therapy among obese type 2 diabetics: a quasi-experimental study. 肥胖2型糖尿病患者代谢手术与强化药物治疗的短期疗效：一项准实验研究

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.10425

Zahra Raza, Muhammad Burhan Ul Haq, Tashfeen Imtiaz, Muhammad Adnan Khokhar, Aatif Inam

{"title":"Short-term outcome of metabolic surgery versus intensive medical therapy among obese type 2 diabetics: a quasi-experimental study.","authors":"Zahra Raza, Muhammad Burhan Ul Haq, Tashfeen Imtiaz, Muhammad Adnan Khokhar, Aatif Inam","doi":"10.47391/JPMA.10425","DOIUrl":"10.47391/JPMA.10425","url":null,"abstract":"Objective: To compare the short-term outcomes of metabolic surgery and intensive medical therapy in the management of diabetes mellitus among obese persons with type 2 diabetes mellitus.Methods: The quasi-experimental study was conducted at the Pakistan Institute of Medical Sciences, Islamabad, Pakistan, from March 2018 to February 2019, and comprised obese type 2 diabetes mellitus patients of either gender aged 20-65 years. Those undergoing metabolic and bariatric surgery were assigned group A, while those undergoing intensive medical therapy formed control group B. All patients were followed up for 6 months to monitor their metabolic profile, including body mass index, glycosylated haemoglobin and fasting plasma glucose. Data was analysed using SPSS 20.Results: Of the 72 patients, 36(50%) were in group A; 23(63.9%) females and 13(36.1%) males with mean age 41.2 ± 10.2 years. The remaining 36(50%) patients were in group B; 22(61.1%) males and 14(38.9%) females with mean age 42.5 ± 10.6 years (p>0.05). At 6 months, mean body mass index, glycosylated haemoglobin and fasting plasma glucose values were significantly lower in group A compared to group B (p<0.001). There were 33(91.7%) patients in group A with remission of diabetes compared to 1(2.8%) patients in group B (p<0.001).Conclusions: Bariatric surgery was found to produce a good early outcome in the management of diabetes in the obese population, leading to remission post-surgery.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 2","pages":"186-191"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential hip fracture early death predictors - a retrospective analysis from prospective trauma registry. 潜在的髋部骨折早期死亡预测因素——来自前瞻性创伤登记的回顾性分析。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.20102

Tashfeen Ahmad, Zehra Abdul Muhammad

{"title":"Potential hip fracture early death predictors - a retrospective analysis from prospective trauma registry.","authors":"Tashfeen Ahmad, Zehra Abdul Muhammad","doi":"10.47391/JPMA.20102","DOIUrl":"10.47391/JPMA.20102","url":null,"abstract":"Objective: To explore the blood pressure, fracture anatomical site, and age as potential predictors of death within 3 months after proximal femoral fracture management.Methods: The retrospective study was conducted from June 2015 and March 2020 at the Aga Khan University Hospital, Karachi and comprised orthopaedic trauma registry data of isolated proximal femur fracture patients managed between June 2015 and March 2020. Data of those who expired within 3 months of the management was pooled in group A, while data of those who survived >3 months post-treatment formed group B. Blood pressure at the time of hospital admission was considered normal at 90-120mmHg systolic and 60-80mmHg diastolic. Data was analysed using SPSS version 19.0.Results: Of the 242 patients, 9(3.7%) were in group A; 5(55.5%) males and 4(44.4%) females with median age 78 years (interquartile range: 7 years). There were 233(96.3%) patients in group B; 123(52.7%) females and 110(47.2%) males with median age 70 years (interquartile range: 17 years). In 12 months post-treatment, 16(6.6%) patients expired; 9(56.25%) in group A, and 7(43.75%) in group B. Age >75 years and femoral neck fractures had a significant positive relationship with death within 3 months of surgical management (p<0.05).Conclusion: Patients with femoral neck fracture and aged ≥75 years were found to be at the risk of death within 3 months post-management.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 2","pages":"249-254"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Making semaglutide accessible in Pakistan: A crucial step for heart failure treatment. 在巴基斯坦获得西马鲁肽：心脏衰竭治疗的关键一步。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.21483

Saqib Sattar, Khansa Sattar, Rahman Tanveer

引用次数: 0

Waiting areas in tertiary-care hospitals in Pakistan, a major risk for airborne infections. 巴基斯坦三级医院的候诊区是空气传播感染的主要风险。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.21321

Muhammad Shahwaiz Lund, Muhammad Uzair Ishaq, Moeen Nawaz

引用次数: 0

Professional consensus on orthodontic risks: what orthodontists should tell their patients. A cross-sectional study at Saidu college of dentistry, Swat. 关于正畸风险的专业共识：正畸医生应该告诉他们的病人什么。斯瓦特赛杜牙科学院的横断面研究。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.11372

Erum Behroz Khan, Huda Ghaffar, Neelam Shah Jehan, Muhammad Zaheen, Tufail Muhammad, Ali Raza Jafri

{"title":"Professional consensus on orthodontic risks: what orthodontists should tell their patients. A cross-sectional study at Saidu college of dentistry, Swat.","authors":"Erum Behroz Khan, Huda Ghaffar, Neelam Shah Jehan, Muhammad Zaheen, Tufail Muhammad, Ali Raza Jafri","doi":"10.47391/JPMA.11372","DOIUrl":"10.47391/JPMA.11372","url":null,"abstract":"The importance of transparent communication regarding orthodontic risks during the informed consent process in paramount in terms of ensuring a strong orthodontistpatient relationship. Conducted on a national scale in Pakistan, the current study was planned to establish a consensus among orthodontic professionals regarding critical risks involved in such a discussion. The crosssectional survey involving 132 orthodontists across Pakistan led to the emergence of 10 key risks, including relapse, treatment duration and gingivitis. However, the study's sole focus on orthodontists' perspectives limited its insights, overlooking invaluable input from patients' experiences. Nevertheless, the consensus underscored the significance of addressing these risks to ensure informed consent and patient autonomy. Going forward, it is imperative to customise this evidence-based information according to individual patient needs, and maintain an ongoing dialogue regarding potential risks, fostering a collaborative approach to orthodontic care and decision-making.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 2","pages":"293-296"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to broaden pharmacological treatment of cardiovascular disorders with physiological dimensions of Adropin. 是时候用Adropin的生理维度拓宽心血管疾病的药理学治疗了。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.20691

Sana Akhlaq

{"title":"Time to broaden pharmacological treatment of cardiovascular disorders with physiological dimensions of Adropin.","authors":"Sana Akhlaq","doi":"10.47391/JPMA.20691","DOIUrl":"10.47391/JPMA.20691","url":null,"abstract":"Adropin, an emerging substance hailed for its heartprotective potential, presents a promising avenue for combating cardiovascular ailments. The current narrative review was planned to underscore its link with metabolic syndrome and its role in preventing ischaemic heart disease, accentuating its multifaceted impact on metabolism and cardiac wellbeing. Mechanistically, it operates through diverse pathways, including modulation of endothelial nitric oxide synthase, antiapoptotic properties, and regulation of pyruvate dehydrogenase phosphorylation to boost cellular energy production and mitochondrial function. Furthermore, its interactions with cellular receptors, signalling cascades and metabolic regulators unveil its prowess in mitigating cardiovascular risks and enhancing glycaemic control. To transition adropin from bench to bedside, rigorous human trials are imperative, encompassing dose optimisation, long-term safety assessments, and exploration of genetic influences. Inclusive research targetting diverse populations, especially high-risk cohorts, is advocated to unravel its full therapeutic potential. Interdisciplinary collaboration is pivotal for unravelling its mechanisms as a targetted therapy for cardiovascular disorders.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 2","pages":"275-284"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Depression Dialyzable? 抑郁症是可以透析的吗？

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.25-13

Sourabh Sharma, Sanjay Sanjay

引用次数: 0

Thromboembolic event in a patient of immune thrombocytopenic purpura: a case report. 免疫性血小板减少性紫癜患者的血栓栓塞事件1例报告。

IF 0.8 4区医学

Journal of the Pakistan Medical Association Pub Date : 2025-02-01 DOI: 10.47391/JPMA.10689

Maimoona Nazar, Nasir Ashraf, Laiba Sultan, Laiba Sultan

引用次数: 0